1. Articles from Nigel R. Munce

    1-10 of 10
    1. Hybrid intravascular ultrasound and optical coherence tomography catheter for imaging of coronary atherosclerosis

      Hybrid intravascular ultrasound and optical coherence tomography catheter for imaging of coronary atherosclerosis

      Objective To demonstrate the feasibility of imaging human coronary atherosclerosis using a novel hybrid intravascular ultrasound (IVUS) and optical coherence tomography (OCT) imaging catheter. Background IVUS and OCT have synergistic advantages and recent studies involving both modalities suggest the use of a hybrid imaging catheter may offer improved guidance of coronary interventions and plaque characterization. Methods A 1.3 m custom hybrid IVUS-OCT imaging probe was built within a 4F catheter using a 42 MHz ultrasound transducer and an OCT imaging fiber. Coplanar images were simultaneously acquired ex vivo by both modalities in 31 arterial segments from 11 cadaveric human ...

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    2. Doppler optical coherence tomography for interventional cardiovascular guidance: in vivo feasibility and forward-viewing probe flow phantom demonstration

      Doppler optical coherence tomography for interventional cardiovascular guidance: in vivo feasibility and forward-viewing probe flow phantom demonstration
      We demonstrate the potential of a forward-looking Doppler optical coherence tomography (OCT) probe for color flow imaging in several commonly seen narrowed artery morphologies. As a proof of concept, we present imaging results of a surgically exposed thrombotic occlusion model that was imaged superficially to demonstrate that Doppler OCT can identify flow within the recanalization channels of a blocked artery. We present Doppler OCT images in which the flow is nearly antiparallel to the imaging direction. These images are acquired using a flexible 2.2-mm-diam catheter that used electrostatic actuation to scan up to 30 deg ahead of the distal ...
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    3. In vivo endoscopic multi-beam optical coherence tomography

      In vivo endoscopic multi-beam optical coherence tomography
      multichannel optical coherence tomography (multi-beam OCT) system and an in vivo endoscopic imaging probe were developed using a swept-source OCT system. The distal optics were micro-machined to produce a high numerical aperture, multi-focus fibre optic array. This combination resulted in a transverse design resolution of <10 µm full width half maximum (FWHM) throughout the entire imaging range, while also increasing the signal intensity within the focus of the individual channels. The system was used in a pre-clinical rabbit study to acquire in vivo structural images of the colon and ex vivo images of the oesophagus and trachea. A good correlation ...
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    4. High-power wavelength-swept laser in Littman telescope-less polygon filter and dual-amplifier configuration for multichannel optical coherence tomography

      High-power wavelength-swept laser in Littman telescope-less polygon filter and dual-amplifier configuration for multichannel optical coherence tomography
      We report a high-power wavelength-swept laser source for multichannel optical coherence tomography (OCT) imaging. Wavelength tuning is performed by a compact telescope-less polygon-based filter in Littman arrangement. High output power is achieved by incorporating two serial semiconductor optical amplifiers in the laser cavity in Fourier domain mode-locked configuration. The measured wavelength tuning range of the laser is 111 nm centered at 1329 nm, coherence length of 5.5 mm, and total average output power of 131 mW at 43 kHz sweeping rate. Multichannel simultaneous OCT imaging at an equivalent A-scan rate of 258 kHz is demonstrated. © 2009 Optical Society of ...
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    5. Conducting polymer actuator driven catheter: overview and applications

      In this paper conducting polymer based active catheters are presented. Design considerations along with the promise and challenges associated with conducting polymer driven devices are discussed. A conducting polymer driven intravascular catheter is described briefly and its design challenges such as structural rigidity and angle of bending are studied. Then a detailed description of a polypyrrole based active catheter that is ultimately intended for in-vivo imaging applications will be presented. The active catheter contains an optical fibre and is designed to scan the fibre in two dimensions at a speed of 30 Hz to provide real time imaging. The preliminary ...
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    6. Interstitial Doppler Optical Coherence Tomography as a Local Tumor Necrosis Predictor in Photodynamic Therapy of Prostatic Carcinoma: An In vivo Study

      We have tested the feasibility of real-time localized blood flow measurements, obtained with interstitial (IS) Doppler optical coherence tomography (DOCT), to predict photodynamic therapy (PDT)-induced tumor necrosis deep within solid Dunning rat prostate tumors. IS-DOCT was used to quantify the PDT-induced microvascular shutdown rate in s.c. Dunning prostate tumors (n = 28). Photofrin (12.5 mg/kg) was administered 20 to 24 hours before tumor irradiation, with 635 nm surface irradiance of 8 to 133 mWcm–2 for 25 minutes. High frequency ultrasound and calipers were used to measure the thickness of the skin covering the tumor and the ...
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    7. High power wavelength linearly swept mode locked fiber laser for OCT imaging

