1. Articles from Yong Yang

    1-2 of 2
    1. Monitoring of drug and stimulation induced cerebral blood flow velocity changes in rat sensory cortex using spectral domain Doppler optical coherence tomography

      Monitoring of drug and stimulation induced cerebral blood flow velocity changes in rat sensory cortex using spectral domain Doppler optical coherence tomography

      Doppler optical coherence tomography (DOCT) provides a novel method to measure blood flow velocity in vessels with diameter at micrometer scale. In this study, a developed spectral domain DOCT system is applied to monitor cerebral blood flow velocity changes in a rat. An animal model with a cranial window is used, and by application of a drug, light, and electric stimulations, changes in blood flow velocity of the pial artery in sensory cortex are measured in real time. The results show significant differences in blood flow velocity before and after drug administration or light and electric stimulations, demonstrating the feasibility ...

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    2. Time-frequency distributions in spectroscopic Fourier-domain optical coherence tomography

      Current analysis for spectroscopic optical coherence tomography (SOCT) signals is limited by an uncertainty relationship between time (depth) and frequency (wavelength). Various joint time-frequency distributions (TFDs) can meliorate the limits to obtain the best information. Synthesized signals which correspond to three typical SOCT signals in the Fourier-domain under different SOCT imaging schemes, were generated and validate several different TFDs, including short time Fourier transform (STFT), continuous wavelet transform (CWT), Wigner-Villy distribution (WVD), and smoothed pseudo WVD (SPWVD). We found that different SOCT imaging scheme requires different optimal TFDs. STFT offers the most reliable and fast time-frequency (TF) analysis, which is ...
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    1-2 of 2
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    1. (1 articles) Zhejiang University
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