1. Articles from Cong Ye

    1-18 of 18
    1. Impact of segmentation errors and retinal blood vessels on retinal nerve fibre layer measurements using spectral-domain optical coherence tomography

      Impact of segmentation errors and retinal blood vessels on retinal nerve fibre layer measurements using spectral-domain optical coherence tomography

      Purpose To investigate the impact of retinal blood vessels and retinal nerve fibre layer (RNFL) segmentation errors on RNFL measurement. Methods One eye of 180 subjects (60 normal, 66 mild-to-moderate and 54 advanced glaucoma subjects) was randomly selected for RNFL imaging with a spectral-domain OCT. The boundaries of the RNFL detected by the instrument software were checked, and the segmentation errors were corrected by a customized computer program. The differences in average and regional RNFL thicknesses (RNFLT) before and after the correction were analysed to determine the frequency of segmentation error (defined as an absolute difference in average RNFLT >5 ...

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    2. Stromal Bed Thickness Measurement During Laser in Situ Keratomileusis Using Intraoperative Optical Coherence Tomography

      Stromal Bed Thickness Measurement During Laser in Situ Keratomileusis Using Intraoperative Optical Coherence Tomography

      Purpose: The aim of this study was to compare repeatability and agreement of stromal bed thickness (SBT) measurements with intraoperative spectral domain optical coherence tomography (SD-OCT) and ultrasound pachymetry (USP). Methods: The SBT was measured in 14 eyes of 14 patients during femtosecond laser in situ keratomileusis (LASIK). Intraoperative SD-OCT was positioned on the eye to acquire images after creation of LASIK flaps. Patients were then asked to sit in front of a swept-source optical coherence tomography (SS-OCT) for measurements. Subsequently, LASIK flaps were lifted and SBT was measured with USP. Three readings were obtained with each instrument. Repeatability of ...

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    3. Optical quality assessment in normal and forme fruste keratoconus eyes with a double-pass system: a comparison and variability study

      Optical quality assessment in normal and forme fruste keratoconus eyes with a double-pass system: a comparison and variability study

      Purpose To comparatively evaluate the image quality in normal and forme fruste keratoconus patients using a double-pass system. Methods Fourteen normal eyes and 15 eyes with forme fruste keratoconus were included. Corneal tomographic parameters were obtained with optical coherence tomography. Image quality characteristics were determined by an optical quality analysis system (OQAS). Two readings were obtained from each eye. The following parameters were analysed: modulation transfer function cutoff frequency (MTF), Strehl ratio and OQAS values (OV) at contrasts of 100% (OV-100), 20% (OV-20) and 9% (OV-9). Repeatability coefficient (RC), coefficient of variation (CVw) and intraclass correlation coefficient (ICC) were evaluated ...

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    4. Assessing sodium iodate induced outer retinal changes in rats using confocal scanning laser ophthalmoscopy and optical coherence tomography

      Assessing sodium iodate induced outer retinal changes in rats using confocal scanning laser ophthalmoscopy and optical coherence tomography

      Purpose: Sodium iodate induces retinal pigment epithelium (RPE) atrophy and photoreceptor degeneration, as seen in the pathogenesis of many retinal diseases. We investigated a new approach of analyzing retinal images using confocal scanning laser ophthalmoscopy (cSLO), which allows longitudinal assessment of sodium iodate induced lesions in the retina of living rats. Methods: Single dose of sodium iodate (25 to 75 mg/kg) was given intravenously to adult Sprague-Dawley rats. Control animals were given normal saline or sodium iodide. The retina was examined by cSLO and optical coherence tomography (OCT) in living rats, which were then sacrificed for histological assessments. Results ...

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    5. Corneal thickness and elevation measurements using swept source optical coherence tomography and slit scanning topography in normal and keratoconic eyes

      Corneal thickness and elevation measurements using swept source optical coherence tomography and slit scanning topography in normal and keratoconic eyes

      Background Optical coherence tomography is being used increasingly for corneal measurements. The current study compared corneal thickness and corneal elevation using SS-OCT (Casia, Tomey, Nagoya, Japan) and slit scanning topography (Orbscan IIz, Bausch & Lomb, Rochester, New York). Design Prospective study Participants 41 normal and 46 keratoconus subjects Methods All eyes were imaged using SS-OCT and slit scanning tomography during the same visit. Mean central (CCT) and thinnest (TCT) corneal thickness and best-fit sphere (BFS) measurements were compared between the instruments. Corneal thickness was also measured with ultrasound pachymetry (USP). Main outcome measures Agreement of measurements between SS-OCT and scanning slit ...

