1. Articles from Jeremiah Wierwille

    1-12 of 12
    1. Apparatus and methods for non-invasive assessment of transplant kidney viability

      Apparatus and methods for non-invasive assessment of transplant kidney viability

      A kidney viability assessment system (KVAS) is disclosed which provides objective and reliable tests to assess the viability of transplant or donor kidneys in vivo and predict their post-transplant outcomes. KVAS includes an optical device augmented by an intelligent algorithm that can evaluate the viability or quality of the donor kidney in a real-time, non-invasive way. In particular, it includes a handheld optical coherence tomography (OCT) imaging device and at least one processor configured for executing a set of instructions corresponding to an automatic image processing algorithm for quantification of kidney microstructures and functions. Handheld OCT can survey the entire ...

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    2. Apparatus And Methods For NON-INVASIVE Assessment Of Transplant Kidney Viability

      Apparatus And Methods For NON-INVASIVE Assessment Of Transplant Kidney Viability

      A kidney viability assessment system (KVAS) is disclosed which provides objective and reliable tests to assess the viability of transplant or donor kidneys in vivo and predict their post-transplant outcomes. KVAS includes an optical device augmented by an intelligent algorithm that can evaluate the viability or quality of the donor kidney in a real-time, non-invasive way. In particular, it includes a handheld optical coherence tomography (OCT) imaging device and at least one processor configured for executing a set of instructions corresponding to an automatic image processing algorithm for quantification of kidney microstructures and functions. Handheld OCT can survey the entire ...

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    3. Optical Coherence Tomography of the Living Human Kidney

      Optical Coherence Tomography of the Living Human Kidney

      Acute tubular necrosis (ATN) induced by ischemia is the most common insult to donor kidneys destined for transplantation. ATN results from swelling and subsequent damage to cells lining the kidney tubules. In this study, we demonstrate the capability of optical coherence tomography (OCT) to image the renal microstructures of living human donor kidneys and potentially provide a measure to determine the extent of ATN. We also found that Doppler-based OCT (i.e., DOCT) reveals renal blood flow dynamics that is another major factor which could relate to post-transplant renal function. All OCT/DOCT observations were performed in a noninvasive, sterile ...

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    4. Endoscopic Microscopy Using Optical Coherence Tomography

      Endoscopic Microscopy Using Optical Coherence Tomography

      Optical coherence tomography (OCT) can perform high-speed, micron-level high resolution imaging of tissue microstructures in vivo and in real time and can function as a type of optical biopsy to visualize the structural and functional alterations associated with various diseases. The advances in endoscopic OCT and optical coherence microscopy (OCM) provide an exciting avenue for many promising clinical applications with the potential of enhancing diagnostic capabilities and treatment efficacies. In this review paper, we first review the basic principles for time- and Fourierdomain OCT. We then survey the various endoscopic OCT technologies followed by the review of several representative clinical ...

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    5. Congratulations to Chia-Pin Liang From the University of Maryland a Winner of a 2012 Student Travel Grant Award

      Congratulations to Chia-Pin Liang From the University of Maryland a Winner of a 2012 Student Travel Grant Award
      Chia-Pin Liang from the University of Maryland is one of four winners of the OCT News 2012 student travel grant awards (see prior announcement Here). Below is a summary of his work. Stereotactic procedures that require insertion of needle-based instruments into the brain serve important roles in a variety of neurosurgical interventions such as biopsy, catheterization, and electrode placement. The laceration of blood vessels in the path of the advancing needle can result in stroke and even death and is perhaps the most worried complication. Also, the brain may shift during surgery because of cerebrospinal fluid (CSF) leakage so that ...
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    6. A forward-imaging needle-type OCT probe for image guided stereotactic procedures

      A forward-imaging needle-type OCT probe for image guided stereotactic procedures
      A forward-imaging needle-type optical coherence tomography (OCT) probe with Doppler OCT (DOCT) capability has the potential to solve critical challenges in interventional procedures. A case in point is stereotactic neurosurgery where probes are advanced into the brain based on predetermined coordinates. Laceration of blood vessels in front of the advancing probe is an unavoidable complication with current methods. Moreover, cerebrospinal fluid (CSF) leakage during surgery can shift the brain rendering the predetermined coordinates unreliable. In order to address these challenges, we developed a forward-imaging OCT probe (740 μm O.D.) using a gradient-index (GRIN) rod lens that can provide real-time ...
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    7. Feature Of The Week 9/25/11: University of Maryland and NIH Researchers Investigate Combined OCT and Fluorescence Imaging for Improved Colon Cancer Detection

      Feature Of The Week 9/25/11: University of Maryland and NIH Researchers Investigate Combined OCT and Fluorescence Imaging for Improved Colon Cancer Detection
      Optical Coherence Tomography (OCT) offers high-resolution imaging of the tissue microstructure. But there are numerous limitations to OCT including providing direct molecular imaging capability. A popular research thrust has recently been to combine OCT with other imaging technology such as Raman, Fluorescence, and other molecular imaging techniques to achieve a multi-modality imaging capability. This multi-modality imaging offers improved capabilities including all the normal OCT benefits as well as allowing the molecular imaging signals to be spatial registered within the tissue microstructure. This can lead to significant improvements in clinical capability including cancer detection. Researchers at the University of Maryland and ...
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    8. In vivo, label-free, three-dimensional quantitative imaging of kidney microcirculation using Doppler optical coherence tomography

