1. Articles from Sotaro Ooto

    1-24 of 38 1 2 »
    1. Effect of image averaging on optical coherence tomography angiography data in eyes with branch retinal vein occlusion

      Effect of image averaging on optical coherence tomography angiography data in eyes with branch retinal vein occlusion

      Purpose To investigate the effect of image averaging on qualitative and quantitative assessments of optical coherence tomography angiography (OCTA) images from eyes of patients with branch retinal vein occlusion (BRVO). Methods Macular OCTA images of 33 eyes of 33 patients with BRVO were obtained using the HS100 HR-SD-OCT system (Canon, Inc.). For each eye, five OCTA cube scans were obtained with a 3 × 3 mm scan protocol, and the data were averaged and compounded into a single high image quality cube data using built-in software. Pre- and post-averaging images were compared qualitatively and quantitatively in superficial capillary plexus (SCP) and ...

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    2. Usefulness of Denoising Process to Depict Myopic Choroidal Neovascularisation Using a Single Optical Coherence Tomography Angiography Image

      Usefulness of Denoising Process to Depict Myopic Choroidal Neovascularisation Using a Single Optical Coherence Tomography Angiography Image

      Quality of single optical coherence tomography angiography (OCTA) images of myopic choroidal neovascularisation (mCNV) is poorer than in averaged images, although obtaining averaged images takes much time. This study evaluated the clinical usefulness of novel denoising process for depicting mCNV. This study included 20 eyes of 20 patients with mCNV. Ten en face images taken in a 3 × 3 mm macular cube were obtained from outer-retina-to-choriocapillaris layer. Three image types were prepared for analysis; single images before and after the denoising process accomplished deep learning (single and denoising groups, respectively) and up to 10 images were averaged (averaging group). Pairwise ...

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    3. Angiographic Risk Features of Branch Retinal Vein Occlusion Onset as Determined by Optical Coherence Tomography Angiography

      Angiographic Risk Features of Branch Retinal Vein Occlusion Onset as Determined by Optical Coherence Tomography Angiography

      Purpose : Examine associations between the vasculature at arteriovenous (AV) crossings and the onset of branch retinal vein occlusion (BRVO). Methods : We included 78 patients with major BRVO, 35 patients with macular BRVO, and 110 controls without BRVO and determined the vessel positions at AV crossings, where the first- or second-order branches of the retinal veins associate, using a viewing angle of 12 × 12 mm 2 in optical coherence tomography angiography (OCTA). Results : We reviewed 1349 and 1276 AV crossings in BRVO patients and control subjects, respectively. The proportions of venous overcrossing were 26.5%, 28.6%, and 26.8% at ...

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    4. Segmentation of the Four-Layered Retinal Vasculature Using High-Resolution Optical Coherence Tomography Angiography Reveals the Microcirculation Unit

      Segmentation of the Four-Layered Retinal Vasculature Using High-Resolution Optical Coherence Tomography Angiography Reveals the Microcirculation Unit

      Purpose : To differentiate the four layers of the retinal vessel network in the human macula and examine their morphologic features using high-resolution optical coherence tomography angiography (HR-OCTA). Methods : Macular areas measuring 464 × 464 pixels of 10 right eyes of 10 healthy subjects without ocular disease were scanned 10 times using a HR-OCTA device. Averaged OCTA images were created. Based on clear decorrelation signals, four vascular slabs were segmented, comprising one each in the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), and top and bottom of the inner nuclear layer (INL). Qualitative features and quantitative measurements in each slab ...

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    5. EVALUATION OF MACULAR ISCHEMIA IN EYES WITH BRANCH RETINAL VEIN OCCLUSION: An Optical Coherence Tomography Angiography Study

      EVALUATION OF MACULAR ISCHEMIA IN EYES WITH BRANCH RETINAL VEIN OCCLUSION: An Optical Coherence Tomography Angiography Study

      Purpose: To quantitatively assess macular morphology and perfusion status using optical coherence tomography, and optical coherence tomography angiography in eyes with branch retinal vein occlusion when macular edema has completely resolved, and to investigate the impact on visual function. Methods: Thirty consecutive eyes with branch retinal vein occlusion–macular edema that resolved after treatment with intravitreal ranibizumab injections were included. Macular sensitivity was measured by microperimetry; defect length of foveal ellipsoid zone band was measured using optical coherence tomography; foveal avascular zone and parafoveal nonperfusion areas (NPA) were measured by optical coherence tomography angiography. Results: The logarithm of minimum angle ...

