1. Articles from susanna s. park

    1-23 of 23

    1. Prospective Cross-Sectional Study of Repeatability of Peripapillary Capillary Density Measurement Using Optical Coherence Tomography Angiography in Eyes With Optic Nerve and Retinal Vascular Pathology

      Explore LWW Online Neurology , Ophthalmology
      Prospective Cross-Sectional Study of Repeatability of Peripapillary Capillary Density Measurement Using Optical Coherence Tomography Angiography in Eyes With Optic Nerve and Retinal Vascular Pathology

      Background: Optical coherence tomography angiography (OCTA) is a new noninvasive imaging modality that provides high resolution images of the optic nerve head and peripapillary retinal capillary vasculature which can be affected by optic nerve or retinal pathologies. High repeatability of peripapillary capillary density measurement using OCTA has been demonstrated in normal eyes and eyes with glaucoma. The purpose of our study was to quantify the repeatability of peripapillary capillary density measurement using OCTA in both normal eyes and eyes with optic atrophy, optic disc edema, and retinal vasculopathy. Methods: This prospective cross-sectional study enrolled 31 patients (59 eyes) including 16 ...

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      Mentions: Visionix

    2. Repeatability of Vascular Density Measurement of the Three Retinal Plexus Layers Using OCT Angiography in Pathologic Eyes (OCTA Vascular Density Repeatability of Three Plexus Layers)

      Explore Medical Journals Publisher Ophthalmology
      Repeatability of Vascular Density Measurement of the Three Retinal Plexus Layers Using OCT Angiography in Pathologic Eyes (OCTA Vascular Density Repeatability of Three Plexus Layers)

      Purpose: Although commercial optical coherence tomography angiography (OCTA) machines quantitate retinal vascular density (VD) by dividing the vasculature into superficial and deep capillary plexus (SCP, DCP), histology reveals three distinct plexus layers. This study tested the hypothesis that the VD measurement of three distinct retinal plexus layers obtained using custom segmentation has high repeatability comparable to that of automatically segmented SCP and DCP layers. Materials and Methods: Forty-four participants (86 eyes) were enrolled – 54 eyes with retinal vasculopathy and 25 eyes with macular edema. Macular OCTA images (3x3 mm and 6x6 mm) were obtained twice within 30 minutes by the ...

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      Mentions: Visionix University of Southern California

    3. Factors Affecting Repeatability of Foveal Avascular Zone Measurement Using Optical Coherence Tomography Angiography in Pathologic Eyes

      Explore Medical Journals Publisher Ophthalmology
      Factors Affecting Repeatability of Foveal Avascular Zone Measurement Using Optical Coherence Tomography Angiography in Pathologic Eyes

      Purpose: To determine factors that may affect the repeatability of the foveal avascular zone (FAZ) measurement obtained using optical coherence tomography angiography (OCTA) including instrument type, image segmentation, image quality, and fundus pathology. Patients and Methods: This prospective single-center study enrolled 43 subjects (85 eyes) with retinal vasculopathy, macular edema, optic pathology or normal contralateral eye. The macula was imaged twice using Optovue Angiovue and once using Cirrus Angioplex to obtain 3x3mm OCTA images centered on the fovea. Images were generated by the same operator within 30 mins. The FAZ size for the entire retinal thickness (“overall FAZ”) was measured ...

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      Mentions: Visionix Carl Zeiss Meditec UC Davis

    4. Retinal Vessel Density in Exudative and Non-Exudative Age-Related Macular Degeneration on Optical Coherence Tomography Angiography

      Explore American Journal of Ophthalmology Ophthalmology
      Retinal Vessel Density in Exudative and Non-Exudative Age-Related Macular Degeneration on Optical Coherence Tomography Angiography

      Importance Although the choroid contributes to the pathogenesis of age-related macular degeneration (AMD), the role of retinal perfusion is unclear. Purpose To compare retinal vascular measurements between eyes with non-exudative and exudative AMD using optical coherence tomography angiography (OCT-A). Design Retrospective, cross-sectional study. Methods OCT-A images were analyzed from 310 eyes of 182 patients (mean age 78.8±8.8) with non-exudative (54.2%) and exudative (45.8%) AMD to measure retinal vessel density (VD) from the superficial capillary plexus in the foveal, parafoveal, and full macular regions and foveal avascular zone (FAZ) area, perimeter, and circularity. Multivariate regressions were ...

