All Articles from Hiram G. Bezerra -Optical Coherence Tomography News

Articles from Hiram G. Bezerra

1-24 of 72 1 2 3 »
1. New Volumetric Analysis Method for Stent Expansion and its Correlation With Final Fractional Flow Reserve and Clinical Outcome An ILUMIEN I Substudy
  
  Explore interventions.onlinejacc.org Aug 12 2018 Cardiology
  
  Download figure Open in new tab Download powerpoint Abstract Objectives This study sought to compare conventional methodology (CM) with a newly described optical coherence tomography (OCT)-derived volumetric stent expansion analysis in terms of fractional flow reserve (FFR)-derived physiology and device-oriented composite endpoints (DoCE). Background The analysis of coronary stent expansion with intracoronary imaging has used CM that relies on the analysis of selected single cross-sections for several decades. The introduction of OCT with its ability to perform semiautomated volumetric analysis opens opportunities to redefine optimal stent expansion. Methods A total of 291 lesions treated with post-stent OCT and ...
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  Mentions: Case Western Reserve University Cardiovascular Research Foundation David Holmes
2. Optimizing Percutaneous Coronary Intervention in Calcified Lesions Insights From Optical Coherence Tomography of Atherectomy
  
  Explore Circulation May 11 2018 Cardiology
  
  Optimal coronary stent implantation is among the few successful strategies in preventing stent failures, notably in-stent restenosis and stent thrombosis. 1 Understanding the intravascular milieu is a prerequisite for optimization of percutaneous coronary intervention (PCI). Calcified lesions limit stent expansion, the most robust predictor of target lesion revascularization, and are thus associated with worst outcomes. 2 Coronary angiography is a poor discriminator of calcium distribution and thickness. Reliance on angiography to guide PCI and define procedural success in severe coronary calcification is associated with poor outcomes. 3 Both intravascular ultrasound and optical coherence tomography (OCT) enable detailed evaluation of cross-sectional ...
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  Mentions: Case Western Reserve University Brown University Hiram G. Bezerra
3. Association of skin autofluorescence with plaque vulnerability evaluated by optical coherence tomography in patients with cardiovascular disease
  
  Explore atherosclerosis-journal.com Mar 2 2018 Cardiology , Dermatology
  
  Background and aims Accumulation of advanced glycation end products (AGEs) can be measured non-invasively by skin autofluorescence (SAF) whose values are elevated in patients with cardiovascular disease (CVD). Optical coherence tomography (OCT) is an intravascular imaging modality that could allow visualization of plaque composition. We aim to examine the relationship between SAF and plaque composition evaluated by frequency-domain OCT in patients with CVD. Methods We prospectively enrolled 108 patients with CVD who underwent OCT images during percutaneous coronary intervention (PCI). We divided the population into two groups: high SAF group (greater than or equal to 2.6) and low SAF ...
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  Mentions: Case Western Reserve University Sun Yat-Sen University Hiram G. Bezerra
4. Optical Coherence Tomography Assessment Prevented Unnecessary Intervention in an “Ambiguous” Angiographic Image
  
  Explore ScienceDirect Nov 15 2017 Cardiology
  
  Images in intervention.
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  Mentions: Hiram G. Bezerra Guilherme F. Attizzani
5. OCT Made Easy (Textbook)
  
  Explore CRC Press Online Oct 20 2017 Cardiology , Textbooks
  
  This book, written by premier authors in the field of OCT intravascular imaging, covers the best practices for using OCT to provide high resolution cross-sectional viewing for atherosclerotic plaque assessment, stent strut coverage and apposition, assessment in stent restenosis evaluation, and PCI guide and optimization. Fully illustrated thorughout in a handy, cath-lab side handbook supplemented by online movie clips, OCT Made Easy includes case studies, angiography, CT correlations, and simple techniques for getting the best image.
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  Mentions: Case Western Reserve University Marco A. Costa Hiram G. Bezerra
6. The REMEDEE-OCT Study : An Evaluation of the Bioengineered COMBO Dual-Therapy CD34 Antibody–Covered Sirolimus-Eluting Coronary Stent Compared With a Cobalt-Chromium Everolimus-Eluting Stent in Patients With Acute Coronary Syndromes: Insights From Optical
  
