1. Articles from Noah Rosenthal

    1-9 of 9
    1. In vivo intracardiac OCT imaging through percutaneous access: Towards image guided radio-frequency ablation

      In vivo intracardiac OCT imaging through percutaneous access: Towards image guided radio-frequency ablation

      BACKGROUND Complete catheter-tissue contact and permanent tissue destruction are essential for efficient radio-frequency ablation (RFA) during cardiac arrhythmia treatment. Current methods of monitoring lesion formation are indirect and unreliable. We aim to develop optical coherence tomography (OCT) as an imaging guidance for RFA. OBJECTIVES The purpose of this study is to evaluate the feasibility of using OCT catheter to image endocardia wall in active beating hearts through percutaneous access. This is a critical step toward image guided RFA in a clinic setting. METHODS A cone-scanning forward-viewing OCT catheter was advanced into active beating hearts through percutaneous access in four swine ...

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    2. In vivo intracardiac optical coherence tomography imaging through percutaneous access: toward image-guided radio-frequency ablation

      In vivo intracardiac optical coherence tomography imaging through percutaneous access: toward image-guided radio-frequency ablation
      Complete catheter-tissue contact and permanent tissue destruction are essential for efficient radio-frequency ablation (RFA) during cardiac arrhythmia treatment. Current methods of monitoring lesion formation are indirect and unreliable. The purpose of this study is to evaluate the feasibility of using optical coherence tomography (OCT) catheter to image endocardial wall in actively beating hearts through percutaneous access. We reported the first in vivo intracardiac OCT imaging through percutaneous access with a thin and flexible OCT catheter. This is a critical step toward image-guided RFA in a clinical setting. A cone-scanning forward-viewing OCT catheter was advanced into beating hearts through percutaneous access ...
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    3. The impact of an eccentric intravascular ImageWire during coronary optical coherence tomography imaging

      The impact of an eccentric intravascular ImageWire during coronary optical coherence tomography imaging
      Optical Coherence Tomography (OCT) provides high-resolution imaging which enables characterisation of atherosclerosis and vascular response to injury, but to ensure optimal analysis, one must realise potential sources of image distortion. We designed a series of analysesl, using coronary stents as a model, to investigate the influence of wire position on OCT-derived vascular images.
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    4. First in vivo Real-Time Imaging of Endocardial Radiofrequency Ablation by Optical Coherence Tomography: Implications on Safety and The Birth of ‘‘Electro-structural’’ Substrate-Guided Ablation

      First in vivo Real-Time Imaging of Endocardial Radiofrequency Ablation by Optical Coherence Tomography: Implications on Safety and The Birth of ‘‘Electro-structural’’ Substrate-Guided Ablation

      We report the first in vivo use of optical coherence tomography (OCT), a high-resolution (~10 µm) real-time imaging technology, to scan subendocardial tissue and to monitor radiofrequency (RF) lesion formation. Endocardial imaging during an open chest procedure in a female pig was conducted with a forward imaging catheter with a Fourier Domain OCT system at 20 frames per second. Images of the endocardial surface and subendocardial tissue were obtained when the catheter was in direct contact with the endocardial surface. The formation and progressive increase in size of cavities within the myocardium were observed in the OCT images when a ...

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    5. Angiographic, IVUS and OCT evaluation of the long-term impact of coronary disease severity at the site of overlapping drug-eluting and bare metal stents: a substudy of the ODESSA trial

      Angiographic, IVUS and OCT evaluation of the long-term impact of coronary disease severity at the site of overlapping drug-eluting and bare metal stents: a substudy of the ODESSA trial
      Background A potentially adverse vascular response to overlapping drug eluting stents (DES) has been suggested in current research. Objective To evaluate the impact of baseline disease severity at the site of stent overlap. Methods and results This is a substudy of ODESSA, a prospective, randomised controlled trial designed to evaluate healing of overlapping stents. 71/77 patients with a total of 86 overlapping stents were studied: 25 sirolimus, 24 paclitaxel, 26 zotarolimus-eluting stents; and 11 bare metal stents (BMS). Patients were categorised into high-grade stenosis (HGS, ≥70% diameter stenosis) and low-grade stenosis (LGS, <70%) at the site of stent overlap ...
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    6. Optical coherence tomography (OCT) strut-level analysis of drug-eluting stents (DES) in human coronary bifurcations