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      Mentions: UC Davis

    5. Phase-Variance Optical Coherence Tomographic Angiography Imaging of Choroidal Perfusion Changes Associated With Acute Posterior Multifocal Placoid Pigment Epitheliopathy

      Explore JAMA Network Ophthalmology
      Phase-Variance Optical Coherence Tomographic Angiography Imaging of Choroidal Perfusion Changes Associated With Acute Posterior Multifocal Placoid Pigment Epitheliopathy

      This case report uses phase-variance optical coherence tomographic angiography to demonstrate transient inner choroidal flow changes associated with acute posterior multifocal placoid pigment epitheliopathy. Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is characterized by bilateral multiple placoid white-gray lesions of the posterior pole at the level of the retinal pigment epithelium (RPE) and/or choriocapillaris, which self-resolve with recovery of vision. 1 , 2 The etiology is unknown, but APMPPE has been associated with viral prodromes and vasculitis. The placoid lesions are thought to represent focal RPE inflammation or choriocapillaris ischemia based on fluorescein angiogram findings of early hypofluorescence and late ...

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      Mentions: UC Davis

    6. Detection of PED vascularization using phase-variance OCT angiography

      Explore Medical Journals Publisher Ophthalmology
      Detection of PED vascularization using phase-variance OCT angiography

      Purpose: To demonstrate the use of phase-variance optical coherence tomography (PV-OCT) angiography for detection of pigment epithelial detachment (PED) vascularization in age-related macular degeneration (AMD). Patients and methods: Patients with PEDs and exudative AMD were evaluated by the Retina Services at the University of California, Davis, and the University of California, San Francisco. Each subject underwent fluorescein angiography and structural optical coherence tomography (OCT). Phase-variance OCT analysis was used to create angiographic images of the retinal and choroidal vasculature. PV-OCT-generated B-scans were superimposed on structural OCT B-scans to allow easy identification of perfused vascular structures. Results: Three patients with vascularized ...

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      Mentions: Oregon Health & Science University University of Southern California UC Davis

    7. Phase-Variance Optical Coherence Tomography: A New Technique for Noninvasive Angiography

      Explore Ophthalmology Ophthalmology
      Phase-Variance Optical Coherence Tomography: A New Technique for Noninvasive Angiography

      Purpose Phase-variance optical coherence tomography (PV-OCT) provides volumetric imaging of the retinal vasculature without the need for intravenous injection of a fluorophore. We compare images from PV-OCT and fluorescein angiography (FA) for normal individuals and patients with age-related macular degeneration (AMD) and diabetic retinopathy. Design This is an evaluation of a diagnostic technology. Participants Four patients underwent comparative retinovascular imaging using FA and PV-OCT. Imaging was performed on 1 normal individual, 1 patient with dry AMD, 1 patient with exudative AMD, and 1 patient with nonproliferative diabetic retinopathy. Methods Fluorescein angiography imaging was performed using a Topcon Corp (Tokyo, Japan ...

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      Mentions: California Institute of Technology UCSF

    8. Optical imaging of the chorioretinal vasculature in the living human eye

      Explore pnas.org Ophthalmology
      Optical imaging of the chorioretinal vasculature in the living human eye

      Detailed visualization of microvascular changes in the human retina is clinically limited by the capabilities of angiography imaging, a 2D fundus photograph that requires an intravenous injection of fluorescent dye. Whereas current angiography methods enable visualization of some retinal capillary detail, they do not adequately reveal the choriocapillaris or other microvascular features beneath the retina. We have developed a noninvasive microvascular imaging technique called phase-variance optical coherence tomography (pvOCT), which identifies vasculature three dimensionally through analysis of data acquired with OCT systems. The pvOCT imaging method is not only capable of generating capillary perfusion maps for the retina, but it ...

