1. Articles from X. Yang

    1-3 of 3
    1. Accurate Modeling and Design of Graded-Index Fiber Probes for Optical Coherence Tomography using the Beam Propagation Method

      Accurate Modeling and Design of Graded-Index Fiber Probes for Optical Coherence Tomography using the Beam Propagation Method

      Fiber-optic probes for sensing and biomedical imaging applications such as optical coherence tomography (OCT) frequently employ sections of graded-index (GRIN) fiber to re-focus the diverging light from the delivery fiber. Such GRIN fiber microlenses often possess aberrations that cause significant distortions of the focused output beam. Current design methods based on ABCD matrix transformations of Gaussian beams cannot model such effects and are therefore inadequate for the analysis and design of high-performance probes that require diffraction-limited output beams. We demonstrate use of the beam propagation method (BPM) to analyze beam distortion in GRINlensed fibers resulting from index profiles that exhibit ...

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    2. 3D imaging of internal structures of skeletal muscle with an ultrathin side-viewing optical needle probe

      3D imaging of internal structures of skeletal muscle with an ultrathin side-viewing optical needle probe

      Evaluation of degradation in the structure of skeletal muscle is important for the assessment or diagnosis of many myopathies, such as Duchenne muscular dystrophy. Histological analysis is the gold standard to evaluate such degradation but requires excision and fixation of the tissue. This is undesirably invasive in patients and precludes longitudinal study of disease progression in patients or animal models. Optical coherence tomography (OCT) is a high-resolution (∼10μm) imaging modality capable of visualising muscle structure and the morphological changes in muscular dystrophy. However, because of the limited image penetration of OCT (∼2mm), previous studies have been restricted to imaging ...

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    3. Ultrathin side-viewing needle probe for optical coherence tomography

      Ultrathin side-viewing needle probe for optical coherence tomography

      We present the smallest reported side-viewing needle probe for optical coherence tomography (OCT). Design, fabrication, optical characterization, and initial application of a 30-gauge (outer diameter 0.31 mm) needle probe are demonstrated. Extreme miniaturization is achieved by using a simple all-fiber probe design incorporating an angle-polished and reflection-coated fiber-tip beam deflector. When inserted into biological tissue, aqueous interstitial fluids reduce the probe’s inherent astigmatism ratio to 1.8, resulting in a working distance of 300 μm and a depth-of-field of 550 μm with beam diameters below 30 μm. The needle probe was interfaced with an 840 nm spectral-domain OCT ...

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    1-3 of 3
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  2. Topics in the News

    1. (3 articles) University of Western Australia
    2. (3 articles) Dirk Lorenser
    3. (3 articles) David D. Sampson
    4. (3 articles) Harvard University
    5. (2 articles) Xiaojie Yang
    6. (2 articles) Rodney W. Kirk
    7. (2 articles) UCSD
    8. (2 articles) Tadamichi Akagi
    9. (2 articles) Linda M. Zangwill
    10. (2 articles) Robert N. Weinreb
    11. (2 articles) Optovue
    12. (2 articles) Topcon Medical Systems
    13. (1 articles) Robert A. McLaughlin
    14. (1 articles) University of Coimbra
    15. (1 articles) Capital Medical University
    16. (1 articles) Brigham and Women’s Hospital
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    Ultrathin side-viewing needle probe for optical coherence tomography 3D imaging of internal structures of skeletal muscle with an ultrathin side-viewing optical needle probe Accurate Modeling and Design of Graded-Index Fiber Probes for Optical Coherence Tomography using the Beam Propagation Method Flatly Broadened and Highly Coherent Supercontinuum Generation by Induced Modulation Instability in ANDi-PCF Impact of vessel curvature on neointimal healing after stent implantation as assessed by optical coherence tomography Optical coherence tomography angiography characterization of acute and late stage Purtscher retinopathy In Vivo Characterization of Spontaneous Retinal Neovascularization in the Mouse Eye by Multifunctional Optical Coherence Tomography The Use of Optical Coherence Tomography for the Detection of Early Diabetic Retinopathy Predicting surgical success in patients with idiopathic epiretinal membrane using the spectral-domain optical coherence tomography segmentation module for single retinal layer analysis Understanding and improving optical coherence tomography imaging depth in selective laser sintering nylon 12 parts and powder Comparison of choroidal vessel thickness in children and adult eyes by enhanced-depth imaging optical coherence tomography imaging Optical coherence tomography reveals complex motion between the basilar membrane and organ of corti in the gerbil cochlea