1. Articles from Tsuyoshi Nishiguchi

    1-19 of 19
    1. Imaging assessment and accuracy in coronary artery autopsy: comparison of frequency-domain optical coherence tomography with intravascular ultrasound and histology

      Imaging assessment and accuracy in coronary artery autopsy: comparison of frequency-domain optical coherence tomography with intravascular ultrasound and histology

      ptical coherence tomography (OCT) is a coronary artery imaging technique with high resolution. Second-generation frequency-domain OCT (FD-OCT) technology allows safer and faster clinical application compared with first-generation time-domain OCT (TD-OCT). Only limited validation studies compare FD-OCT with other modes of analysis: histology, which is the current gold standard, and intravascular ultrasound (IVUS). This study therefore aims to demonstrate the accuracy of FD-OCT images compared with IVUS and histology. FD-OCT and IVUS images were acquired from 203 segments from 31 coronary arteries obtained at autopsy from 20 cadavers. Of these, 30 randomly-selected pairs were used to create three classifications of plaque ...

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    2. Role of Optical Coherence Tomography in the Diagnosis of Spontaneous Coronary Artery Dissection

      Role of Optical Coherence Tomography in the Diagnosis of Spontaneous Coronary Artery Dissection

      Spontaneous coronary artery dissection (SCAD) is an infrequent and often missed diagnosis among patients with acute coronary syndrome (ACS), especially young healthy females. Unfortunately, SCAD can result in significant morbidity, such as ischemia and infarction. Currently, there has been a surge in the diagnosis of SCAD due to the widespread use of new intracoronary imaging modalities, especially optical coherence tomography (OCT).However, no specific guidelines exist concerning appropriate treatment for SCAD. Moreover, the role of intracoronary imaging with OCT has yet to be fully established. The aim of our review is to provide a comprehensive contemporary update of SCAD; the ...

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    3. In vivo optical coherence tomography imaging and histopathology of healed coronary plaques

      In vivo optical coherence tomography imaging and histopathology of healed coronary plaques

      Background and aims The aims of this study were to assess agreement between optical coherence tomography (OCT) and histopathology for healed coronary plaques (HCPs) in human coronary arteries ex vivo , and to evaluate the prevalence and characteristics of HCPs in vivo . Methods Ex vivo OCT images were co-registered with histopathology in 144 cross-sections with ≥50% stenosis. Of these, 30 randomly selected pairs were employed to define morphological features of OCT for HCPs (OCT-derived HCPs); the remaining 114 pairs were used to evaluate the accuracy of OCT in detecting histologically-defined HCPs. In a clinical study, 60 target lesions from 60 patients ...

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    4. Effect of Early Pitavastatin Therapy on Coronary Fibrous-Cap Thickness Assessed by Optical Coherence Tomography in Patients With Acute Coronary Syndrome : The ESCORT Study

      Effect of Early Pitavastatin Therapy on Coronary Fibrous-Cap Thickness Assessed by Optical Coherence Tomography in Patients With Acute Coronary Syndrome : The ESCORT Study

      Objectives The aim of the present study was to assess the effect of early statin therapy on fibrous-cap thickness in coronary plaques of patients with acute coronary syndrome (ACS) by using optical coherence tomography. Background Statins can contribute to the stabilization of coronary plaques. Methods This is a prospective, randomized, active-controlled, single-center study. Patients with ACS and untreated dyslipidemia were enrolled and randomly allocated (ratio 1:1) to either the early statin group (received pitavastatin 4 mg/day from baseline) or the late statin group (received pitavastatin 4 mg/day from 3 weeks after the baseline). Optical coherence tomography was ...

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    5. Prognosis of spontaneous coronary artery dissection treated by percutaneous coronary intervention with optical coherence tomography

      Prognosis of spontaneous coronary artery dissection treated by percutaneous coronary intervention with optical coherence tomography

      Background Although about half of patients with spontaneous coronary artery dissection (SCAD) face ongoing necrosis, conservative therapy is recommended due to a high complication rate in angiography-guided percutaneous coronary intervention (PCI). The aim of this study was to investigate clinical outcomes of SCAD treated by optical coherence tomography (OCT)-guided PCI. Methods This study consisted of consecutive 306 patients with acute coronary syndrome (ACS) who underwent OCT-guided PCI. Based on the culprit lesion morphology by OCT, patients were assigned to four groups: a SCAD group, a plaque rupture (PR) group, a calcified nodule (CN) group, and an undetermined etiology (UE ...