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      Mentions: California Institute of Technology UC Davis UCSF

    9. Staging of Macular Telangiectasia: Power-Doppler Optical Coherence Tomography and Macular Pigment Optical Density

      Explore iovs.org Ophthalmology
      Staging of Macular Telangiectasia: Power-Doppler Optical Coherence Tomography and Macular Pigment Optical Density

      Purpose: Two methods were used to study the stages of macular telangiectasia (MacTel): Power-Doppler optical coherence tomography (PD-OCT) which allows imaging of retinal circulation in three-dimensions, and macular pigment optical density (MPOD) which quantifies the distribution of macular carotenoids. Methods: Among 49 patients with MacTel identified, 12 eyes (6 patients) with MacTel and 7 age-matched control eyes (7 patients) were imaged with a custom-built Fourier-domain OCT instrument to acquire PD-OCT images. MPOD was measured using heterochromatic flicker photometry in 10 eyes (5 patients) with MacTel and compared to 44 age-matched control eyes (44 patients). Clinical staging of MacTel was based ...

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      Mentions: UC Davis

    10. FIVE-YEAR FOLLOW-UP OF MACULAR MORPHOLOGIC CHANGES AFTER RHEGMATOGENOUS RETINAL DETACHMENT REPAIR: Fourier Domain OCT Findings

      Explore LWW Online Ophthalmology
      FIVE-YEAR FOLLOW-UP OF MACULAR MORPHOLOGIC CHANGES AFTER RHEGMATOGENOUS RETINAL DETACHMENT REPAIR: Fourier Domain OCT Findings

      Purpose: To evaluate serially long-term macular morphologic changes after successful macula-involving rhegmatogenous retinal detachment repair and correlate changes with macular function. Methods: Repeat Fourier domain optical coherence tomography (FD OCT) imaging and microperimetry (MP-1) testing of 8 of the initial cohort of 17 eyes studied 5 years earlier. Results: The mean follow-up after rhegmatogenous retinal detachment repair was 3.4 months (range, 1-8.5 months) for the first FD OCT and 5 years (range, 3.75-5.75 years) for the follow-up FD OCT. The final postoperative best-corrected visual acuity mean was 20/201 (range, 20/20 to counting fingers). Six ...

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      Mentions: UC Davis

    11. Feature Of The Week 2/19/12: UC Davis Researchers Investigate the Reproducibility of Macular Thickness Measurements Among Five Commercial OCT Instruments

      Explore Optical Coherence Tomography News Ophthalmology
      Feature Of The Week 2/19/12: UC Davis Researchers Investigate the Reproducibility of Macular Thickness Measurements Among Five Commercial OCT Instruments

      There are now over 10 ophthalmic OCT instrument makers selling into the commercial OCT ophthalmology market. Today there are both time-domain, spectral-domain, and swept-source commercial OCT systems. There have been various studies comparing different aspects of these instruments.  One such study was by researchers at the University of California Davis Eye Center compared five instruments (Stratus/Zeiss, Cirrus/Zeiss, Spectralis/Heidelberg, RTVue/Optovue, and SD-OCT/Topcon in their central macular thickness measurements.For more information see recent Article. Courtesy Sussana Park and  Eric Chin from UC Davis.

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      Mentions: Visionix Heidelberg Engineering Topcon Medical Systems

    12. Noninvasive Imaging of the Foveal Avascular Zone with High-Speed, Phase-Variance Optical Coherence Tomography

      Explore iovs.org Ophthalmology
      Noninvasive Imaging of the Foveal Avascular Zone with High-Speed, Phase-Variance Optical Coherence Tomography

      Purpose. To demonstrate the application of phase-variance optical coherence tomography (pvOCT) for contrast agent–free in vivo imaging of volumetric retinal microcirculation in the human foveal region and for extraction of foveal avascular zone dimensions. Methods. A custom-built, high-speed Fourier-domain OCT retinal imaging system was used to image retinas of two healthy subjects and eight diabetic patients. Through the acquisition of multiple B-scans for each scan location, phase differences between consecutive scans were extracted and used for phase-variance contrast, identifying motion signals from within blood vessels and capillaries. The en face projection view of the inner retinal layers segmented out ...