      We report a long coherence length, high power, and wide tuning range wavelength linearly swept fiber mode-locked laser based on polygon scanning filters. An output power of 52.6 mW with 112 nm wavelength tuning range at 62.6 kHz sweeping rate has been achieved. The coherence length is long enough ... [Opt. Express 16, 14095-14105 (2008)]
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    8. Speckle variance detection of microvasculature using swept-source optical coherence tomography

      Speckle variance detection of microvasculature using swept-source optical coherence tomography
      Adrian Mariampillai, Beau A. Standish, Eduardo H. Moriyama, Mamta Khurana, Nigel R. Munce, Michael K. Leung, James Jiang, Alex Cable, Brian C. Wilson, I. Alex Vitkin, Victor X. Yang. We report on imaging of microcirculation by calculating the speckle variance of optical coherence tomography (OCT) structural images acquired using a Fourier domain mode-locked swept-wavelength laser. The algorithm calculates interframe speckle variance in two-dimensional and three-dimensional OCT ... [Opt. Lett. 33, 1530-1532 (2008)]
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    9. Electrostatic forward-viewing scanning probe for Doppler optical coherence tomography using a dissipative polymer catheter

      Nigel R. Munce, Adrian Mariampillai, Beau A. Standish, Mihaela Pop, Kevan J. Anderson, George Y. Liu, Tim Luk, Brian K. Courtney, Graham A. Wright, I. Alex Vitkin, Victor X. D. Yang. A novel flexible scanning optical probe is constructed with a finely etched optical fiber strung through a platinum coil in the lumen of a dissipative polymer. The packaged probe is 2.2mm in diameter with a rigid length of 6mm when using a ball lens or 12mm when scanning the fiber proximal to a ... [Opt. Lett. 33, 657-659 (2008)]
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    10. Innovations in imaging for chronic total occlusions: a glimpse into the future of angiography’s blind-spot

      Brian K. Courtney1,3, Nigel R. Munce2, Kevan J. Anderson2, Amandeep S. Thind2, General Leung2, Perry E. Radau3, F. Stuart Foster2,3, I. Alex Vitkin2,5, Robert S. Schwartz6, Alexander J. Dick1,3,4, Graham A. Wright2,3 and Bradley H. Strauss1,3,4,* 1 Division of Cardiology, Schulich Heart Program, Sunnybrook Health Sciences Centre, Room A-253, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada 2 Department of Medical Biophysics, Sunnybrook Research Institute, University of Toronto, Toronto, Ont
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    1-10 of 10
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  2. Topics in the News

    1. (10 articles) Nigel R. Munce
    2. (8 articles) University of Toronto
    3. (8 articles) Victor X. D. Yang
    4. (8 articles) I. Alex Vitkin
    5. (7 articles) Sunnybrook Health Sciences Centre
    6. (7 articles) Ryerson University
    7. (7 articles) Adrian Mariampillai
    8. (7 articles) Beau A. Standish
    9. (4 articles) Graham A. Wright
    10. (4 articles) Kenneth K. C. Lee
    11. (1 articles) Institute of Applied Physics
    12. (1 articles) Medical University of Vienna
    13. (1 articles) Kyungpook National University
    14. (1 articles) Singapore Eye Research Institute
    15. (1 articles) University of Western Australia
    16. (1 articles) Stefan G. Sacu
    17. (1 articles) Brendan F. Kennedy
    18. (1 articles) Yongyang Huang
    19. (1 articles) Jeehyun Kim
    20. (1 articles) Ursula Schmidt-Erfurth
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    Speckle variance detection of microvasculature using swept-source optical coherence tomography High-power wavelength-swept laser in Littman telescope-less polygon filter and dual-amplifier configuration for multichannel optical coherence tomography In vivo endoscopic multi-beam optical coherence tomography Doppler optical coherence tomography for interventional cardiovascular guidance: in vivo feasibility and forward-viewing probe flow phantom demonstration Hybrid intravascular ultrasound and optical coherence tomography catheter for imaging of coronary atherosclerosis Full-range space-division multiplexing optical coherence tomography angiography Measuring 3D Optic Nerve Head Deformations using Digital Volume Correlation of in vivo Optical Coherence Tomography Data (Thesis) Optical coherence tomography for characterization of nanocomposite materials (Thesis) In Vivo Corneal Microstructural Changes in Herpetic Stromal Keratitis: A Spectral-Domain Optical Coherence Tomography Analysis Non-invasive optical screening of Streptococcus Pneumonia based inflammatory changes of the tympanic membrane and mastoid mucosa in guinea pig otitis media using optical coherence tomography Visual function tests including the role of optical coherence tomography in neurofibromatosis Strain and elasticity imaging in compression optical coherence elastography: the two‐decade perspective and recent advances