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    6. Optical Coherence Tomography Predictors for Edge Restenosis After Everolimus-Eluting Stent Implantation

      Optical Coherence Tomography Predictors for Edge Restenosis After Everolimus-Eluting Stent Implantation

      Background— Stent edge restenosis (SER) remains a potential limitation of drug-eluting stents. The aim of this study was to determine optical coherence tomography (OCT) predictors for angiographic late SER after everolimus-eluting stent implantation. Methods and Results— We retrospectively analyzed 319 patients who underwent OCT immediately after everolimus-eluting stent implantation and scheduled 9- to 12-month follow-up angiography. The binary angiographic SER rate was 10% (32/319) in the patients, 8.4% (32/382) in lesions, and 4.4% (33/744) in stent edge segments. In the stent edge segments at post stenting, OCT-derived lipidic plaque (61% versus 20%; P <0.001 ...

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    7. Reduction of in-stent thrombus immediately after percutaneous coronary intervention by pretreatment with prasugrel compared with clopidogrel: An optical coherence tomography study

      Reduction of in-stent thrombus immediately after percutaneous coronary intervention by pretreatment with prasugrel compared with clopidogrel: An optical coherence tomography study

      Background Prasugrel is a new-generation thienopyridine antiplatelet agent that provides more consistent and prompt platelet inhibition than clopidogrel. The aim of this study was to compare in-stent thrombus inhibition effect of pretreatment with prasugrel and clopidogrel by using optical coherence tomography (OCT) immediately after percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS). Methods We performed OCT immediately after PCI in 108 ACS patients pretreated with either prasugrel ( n = 51) or clopidogrel ( n = 57). OCT detected thrombus/plaque protrusion in all stented segments. Results Although stent volume (190.4 ± 119.1 mm 3 vs. 189.4 ± 95.8 mm 3 ...

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    8. Optical coherence tomography assessment of efficacy of thrombus aspiration in patients undergoing a primary percutaneous coronary intervention for acute ST-elevation myocardial infarction

      Optical coherence tomography assessment of efficacy of thrombus aspiration in patients undergoing a primary percutaneous coronary intervention for acute ST-elevation myocardial infarction

      Objective: We used optical coherence tomography (OCT) to assess the impact of thrombus aspiration before angioplasty on poststenting tissue protrusions in patients undergoing a primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI). Methods and results: A total of 188 patients with STEMI who underwent thrombus-aspiration PCI ( n =113) or standard PCI ( n =75) were examined in this study. OCT was performed immediately after primary PCI to assess lesion morphology in the stented segment. The minimum stent area was similar between the thrombus-aspiration PCI group and the standard PCI group [7.4 interquartile range (IQR): 5.8–9 ...

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    9. Optical coherence tomography assessment of efficacy of thrombus aspiration in patients undergoing a primary percutaneous coronary intervention for acute ST-elevation myocardial infarction

      Optical coherence tomography assessment of efficacy of thrombus aspiration in patients undergoing a primary percutaneous coronary intervention for acute ST-elevation myocardial infarction

      Objective: We used optical coherence tomography (OCT) to assess the impact of thrombus aspiration before angioplasty on poststenting tissue protrusions in patients undergoing a primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI). Methods and results: A total of 188 patients with STEMI who underwent thrombus-aspiration PCI ( n =113) or standard PCI ( n =75) were examined in this study. OCT was performed immediately after primary PCI to assess lesion morphology in the stented segment. The minimum stent area was similar between the thrombus-aspiration PCI group and the standard PCI group [7.4 interquartile range (IQR): 5.8–9 ...

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    10. Optimal threshold of postintervention minimum stent area to predict in-stent restenosis in small coronary arteries: An optical coherence tomography analysis

      Optimal threshold of postintervention minimum stent area to predict in-stent restenosis in small coronary arteries: An optical coherence tomography analysis

      Objectives The aim of this study was to determine the best threshold of postintervention minimum stent area (MSA) assessed by optical coherence tomography (OCT) to predict long-term in-stent restenosis (ISR) for 2.5 mm-diameter everolimus-eluting stents (EES). Background Percutaneous coronary intervention (PCI) for small coronary arteries remains challenging. Stent underexpansion is a strong predictor of late ISR. Methods We performed a retrospective analysis of 69 lesions in 69 patients undergoing PCI with 2.5 mm-diameter stents using OCT for the assessment of postintervention MSA and subsequent 9-month angiographic follow-up. Results The rates of angiographic ISR and target lesion revascularization were ...

