1. Articles from Yi Jiang

    1-6 of 6
    1. Profound Macular Ischemia on Optical Coherence Tomography Angiography in Severe Diabetic Retinopathy

      Profound Macular Ischemia on Optical Coherence Tomography Angiography in Severe Diabetic Retinopathy

      A 24-year-old woman with type I diabetes mellitus with significant macular ischemia in her left eye with a large net of neovascularization of the disc (Fig 1A). There is profound retinal capillary nonperfusion contrasting with perfusion of the neovascularization of the disc demonstrated on a full thickness 6×6-mm optical coherence tomography−angiography scan (Fig 1B), using Angiovue software (Optovue, Inc. Fremont, CA).

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      Mentions: Optovue
    2. Aqueous outflow regulation: Optical coherence tomography (OCT) imaging implicates pressure-dependent tissue motion

      Aqueous outflow regulation: Optical coherence tomography (OCT) imaging implicates pressure-dependent tissue motion

      Glaucoma is a leading cause of blindness worldwide and results from damage to the optic nerve. Currently, intraocular pressure is the only treatable risk factor. Changes in aqueous outflow regulate pressure; regulation becomes abnormal in glaucoma. From inside the eye aqueous flows out through the trabecular meshwork into a venous sinus called Schlemm's canal, next into collector channels and finally returns to the episcleral vessels of the venous system. The location of aqueous outflow regulation is unknown. Ex vivo and in vivo studies implicate both pressure-dependent trabecular tissue motion and tissues distal to Schlemm's canal in regulation of ...

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    3. Platform to investigate aqueous outflow system structure and pressure-dependent motion using high-resolution spectral domain optical coherence tomography

      Platform to investigate aqueous outflow system structure and pressure-dependent motion using high-resolution spectral domain optical coherence tomography

      The aqueous outflow system (AOS) is responsible for maintaining normal intraocular pressure (IOP) in the eye. Structures of the AOS have an active role in regulating IOP in healthy eyes and these structures become abnormal in the eyes with glaucoma. We describe a newly developed system platform to obtain high-resolution images of the AOS structures. By incorporating spectral domain optical coherence tomography (SD-OCT), the platform allows us to systematically control, image, and quantitate the responses of AOS tissue to pressure with a millisecond resolution of pulsed flow. We use SD-OCT to image radial limbal segments from the surface of the ...

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    4. High-resolution second-harmonic optical coherence tomography of collagen in rat-tail tendon

      High-resolution second-harmonic optical coherence tomography of collagen in rat-tail tendon

      A high-resolution second-harmonic optical coherence tomography (SH-OCT) system is demonstrated using a spectrum broadened femtosecond Ti:sapphire laser. An axial resolution of 4.2 μm at the second-harmonic wave center wavelength of 400 nm has been achieved. Because the SH-OCT system uses the second-harmonic generation signals that strongly depend on the orientation, polarization, and local symmetry properties of chiral molecules, this technique provides unique contrast enhancement to conventional optical coherence tomography. The system is applied to image biological tissues of the rat-tail tendon. Highly organized collagen fibrils in the rat-tail tendon can be visualized in recorded images.

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    5. Ultrahigh-resolution optical coherence tomography with a fiber laser source at 1 µm

      Ultrahigh-resolution optical coherence tomography with a fiber laser source at 1 µm
      We report a compact, high-power, fiber-based source for ultrahigh-resolution optical coherence tomography (OCT) near 1 µm. The practical source is based on a short-pulse, ytterbium-doped fiber laser and on generation of a continuum spectrum in a photonic crystal fiber. The broadband emission has an average power of 140 mW and offers an axial resolution of 2.1 µm in air (<1.6 µm in biological tissue). The generation of a broad bandwidth is robust and efficient. We demonstrate ultrahigh-resolution, time-domain OCT imaging of in vitro and in vivo biological tissues.
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    6. Second-harmonic optical coherence tomography

      Second-harmonic optical coherence tomography

      Second-harmonic optical coherence tomography, which uses coherence gating of second-order nonlinear optical responses of biological tissues for imaging, is described and demonstrated. Femtosecond laser pulses were used to excite second-harmonic waves from collagen harvested from rat tail tendon and a reference nonlinear crystal. Second-harmonic interference fringe signals were detected and used for image construction. Because of the strong dependence of second-harmonic generation on molecular and tissue structures, this technique imparts contrast and resolution enhancement to conventional optical coherence tomography.

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    1-6 of 6
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  2. Topics in the News

    1. (3 articles) UC Irvine
    2. (3 articles) James Y. Jiang
    3. (3 articles) Zhongping Chen
    4. (2 articles) University of Washington
    5. (2 articles) Ruikang K. Wang
    6. (2 articles) Yimin Wang
    7. (2 articles) Massachusetts General Hospital
    8. (1 articles) Sepideh Hariri
    9. (1 articles) Roberto Reif
    10. (1 articles) Optovue
    11. (1 articles) Harvard University
    12. (1 articles) The Chinese University of Hong Kong
    13. (1 articles) University of Miami
    14. (1 articles) VU University Amsterdam
    15. (1 articles) David A. Boas
    16. (1 articles) Brett E. Bouma
    17. (1 articles) Johannes F. de Boer
    18. (1 articles) Frank D. Verbraak
    19. (1 articles) Apollo Medical Optics
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    Second-harmonic optical coherence tomography High-resolution second-harmonic optical coherence tomography of collagen in rat-tail tendon Ultrahigh-resolution optical coherence tomography with a fiber laser source at 1 µm Platform to investigate aqueous outflow system structure and pressure-dependent motion using high-resolution spectral domain optical coherence tomography Aqueous outflow regulation: Optical coherence tomography (OCT) imaging implicates pressure-dependent tissue motion Profound Macular Ischemia on Optical Coherence Tomography Angiography in Severe Diabetic Retinopathy Optical Coherence Tomography: Critical Tool to Manage Expectations after Cataract Extraction Improving the characterization of ex vivo human brain optical properties using high numerical aperture optical coherence tomography by spatially constraining the confocal parameters Choroidal, macular and ganglion cell layer thickness assessment in Caucasian children measured with spectral domain optical coherence tomography Examination of retinal vascular density changes via optical coherence tomography angiography in patients with glaucoma 3D reconstruction of coronary artery bifurcations from coronary angiography and optical coherence tomography: feasibility, validation, and reproducibility Age- and refraction-related changes in anterior segment anatomical structures measured by swept-source anterior segment OCT