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      Mentions: California Institute of Technology UC Davis UCSF

    13. Reproducibility of Macular Thickness Measurement Among Five OCT Instruments: Effects of Image Resolution, Image Registration, and Eye Tracking

      Explore SLACK Journals Ophthalmology
      Reproducibility of Macular Thickness Measurement Among Five OCT Instruments: Effects of Image Resolution, Image Registration, and Eye Tracking

      BACKGROUND AND OBJECTIVE: To study the effect of image resolution, eye tracking, and image registration on central macular thickness reproducibility (rCMT) among spectral-domain and time-domain optical coherence tomography (SD-OCT and TD-OCT) instruments. PATIENTS AND METHODS: Seventy-six eyes were imaged (44 normal, 32 maculopathy) either twice using four SD-OCT and one TD-OCT devices or three times using Spectralis SD-OCT (with and without eye tracking) (Heidelberg Engineering, Inc., Heidelberg, Germany). Cirrus images (Carl Zeiss Meditec, Dublin, CA) were further analyzed with three-point image registration. RESULTS: All instruments had superior rCMT in normal versus pathologic eyes (P < .001). No difference in rCMT was noted among instruments in normal eyes (P = .92), but TD-OCT was superior to SD-OCT (P = .017) in pathologic eyes. Cirrus image registration improved rCMT for normal eyes (P = .04), with borderline improvement in pathologic eyes (P = .06). Spectralis eye tracking improved rCMT in normal (P = .01) and pathologic (P = .004) eyes. CONCLUSION: Higher image resolution with SD-OCT may not improve rCMT, but image registration and eye tracking options may improve rCMT.

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      Mentions: Visionix Heidelberg Engineering Topcon Medical Systems

    14. Comparison of Retinal Nerve Fiber Layer and Central Macular Thickness Measurements Among Five Different Optical Coherence Tomography Instruments in Patients With Multiple Sclerosis and Optic Neuritis

      Explore LWW Online Ophthalmology
      Comparison of Retinal Nerve Fiber Layer and Central Macular Thickness Measurements Among Five Different Optical Coherence Tomography Instruments in Patients With Multiple Sclerosis and Optic Neuritis

      Background: To compare the mean central macular thickness (CMT) and the mean average optic nerve retinal nerve fiber layer (RNFL) thickness in the eyes of patients with a history of optic neuritis and/or multiple sclerosis (MS) using 5 commercially available optical coherence tomography (OCT) instruments. Methods: Cross-sectional study including 46 patients (92 eyes) with a history of optic neuritis and/or MS. Both eyes were imaged on the same day with 5 OCT instruments: 1 time-domain OCT (Stratus) and 4 different Fourier-domain (spectral-domain) OCT (3D OCT-1000, Cirrus, RTVue-100, and Spectralis). Results: Twenty-five patients (50 eyes) were included in the ...

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      Mentions: Visionix Heidelberg Engineering Topcon Medical Systems

    16. High-Resolution Fourier-Domain Optical Coherence Tomography of Choroidal Neovascular Membranes Associated with Age-Related Macular Degeneration

      Explore iovs.org Ophthalmology
      High-Resolution Fourier-Domain Optical Coherence Tomography of Choroidal Neovascular Membranes Associated with Age-Related Macular Degeneration
      High-resolution Fourier-domain optical coherence tomography (Fd-OCT) provided visualization of choroidal neovascular membrane (CNVM) and associated morphologic changes in the retina in eyes with neovascular age-related macular degeneration. The growth pattern and size of CNVM was determined with Fd-OCT and correlated better with findings on fluorescein angiography in eyes with classic lesions.
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      Mentions: UC Davis