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    11. Optical coherence tomography assessment of efficacy of thrombus aspiration in patients undergoing a primary percutaneous coronary intervention for acute ST-elevation myocardial infarction

      Optical coherence tomography assessment of efficacy of thrombus aspiration in patients undergoing a primary percutaneous coronary intervention for acute ST-elevation myocardial infarction

      Objective: We used optical coherence tomography (OCT) to assess the impact of thrombus aspiration before angioplasty on poststenting tissue protrusions in patients undergoing a primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI). Methods and results: A total of 188 patients with STEMI who underwent thrombus-aspiration PCI (n=113) or standard PCI (n=75) were examined in this study. OCT was performed immediately after primary PCI to assess lesion morphology in the stented segment. The minimum stent area was similar between the thrombus-aspiration PCI group and the standard PCI group [7.4 interquartile range (IQR): 5.8-9.4 ...

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    12. Vasa Vasorum Restructuring in Human Atherosclerotic Plaque Vulnerability

      Vasa Vasorum Restructuring in Human Atherosclerotic Plaque Vulnerability

      Background Previous studies have suggested that vasa vasorum (VV) is associated with plaque progression and vulnerability. Objectives The aim of this study was to investigate the relationship between coronary neovascularization structures and plaque characteristics. Methods We included 53 patients who underwent optical coherence tomography to observe the proximal left anterior descending coronary artery. Patients were classified into 5 groups according to lesion characteristics: normal; fibrous plaque (FP); fibroatheroma (FA); plaque rupture (PR); and fibrocalcific plaque (FC). We defined signal-poor tubuloluminal structures recognized in cross-sectional and longitudinal profiles located in adventitial layer as VV, and within plaque as intraplaque neovessels. Two ...

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    13. Successful Stenting With Optical Frequency Domain Imaging Guidance For Spontaneous Coronary Artery Dissection

      Successful Stenting With Optical Frequency Domain Imaging Guidance For Spontaneous Coronary Artery Dissection

      A 51-year-old woman was urgently admitted because of chest pain. Emergent coronary angiography revealed diffuse stenosis from the proximal to distal portion of the right coronary artery (RCA) with Thrombolysis In Myocardial Infarction (TIMI) flow grade 2 (Figure 1 ). No stenosis was seen in the left coronary artery. Intravascular ultrasound (IVUS) images revealed an intracoronary hematoma from the posterior descending artery (PDA) to the ostium of the RCA, but could not demonstrate the entry point of the hematoma (Figure 1 ). Optical frequency domain imaging (OFDI; Terumo, Tokyo, Japan) images clearly demonstrated, not only intracoronary hematoma from the PDA to the ...

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    14. Feasibility of Optical Coronary Tomography in Quantitative Measurement of Coronary Arteries With Lipid-Rich Plaque

      Feasibility of Optical Coronary Tomography in Quantitative Measurement of Coronary Arteries With Lipid-Rich Plaque

      Background: The aim of the present study was to evaluate the feasibility of optical coherence tomography (OCT) for measurement of vessel area in coronary arteries with lipid-rich plaque as compared with intravascular ultrasound (IVUS). Methods and Results: We investigated 80 coronary artery segments with lipid-rich plaque on OCT and non-attenuated plaque on IVUS. According to the lipid arc on OCT, the plaques were classified into 4 groups: group 1, lipid arc ≤90°; group 2, 90°<lipid arc≤180°; group 3, 180°<lipid arc≤270°; group 4, lipid arc >270°. Vessel circular arcs that could not be identified due to OCT ...

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    15. Difference of Ruptured Plaque Morphology between Asymptomatic Coronary Artery Disease and Non-ST Elevation Acute Coronary Syndrome Patients: an Optical Coherence Tomography Study

      Difference of Ruptured Plaque Morphology between Asymptomatic Coronary Artery Disease and Non-ST Elevation Acute Coronary Syndrome Patients: an Optical Coherence Tomography Study

      Background Autopsy studies have reported that rupture of a thin-cap fibroatheroma and subsequent thrombus formation is the major mechanism leading to acute coronary syndrome (ACS). However, it is not clear why only some plaque ruptures lead to ACS. Optical coherence tomography (OCT) is a high-resolution imaging modality which is capable of investigating detailed coronary plaque morphology in vivo. The objective of this study was to determine whether ruptured plaque morphology assessed by OCT differs between asymptomatic coronary artery disease (CAD) and non-ST elevation acute coronary syndrome (NSTEACS). Methods We examined ruptured plaque morphology using OCT in 80 patients, 33 with ...