      In vivo, label-free, three-dimensional quantitative imaging of kidney microcirculation using Doppler optical coherence tomography
      Doppler optical coherence tomography (DOCT) is a functional extension of optical coherence tomography (OCT) and is currently being employed in several clinical arenas to quantify blood flow in vivo. In this study, the objective was to investigate the feasibility of DOCT to image kidney microcirculation, specifically, glomerular blood flow. DOCT is able to capture three-dimensional (3D) data sets consisting of a series of cross-sectional images in real time, which enables label-free and non-destructive quantification of glomerular blood flow. The kidneys of adult, male Munich–Wistar rats were exposed through laparotomy procedure after being anesthetized. Following exposure of the kidney beneath ...
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    9. Rh-I-UEA-1 Polymerized Liposomes Target and Image Adenomatous Polyps in the APCMin/+ Mouse Using Optical Colonography

      Rh-I-UEA-1 Polymerized Liposomes Target and Image Adenomatous Polyps in the APCMin/+ Mouse Using Optical Colonography
      Mutated adenomatous polyposis coli (APC) genes predispose transformations to neoplasia, progressing to colorectal carcinoma. Early detection facilitates clinical management and therapy. Novel lectin-mediated polymerized targeted liposomes (Rh-I-UEA-1), with polyp specificity and incorporated imaging agents were fabricated to locate and image adenomatous polyps in APCMin/+ mice. The biomarker α-l-fucose covalently joins the liposomal conjugated lectin Ulexeuropaeus agglutinin (UEA-1), via glycosidic linkage to the polyp mucin layer. Multispectral optical imaging (MSI) corroborated a global perspective of specific binding (rhodamine B 532 nm emission, 590–620 nm excitation) of targeted Rh-I-UEA-1 polymerized liposomes to polyps with 1.4-fold labeling efficiency. High-resolution coregistered optical ...
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    10. Feature Of The Week 9/26/10: Researchers from University of Maryland Demonstrated Multimodality Optical Coherence Tomography and Fluorescence Laminar Optical Tomography Imaging

      Feature Of The Week 9/26/10: Researchers from University of Maryland Demonstrated Multimodality Optical Coherence Tomography and Fluorescence Laminar Optical Tomography Imaging
      Feature Of The Week 9/26/10: Multimodal imaging represents one of the current trends in the development of biophotonics imaging technologies for the integration of molecular and physiological information with structural information, enabling in vivo visualization and quantification of disease biomarkers and their progression over time. Multimodal imaging therefore improves the understanding of disease development, enables early diagnosis, and ultimately enhances treatment efficacy. This work presents an integration of optical coherence tomography (OCT) and fluorescence laminar optical tomography (FLOT), which combines the advantages of high-resolution structural imaging from OCT with high-sensitivity functional imaging from FLOT. This platform provides contextual ...
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    11. Integrated Optical Coherence Tomography (OCT) and Fluorescence Laminar Optical Tomography (FLOT)

      Integrated Optical Coherence Tomography (OCT) and Fluorescence Laminar Optical Tomography (FLOT)
      Multimodal imaging represents one of the current trends in the development of biophotonics imaging technologies. This paper briefly reviews current multimodal biophotonics imaging platforms in macroscopic, microscopic, and mesoscopic (or millimeter) scales. We also present a combined optical coherence tomography and line-scan fluorescence laminar optical tomography system for co-registered structural and molecular imaging with millimeter-scale imaging depth. Experimental results using a capillary phantom filled with the fluorescence dye Cy5.5 and a human breast cancer xenograft model are presented.
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    12. Co-registered optical coherence tomography and fluorescence molecular imaging for simultaneous morphological and molecular imaging

      Abstract. Optical coherence tomography (OCT) provides high-resolution, cross-sectional imaging of tissue microstructure in situ and in real time, while fluorescence molecular imaging (FMI) enables the visualization of basic molecular processes. There is a great deal of interest in combining these two modalities so that the tissue's structural and molecular information can be obtained simultaneously. This could greatly benefit biomedical applications such as detecting early diseases and monitoring therapeutic interventions. In this research, an optical system that combines OCT and FMI was developed. The system demonstrated that it could co-register en face OCT and FMI images with a 2.4 ...
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    1-12 of 12
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    1. (12 articles) University of Maryland
    2. (3 articles) National Institutes of Health
    3. (2 articles) Johns Hopkins University
    4. (2 articles) Georgetown University
    5. (2 articles) Thorlabs
    6. (2 articles) Boston University
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    9. (1 articles) Massachusetts General Hospital
    10. (1 articles) Fujian Normal University
    11. (1 articles) Nara Medical University
    12. (1 articles) The Chinese University of Hong Kong
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    Integrated Optical Coherence Tomography (OCT) and Fluorescence Laminar Optical Tomography (FLOT) Feature Of The Week 9/26/10: Researchers from University of Maryland Demonstrated Multimodality Optical Coherence Tomography and Fluorescence Laminar Optical Tomography Imaging Rh-I-UEA-1 Polymerized Liposomes Target and Image Adenomatous Polyps in the APCMin/+ Mouse Using Optical Colonography In vivo, label-free, three-dimensional quantitative imaging of kidney microcirculation using Doppler optical coherence tomography Feature Of The Week 9/25/11: University of Maryland and NIH Researchers Investigate Combined OCT and Fluorescence Imaging for Improved Colon Cancer Detection A forward-imaging needle-type OCT probe for image guided stereotactic procedures Congratulations to Chia-Pin Liang From the University of Maryland a Winner of a 2012 Student Travel Grant Award Endoscopic Microscopy Using Optical Coherence Tomography Optical Coherence Tomography of the Living Human Kidney A novel algorithm for multiplicative speckle noise reduction in ex vivo human brain OCT images Volumetric characterization of microvasculature in ex vivo human brain samples by serial sectioning optical coherence tomography Depth of focus extension in optical coherence tomography using ultrahigh chromatic dispersion of zinc selenide