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    6. Anterior Chamber Angle Imaging With Swept-Source Optical Coherence Tomography: Detecting the Scleral Spur, Schwalbe's Line, and Schlemm's Canal

      Anterior Chamber Angle Imaging With Swept-Source Optical Coherence Tomography: Detecting the Scleral Spur, Schwalbe's Line, and Schlemm's Canal

      Objective: To determine the visibility of the scleral spur (SS), Schwalbe's line (SL), and Schlemm's canal (SC) imaged by a swept-source optical coherence tomographer (OCT). Methods: One eye from each individual was randomly selected from 30 normal subjects and 30 patients with primary open-angle glaucoma for anterior segment imaging with a swept-source OCT. The angles were imaged with 2 protocols: (1) high-density (HD, a raster of 64 B-scans each with 512 A-scans over 8 mm) and (2) low-density scans (LD, 128 radial scans each with 512 A-scans over 16 mm). The visibility of the angle structures was determined ...

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    7. Retinal Nerve Fiber Layer Imaging with Spectral-Domain Optical Coherence Tomography: Interpreting the RNFL maps in Healthy Myopic Eyes

      Retinal Nerve Fiber Layer Imaging with Spectral-Domain Optical Coherence Tomography: Interpreting the RNFL maps in Healthy Myopic Eyes

      Objective: To investigate the association between the distribution profile of the retinal nerve fiber layer (RNFL) bundles and myopia and its impact on interpretation of the RNFL map imaged by a spectral-domain optical coherence tomography (OCT). Methods: The RNFL of 189 myopic eyes from 103 normal healthy myopic participants was imaged by the Cirrus HD-OCT. The angle between the long axes of the superotemporal and inferotemporal RNFL bundles determined in the RNFL thickness map (the RNFL distribution angle) and the abnormal area in the RNFL thickness deviation map were measured. The associations between the RNFL distribution angle and the axial ...

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    8. Optic Disc Imaging with Spectral-Domain Optical Coherence Tomography: Variability and Agreement Study with Heidelberg Retinal Tomograph

      Optic Disc Imaging with Spectral-Domain Optical Coherence Tomography: Variability and Agreement Study with Heidelberg Retinal Tomograph

      Objective To evaluate the agreement of optic disc measurements obtained with the Cirrus high-density optical coherence tomography (HD-OCT) and the Heidelberg retina tomograph (HRT) and compare the intervisit, test–retest variability between the instruments. Design Prospective, cross-sectional study. Participants Two hundred seven subjects (109 glaucoma and 98 normal subjects). Methods One eye from each individual was selected randomly for optic disc imaging by the Cirrus HD-OCT and the HRT. Areas of the optic disc and the cup, cup volume, vertical cup-to-disc ratio and cup-to-disc area ratio were compared between the instruments. The OCT measurements were corrected for ocular magnification using ...

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    9. Retinal Nerve Fiber Layer Imaging with Spectral-Domain Optical Coherence Tomography A Prospective Analysis of Age-Related Loss

      Retinal Nerve Fiber Layer Imaging with Spectral-Domain Optical Coherence Tomography A Prospective Analysis of Age-Related Loss

      Objective To investigate age-related changes of the retinal nerve fiber layer (RNFL) imaged by a spectral-domain optical coherence tomography (OCT). Design Prospective, cross-sectional, and longitudinal studies. Participants One hundred normal individuals were recruited for cross-sectional analysis, 35 of whom were randomly selected for longitudinal analysis. Methods The circumpapillary average and quadrant RNFL thicknesses were measured by the Cirrus HD-OCT. In the longitudinal study, participants were followed at 4-month intervals for a mean of 30 months (range, 24–41 months) for RNFL and visual field measurements. Cross-sectional RNFL data were analyzed with multiple linear regression models with adjustment of spherical error ...

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    10. Comparison of Retinal Nerve Fiber Layer Imaging by Spectral Domain Optical Coherence Tomography and Scanning Laser Ophthalmoscopy

      Comparison of Retinal Nerve Fiber Layer Imaging by Spectral Domain Optical Coherence Tomography and Scanning Laser Ophthalmoscopy
      Objective To compare the area and the angular width of localized retinal nerve fiber layer (RNFL) defects imaged by confocal scanning laser ophthalmoscopy (CSLO) and optical coherence tomography (OCT) and to evaluate their agreement. Design Cross-sectional study. Participants Fifty-one eyes of 41 glaucoma patients. Methods Sixty-one distinctive, localized RNFL defects (17 superior and 44 inferior RNFL defects) detected in RNFL photographs imaged by a CSLO were identified. These patients underwent RNFL imaging with a spectral-domain OCT. The RNFL thickness deviation maps (50×50 pixels) generated by the OCT revealed the locations of abnormal RNFL thicknesses with abnormal pixels denoted in ...
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    11. Anterior Chamber Angle Imaging with Swept-source Optical Coherence Tomography: An Investigation on Variability of Angle Measurement

