1. Articles from Masaharu Ishihara

    1-9 of 9
    1. Impact of low tissue backscattering by optical coherence tomography on endothelial function after drug-eluting stent implantation

      Impact of low tissue backscattering by optical coherence tomography on endothelial function after drug-eluting stent implantation

      This study evaluated the impact of optical coherence tomography (OCT)-derived low-backscattered tissue on mid-term coronary endothelial function after drug-eluting stent (DES) implantation. Although OCT enables detailed in vivo evaluation of neointimal tissue characterization after DES implantation, its association with physiological vascular healing response is unclear. Thirty-three stable angina pectoris patients underwent OCT examination and endothelial function testing with intracoronary infusion of incremental doses of acetylcholine 8-month after DES implantation in a single lesion of the left anterior descending artery. Neointimal tissue was classified into two patterns based on the predominant OCT light backscatter: high backscatter and low backscatter. Although ...

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      Mentions: Kenichi Fujii
    2. Potential of new generation double-layer micromesh stent for carotid artery stenting in patients with unstable plaque ∼ A preliminary result using OFDI analysis ∼

      Potential of new generation double-layer micromesh stent for carotid artery stenting in patients with unstable plaque ∼ A preliminary result using OFDI analysis ∼

      Background One of the disadvantages of carotid artery stenting (CAS) is high incidence of distal embolism (DE) during or after the procedure. It has been reported that unstable plaque cases are at high risk of DE and plaque protrusion (PP) after stent placement which will become a cause of post procedural ischemic complications. Objective The purpose of this study was to compare the rate and size of PP between CASPER stent which is a new generation double-layer micromesh stent and conventional stents detected by optical frequency domain imaging (OFDI) and to evaluate the efficacy of CAS with CASPER stent for ...

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    3. Comparing the vascular response in implantation of self-expanding, bare metal nitinol stents or paclitaxel-eluting nitinol stents in superficial femoral artery lesions: a serial optical frequency domain imaging study

      Comparing the vascular response in implantation of self-expanding, bare metal nitinol stents or paclitaxel-eluting nitinol stents in superficial femoral artery lesions: a serial optical frequency domain imaging study

      Aims: This study sought to investigate differences in vascular response between self-expanding bare metal nitinol stents (BMS) and paclitaxel-eluting nitinol stents (PES), in superficial femoral artery (SFA) disease, using optical frequency domain imaging (OFDI). Methods and results: Six months after stent implantation, follow-up quantitative vascular angiography (QVA) and OFDI assessment were scheduled to evaluate vascular response. Volume index (VI) was defined as volume divided by stent length. The primary endpoint was OFDI-derived late lumen area loss, defined as lumen VI post stent implantation minus lumen VI at follow-up. A total of 28 SFA lesions were analysed, with cases randomised to ...

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    4. Ex Vivo Assessment of Neointimal Characteristics After Drug-eluting Stent Implantation: Optical Coherence Tomography and Histopathology Validation Study

      Ex Vivo Assessment of Neointimal Characteristics After Drug-eluting Stent Implantation: Optical Coherence Tomography and Histopathology Validation Study

      Background Optical coherence tomography (OCT) is one of the tools trying to distinguish neoatherosclerosis from other neointimal tissue but its role has to be still validated. This study evaluated the diagnostic accuracy of OCT for characterization of lipid-atherosclerotic neointima following drug-eluting stent (DES) implantation. Methods Twelve stented coronary arteries from the 7 autopsy hearts were imaged by OCT. These OCT images were compared with histology. By OCT, the morphological appearances of neointima were classified into three patterns: homogeneous pattern, heterogeneous pattern with visible strut, or heterogeneous pattern with invisible strut. Results Of 21 histological cross-sections, 6 were categorized as homogeneous ...

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    5. Restenosis After Drug-Eluting Stent Implantation in a Patient With Polycythemia Vera Optical Coherence Tomography and Pathological Findings

      Restenosis After Drug-Eluting Stent Implantation in a Patient With Polycythemia Vera Optical Coherence Tomography and Pathological Findings

      An 83-year-old woman was referred to our hospital due to diverticular bleeding of the colon. She had a history of everolimus-eluting stent implantation in the left anterior descending artery (31 months before) and the right coronary artery (20 and 31 months before) because of stable angina. She was prescribed aspirin 100 mg/day and clopidogrel 75 mg/day, followed by single antiplatelet therapy by aspirin during the last 8 months. Aspirin was discontinued for the endoscopic therapy at her admission. Complete blood count showed hemoglobin of 17.5 g/dl and hematocrit of 55.2%, from which polycythemia vera (PV ...

