1. Articles from David Wilson

    1-9 of 9
    1. Deep neural networks for A-line-based plaque classification in coronary intravascular optical coherence tomography images

      Deep neural networks for A-line-based plaque classification in coronary intravascular optical coherence tomography images

      We develop neural-network-based methods for classifying plaque types in clinical intravascular optical coherence tomography (IVOCT) images of coronary arteries. A single IVOCT pullback can consist of >500 microscopic-resolution images, creating both a challenge for physician interpretation during an interventional procedure and an opportunity for automated analysis. In the proposed method, we classify each A-line, a datum element that better captures physics and pathophysiology than a voxel, as a fibrous layer followed by calcification (fibrocalcific), a fibrous layer followed by a lipidous deposit (fibrolipidic), or other. For A-line classification, the usefulness of a convolutional neural network (CNN) is compared with that ...

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    2. Optical coherence tomography angiography of a pigmented Fuchs' adenoma (age-related hyperplasia of the nonpigmented ciliary body epithelium) masquerading as a ciliary body melanoma

      Optical coherence tomography angiography of a pigmented Fuchs' adenoma (age-related hyperplasia of the nonpigmented ciliary body epithelium) masquerading as a ciliary body melanoma

      Purpose To report a case of age-related hypertrophy of the nonpigmented ciliary epithelium (ARH-NPCE) clinically resembling a ciliary body melanoma and report the optical coherence tomography angiography (OCTA) findings associated with this lesion. Observations A 51-year-old male was referred for evaluation of a deeply pigmented ciliary body mass with extension through the iris root. Iridocyclectomy was performed due to concern for ciliary body melanoma. Histopathologic analysis was instead consistent with ARH-NPCE, also known as Fuchs' adenoma. Prior to surgery, OCTA images revealed abnormal vasculature in the area of the lesion. Vessels in the peripheral iris approaching the lesion appeared more ...

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    3. Automated Volumetric Intravascular Plaque Classification Using Optical Coherence Tomography

      Automated Volumetric Intravascular Plaque Classification Using Optical Coherence Tomography

      An estimated 17.5 million people died from a cardiovascular disease in 2012, representing 31 percent of all global deaths. Most acute coronary events result from rupture of the protective fibrous cap overlying an atherosclerotic plaque. The task of early identification of plaque types that can potentially rupture is, therefore, of great importance. The state-of-the-art approach to imaging blood vessels is intravascular optical coherence tomography (IVOCT). However, currently, this is an offline approach where the images are first collected and then manually analyzed an image at a time to identify regions at risk of thrombosis. This process is extremely laborious ...

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    4. OCT Vitrectomy Probe

      OCT Vitrectomy Probe

      Disclosed herein is a vitrectomy probe, comprising a beam steering system configured to receive a light beam from a sample fiber of an optical coherence tomography instrument; a fundus illumination system configured to receive a beam of white light from a white light source via a multimode fiber; a dichroic mirror; and a beam delivery system configured to illuminate the retina of a subject.

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    5. Volumetric Characterization of Human Coronary Calcification by Frequency-Domain Optical Coherence Tomography.

      Volumetric Characterization of Human Coronary Calcification by Frequency-Domain Optical Coherence Tomography.

      Background: Coronary artery calcification (CAC) presents unique challenges for percutaneous coronary intervention. Calcium appears as a signal-poor region with well-defined borders by frequency-domain optical coherence tomography (FD-OCT). The objective of this study was to demonstrate the accuracy of intravascular FD-OCT to determine the distribution of CAC. Methods and Results: Cadaveric coronary arteries were imaged using FD-OCT at 100-μm frame interval. Arteries were subsequently frozen, sectioned and imaged at 20-μm intervals using the Case Cryo-Imaging automated system TM . Full volumetric co-registration between FD-OCT and cryo-imaging was performed. Calcium area, calcium-lumen distance (depth) and calcium angle were traced on every ...

