1. Articles from X. Yang

    1-3 of 3
    1. Accurate Modeling and Design of Graded-Index Fiber Probes for Optical Coherence Tomography using the Beam Propagation Method

      Accurate Modeling and Design of Graded-Index Fiber Probes for Optical Coherence Tomography using the Beam Propagation Method

      Fiber-optic probes for sensing and biomedical imaging applications such as optical coherence tomography (OCT) frequently employ sections of graded-index (GRIN) fiber to re-focus the diverging light from the delivery fiber. Such GRIN fiber microlenses often possess aberrations that cause significant distortions of the focused output beam. Current design methods based on ABCD matrix transformations of Gaussian beams cannot model such effects and are therefore inadequate for the analysis and design of high-performance probes that require diffraction-limited output beams. We demonstrate use of the beam propagation method (BPM) to analyze beam distortion in GRINlensed fibers resulting from index profiles that exhibit ...

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    2. 3D imaging of internal structures of skeletal muscle with an ultrathin side-viewing optical needle probe

      3D imaging of internal structures of skeletal muscle with an ultrathin side-viewing optical needle probe

      Evaluation of degradation in the structure of skeletal muscle is important for the assessment or diagnosis of many myopathies, such as Duchenne muscular dystrophy. Histological analysis is the gold standard to evaluate such degradation but requires excision and fixation of the tissue. This is undesirably invasive in patients and precludes longitudinal study of disease progression in patients or animal models. Optical coherence tomography (OCT) is a high-resolution (∼10μm) imaging modality capable of visualising muscle structure and the morphological changes in muscular dystrophy. However, because of the limited image penetration of OCT (∼2mm), previous studies have been restricted to imaging ...

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    3. Ultrathin side-viewing needle probe for optical coherence tomography

      Ultrathin side-viewing needle probe for optical coherence tomography

      We present the smallest reported side-viewing needle probe for optical coherence tomography (OCT). Design, fabrication, optical characterization, and initial application of a 30-gauge (outer diameter 0.31 mm) needle probe are demonstrated. Extreme miniaturization is achieved by using a simple all-fiber probe design incorporating an angle-polished and reflection-coated fiber-tip beam deflector. When inserted into biological tissue, aqueous interstitial fluids reduce the probe’s inherent astigmatism ratio to 1.8, resulting in a working distance of 300 μm and a depth-of-field of 550 μm with beam diameters below 30 μm. The needle probe was interfaced with an 840 nm spectral-domain OCT ...

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    1-3 of 3
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  2. Topics in the News

    1. (3 articles) University of Western Australia
    2. (3 articles) Dirk Lorenser
    3. (3 articles) David D. Sampson
    4. (2 articles) Xiaojie Yang
    5. (2 articles) Rodney W. Kirk
    6. (2 articles) University of Kent
    7. (2 articles) Adrian G. Podoleanu
    8. (1 articles) Robert A. McLaughlin
    9. (1 articles) Center for Ophthalmic Optics and Lasers
    10. (1 articles) Sungkyunkwan University
    11. (1 articles) University of Chicago
    12. (1 articles) University of Hong Kong
    13. (1 articles) Oregon Health & Science University
    14. (1 articles) Gangjun Liu
    15. (1 articles) David Huang
    16. (1 articles) Yali Jia
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    Ultrathin side-viewing needle probe for optical coherence tomography 3D imaging of internal structures of skeletal muscle with an ultrathin side-viewing optical needle probe Accurate Modeling and Design of Graded-Index Fiber Probes for Optical Coherence Tomography using the Beam Propagation Method Comparison of Ocular Biometry and Refractive Outcomes Using IOL Master 700, IOL Master 500, and Ultrasound Two-year vascular responses to drug-eluting stents with biodegradable polymer versus durable polymer: An optical coherence tomography sub-study of the NEXT Research Associate in Optical Coherence Tomography at University of Kent Juvenile Macular Degenerations Stacked Gold Nanodisks for Bimodal Photoacoustic and Optical Coherence Imaging Optical Coherence Tomography Reveals Changes to Corneal Reflectivity and Thickness in Individuals with Tear Hyperosmolarity Wire bias in coronary measurement using optical coherence tomography Regression-based algorithm for bulk motion subtraction in optical coherence tomography angiography POLYPOIDAL CHOROIDAL VASCULOPATHY UPON OPTICAL COHERENCE TOMOGRAPHIC ANGIOGRAPHY