  Explore ScienceDirect Mar 11 2017 Cardiology
  
  Objectives The aim of the present study was to evaluate vascular healing of the bioengineered COMBO Dual Therapy Stent compared with a cobalt-chromium (CoCr) everolimus-eluting stent (EES) as assessed by optical coherence tomography in patients with acute coronary syndromes. Background CD34+ cells promote endothelial repair after vascular injury. The bioengineered COMBO Dual Therapy Stent combines CD34+ cell–capturing technology with abluminal sirolimus release, but more data from clinical studies evaluating the vascular response are needed. Methods In a prospective randomized multicenter clinical trial, 60 patients with acute coronary syndromes were randomized 1:1 to COMBO or CoCr EES implantation. The ...
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  Mentions: Case Western Reserve University Cardiovascular Research Foundation Academic Medical Center at the University of Amsterdam
7. Fate of Nonculprit Plaques in Patients With STEMI Undergoing Primary PCI Followed by Statin Therapy : A Serial Optical Coherence Tomography Analysis From the OCTAVIA Study
  
  Explore ScienceDirect Dec 27 2016 Cardiology
  
  Letter to the editor.
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  Mentions: Giulio Guagliumi Giuseppe Musumeci Vasile Sirbu
8. Difference in Vascular Response between Sirolimus-eluting- and Everolimus-eluting Stents in Ostial Left Circumflex Artery after Unprotected Left Main as Observed by
  
  Explore Elsevier Health Dec 23 2016 Cardiology
  
  Background Kissing-balloon technique (KBT) is commonly performed during percutaneous coronary intervention of distal unprotected left main coronary artery (ULM) aiming at obtaining optimal opening of the side branch (left circumflex artery; LCX) ostium. Nonetheless, detailed evaluation of vascular response to stents in LCX ostium is lacking. We therefore evaluated the vascular response to different drug-eluting stents (DES) in ostial LCX after ULM by means of optical coherence tomography (OCT). Methods We prospectively enrolled 38 consecutive patients with ULM disease, whom were treated with single-stent procedure using DES, crossover the ULM-left anterior descending artery (LAD) following by KBT. Twelve patients were ...
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  Mentions: Case Western Reserve University Hiram G. Bezerra Wei Wang
9. Optical coherence tomography assessment ruled out the need for intervention in a ‘hazy’ angiographic image
  
  Explore Home - Springer Oct 20 2016 Cardiology
  
  No abstract provided.
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  Mentions: Case Western Reserve University Hiram G. Bezerra Guilherme F. Attizzani
10. Failure Mechanisms and Neoatherosclerosis Patterns in Very Late Drug-Eluting and Bare-Metal Stent Thrombosis
  
  Explore Circulation Sep 1 2016 Cardiology
  
  Background— There are few clinical studies on the pathophysiological mechanisms of very late stent thrombosis (VLST). We report optical coherence tomography findings in patients with VLST and compare the findings between bare-metal stents (BMS) and drug-eluting stents (DES). Methods and Results— We conducted a registry of stent thrombosis at 4 North American centers with optical coherence tomography imaging programs SAFE registry (The Study of Late Stent Failure Evaluated by OCT). Images were acquired in 61 patients (42 DES and 19 BMS) presenting with definite VLST. The median duration from implantation to VLST presentation was 51.4 months in the DES ...
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  Mentions: University of Pittsburgh Case Western Reserve University University of British Columbia
11. Dextran or Saline Can Replace Contrast for Intravascular Optical Coherence Tomography in Lower Extremity Arteries
  
