1. Articles from H. J. Wei

    1-7 of 7
    1. Noninvasive monitoring of blood glucose concentration in diabetic patients with optical coherence tomography

      Noninvasive monitoring of blood glucose concentration in diabetic patients with optical coherence tomography

      Optical coherence tomography (OCT) has been used to noninvasively monitor the blood glucose concentration (BGC) in healthy subjects with good accuracy and acceptable specificity. Based on this, the paper further considered the possibility of OCT in noninvasive monitoring BGC in diabetic patients. The OCT signal slope (OCTSS) changed with variation of BGC. The correlation coefficient R between BGC and OCTSS in diabetic patients was 0.91; while the correlation coefficient R in healthy volunteers was 0.78. Thus, a better linear dependence of OCTSS on BGC in diabetic patients was presented in the experiment. The results showed that the capability ...

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    2. Influence of different sized nanoparticles combined with ultrasound on the optical properties of invitro normal and cancerous human lung tissue studied with OCT and diffuse reflectance spectra

      Influence of different sized nanoparticles combined with ultrasound on the optical properties of invitro normal and cancerous human lung tissue studied with OCT and diffuse reflectance spectra

      The present study is concerned with the in vitro study of different sized titanium dioxide (TiO 2 ) nanoparticles' (NPs) penetration and accumulation in human normal lung (NL) tissue and lung adenocarcinoma tumor (LAT) tissue by the methods of continuous optical coherence tomography (OCT) monitoring and diffuse reflectance (DR) spectra measurement, and their evaluating the effects of TiO 2 NPs in two sizes (60 nm and 100 nm) and their combination with ultrasound (US) on the optical properties of human NL and LAT tissue. Spectral measurements indicate that TiO 2 NPs penetrate and accumulate into the tissues and thus induce enhancement ...

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    3. Effect of differently sized nanoparticles' accumulation on the optical properties of ex vivo normal and adenomatous human colon tissue with OCT imaging and diffuse reflectance spectra

      Effect of differently sized nanoparticles' accumulation on the optical properties of ex vivo normal and adenomatous human colon tissue with OCT imaging and diffuse reflectance spectra

      Using optical coherence tomography (OCT) and diffuse reflectance spectra, we investigated the dynamics of titanium dioxide (TiO 2 ) nanoparticles, of different sizes, when penetrating and accumulating in human normal colon tissue (NC) and adenomatous colon tissue (AC). The process of nanoparticle penetration and accumulation in biotissue is accompanied by changes in the optical properties of tissue. Continuous OCT monitoring showed that, after application of TiO 2 nanoparticles, the OCT signal intensities of NC and ac both increase with time, and the larger nanoparticles tend to produce a greater signal enhancement in the same type of tissue. The average attenuation coefficient ...

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    4. In vitro study of the effects of ultrasound-mediated glycerol on optical attenuation of human normaland cancerous esophageal tissues with optical coherence tomography

      In vitro study of the effects of ultrasound-mediated glycerol on optical attenuation of human normaland cancerous esophageal tissues with optical coherence tomography

      Previous studies from our group have demonstrated that glucose solution can induce optical clearing enhancement of esophageal tissues with optical coherence tomography (OCT). The aims of this study were to evaluate the optical clearing effects of ultrasound-mediated optical clearing agents (OCAs) and to find more effective methods to distinguish human normal esophageal tissues (NE) and cancerous esophageal tissues (CE). Here we used the OCT technique to investigate the optical attenuation of NE and CE in vitro after treatment with 30% glycerol alone and glycerol combined with ultrasound, respectively. Experimental results showed that the averaged attenuation coefficient of CE was significantly ...

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    5. Quantifying glucose permeability and enhanced light penetration in ex vivo human normal and cancerous esophagus tissues with optical coherence tomography

      Quantifying glucose permeability and enhanced light penetration in ex vivo human normal and cancerous esophagus tissues with optical coherence tomography

      We report our pilot results on quantification of glucose (G) diffusion permeability in human normal esophagus and ESCC tissues in vitro by using OCT technique. The permeability coefficient of 40% aqueous solution of G was found to be (1.74±0.04)×10–5 cm/s in normal esophagus and (2.45±0.06)×10–5 cm/s in ESCC tissues. The results from this study indicate that ESCC tissues had a higher permeability coefficient compared to normal esophageal tissues, and the light penetration depths gradually increase with the increase of applied topically with G time for the normal esophageal ...

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    6. In vivo quantification of propylene glycol, glucose and glycerol diffusion in human skin with optical coherence tomography

      In vivo quantification of propylene glycol, glucose and glycerol diffusion in human skin with optical coherence tomography

      The purpose of study is to quantify and compare diffusion of propylene glycol, glucose, glycerol in the human skin in vivo noninvasively. Optical coherence tomography (OCT) was utilized in the functional imaging of optical cleaning agents for monitoring and quantifying the permeability coefficients (PCs) of them. Our experiments showed that the permeability coefficient of 40% propylene glycol from different subjects was averaged and found to be (2.52 ± 0.02) × 10−6 cm/s, the permeability coefficient of 40% glucose was (1.94 ± 0.05) × 10−6 cm/s, and the permeability coefficient of 40% glycerol was (1.82 ± 0 ...

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    7. Enhancement of permeability of glycerol with ultrasoundin human normal and cancer breast tissues in vitro using optical coherence tomography

      Enhancement of permeability of glycerol with ultrasoundin human normal and cancer breast tissues in vitro using optical coherence tomography
      Here we examined the effect of human normal breast (NB) and breast cancer (BC) tissues in vitro after treatment with glycerol in conjunction with ultrasound (surgeonperformed, SP) by OCT for functional imaging to monitor. 60% glycerol (G) and SP was simultaneously applied for 5 min. Depth- and time-resolved profiles for OCT signal enhancement were presented. The results show that OCT imaging depth of breast tissues after treatment with 60% G in combined with SP more obviously improved than that after application of glycerol alone. The permeability coefficient of 60% glycerol in 60% G/NB, 60% G/BC, 60% G/SP ...
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    1-7 of 7
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    Enhancement of permeability of glycerol with ultrasoundin human normal and cancer breast tissues in vitro using optical coherence tomography In vivo quantification of propylene glycol, glucose and glycerol diffusion in human skin with optical coherence tomography Quantifying glucose permeability and enhanced light penetration in ex vivo human normal and cancerous esophagus tissues with optical coherence tomography In vitro study of the effects of ultrasound-mediated glycerol on optical attenuation of human normaland cancerous esophageal tissues with optical coherence tomography Effect of differently sized nanoparticles' accumulation on the optical properties of ex vivo normal and adenomatous human colon tissue with OCT imaging and diffuse reflectance spectra Influence of different sized nanoparticles combined with ultrasound on the optical properties of invitro normal and cancerous human lung tissue studied with OCT and diffuse reflectance spectra Noninvasive monitoring of blood glucose concentration in diabetic patients with optical coherence tomography Optical Coherence Tomography of the Middle Ear Using Ossiview Role of Optical Coherence Tomography Angiography Imaging in Patients with Diabetes Vitreomacular Traction Surgery from the DISCOVER Study: Intraoperative OCT Utility, Ellipsoid Zone Dynamics, and Outcomes Investigation of Micro-motion Kinematics of Continuum Robots for Volumetric OCT and OCT-guided Visual Servoing Association of Myopia With Microvascular Alterations in Patients With Type 2 Diabetes: An Optical Coherence Tomography Angiography Study