1. Articles from Brian K. Courtney

    1-12 of 12
    1. Advances in IVUS/OCT and Future Clinical Perspective of Novel Hybrid Catheter System in Coronary Imaging

      Advances in IVUS/OCT and Future Clinical Perspective of Novel Hybrid Catheter System in Coronary Imaging

      Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) have been developed and improved as both diagnostic and guidance tools for interventional procedures over the past three decades. IVUS has a resolution of 100 μm with a high tissue penetration and capability of assessing the entire structure of a coronary artery including the external elastic membrane, whereas OCT has a higher resolution of 10–20 μm to assess endoluminal structures with a limited tissue penetration compared to IVUS. Recently, two companies, CONAVI and TERUMO, integrated IVUS and OCT into a single catheter system. With their inherent strength and limitations, the combined ...

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    2. 30/80 MHz Bidirectional Dual-Frequency IVUS Feasibility Evaluated In Vivo and for Stent Imaging

      30/80 MHz Bidirectional Dual-Frequency IVUS Feasibility Evaluated In Vivo and for Stent Imaging

      Although intravascular ultrasound (IVUS) is an important tool in guiding complex coronary interventions, the resolution of existing commercial IVUS devices is considerably poorer than that of optical coherence tomography. Dual-frequency IVUS (DF IVUS), incorporating a second, higher frequency transducer, has been proposed as a possible method of overcoming this limitation. Although preliminary studies have shown that DF IVUS can produce complementary images, including large-scale morphology and high detail of superficial features, it has not yet been determined that this approach would be feasible in a more clinically relevant environment. The purpose of this study was to demonstrate the first in ...

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    3. Hybrid intravascular imaging: recent advances, technical considerations, and current applications in the study of plaque pathophysiology

      Hybrid intravascular imaging: recent advances, technical considerations, and current applications in the study of plaque pathophysiology

      Cumulative evidence from histology-based studies demonstrate that the currently available intravascular imaging techniques have fundamental limitations that do not allow complete and detailed evaluation of plaque morphology and pathobiology, limiting the ability to accurately identify high-risk plaques. To overcome these drawbacks, new efforts are developing for data fusion methodologies and the design of hybrid, dual-probe catheters to enable accurate assessment of plaque characteristics, and reliable identification of high-risk lesions. Today several dual-probe catheters have been introduced including combined near infrared spectroscopy-intravascular ultrasound (NIRS-IVUS), that is already commercially available, IVUS-optical coherence tomography (OCT), the OCT-NIRS, the OCT-near infrared fluorescence (NIRF) molecular ...

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    4. Intraoperative handheld optical coherence tomography forward-viewing probe: physical performance and preliminary animal imaging

      Intraoperative handheld optical coherence tomography forward-viewing probe: physical performance and preliminary animal imaging

      A prototype intraoperative hand-held optical coherence tomography (OCT) imaging probe was developed to provide micron resolution cross-sectional images of subsurface tissue during open surgery. This new ergonomic probe was designed based on electrostatically driven optical fibers, and packaged into a catheter probe in the form factor of clinically accepted Bayonet shaped neurosurgical probes. Optical properties of the probe were measured to have a ~20 μm spot size, 5 mm working distance and 4 mm field of view. Feasibility of this probe for structural and Doppler shift imaging was tested on porcine femoral blood vessel imaging.

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    5. Hybrid intravascular ultrasound and optical coherence tomography catheter for imaging of coronary atherosclerosis

      Hybrid intravascular ultrasound and optical coherence tomography catheter for imaging of coronary atherosclerosis

      Objective To demonstrate the feasibility of imaging human coronary atherosclerosis using a novel hybrid intravascular ultrasound (IVUS) and optical coherence tomography (OCT) imaging catheter. Background IVUS and OCT have synergistic advantages and recent studies involving both modalities suggest the use of a hybrid imaging catheter may offer improved guidance of coronary interventions and plaque characterization. Methods A 1.3 m custom hybrid IVUS-OCT imaging probe was built within a 4F catheter using a 42 MHz ultrasound transducer and an OCT imaging fiber. Coplanar images were simultaneously acquired ex vivo by both modalities in 31 arterial segments from 11 cadaveric human ...

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    6. Methods and devices for image-guided manipulation or sensing or anatomic structures

      Methods and devices for image-guided manipulation or sensing or anatomic structures

      Forward-looking ultrasound transducers are positioned at the tip of a transseptal catheter to facilitate transseptal puncture and interventions within the left atrium, pulmonary veins and mitral valve. Catheter devices and systems are guided by forward-looking ultrasound or optical coherence tomography imaging for penetrating from one location within a mammalian patient's body to another location, and/or performing diagnostic or therapeutic interventions. A penetrator, diagnostic, or interventional device (eg. probe, biopsy apparatus, electrode, needle) is positioned at the catheter tip and is advanceable from the catheter to a target location outside of the lumen in which the catheter is positioned ...

