1. Articles from lisha ma

    1-7 of 7
    1. Arrhythmia Caused by a Drosophila Tropomyosin Mutation Is Revealed Using a Novel Optical Coherence Tomography Instrument

      Arrhythmia Caused by a Drosophila Tropomyosin Mutation Is Revealed Using a Novel Optical Coherence Tomography Instrument
      Background Dilated cardiomyopathy (DCM) is a severe cardiac condition that causes high mortality. Many genes have been confirmed to be involved in this disease. An ideal system with which to uncover disease mechanisms would be one that can measure the changes in a wide range of cardiac activities associated with mutations in specific, diversely functional cardiac genes. Such a system needs a genetically manipulable model organism that allows in vivo measurement of cardiac phenotypes and a detecting instrument capable of recording multiple phenotype parameters. Methodology and Principal Findings With a simple heart, a transparent body surface at larval stages and ...
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    2. Multiple-depth en face optical coherence tomography using active recirculation loops

      Multiple-depth en face optical coherence tomography using active recirculation loops
      We present a novel low-coherence interferometer configuration, equipped in each arm with an adjustable optical path length ring. By compensating for the losses in the rings using semiconductor optical amplifiers, interference of low-coherence light after traversing the two rings 18 times is obtained. This configuration is employed to demonstrate simultaneous en face optical coherence tomography imaging at five different depths in a Drosophila melanogaster fly.
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    3. Dual optical coherence tomography/fluorescence microscopy for monitoring of Drosophila melanogaster larval heart

      This article demonstrates a combined instrument of two imaging modalities to acquire information on cardiac function in larval Drosophila melanogaster: optical coherence tomography (OCT) and laser scanning fluorescence microscopy (LSFM). For this purpose, a dedicated imaging instrument able to sequentially provide cross-sectional OCT and C-scan LSFM images has been developed. With this dual-imaging system, the heart can be easily located and visualized within the specimen and the change of the heart shape in a cardiac cycle can be monitored. (© 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
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    4. Sequential en-face optical coherence tomography imaging and monitoring of Drosophila Melanogaster larval heart

      This article demonstrates two modalities to acquire information on cardiac function in larval Drosophila Melanogaster: in-vivo imaging and heartbeat monitoring. To achieve these goals a dedicated imaging instrument able to provide simultaneous en-face Optical Coherence Tomography (OCT) and Laser Sca ... [Proc. SPIE 7168, 71680G (2009)] published Thu Feb 19, 2009.
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    5. En-face OCT system at 1060 nm

      En-face OCT system at 1060 nm
      A highly efficient power optical coherence tomography configuration is implemented using a Multiwave Photonics broadband source centred at 1060 nm wavelength, FWHM = 50 nm and a Mach Zehnder interferometer. The interferometer contains a fibre acousto-optic modulator in each arm. One is driven at a fixed frequency of 40 MHz while the other via an RF Function Generation. In this way, the en-face OCT signal is modulated on a carrier frequency adjustable in the range 0 kHz to 1.5 MHz. A circulator is placed in the sample arm. Light retroreflected from the sample is sent via the circulator to a ...
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    6. Combining confocal microscopy and optical coherence tomography for imaging in developmental biology

      A. Bradu, Lisha Ma, J. Bloor et al. In-vivo Optical Coherence Tomography (OCT) imaging of the fruit fly Drosophila melanogaster larval heart allows non invasive visualizations and assesment of its cardiac functions. To image Drosophila melanogaster heart, we have developed a dedicated imaging instrument able to provide simultaneous Op ... [Proc. SPIE Int. Soc. Opt. Eng. 6991, 69910K (2008)] published Fri May 2, 2008.
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    7. Versatile confocal/optical coherence tomography system for embryonic developmental imaging

      An Optical Coherence Tomography (OCT) imaging system has been designed and constructed to acquire images of scattering biological samples. By simultaneously acquiring and displaying high resolution en-face (C-scan) OCT and Laser Scanning Confocal images of Drosophila melanogaster embryos we demonstrate the potential of the system to be used as a powerful tool for imaging in Drosophila embryonic development. The system can equally be used for non invasive visualizations and measurements of the movement of Drosophila melanogaster larval heart and can easily be switched in the OCT B-scan regime. The confocal channel adds guidance as the specimen can be quickly located ...
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    1-7 of 7
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  2. Topics in the News

    1. (7 articles) University of Kent
    2. (7 articles) Adrian Bradu
    3. (7 articles) Adrian G. Podoleanu
    4. (1 articles) University Fernando Pessoa
    5. (1 articles) Antonio Lobo
    6. (1 articles) Multiwave Photonics
    7. (1 articles) Tufts University
    8. (1 articles) UCLA
    9. (1 articles) Universidade Federal de São Paulo
    10. (1 articles) University of Auckland
    11. (1 articles) University of North Carolina
    12. (1 articles) Xuan Liu
    13. (1 articles) Frederique Vanholsbeeck
    14. (1 articles) Yoshiyasu Minami
    15. (1 articles) Amy L. Oldenburg
    16. (1 articles) Carl Zeiss Meditec
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    En-face OCT system at 1060 nm Multiple-depth en face optical coherence tomography using active recirculation loops Arrhythmia Caused by a Drosophila Tropomyosin Mutation Is Revealed Using a Novel Optical Coherence Tomography Instrument Novel Optical Coherence Tomography Parameters as Prognostic Factors for Stage 3 Epiretinal Membranes En-face OCT and OCT angiography analysis of macular choroidal macrovessel Three-dimensional live imaging of bovine embryos by optical coherence tomography Comparison of Subfoveal Choroidal Thickness and Retinal Nerve Fiber Layer Thickness in Patients with Coronary Slow Flow Phenomenon and Microvascular Angina: Optical Coherence Tomography based study Optical Coherence Tomography of the Orbit Through a Staphyloma: A View of Tenon's Capsule, Orbital Fat, and Inferior Oblique Muscle Line field Fourier domain optical coherence tomography based on a spatial light modulator Post-doctoral Scholar Position in OCT Endoscopy at the University of North Carolina at Chapel Hill Early Visual Functional Outcomes and Morphological Responses to Anti-Vascular Growth Factor Therapy in Diabetic Macular Oedema Using Optical Coherence Tomography Angiography Predictors for Rapid Progression of Coronary Calcification: An Optical Coherence Tomography Study