  Explore Journal of Endovascular Therapy Jul 9 2016 Cardiology
  
  Purpose: To examine the hypothesis that alternative flush media could be used for lower extremity optical coherence tomography (OCT) imaging in long lesions that would normally require excessive use of contrast. Methods: The OPTical Imaging Measurement of Intravascular Solution Efficacy (OPTIMISE) trial was a single-center, prospective study ( ClinicalTrials.gov identifier NCT01743872 ) that enrolled 23 patients (mean age 68±11 years; 14 men) undergoing endovascular intervention involving the superficial femoral artery. Four flush media (heparinized saline, dextran, carbon dioxide, and contrast) were used in succession in random order for each image pullback. Quality was defined as ≥270° visualization of vessel wall ...
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  Mentions: Case Western Reserve University Hiram G. Bezerra
12. Three-dimensional registration of intravascular optical coherence tomography and cryo-image volumes for microscopic-resolution validation
  
  Explore SPIE | Journal Jul 5 2016 Cardiology
  
  Evidence suggests high-resolution, high-contrast, 100 frames / s 100 frames/s intravascular optical coherence tomography (IVOCT) can distinguish plaque types, but further validation is needed, especially for automated plaque characterization. We developed experimental and three-dimensional (3-D) registration methods to provide validation of IVOCT pullback volumes using microscopic, color, and fluorescent cryo-image volumes with optional registered cryo-histology. A specialized registration method matched IVOCT pullback images acquired in the catheter reference frame to a true 3-D cryo-image volume. Briefly, an 11-parameter registration model including a polynomial virtual catheter was initialized within the cryo-image volume, and perpendicular images were extracted, mimicking IVOCT image acquisition ...
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  Mentions: Case Western Reserve University Marco A. Costa Madhusudhana Gargesha
13. Optical coherence tomography assessment ruled out the need for intervention in a 'hazy' angiographic image
  
  Explore Home - Springer May 22 2016 Cardiology
  
  No abstract provided
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  Mentions: Case Western Reserve University Hiram G. Bezerra Guilherme F. Attizzani
14. Optical coherence tomography assessment of in-stent restenosis after percutaneous coronary intervention with two-stent technique in unprotected left main
  
  Explore International Journal of Cardiology May 19 2016 Cardiology
  
  Background Optical coherence tomography (OCT) has contributed to a better understanding of in-stent restenosis (ISR); however, studies evaluating ISR pattern after two-stent technique in unprotected left main (ULM) are lacking. We aim to evaluate the ISR pattern of proximal LAD and LCX after two-stent technique in ULM. Methods We performed OCT in 26 patients with isolated or combined ISR (identified by angiography as >50%) after two stent implantation in the proximal LCX and LAD. Finally, 13 LAD and 22 LCX ISR lesions underwent OCT assessments. OCT analyses were undertaken in the proximal segments of the LAD and LCX. In addition ...
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  Mentions: National Institutes of Health Hiram G. Bezerra Wei Wang
15. Processing to determine optical parameters of atherosclerotic disease from phantom and clinical intravascular optical coherence tomography three-dimensional pullbacks
  
  Explore SPIE | Journal May 15 2016 Cardiology
  
  Analysis of intravascular optical coherence tomography (IVOCT) data has potential for real-time in vivo plaque classification. We developed a processing pipeline on a three-dimensional local region of support for estimation of optical properties of atherosclerotic plaques from coronary artery, IVOCT pullbacks. Using realistic coronary artery disease phantoms, we determined insignificant differences in mean and standard deviation estimates between our pullback analyses and more conventional processing of stationary acquisitions with frame averaging. There was no effect of tissue depth or oblique imaging on pullback parameter estimates. The method’s performance was assessed in comparison with observer-defined standards using clinical pullback data ...
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  Mentions: Andrew M. Rollins Case Western Reserve University Guy Lamouche
16. 3D registration of intravascular optical coherence tomography and cryo-image volumes for microscopic-resolution validation
  