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    6. Visualizing ocular perfusion with optical microangiography

      Visualizing ocular perfusion with optical microangiography
      Better assessment of ocular blood circulation may provide important diagnostic and treatment information for eye pathologies such as age-related macular degeneration, diabetic retinopathy, and glaucoma. Currently, the preferred methods to visualize ocular blood perfusion in the clinic are fluorescein angiography (FA) and indocyanine green angiography (ICGA). Both provide detailed maps of the retina and choroid that are useful in decision making. However, injecting dyes with possible side effects is undesirable. Moreover, those methods cannot provide depth-resolved visualization of vasculatures. Therefore, a noninvasive technique that can show retinal and choroidal blood perfusion in depth would be a significant advance. We have ...
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    7. Spotting the signs: Improving resolution of systems used to image human tissue could help early identification of life-threatening diseases

      Spotting the signs: Improving resolution of systems used to image human tissue could help early identification of life-threatening diseases
      Researchers at the National Physical Laboratory (NPL) have developed a new means to ensure that a screening technique using Optical Coherence Tomography (OCT) systems can be relied upon by clinicians so that they can accurately spot early signs of cancer. OCT is an increasingly popular method for looking beneath the surface of certain materials, notably human tissue. Although it can only be used to image tissue at depths of a few millimetres, it can produce higher-resolution images than either MRI or ultrasound, making it suitable for detecting changes in tissue structure that can indicate the early stages of cancer.
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    8. Imaging algorithm visualizes early heart abnormalities

      Imaging algorithm visualizes early heart abnormalities
      Combining a post-acquisition rearrangement procedure with optical coherence tomography can provide high temporal resolution for capturing subtle dynamics in the early avian embryonic heart. ying abnormalities that occur during early cardiac development is very important for understanding congenital heart defects. Optical coherence tomography (OCT) is a noninvasive imaging modality based on low-coherence interferometry that is capable of micrometer-scale resolution and 1–2mm of depth penetration in embryonic tissue. OCT can visualize and quantify real-time heart dynamics in 3D, making it a useful tool for assessing cardiac development. Real-time volume imaging performed with current systems, however, does not provide the necessary ...
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    1-9 of 9
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  2. Topics in the News

    1. (4 articles) Case Western Reserve University
    2. (4 articles) Oregon Health & Science University
    3. (4 articles) David L. Wilson
    4. (3 articles) Center for Ophthalmic Optics and Lasers
    5. (3 articles) David Huang
    6. (3 articles) Hiram G. Bezerra
    7. (2 articles) Yimin Wang
    8. (2 articles) Andrew M. Rollins
    9. (2 articles) Madhusudhana Gargesha
    10. (1 articles) Wei Wang
    11. (1 articles) Sun Yat-Sen University
    12. (1 articles) National Institutes of Health
    13. (1 articles) University of Illinois at Urbana-Champaign
    14. (1 articles) Tianjin University
    15. (1 articles) Zhejiang University
    16. (1 articles) New York Eye and Ear Infirmary
    17. (1 articles) Eric J. Chaney
    18. (1 articles) Jun Zhang
    19. (1 articles) Robert Ritch
    20. (1 articles) Stephen A. Boppart
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    Imaging algorithm visualizes early heart abnormalities Spotting the signs: Improving resolution of systems used to image human tissue could help early identification of life-threatening diseases Visualizing ocular perfusion with optical microangiography Volumetric Characterization of Human Coronary Calcification by Frequency-Domain Optical Coherence Tomography. OCT Vitrectomy Probe Automated Volumetric Intravascular Plaque Classification Using Optical Coherence Tomography Optical coherence tomography angiography of a pigmented Fuchs' adenoma (age-related hyperplasia of the nonpigmented ciliary body epithelium) masquerading as a ciliary body melanoma OCT vitrectomy probe Deep neural networks for A-line-based plaque classification in coronary intravascular optical coherence tomography images Optical coherence tomography angiography in glaucoma Handheld optical coherence tomography for clinical assessment of dental plaque and gingiva Characterisation of macular superficial vessel density alteration in preclinical ethambutol-induced optic neuropathy using optical coherence tomography angiography