      Anterior Chamber Angle Imaging with Swept-source Optical Coherence Tomography: An Investigation on Variability of Angle Measurement
      Purpose: To evaluate the reproducibility of anterior chamber angle measurements obtained by a swept-source optical coherence tomographer (OCT) and identify factors associated with its measurement variability. Methods: One eye from each individual was randomly selected from 30 normal subjects for anterior segment imaging with the Casia SS-1000 OCT (Tomey, Nogaya, Japan) in 3 separate visits within a week. The angle opening distance (AOD), the trabecular iris space area (TISA) and the trabecular-iris angle (TIA) at the superior (90°), nasal (0°), inferior (270°), and temporal (180°), angles were measured. The intra- and inter-observer reproducibility coefficient (RC) and intraclass correlation coefficient (ICC ...
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    12. Comparison with Scanning Laser Tomograph Reflectance Image

      Comparison with Scanning Laser Tomograph Reflectance Image
      jective To compare the area and the angular width of localized retinal nerve fiber layer (RNFL) defects imaged by confocal scanning laser ophthalmoscopy (CSLO) and optical coherence tomography (OCT) and to evaluate their agreement. Design Cross-sectional study. Participants Fifty-one eyes of 41 glaucoma patients. Methods Sixty-one distinctive, localized RNFL defects (17 superior and 44 inferior RNFL defects) detected in RNFL photographs imaged by a CSLO were identified. These patients underwent RNFL imaging with a spectral-domain OCT. The RNFL thickness deviation maps (50×50 pixels) generated by the OCT revealed the locations of abnormal RNFL thicknesses with abnormal pixels denoted in ...
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    13. Retinal Nerve Fiber Layer Imaging With Spectral-domain Optical Coherence Tomography: Effect of Multiple B-Scan Averaging on RNFL Measurement

      Retinal Nerve Fiber Layer Imaging With Spectral-domain Optical Coherence Tomography: Effect of Multiple B-Scan Averaging on RNFL Measurement

      Purpose: To determine the effect of multiple B-scan averaging on retinal nerve fiber layer (RNFL) thickness measurement taken with a spectral-domain optical coherence tomographer (OCT). Methods: Twenty-five normal individuals and 29 patients with glaucoma were examined. One eye was selected randomly of each participant for circumpapillary RNFL scanning by the Spectralis OCT (Heidelberg Engineering, Heidelberg, GmbH, Dossenheim, Germany). Three sets of OCT image series comprising 2, 8, and 16 consecutive B-scans were obtained in the same visit. After multiple B-scan averaging, the respective global and sectoral (superonasal, nasal, inferonasal, inferotemporal, temporal, and superotemporal) RNFL thicknesses were compared with linear mixed ...

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    14. Evaluation of Retinal Nerve Fiber Layer Progression in Glaucoma: A Comparison between Spectral-Domain and Time-Domain Optical Coherence Tomography

      Evaluation of Retinal Nerve Fiber Layer Progression in Glaucoma: A Comparison between Spectral-Domain and Time-Domain Optical Coherence Tomography
      Objective: To compare the performance of a spectral-domain optical coherence tomography (OCT) device and a time-domain OCT device to detect retinal nerve fiber layer (RNFL) progression in glaucoma patients.Design: Prospective study.Participants: One hundred twenty-eight eyes of 81 glaucoma patients.Methods: Patients were followed up at 4-month intervals for at least 24 months for RNFL imaging and visual field examination. Both eyes were imaged by the Cirrus HD-OCT (Carl Zeiss Meditec, Inc., Dublin, CA) and the Stratus OCT (Carl Zeiss Meditec, Inc.) and underwent visual field testing at the same visit. Linear regression analyses between circumpapillary RNFL measurements (average ...
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    15. Evaluation of Retinal Nerve Fiber Layer Progression in Glaucoma: A Comparison between the Fast and the Regular Retinal Nerve Fiber Layer Scans

      Evaluation of Retinal Nerve Fiber Layer Progression in Glaucoma: A Comparison between the Fast and the Regular Retinal Nerve Fiber Layer Scans
      Objective: To compare the performance of the fast (256 A-scans in each scan circle) and the regular (512 A-scans in each scan circle) retinal nerve fiber layer (RNFL) scan protocols for detection of glaucoma progression using the Stratus optical coherence tomography (OCT) device (Carl Zeiss Meditec, Dublin, CA). Design: Retrospective, longitudinal study. Participants: One hundred twenty-nine eyes from 72 glaucoma patients. Methods: All patients had been followed up for 2.9 to 6.1 years with a median follow-up of 4 months. All eyes had at least 4 serial RNFL measurements obtained with both the fast and the regular RNFL ...
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    16. Retinal Nerve Fiber Layer Imaging with Spectral-Domain Optical Coherence Tomography: Pattern of RNFL Defects in Glaucoma