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    6. Morphological and Functional Retinal Vessel Changes in Branch Retinal Vein Occlusion: An Optical Coherence Tomography Angiography Study

      Morphological and Functional Retinal Vessel Changes in Branch Retinal Vein Occlusion: An Optical Coherence Tomography Angiography Study

      Purpose The present study aimed to investigate the morphology of the retinal vasculature in eyes with branch retinal vein occlusion (BRVO) using optical coherence tomography (OCT) angiography. Design Observational case series. Methods Fluorescein angiography (FA) and OCT angiography were used to examine macular area and the retinal vasculature at the affected arteriovenous (AV) crossing in 46 patients with BRVO. Results FA revealed that the affected AV crossing pattern involved arterial overcrossing in 23 eyes (50.0%) and venous overcrossing in 11 eyes (23.9%). However, FA failed to detect the crossing pattern in 10 eyes (21.7%). OCT angiography was ...

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    7. EVALUATION OF MACULAR ISCHEMIA IN EYES WITH CENTRAL RETINAL VEIN OCCLUSION: An Optical Coherence Tomography Angiography Study

      EVALUATION OF MACULAR ISCHEMIA IN EYES WITH CENTRAL RETINAL VEIN OCCLUSION: An Optical Coherence Tomography Angiography Study

      Purpose: To quantitatively assess macular perfusion status using optical coherence tomography angiography in eyes with aflibercept-treated central retinal vein occlusion and resolved macular edema and to investigate the impact of macular morphology and perfusion status on visual function. Methods: This prospective consecutive case series included 23 patients with central retinal vein occlusion. All patients received intravitreal aflibercept injections before analysis. Visual acuity, macular sensitivity, and the macular nonperfusion area (NPA) were evaluated in eyes without macular edema. The macular NPA was evaluated by optical coherence tomography angiography using 3 mm x 3 mm images of the macula. Foveal ellipsoid zone ...

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    8. Optical Coherence Tomography Angiography to Estimate Retinal Blood Flow in Eyes with Retinitis Pigmentosa

      Optical Coherence Tomography Angiography to Estimate Retinal Blood Flow in Eyes with Retinitis Pigmentosa

      Ophthalmologists sometimes face difficulties in identifying the origin of visual acuity (VA) loss in a retinitis pigmentosa (RP) patient, particularly before cataract surgery: cataract or the retinal disease state. Therefore, it is important to identify the significant factors correlating with VA. Nowadays, retinal blood flow in superficial and deep layers can be estimated non-invasively using optical coherence tomography angiography (OCTA). We estimated blood flow per retinal layer by using OCTA; investigated the correlation between VA and other parameters including blood flow and retinal thickness; and identified the most associated factor with VA in patients with RP. OCTA images in 68 ...

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    9. CHANGES IN THE POSTERIOR VITREOUS AFTER CATARACT SURGERY ASSESSED BY SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY

      CHANGES IN THE POSTERIOR VITREOUS AFTER CATARACT SURGERY ASSESSED BY SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY

      Purpose: To assess changes in the posterior vitreous caused directly by phacoemulsification with implantation of an intraocular lens, using the enhanced vitreous swept-source optical coherence tomography system (Topcon, Tokyo, Japan). Methods: Consecutive patients with cataract without posterior vitreous detachment were enrolled. Swept-source optical coherence tomography examinations were performed 1 day before and several days after surgery, using enhanced vitreous visualization. We compared preoperative and postoperative posterior vitreous status and measured the distance between the internal limiting membrane and the posterior vitreous membrane at 26 locations at the posterior pole. Results: Images of 33 eyes (21 patients) could be analyzed. The ...

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    10. EVALUATION OF MACULAR ISCHEMIA IN EYES WITH BRANCH RETINAL VEIN OCCLUSION: An Optical Coherence Tomography Angiography Study

      EVALUATION OF MACULAR ISCHEMIA IN EYES WITH BRANCH RETINAL VEIN OCCLUSION: An Optical Coherence Tomography Angiography Study

      Purpose: To quantitatively assess macular morphology and perfusion status using optical coherence tomography, and optical coherence tomography angiography in eyes with branch retinal vein occlusion when macular edema has completely resolved, and to investigate the impact on visual function. Methods: Thirty consecutive eyes with branch retinal vein occlusion-macular edema that resolved after treatment with intravitreal ranibizumab injections were included. Macular sensitivity was measured by microperimetry; defect length of foveal ellipsoid zone band was measured using optical coherence tomography; foveal avascular zone and parafoveal nonperfusion areas (NPA) were measured by optical coherence tomography angiography. Results: The logarithm of minimum angle of ...