  Explore Conference Proceedings Apr 2 2016 Cardiology
  
  High resolution, 100 frames/sec intravascular optical coherence tomography (IVOCT) can distinguish plaque types, but further validation is needed, especially for automated plaque characterization. We developed experimental and 3D registration methods, to provide validation of IVOCT pullback volumes using microscopic, brightfield and fluorescent cryoimage volumes, with optional, exactly registered cryo-histology. The innovation was a method to match an IVOCT pullback images, acquired in the catheter reference frame, to a true 3D cryo-image volume. Briefly, an 11-parameter, polynomial virtual catheter was initialized within the cryo-image volume, and perpendicular images were extracted, mimicking IVOCT image acquisition. Virtual catheter parameters were optimized to ...
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  Mentions: Case Western Reserve University Marco A. Costa Madhusudhana Gargesha
17. Classification of calcium in intravascular OCT images for the purpose of intervention planning
  
  Explore Conference Proceedings Mar 24 2016 Cardiology
  
  The presence of extensive calcification is a primary concern when planning and implementing a vascular percutaneous intervention such as stenting. If the balloon does not expand, the interventionalist must blindly apply high balloon pressure, use an atherectomy device, or abort the procedure. As part of a project to determine the ability of Intravascular Optical Coherence Tomography (IVOCT) to aid intervention planning, we developed a method for automatic classification of calcium in coronary IVOCT images. We developed an approach where plaque texture is modeled by the joint probability distribution of a bank of filter responses where the filter bank was chosen ...
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  Mentions: Case Western Reserve University David L. Wilson Hiram G. Bezerra
18. Comparison of Stent Expansion Guided by Optical Coherence Tomography Versus Intravascular Ultrasound : The ILUMIEN II Study (Observational Study of Optical Coherence Tomography [OCT] in Patients Undergoing Fractional Flow Reserve [FFR] and Percutaneous Co
  
  Explore ScienceDirect Nov 21 2015 Cardiology
  
  Background The most important predictor of adverse outcomes (thrombosis and restenosis) after stent implantation with IVUS guidance is the degree of stent expansion achieved. Methods We compared the relative degree of stent expansion (defined as the minimal stent area divided by the mean of the proximal and distal reference lumen areas) after OCT-guided stenting in patients in the ILUMIEN (Observational Study of Optical Coherence Tomography [OCT] in Patients Undergoing Fractional Flow Reserve [FFR] and Percutaneous Coronary Intervention) (N = 354) and IVUS-guided stenting in patients in the ADAPT-DES (Assessment of Dual Antiplatelet Therapy With Drug-Eluting Stents) study (N = 586). Stent expansion ...
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  Mentions: Case Western Reserve University Columbia University Cardiovascular Research Foundation
19. 3-D Stent Detection in Intravascular OCT Using a Bayesian Network and Graph Search
  
  Explore IEEE Xplore Mar 11 2015 Cardiology
  
  Worldwide, many hundreds of thousands of stents are implanted each year to revascularize occlusions in coronary arteries. Intravascular optical coherence tomography (OCT) is an important emerging imaging technique, which has the resolution and contrast necessary to quantitatively analyze stent deployment and tissue coverage following stent implantation. Automation is needed, as current, it takes up to 16 hours to manually analyze hundreds of images and thousands of stent struts from a single pullback. For automated strut detection, we used image formation physics and machine learning via a Bayesian network, and 3-D knowledge of stent structure via graph search. Graph search was ...
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  Mentions: Andrew M. Rollins Case Western Reserve University Marco A. Costa
20. Parameter estimation of atherosclerotic tissue optical properties from three-dimensional intravascular optical coherence tomography
  
