1. Articles from J. Sun

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    1. Measurement of viscoelastic properties in multiple anatomical regions of acute rat brain tissue slices

      Measurement of viscoelastic properties in multiple anatomical regions of acute rat brain tissue slices

      Mechanical property data for brain tissue are needed to understand the biomechanics of neurological disorders and response of the brain to different mechanical and surgical forces. Most studies have characterized mechanical behavior of brain tissues over large regions or classified tissue properties for either gray or white matter regions only. In this study, spatially heterogeneous viscoelastic properties of ex vivo rat brain tissue slices were measured in different anatomical regions including the cerebral cortex, caudate/putamen, and hippocampus using an optical coherence tomography (OCT) indentation system. Cell viability was also tested to observe neuronal degeneration and morphological changes in tissue ...

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    2. Optically based-indentation technique for acute rat brain tissue slices and thin biomaterials

      Optically based-indentation technique for acute rat brain tissue slices and thin biomaterials
      Currently, micro-indentation testing of soft biological materials is limited in its capability to test over long time scales due to accumulated instrumental drift errors. As a result, there is a paucity of measures for mechanical properties such as the equilibrium modulus. In this study, indentation combined with optical coherence tomography (OCT) was used for mechanical testing of thin tissue slices. OCT was used to measure the surface deformation profiles after placing spherical beads onto submerged test samples. Agarose-based hydrogels at low-concentrations (w/v, 0.3–0.6%) and acute rat brain tissue slices were tested using this technique over a ...
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    1. (2 articles) University of Florida
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