      Retinal Nerve Fiber Layer Imaging with Spectral-Domain Optical Coherence Tomography: Pattern of RNFL Defects in Glaucoma
      Objective To characterize the distribution pattern, angular width, and area of retinal nerve fiber layer (RNFL) defects in glaucoma using spectral-domain optical coherence tomography (OCT). Design Prospective, cross-sectional study. Participants We included 113 normal subjects and 116 glaucoma patients. Methods One eye from each individual was randomly selected for Cirrus HD-OCT (Carl Zeiss Meditec Inc., Dublin, CA) RNFL imaging of the 6 × 6-mm2 parapapillary region. The RNFL defects were identified in the RNFL thickness deviation map as superpixels coded in red. The angular location and the angular width of RNFL defects were measured. The proportion of area with RNFL measurements ...
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    17. Retinal Nerve Fiber Layer Imaging with Spectral-Domain Optical Coherence Tomography: Analysis of the Retinal Nerve Fiber Layer Map for Glaucoma Detection

      Retinal Nerve Fiber Layer Imaging with Spectral-Domain Optical Coherence Tomography: Analysis of the Retinal Nerve Fiber Layer Map for Glaucoma Detection
      Objective To evaluate the diagnostic performance of the retinal nerve fiber layer (RNFL) thickness deviation map imaged by a spectral-domain optical coherence tomography (OCT; Cirrus HD-OCT, Carl Zeiss Meditec Inc, Dublin, CA) and compare its sensitivity and specificity for glaucoma detection with circumpapillary RNFL measurement derived from the standard 3.46 mm diameter circle scan. Design Prospective, cross-sectional study. Participants We included 102 normal subjects and 121 glaucoma patients. Methods One eye from each individual was imaged with Cirrus HD-OCT and Stratus OCT (Carl Zeiss Meditec Inc.). Glaucoma was defined based on the presence of visual field defects with the ...
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    18. Retinal Nerve Fiber Layer Imaging with Spectral-Domain Optical Coherence Tomography: A Study on Diagnostic Agreement with Heidelberg Retinal Tomograph

      Objective To evaluate and compare the diagnostic agreement and performance for glaucoma detection between a confocal scanning laser ophthalmoscope and a spectral-domain optical coherence tomograph (OCT). Design Prospective, cross-sectional study. Participants One hundred fifty-five subjects (79 glaucoma and 76 normal subjects). Methods One eye from each individual was selected randomly for optic disc and retinal nerve fiber layer (RNFL) imaging by the Heidelberg Retinal Tomograph (HRT; Heidelberg Engineering, GmbH, Dossenheim, Germany) and the Spectralis OCT (Heidelberg Engineering), respectively. Glaucoma was defined based on the presence of visual field defects with the Humphrey visual field analyzer (Carl Zeiss Meditec, Dublin, CA ...
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    1-18 of 18
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    Retinal Nerve Fiber Layer Imaging with Spectral-Domain Optical Coherence Tomography: Analysis of the Retinal Nerve Fiber Layer Map for Glaucoma Detection Retinal Nerve Fiber Layer Imaging with Spectral-Domain Optical Coherence Tomography: Pattern of RNFL Defects in Glaucoma Evaluation of Retinal Nerve Fiber Layer Progression in Glaucoma: A Comparison between the Fast and the Regular Retinal Nerve Fiber Layer Scans Evaluation of Retinal Nerve Fiber Layer Progression in Glaucoma: A Comparison between Spectral-Domain and Time-Domain Optical Coherence Tomography Comparison with Scanning Laser Tomograph Reflectance Image Anterior Chamber Angle Imaging with Swept-source Optical Coherence Tomography: An Investigation on Variability of Angle Measurement Comparison of Retinal Nerve Fiber Layer Imaging by Spectral Domain Optical Coherence Tomography and Scanning Laser Ophthalmoscopy Retinal Nerve Fiber Layer Imaging with Spectral-Domain Optical Coherence Tomography A Prospective Analysis of Age-Related Loss Optic Disc Imaging with Spectral-Domain Optical Coherence Tomography: Variability and Agreement Study with Heidelberg Retinal Tomograph In vivo evaluation of corneal biomechanical properties by optical coherence elastography at different cross-linking irradiances The Association of Optical Coherence Tomography Results With Neuroimaging Signs and Some Clinical Parameters in Idiopathic Intracranial Hypertension Low cost scalable monolithic common path probe design for the application in endoscopic optical coherence tomography