  Explore SPIE | Journal Jan 6 2015 Cardiology
  
  We developed robust, three-dimensional methods, as opposed to traditional A-line analysis, for estimating the optical properties of calcified, fibrotic, and lipid atherosclerotic plaques from in vivo coronary artery intravascular optical coherence tomography clinical pullbacks. We estimated attenuation μ t and backscattered intensity I 0 from small volumes of interest annotated by experts in 35 pullbacks. Some results were as follows: noise reduction filtering was desirable, parallel line (PL) methods outperformed individual line methods, root mean square error was the best goodness-of-fit, and α -trimmed PL ( α -T-PL) was the best overall method. Estimates of μ t were calcified ( 3.84 ± 0.95 mm − 1 ...
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  Mentions: Andrew M. Rollins Case Western Reserve University Marco A. Costa
21. Proximal optimization technique and kissing balloon inflations with the bioresorbable vascular scaffold for coronary bifurcation percutaneous coronary intervention
  
  Explore Canadian Journal of Cardiology Dec 7 2014 Cardiology
  
  Proximal optimization technique and final kissing balloon inflations with noncompliant balloons facilitate success with coronary bifurcation intervention. The use of bioresorbable vascular scaffolds has been postulated to reduce the risk of in-stent restenosis, a particular problem with bifurcation intervention. We present a case of bifurcation intervention in a 49-year-old woman, using for the first time, proximal optimization and kissing balloon inflation within bioresorbable vascular scaffolds, using optical coherence tomography guidance.
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  Mentions: Ontario Cancer Institute Case Western Reserve University Hiram G. Bezerra
22. Differences determined by optical coherence tomography volumetric analysis in non-culprit lesion morphology and inflammation in ST-segment elevation myocardial infarction and stable angina pectoris patients
  
  Explore Wiley Online Library Sep 3 2014 Cardiology
  
  Background: While the current methodology for determining fibrous cap (FC) thickness of lipid plaques is based on manual measurements of arbitrary points, which could lead to high variability and decreased accuracy, it ignores the three-dimensional (3-D) morphology of coronary artery disease. Objective: To compare, utilizing optical coherence tomography (OCT) assessments, volumetric quantification of FC and macrophage detection using both visual assessment and automated image processing algorithms in non-culprit lesions of STEMI and stable angina pectoris (SAP) patients. Methods: Lipid plaques were selected from 67 consecutive patients (1 artery/patient). FC was manually delineated by a computer-aided method and automatically classified ...
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  Mentions: Andrew M. Rollins Case Western Reserve University University of São Paulo
23. Impact of Main-Branch Calcified Plaque on Side-Branch Stenosis in Bifurcation Stenting: An Optical Coherence Tomography Study
  
  Explore International Journal of Cardiology Aug 1 2014 Cardiology
  
  Percutaneous coronary intervention (PCI) in bifurcations is routinely performed, however this procedure is associated with higher rates of adverse events compared non-bifurcation PCI [1,2]. While bifurcation PCI per se leads to progressively higher rates of periprocedural myocardial infarction as its complexity increases (i.e., 1- vs. 2-stent technique) [3], side-branch (SB) stenosis (SBS) after main-branch (MB) stenting may further contribute to myocardial ischemia and necrosis; in addition, it might require additional intervention and resource utilization.
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  Mentions: Case Western Reserve University Marco A. Costa Hiram G. Bezerra
24. Comparison of scanning electron microscopy and optical coherence tomography (OCT) for imaging of coronary bifurcation stents
  
  Explore Wiley Online Library Jul 23 2014 Cardiology
  
  Background: Optical coherence tomography (OCT) is a new intracoronary imaging modality that has excellent resolution and image quality and has been used to image neointimal coverage after stent implantation. OCT has been compared to histologic, intravascular ultrasound, and scanning electron microscopy (SEM) studies. However, OCT has not been compared with SEM for imaging stent coverage over side branches. Objective: The aim of this study was to compare OCT with scanning electron microscopy (SEM) in imaging neointimal coverage over stent struts bridging coronary side-branch ostia. Methods: Using a balloon-overstretch in-stent restenosis model, we deployed 38 everolimus-eluting stents across coronary bifurcations in ...
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  Mentions: Case Western Reserve University Marco A. Costa Hiram G. Bezerra
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