1. Articles from Andreas Synetos

    1-9 of 9
    1. In vivo correlation between morphological characteristics of coronary plaques and functional characteristics of carotid arteries in acute coronary syndrome

      In vivo correlation between morphological characteristics of coronary plaques and functional characteristics of carotid arteries in acute coronary syndrome

      Background: Carotid artery temperature heterogeneity (ΔΤ) measured by microwave radiometry (MWR) has been associated with future cardiovascular events including acute coronary syndromes. The vulnerable plaques of the coronary arterial tree, that can be ideally depicted by intracoronary imaging such as optical coherence tomography (OCT) have anatomical characteristics such as the thin fibrous cap (TCFA), that make them vulnerable to rupture. The scope of the study was to assess the implication of the carotid artery temperature heterogeneity on the culprit coronary plaque morphology in patients presenting with acute myocardial infarction. Methods: 34 patients presented with an acute myocardial infarction were enrolled in ...

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    2. Optical Coherence Tomography guided treatment of recurrent drug-eluting stent failure using drug-eluting balloon

      Optical Coherence Tomography guided treatment of recurrent drug-eluting stent failure using drug-eluting balloon

      A 52-year old gentleman was admitted to our department to undergo catheterization due to recent onset stable angina in minimal effort. He had a history of myocardial infarction 10 years ago, with coronary artery bypass graft surgery 8 years ago. A left internal mammary artery (LIMA) graft had been anastomosed in the mid left anterior descending (LAD) artery and two saphenous vein grafts (SVGs) in the left circumflex (LCx) and the right coronary artery (RCA), respectively. Six years ago, he underwent percutaneous coronary intervention (PCI) of the native LCx, with implantation of two overlapping second generation drug-eluting stents (DES), due ...

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    3. Metabolic syndrome predicts plaque rupture in patients with acute myocardial infarction. An optical coherence study

      Metabolic syndrome predicts plaque rupture in patients with acute myocardial infarction. An optical coherence study

      The metabolic syndrome (MS) is conceptualized as a clustering of risk factors-including insulin resistance, dyslipidemia, central adiposity, and elevated blood pressure (BP)-that increase the risk for cardiovascular disease and type 2 diabetes mellitus (DM) [1]. Metabolic syndrome is known to be a low-grade systemic inflammatory condition with its origins in the perinatal period and childhood, while recent evidence suggests that markers of systemic inflammation may be included in the definition of the syndrome and play some role in its pathogenesis

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    4. Optical coherence tomography assessment of the spatial distribution of culprit ruptured plaques and thin-cap fibroatheromas in acute coronary syndrome

      Optical coherence tomography assessment of the spatial distribution of culprit ruptured plaques and thin-cap fibroatheromas in acute coronary syndrome

      Aims: Plaque rupture and subsequent thrombosis is known to be the most important pathology leading to acute coronary syndrome (ACS). We investigated by optical coherence tomography (OCT) whether in ACS there is an association of the location of the culprit plaque in the coronary tree with plaque rupture and/or thin cap fibroatheroma (TCFA). Methods and results: We included 74 patients presenting with ACS that underwent OCT study of the culprit lesion. The distance of the culprit lesion from the ostium was measured angiographically, and the presence of rupture and/or TCFA was assessed by OCT. Sixty-seven patients were analysed ...

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      Mentions: Abbott
    5. New insights by optical coherence tomography into the differences and similarities of culprit ruptured plaque morphology in non–ST-elevation myocardial infarction and ST-elevation myocardial infarction

      New insights by optical coherence tomography into the differences and similarities of culprit ruptured plaque morphology in non–ST-elevation myocardial infarction and ST-elevation myocardial infarction

      BackgroundPlaque rupture is the most common pathology associated with non–ST-elevation myocardial infarction (NSTEMI) and ST-elevation myocardial infarction (STEMI). However, limited data are available regarding ruptured plaque morphology and its relationship with the clinical syndrome. This study aimed (1) to provide a morphologic description of ruptured culprit lesions by optical coherence tomography (OCT) and (2) to investigate whether ruptured plaque morphology differs between NSTEMI and STEMI.MethodsWe included 84 consecutive patients with NSTEMI and STEMI undergoing OCT study of the culprit lesion. We identified patients with plaque rupture in the OCT study and used them as the study population. Qualitative ...

