1. Articles from Olga Roche

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    1. Oxygen-independent degradation of HIF- via bioengineered VHL tumour suppressor complex

      Tumour hypoxia promotes the accumulation of the otherwise oxygen-labile hypoxia-inducible factor (HIF)- subunit whose expression is associated with cancer progression, poor prognosis and resistance to conventional radiation and chemotherapy. The oxygen-dependent degradation of HIF- is carried out by the von Hippel-Lindau (VHL) protein-containing E3 that directly binds and ubiquitylates HIF- for subsequent proteasomal destruction. Thus, the cellular proteins involved in the VHL-HIF pathway have been recognized as attractive molecular targets for cancer therapy. However, the various compounds designed to inhibit HIF- or HIF-downstream targets, although promising, have shown limited success in the clinic. In the present study, we describe the ...
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  2. Topics in the News

    1. (1 articles) Ontario Cancer Institute
    2. (1 articles) University of Toronto
    3. (1 articles) FDA
    4. (1 articles) University of Rochester
    5. (1 articles) Notal Vision
    6. (1 articles) Topcon Medical Systems
    7. (1 articles) Tomey Corporation
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