    17. Maculopathy Diagnosed With High-Resolution Fourier-Domain Optical Coherence Tomography in Eyes With Previously Unexplained Visual Loss

      Explore LWW Online Ophthalmology
      Maculopathy Diagnosed With High-Resolution Fourier-Domain Optical Coherence Tomography in Eyes With Previously Unexplained Visual Loss
      Purpose: To describe maculopathy diagnosed with high-resolution Fourier-domain optical coherence tomography among eyes with previously unexplained visual loss. Methods: Nine eyes from six patients with previously unexplained vision loss based on funduscopy, fluorescein angiography, and Stratus optical coherence tomography and 32 eyes from 25 asymptomatic age-matched control subjects were imaged with a Fourier-domain optical coherence tomography instrument with axial resolution of 4 [mu]m to 4.5 [mu]m and transverse resolution of 10 [mu]m to 15 [mu]m. Results: Among eyes with unexplained vision loss, visual acuity ranged from 20/20 to 20/80 and central scotoma was ...
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      Mentions: Carl Zeiss Meditec UC Davis

    18. Comparison of Macular Thickness Measurement and Segmentation Error Rate Between Stratus and Fourier-Domain Optical CoherenceTomography

      Explore Ophthalmic Surgery, Lasers and Imaging Ophthalmology
      Comparison of Macular Thickness Measurement and Segmentation Error Rate Between Stratus and Fourier-Domain Optical CoherenceTomography
      To compare macular thickness measurements and segmentation error rates between Stratus optical coherence tomography (OCT) (Carl Zeiss Meditec, Inc., Dublin, CA), and Fourier-domain OCT (RTVue, Optovue, Inc., Fremont, CA). A retrospective study was performed of 93 normal and pathologic eyes from 79 subjects imaged with both OCT instruments on the same day. Both the macular thickness measurement for each Early Treatment Diabetic Retinopathy Study (ETDRS) zone and the incidence of segmentation erro
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      Mentions: Visionix Carl Zeiss Meditec

    19. High Resolution Fourier-Domain Optical Coherence Tomography of Choroidal Neovascular Membranes Associated with Age-Related Macular Degeneration

      Explore iovs.org Ophthalmology
      Purpose: To investigate to use of high resolution Fourier-domain optical coherence tomography (Fd-OCT) to image choroidal neovascular membranes (CNVM) associated with exudative age-related macular degeneration (eAMD). Methods: An Fd-OCT instrument with axial resolution of 4 to 4.5 µm and transverse resolution of 10 to 15 µm was used to image 21 eyes (19 subjects) with newly-diagnosed eAMD. A raster series of 100 B-scans separated by 60 µm was used study the growth pattern of CNVM and associated morphologic changes. CNVM size was determined using 250 to 300 serial virtual C-scans of reconstructed 3-dimensional macular volume. Results: A highly reflective ...
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      Mentions: UC Davis

    20. Effect of Diabetic Retinopathy and Panretinal Photocoagulation on Retinal Nerve Fiber Layer and Optic Nerve Appearance

      Explore Archives of Ophthalmology Ophthalmology
      Objective  To determine if panretinal photocoagulation (PRP) alters retinal nerve fiber layer (RNFL) thickness and optic nerve appearance. Methods  Patients with diabetes who did and did not undergo PRP and nondiabetic control subjects were enrolled in a prospective study. Participants underwent optical coherence tomography of the peripapillary retina and optic nerve. Stereoscopic optic nerve photographs were graded in a masked fashion. Results  Ninety-four eyes of 48 healthy individuals, 89 eyes of 55 diabetic patients who did not undergo PRP, and 37 eyes of 24 subjects with diabetes who underwent PRP were included in this study. Eyes that had been treated ...
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      Mentions: Universidade Federal de São Paulo UC Davis

    21. Microcystoid Maculopathy Associated With Tamoxifen Use Diagnosed By High-Resolution Fourier-Domain Optical Coherence Tomography.