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    6. Morphological Characteristics of Culprit Atheromatic Plaque Are Associated With Coronary Flow After Thrombolytic Therapy

      Morphological Characteristics of Culprit Atheromatic Plaque Are Associated With Coronary Flow After Thrombolytic Therapy

      ObjectivesThis study investigated the association between morphological characteristics of culprit atheromatic lesions as assessed by optical coherence tomography and Thrombolysis In Myocardial Infarction (TIMI) flow grade after thrombolysis in patients with ST-segment elevation myocardial infarction (STEMI).BackgroundAlthough several variables have been found to predict coronary flow after thrombolysis in patients with STEMI, the impact of culprit lesion morphology has not been studied.MethodsFifty-five patients with STEMI from 3 tertiary centers that were treated with thrombolysis and underwent optical coherence tomography examination in the culprit lesion between 24 and 48 h after thrombolysis were included in the study. Patients were categorized ...

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    7. Assessment of a New Biodegradable Drug Eluting Stent for the Inhibition of Neovascularisation and Neointimal Hyperplasia: An Experimental Study With Optical Coherence Tomography

      Background: Vascular endothelial growth factor (VEGF) appears to be the most important mediator of neovascularisation. We assumed that inhibition of VEGF, using local delivery of bevacizumab, a monoclonal antibody specific for VEGF, could affect neovascularization and intimal hyperplasia in hypercholesterolemic rabbits. Methods: We used 10 New Zealand white rabbits under atherogenic diet for 3 weeks. Eleven biodegradable bevacizumab-eluting stents (BES) were implanted in the distal aorta. The control group consisted of 7 New Zealand white rabbits that were treated with 7 bare metal stents covered by biodegradable polymer. All animals were treated with aspirin and clopidogrel for 4 weeks. Follow-up ...

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    8. Morphological Characteristics of the Culprit Lesion Correlate With the Angiographic Flow Grade Following Thrombolysis in Myocardial Infarction. An Optical Coherence Tomography Study

      Background: Intravenous thrombolysis fails to restore blood flow in a significant percentage of patients with ST-elevation myocardial infarction (STEMI). It remains unknown, whether certain morphological characteristics of the culprit lesion (CL) can predict the success of thrombolysis. We hypothesized that the thickness of the fibrous cap and the incidence of plaque rupture at the CL, as measured by Optical Coherence Tomography (OCT), may correlate with the outcome of thrombolysis. Methods: We prospectively enrolled 55 consecutive patients with STEMI that were treated with thrombolysis 6 hours from symptom onset. All patients underwent coronary angiography within 24 hours from thrombolysis. We estimated ...

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      Mentions: Abbott
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    1. (3 articles) Abbott
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    Morphological Characteristics of Culprit Atheromatic Plaque Are Associated With Coronary Flow After Thrombolytic Therapy New insights by optical coherence tomography into the differences and similarities of culprit ruptured plaque morphology in non–ST-elevation myocardial infarction and ST-elevation myocardial infarction A Honeycomb-Like Structure in the Left Anterior Descending Coronary Artery: Demonstration of Recanalized Thrombus by Optical Coherence Tomography Optical coherence tomography assessment of the spatial distribution of culprit ruptured plaques and thin-cap fibroatheromas in acute coronary syndrome Metabolic syndrome predicts plaque rupture in patients with acute myocardial infarction. An optical coherence study Optical Coherence Tomography guided treatment of recurrent drug-eluting stent failure using drug-eluting balloon In vivo correlation between morphological characteristics of coronary plaques and functional characteristics of carotid arteries in acute coronary syndrome Comparison of Anterior Segment Measurements with a New Multifunctional Unit and Five Other Devices Efficacy of Notal Vision Home OCT demonstrated by a series of scientific and clinical work Synergy Between morpHOlogical and inflammatoRy Evaluation in Predicting Long-term Coronary Plaque Progression Altered ocular microvasculature in patients with systemic sclerosis and very early disease of systemic sclerosis using optical coherence tomography angiography Assessment of macular findings by OCT angiography in patients without clinical signs of diabetic retinopathy: radiomics features for early screening of diabetic retinopathy