1. Articles from Con Yiannikas

    1-6 of 6
    1. Progressive Loss of Retinal Ganglion Cells and Axons in Nonoptic Neuritis Eyes in Multiple Sclerosis: A Longitudinal Optical Coherence Tomography Study

      Progressive Loss of Retinal Ganglion Cells and Axons in Nonoptic Neuritis Eyes in Multiple Sclerosis: A Longitudinal Optical Coherence Tomography Study

      Purpose : To examine the rate of retinal ganglion cell (RGC) layer and retinal nerve fiber layer (RNFL) changes in nonoptic neuritis (NON) eyes of relapsing remitting multiple sclerosis (RRMS) patients, and to find a specific imaging parameter useful for identifying disease progression. Methods : Forty-five consecutive RRMS patients and 20 age- and sex-matched healthy subjects were enrolled. All patients were followed up for 3 years with annual optical coherence tomography (OCT) scans, which included a peripapillary ring scan protocol for RNFL analysis and a macular radial star-like scan to obtain RGC/inner plexiform layer (IPL) thickness measures. Healthy controls were scanned ...

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    2. Relationship between Optical Coherence Tomography and Electrophysiology of the Visual Pathway in Non-Optic Neuritis Eyes of Multiple Sclerosis Patients

      Relationship between Optical Coherence Tomography and Electrophysiology of the Visual Pathway in Non-Optic Neuritis Eyes of Multiple Sclerosis Patients

      Purpose Loss of retinal ganglion cells in in non-optic neuritis eyes of Multiple Sclerosis patients (MS-NON) has recently been demonstrated. However, the pathological basis of this loss at present is not clear. Therefore, the aim of the current study was to investigate associations of clinical (high and low contrast visual acuity) and electrophysiological (electroretinogram and multifocal Visual Evoked Potentials) measures of the visual pathway with neuronal and axonal loss of RGC in order to better understand the nature of this loss. Methods Sixty-two patients with relapsing remitting multiple sclerosis with no previous history of optic neuritis in at least one ...

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    3. Transsynaptic Retinal Degeneration in Optic Neuropathies: Optical Coherence Tomography Study

      Transsynaptic Retinal Degeneration in Optic Neuropathies: Optical Coherence Tomography Study

      Purpose. Recently demonstrated neuronal loss in the inner nuclear layer of the retina in multiple sclerosis (MS) and glaucoma raises the question of a primary (possibly immune-mediated) or secondary (transsynaptic) mechanism of retinal damage in these diseases. In the present study we used optical coherence tomography to investigate retrograde retinal transsynaptic degeneration in patients with long-standing and severe loss of ganglion cells due to optic neuropathy. Methods. Fifteen eyes of glaucoma patients with visual field defect limited to upper hemifield and 15 eyes of MS patients with previous episode of optic neuritis (ON) and extensive loss of ganglion cells were ...

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    4. Trans-synaptic retinal degeneration in optic neuropathies: Optical Coherence Tomography study

      Trans-synaptic retinal degeneration in optic neuropathies: Optical Coherence Tomography study
      Purpose. Recently demonstrated neuronal loss in the inner nuclear layer of the retina in multiple sclerosis (MS) and glaucoma raises the question of a primary (possibly immune-mediated) or secondary (trans-synaptic) mechanism of retinal damage in these diseases. In the present study we used Optical Coherence Tomography to investigate retrograde retinal trans-synaptic degeneration in patients with long-standing and severe loss of ganglion cells due to optic neuropathy. Methods. Ten eyes of glaucoma patients with visual field defect limited to upper hemifield and 10 eyes of MS patients with previous episode of optic neuritis (ON) and extensive loss of ganglion cells were ...
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    5. Interrelationship of Optical Coherence Tomography and Multifocal Visual-Evoked Potentials after Optic Neuritis

      Interrelationship of Optical Coherence Tomography and Multifocal Visual-Evoked Potentials after Optic Neuritis

      Purpose. Acute optic neuritis (ON) is often followed by recovery of visual function. Although this recovery is mainly attributable to resolution of the acute inflammation, the redistribution of ion channels along the demyelinated membrane, and subsequent remyelination, part of it may be the result of neural plasticity. In the present study, the interrelationship was examined between structural (retinal nerve fiber layer [RNFL] thickness) and functional (amplitude of multifocal visual evoked potentials [mfVEPs]) measures of the integrity of the visual pathway in the postacute stage of ON, to determine whether there was any evidence of ongoing neural reorganization. Methods. Twenty-five subjects ...

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    6. Correlation of Optical Coherence Tomography and Multifocal Visual-Evoked Potential After Optic Neuritis

      Purpose. Acute optic neuritis (ON) is often followed by recovery of visual function. While this recovery is mainly attributed to resolution of acute inflammation, the redistribution of ion channels along the demyelinated membrane and subsequent remyelination, part of this recovery may result from neural plasticity. In the current study we examined the interrelationship between structural (Retinal Nerve Fiber Layer (RNFL) thickness) and functional (amplitude of Multifocal Visual Evoked Potentials (mfVEP)) measures of the integrity of the visual pathway in the post-acute stage of ON with an aim to determine if there was any evidence for an ongoing neural reorganization. Method ...
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    1-6 of 6
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