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    7. Doppler optical coherence tomography for interventional cardiovascular guidance: in vivo feasibility and forward-viewing probe flow phantom demonstration

      Doppler optical coherence tomography for interventional cardiovascular guidance: in vivo feasibility and forward-viewing probe flow phantom demonstration
      We demonstrate the potential of a forward-looking Doppler optical coherence tomography (OCT) probe for color flow imaging in several commonly seen narrowed artery morphologies. As a proof of concept, we present imaging results of a surgically exposed thrombotic occlusion model that was imaged superficially to demonstrate that Doppler OCT can identify flow within the recanalization channels of a blocked artery. We present Doppler OCT images in which the flow is nearly antiparallel to the imaging direction. These images are acquired using a flexible 2.2-mm-diam catheter that used electrostatic actuation to scan up to 30 deg ahead of the distal ...
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    8. Electrostatic forward-viewing scanning probe for Doppler optical coherence tomography using a dissipative polymer catheter

      Nigel R. Munce, Adrian Mariampillai, Beau A. Standish, Mihaela Pop, Kevan J. Anderson, George Y. Liu, Tim Luk, Brian K. Courtney, Graham A. Wright, I. Alex Vitkin, Victor X. D. Yang. A novel flexible scanning optical probe is constructed with a finely etched optical fiber strung through a platinum coil in the lumen of a dissipative polymer. The packaged probe is 2.2mm in diameter with a rigid length of 6mm when using a ball lens or 12mm when scanning the fiber proximal to a ... [Opt. Lett. 33, 657-659 (2008)]
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    9. Innovations in imaging for chronic total occlusions: a glimpse into the future of angiography’s blind-spot

      Brian K. Courtney1,3, Nigel R. Munce2, Kevan J. Anderson2, Amandeep S. Thind2, General Leung2, Perry E. Radau3, F. Stuart Foster2,3, I. Alex Vitkin2,5, Robert S. Schwartz6, Alexander J. Dick1,3,4, Graham A. Wright2,3 and Bradley H. Strauss1,3,4,* 1 Division of Cardiology, Schulich Heart Program, Sunnybrook Health Sciences Centre, Room A-253, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada 2 Department of Medical Biophysics, Sunnybrook Research Institute, University of Toronto, Toronto, Ont
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    10. Embolization protection system for vascular procedures

      Apparatus and methods are described for effective removal of emboli or harmful fluids during vascular procedures, such as angiography, balloon angioplasty, stent deployment, laser angioplasty, atherectomy, intravascular ultrasonography and other therapeutic and diagnostic procedures. A catheter with an occluder mounted at its distal end creates an occlusion proximal to the lesion. The catheter provides a pathway for introducing a treatment catheter. Prior to, during or subsequent to the procedure, suction is activated to establish retrograde flow to remove emboli from the site. Additionally, a thin catheter with a distal fluid ejection nozzle maybe introduced distal to the treatment site to ...
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    11. Fluid exchange system for controlled and localized irrigation and aspiration

      The control of fluid introduction into and out of body conduits such as vessels, is of great concern in medicine. As the development of more particular treatments to vessels and organs continues it is apparent that controlled introduction and removal of fluids is necessary. Fluid delivery and removal from such sites, usually referred to as irrigation and aspiration, using fluid exchange devices that control also need to be considerate of potential volume and/or pressure in the vessel or organ are described together with catheter and lumen configurations to achieve the fluid exchange. The devices include several electrically or mechanically ...
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    12. Fluid exchange system for controlled and localized irrigation and aspiration

      The control of fluid introduction into and out of body conduits such as vessels, is of great concern in medicine. As the development of more particular treatments to vessels and organs continues it is apparent that controlled introduction and removal of fluids is necessary. Fluid delivery and removal from such sites, usually referred to as irrigation and aspiration, using fluid exchange devices that control also need to be considerate of potential volume and/or pressure in the vessel or organ are described together with catheter and lumen configurations to achieve the fluid exchange. The devices include several electrically or mechanically ...
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    1-12 of 12
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  2. Topics in the News

    1. (12 articles) Brian K. Courtney
    2. (8 articles) University of Toronto
    3. (7 articles) Sunnybrook Health Sciences Centre
    4. (5 articles) Nigel R. Munce
    5. (4 articles) Victor X. D. Yang
    6. (4 articles) Graham A. Wright
    7. (4 articles) Conavi Medical Inc.
    8. (3 articles) I. Alex Vitkin
    9. (3 articles) FoxHollow Technologies
    10. (3 articles) ev3
    11. (1 articles) Capital Medical University
    12. (1 articles) Nanjing University of Science and Technology
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    Doppler optical coherence tomography for interventional cardiovascular guidance: in vivo feasibility and forward-viewing probe flow phantom demonstration Methods and devices for image-guided manipulation or sensing or anatomic structures Hybrid intravascular ultrasound and optical coherence tomography catheter for imaging of coronary atherosclerosis Intraoperative handheld optical coherence tomography forward-viewing probe: physical performance and preliminary animal imaging Hybrid intravascular imaging: recent advances, technical considerations, and current applications in the study of plaque pathophysiology Correlation between optical coherence tomography, multifocal electroretinogram findings and visual acuity in diabetic macular edema Ciliary body length revisited by anterior segment optical coherence tomography: implications for safe access to the pars plana for intravitreal injections Evaluation of retinal vascular structure after epiretinal membrane surgery by optical coherence tomography angiography Bivalirudin vs. Heparin on Radial Artery Thrombosis during Transradial Coronary Intervention: An Optical Coherence Tomography Study Superficial Calcification With Rotund Shape Is Associated With Carotid Plaque Rupture: An Optical Coherence Tomography Study Longitudinal retinal layer changes in preclinical Alzheimer’s disease Clinical expert consensus document on rotational atherectomy from the Japanese association of cardiovascular intervention and therapeutics