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    16. Association between P-selectin Glycoprotein Ligand-1 and Pathogenesis in Acute Coronary Syndrome Assessed by Optical Coherence Tomography

      Association between P-selectin Glycoprotein Ligand-1 and Pathogenesis in Acute Coronary Syndrome Assessed by Optical Coherence Tomography

      Objective Although monocytes appear to be actively involved in the onset of acute coronary syndrome (ACS), they are heterogenous in human peripheral blood. How up-regulation of monocyte subsets leads to coronary plaque rupture followed by thrombus formation remains unclear. Recent studies have shown that P-selectin glycoprotein ligand-1 (PSGL-1) is involved in monocyte activation in patients with thrombus formation. We therefore investigated the relationship between the expression of PSGL-1 on monocyte subsets and thrombus formation using frequency-domain optical coherence tomography (FD-OCT) in patients with ACS. Methods We enrolled a total of 100 individuals in this study: patients with acute myocardial infarction ...

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    17. Prevalence of spontaneous coronary artery dissection in patients with acute coronary syndrome

      Prevalence of spontaneous coronary artery dissection in patients with acute coronary syndrome

      Aims: Spontaneous coronary artery dissection (SCAD) found typically in young females without classical coronary risk factors is thought to be a very rare cause of acute coronary syndrome (ACS). The prevalence of SCAD in ACS subjects has been unclear, probably due to the nature of coronary angiography. The aim of this study was to use optical coherence tomography (OCT) to investigate the prevalence of SCAD in ACS. Methods and results: This study consisted of 326 patients with ACS (with or without ST-segment elevation) who underwent OCT to explore the entire culprit artery. According to OCT findings, patients were divided into ...

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    18. Activated Platelet is Associated With Subclinical Stent Thrombosis Detected by Optical Coherence Tomography

      Activated Platelet is Associated With Subclinical Stent Thrombosis Detected by Optical Coherence Tomography

      Backgrounds: While stent thrombosis is a critical issue in the drug-eluting stent era, there are few monitoring markers for stent thrombosis. Optical coherence tomography (OCT) introducing as a high-resolution modality allows us to assess plaque characteristics, including in-stent micro-thrombus. We hypothesized that in vivo activated platelet was associated with in-stent thrombus formation. The aim of this study was to investigate the relationship between in vivo platelet activity and in-stent thrombus formation assessed by OCT. Methods: We enrolled 54 patients who were treated with coronary stent. OCT was performed at a 8-month follow-up angiography. The frequency of uncovered struts was assessed ...

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    1-19 of 19
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    Activated Platelet is Associated With Subclinical Stent Thrombosis Detected by Optical Coherence Tomography Prevalence of spontaneous coronary artery dissection in patients with acute coronary syndrome Association between P-selectin Glycoprotein Ligand-1 and Pathogenesis in Acute Coronary Syndrome Assessed by Optical Coherence Tomography Difference of Ruptured Plaque Morphology between Asymptomatic Coronary Artery Disease and Non-ST Elevation Acute Coronary Syndrome Patients: an Optical Coherence Tomography Study Feasibility of Optical Coronary Tomography in Quantitative Measurement of Coronary Arteries With Lipid-Rich Plaque Successful Stenting With Optical Frequency Domain Imaging Guidance For Spontaneous Coronary Artery Dissection Vasa Vasorum Restructuring in Human Atherosclerotic Plaque Vulnerability Optical coherence tomography assessment of efficacy of thrombus aspiration in patients undergoing a primary percutaneous coronary intervention for acute ST-elevation myocardial infarction Optimal threshold of postintervention minimum stent area to predict in-stent restenosis in small coronary arteries: An optical coherence tomography analysis Optical Coherence Tomography Predictors for Edge Restenosis After Everolimus-Eluting Stent Implantation Structure–Function Correlation Using OCT Angiography And Microperimetry In Diabetic Retinopathy Response to Re: Evaluation of choroidal changes in adolescent idiopathic scoliosis using enhanced depth imaging optical coherence tomography