      Optical coherence tomography (OCT) strut-level analysis of drug-eluting stents (DES) in human coronary bifurcations
      Aims: We sought to evaluate the vascular response of stent struts deployed in bifurcation segments using optical coherence tomography (OCT). Conclusions: This study demonstrates a variable patter of strut coverage in the bifurcation among stent technologies, with a high percentage of PES floating struts remaining uncovered at 6-month follow-up.
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    7. Use of optical coherence tomography for accurate characterization of atherosclerosis

      Use of optical coherence tomography for accurate characterization of atherosclerosis
      Optical coherence tomography (OCT) is a novel imaging technology based on low-coherence interferometry that uses scattering of near-infrared light as a signal source to provide vascular cross-sectional imaging with definition far superior to any other available modality. With spatial resolution of up to 10μm, OCT provides 20-fold higher resolution than intravascular ultrasound (IVUS), currently the most used modality for intra-coronary imaging. OCT has the capacity to provide invaluable insight into the various phases of atherosclerotic disease and vascular response to therapeutics. Studies have shown the ability of OCT to detect arterial structures and assist in the determination of different histological ...
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    8. Unravelling the endovascular microenvironment by optical coherence tomography

      Undoubtedly, the field of interventional cardiology has evolved significantly over the past decades. A myriad of technologies, from mechanical devices that simply remove or displace obstructive atheroma to more complex energy-emitting or local drug delivery systems that interfere with critical molecular pathways, have been incorporated into our clinical armamentarium. This rapid pace of cardiovascular device development poses considerable challenges to contemporary clinician-investigators, who have at their disposal ageing X-ray coronary angiography and intravascular ultrasound (IVUS) imaging systems to take on the difficult task of judging these therapies (Figure 1). We have relied on a presbyopic view of what happens in ...
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    9. Assessment of Heterogeneity of Strut-Level Neointima Hyperplasia After Stent Implantation by Optical Coherence Tomography

      Background: Optical coherence tomography (OCT) permits a highly accurate NIH assessment at each strut level within a cross-section. The aim of this study is to evaluate heterogeneity of NIH among different stents. Methods: Patients enrolled in ODESSA were assessed. ODESSA was a prospective randomized trial designed to evaluate strut coverage of overlapped (OLP) vs. non-OLP stent segments for the treatment of de-novo, native coronary artery stenosis with four different stent types: Sirolimus-eluting stent (SES); Paclitaxel-eluting stent (PES); Zotarolimus-eluting stent (ZES); and Liberte BMS (BMS). Distance between strut and lumen was measured in every 5 frames (0.3mm) along the stented ...
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    1-9 of 9
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    1. (9 articles) Case Western Reserve University
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    Use of optical coherence tomography for accurate characterization of atherosclerosis Optical coherence tomography (OCT) strut-level analysis of drug-eluting stents (DES) in human coronary bifurcations Angiographic, IVUS and OCT evaluation of the long-term impact of coronary disease severity at the site of overlapping drug-eluting and bare metal stents: a substudy of the ODESSA trial The impact of an eccentric intravascular ImageWire during coronary optical coherence tomography imaging In vivo intracardiac optical coherence tomography imaging through percutaneous access: toward image-guided radio-frequency ablation In vivo intracardiac OCT imaging through percutaneous access: Towards image guided radio-frequency ablation First in vivo Real-Time Imaging of Endocardial Radiofrequency Ablation by Optical Coherence Tomography: Implications on Safety and The Birth of ‘‘Electro-structural’’ Substrate-Guided Ablation New World Resources and Perimeter Medical Imaging Provide Updates Regarding Their Amalgamation Transaction and Announce Amended and Restated Arrangement Agreement Retinal Vessel Density in Exudative and Non-Exudative Age-Related Macular Degeneration on Optical Coherence Tomography Angiography Use of Optical Coherence Tomography in a Patient with Erosive Oral Lichen Planus Treated with Low-Level Laser Therapy. Preliminary Findings Selective retinex enhancement based on the clustering algorithm and block-matching 3D for optical coherence tomography images Artificial intelligence, the internet of things, and virtual clinics: ophthalmology at the digital translation forefront