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      Mentions: Abbot Kenichi Fujii
    6. Longitudinal extent of lipid pool assessed by optical coherence tomography predicts microvascular no-reflow after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction

      Longitudinal extent of lipid pool assessed by optical coherence tomography predicts microvascular no-reflow after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction

      Background Distal embolization during percutaneous coronary intervention (PCI) may deteriorate microvascular reperfusion in patients with ST-elevation myocardial infarction (STEMI). Reperfusion at the coronary microvascular level is important for STEMI and culprit plaque is associated with distal embolization and microvascular reperfusion. ST-segment resolution (ST-R) in the electrocardiogram reflects microvascular reperfusion after primary PCI. Longitudinal extent of lipid pool assessed by optical coherence tomography (OCT) may predict the risk of failure of microvascular reperfusion after primary PCI. Methods and results This study consisted of 39 patients with STEMI who underwent primary PCI within 24 h after the onset of chest pain. Immediately ...

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    7. Very Late Stent Thrombosis after Sirolimus-Eluting Stent Implantation Observed Using Optical Coherence Tomography and Coronary Angioscopy

      Very Late Stent Thrombosis after Sirolimus-Eluting Stent Implantation Observed Using Optical Coherence Tomography and Coronary Angioscopy
      Sirolimus-eluting stents (SES) are now commonly used for percutaneous coronary intervention (PCI) because they dramatically reduce the rates of restenosis and target lesion revascularization, even in small vessels and long lesions as compared with bare-metal stent.1 The unresolved issue about SES use is the possibility of late stent thrombosis. Late stent thrombosis is a very rare, but serious complication that may result in acute myocardial infarction or sudden cardiac death.2 However, the mechanism of late stent thrombosis with SES has not been established. We report a patient with very late stent thrombosis 37 months after SES implantation who ...
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      Mentions: Cordis Abbot
    8. Correlation Between Plaque Color Classification by Coronary Angioscopy and Fibrous Cap Thickness by Optical Coherence Tomography

      Correlation Between Plaque Color Classification by Coronary Angioscopy and Fibrous Cap Thickness by Optical Coherence Tomography
      Background: Yellow color intensity of coronary plaque evaluated by coronary angioscopy (CAS) might be associated with plaque vulnerability. Pathological studies have reported that vulnerable plaque have the thin cap fibroatheroma (TCFA) with a cap thickness of 65 µm. Optical coherence tomography (OCT) permit us to evaluate fibrous cap thickness, because OCT has higher resolution than intravascular ultrasound (IVUS), which resolution is approximately 10 to 20 times higher than IVUS. Purpose: This study was undertaken to assess the relationship between plaque color evaluated by CAS and fibrous cap thickness estimated by OCT in patients with acute coronary syndrome (ACS). Methods: 84 ...
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    1-9 of 9
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  2. Topics in the News

    1. (3 articles) Kenichi Fujii
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    Correlation Between Plaque Color Classification by Coronary Angioscopy and Fibrous Cap Thickness by Optical Coherence Tomography Very Late Stent Thrombosis after Sirolimus-Eluting Stent Implantation Observed Using Optical Coherence Tomography and Coronary Angioscopy Mechanisms of Very Late Stent Thrombosis After Drug-Eluting Stent Implantation: Findings From Coronary Angioscopy and Optical Coherence Tomography Longitudinal extent of lipid pool assessed by optical coherence tomography predicts microvascular no-reflow after primary percutaneous coronary intervention for ST-segment elevation myocardial infarction Restenosis After Drug-Eluting Stent Implantation in a Patient With Polycythemia Vera Optical Coherence Tomography and Pathological Findings Ex Vivo Assessment of Neointimal Characteristics After Drug-eluting Stent Implantation: Optical Coherence Tomography and Histopathology Validation Study Comparing the vascular response in implantation of self-expanding, bare metal nitinol stents or paclitaxel-eluting nitinol stents in superficial femoral artery lesions: a serial optical frequency domain imaging study Potential of new generation double-layer micromesh stent for carotid artery stenting in patients with unstable plaque ∼ A preliminary result using OFDI analysis ∼ Impact of low tissue backscattering by optical coherence tomography on endothelial function after drug-eluting stent implantation Customized Slab-Segmentation Method for Projection-Artifact Elimination in Best Vitelliform Macular Dystrophy: A Swept-Source Optical Coherence Tomography Angiography Study Corneal Epithelial Thickness Profile in Healthy Portuguese Children by High-Definition Optical Coherence Tomography Prediction model for best focus, power, and spherical aberration of the cornea: Raytracing on a large dataset of OCT data