      Explore RETINAL Cases & Brief Reports Ophthalmology
      Purpose: To describe a case of microcystoid maculopathy diagnosed by high-resolution Fourier-domain optical coherence tomography (Fd-OCT) in a patient treated with tamoxifen who had previously unexplained vision loss. Methods: Report of a case of a 66-year-old woman treated with tamoxifen for 4 years who had progressive unexplained vision loss in the left eye for 2 years. Results: Visual acuity was 20/25 in the right eye and 20/70 in the left eye. Findings of funduscopy and fluorescein angiography were unremarkable except for minimal pigment alteration in the macula in the left eye. Stratus OCT showed possible microcystoid changes in ...
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      Mentions: Carl Zeiss Meditec UC Davis

    22. High-resolution Fourier-Domain Optical Coherence Tomography and Microperimetric Findings After Macula-off Retinal Detachment Repair

      Explore OphSource Ophthalmology
      Objective To evaluate the morphologic changes in the macula of subjects with repaired macula-off retinal detachment (RD) using high-resolution Fourier-domain optical coherence tomography (FD OCT) and to perform functional correlation in a subset of patients using microperimetry (MP-1). Design Prospective observational case series. Participants Seventeen eyes from 17 subjects who had undergone anatomically successful repair for macula-off, rhegmatogenous RD at least 3 months earlier and without visually significant maculopathy on funduscopy. Methods FD OCT with axial and transverse resolution of 4.5 μm and 10 to 15 μm, respectively, was used to obtain rapid serial B-scans of the macula, which ...
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      Mentions: Carl Zeiss Meditec UC Davis

    23. High-resolution Fourier-Domain Optical Coherence Tomography and Microperimetric Findings After Macula-off Retinal Detachment Repair.

      Explore NCBI HomePage Ophthalmology
      High-resolution Fourier-Domain Optical Coherence Tomography and Microperimetric Findings After Macula-off Retinal Detachment Repair. Ophthalmology. 2008 Jul 30; Authors: Smith AJ, Telander DG, Zawadzki RJ, Choi SS, Morse LS, Werner JS, Park SS OBJECTIVE: To evaluate the morphologic changes in the macula of subjects with repaired macula-off retinal detachment (RD) using high-resolution Fourier-domain optical coherence tomography (FD OCT) and to perform functional correlation in a subset of patients using microperimetry (MP-1). DESIGN: Prospective observational case series. PARTICIPANTS: Seventeen eyes from 17 subjects who had undergone anatomically successful repair for macula-off, rhegmatogenous RD at least 3 months earlier and without visually significant ...
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      Mentions: Carl Zeiss Meditec UC Davis
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    Comparison of Macular Thickness Measurement and Segmentation Error Rate Between Stratus and Fourier-Domain Optical CoherenceTomography Comparison of Retinal Nerve Fiber Layer and Central Macular Thickness Measurements Among Five Different Optical Coherence Tomography Instruments in Patients With Multiple Sclerosis and Optic Neuritis Reproducibility of Macular Thickness Measurement Among Five OCT Instruments: Effects of Image Resolution, Image Registration, and Eye Tracking Feature Of The Week 2/19/12: UC Davis Researchers Investigate the Reproducibility of Macular Thickness Measurements Among Five Commercial OCT Instruments Optical imaging of the chorioretinal vasculature in the living human eye Phase-Variance Optical Coherence Tomography: A New Technique for Noninvasive Angiography Macular and choroidal perfusion using optical coherence tomography angiography in type-2 diabetic patients without diabetic retinopathy Short-term evaluation of clear corneal incision after phacoemulsification using anterior segment optical coherence tomography Evaluation of the central vault following implantable phakic contact lens and its correlation to horizontal white to white corneal diameter by anterior segment optical coherence tomography Automatic bifurcation detection utilizing pullback characteristics of bifurcation in intravascular optical coherence tomography An IoT based predictive modeling for Glaucoma detection in optical coherence tomography images using hybrid genetic algorithm The Value of Optical Coherence Tomography Angiography in Pituitary Adenomas