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    11. Increased Choroidal Vascularity in Central Serous Chorioretinopathy Quantified Using Swept-Source Optical Coherence Tomography

      Increased Choroidal Vascularity in Central Serous Chorioretinopathy Quantified Using Swept-Source Optical Coherence Tomography

      Purpose To investigate the choroidal vascular structural changes in eyes with central serous chorioretinopathy (CSC) by using swept-source optical coherence tomography (SS-OCT). Design Prospective cross-sectional study. Methods We prospectively examined 40 eyes of 34 consecutive patients with CSC. Three-dimensional choroidal images of the macular area, covering 3 × 3 mm and 6 × 6 mm, were obtained with SS-OCT. En face images of the microvasculature of the inner choroid and large choroidal vessel layers were converted to binary images. Choroidal vascular areas were analyzed quantitatively using the binary images. Results The choroidal vascular area was larger in eyes with CSC (the microvasculature ...

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    12. Detection of Myopic Choroidal Neovascularization Using Optical Coherence Tomography Angiography

      Detection of Myopic Choroidal Neovascularization Using Optical Coherence Tomography Angiography

      Purpose To assess whether optical coherence tomography angiography (OCTA) can be used as an alternative to conventional fundus fluorescein angiography (FFA) for the detection of myopic choroidal neovascularization (CNV) Design Validity and reliability analysis Methods Twenty-eight eyes of 26 consecutive Japanese patients with exudative lesions associated with pathological myopia were included in this institutional study. Myopic CNV was detected in 23 eyes of 22 patients; five eyes exhibited simple hemorrhage. The main outcome measure was CNV detection by OCTA and FFA. The CNV area was individually measured by FFA and OCTA. Intraclass correlation coefficients (ICCs) for the CNV area independently ...

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    13. Comparison of retinal vessel measurements using adaptive optics scanning laser ophthalmoscopy and optical coherence tomography

      Comparison of retinal vessel measurements using adaptive optics scanning laser ophthalmoscopy and optical coherence tomography

      Purpose We compared adaptive optics scanning laser ophthalmoscopy (AOSLO) and optical coherence tomography (OCT) vessel caliber measurements. Methods AOSLO videos were acquired from 28 volunteers with healthy eyes. Artery measurements were made 0.5–1 disc diameters away from the optic disc margin. Individual segmented retinal arterial caliber was measured in synchronization with cardiac pulsation and averaged to obtain final horizontal retinal arterial caliber (ACH) and horizontal retinal arterial lumen (ALH). All OCT images were obtained with the Spectralis OCT, a spectral-domain OCT system. Vertical retinal arterial caliber (ACV) and vertical retinal arterial lumen (ALV) were measured on the same ...

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    14. High-Resolution Imaging of Photoreceptors in Macular Microholes [Retina]

      High-Resolution Imaging of Photoreceptors in Macular Microholes [Retina]

      Purpose. To assess photoreceptor structure in macular microholes by using adaptive optics scanning laser ophthalmoscopy (AO-SLO) and spectral-domain optical coherence tomography (SD-OCT) and compare with visual acuity. Methods. Fourteen eyes from 12 patients with macular microholes underwent a full ophthalmologic examination and imaging with a fundus camera, SD-OCT, and an original prototype AO-SLO system at each visit. Results. All eyes had a cone outer segment tip line disruption and a normal retinal pigment epithelium line on SD-OCT images. Adaptive optics scanning laser ophthalmoscopy revealed foveal cone disruption (13 eyes, round or oval; 1 eye, T-shaped) in all eyes. Cone disruption ...

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    15. Effects of Sex and Age on the Normal Retinal and Choroidal Structures on Optical Coherence Tomography

      Effects of Sex and Age on the Normal Retinal and Choroidal Structures on Optical Coherence Tomography

      Optical coherence tomography (OCT) has become an essential tool in ophthalmology. Advances in OCT technology have made it possible to measure the thickness of the retina, specific retinal layers, and the choroid. In the present study, the body of the literature documenting the normal retinal and choroidal thickness are reviewed and the effects of sex, age, and axial length on retinal/choroidal thickness are discussed. Macular, retinal layer, and choroidal thickness measured on OCT images in normal eyes showed significant variations by sex and age. Macular retinal thickness was greater in men than in women, especially in the center, inner ...

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    16. Dome-Shaped Macular Configuration: Longitudinal Changes in the Sclera and Choroid by Swept-Source Optical Coherence Tomography Over Two Years

      Dome-Shaped Macular Configuration: Longitudinal Changes in the Sclera and Choroid by Swept-Source Optical Coherence Tomography Over Two Years

      Purpose To study longitudinal changes in the posterior pole in eyes with dome-shaped macular configuration within the staphyloma. Design Prospective, longitudinal study. Methods We prospectively examined the macular area in 35 eyes (26 patients) with dome-shaped macular configuration and high myopia (mean spherical equivalent, −14.83 ± 4.50 diopters) using swept-source optical coherence tomography. Scleral and choroidal thicknesses were measured at the fovea and four parafoveal locations 2000 μm from the foveal center. Height of the macular bulge was measured as well. Results During the mean follow-up of 24.8 ± 2.5 months, the scleral thickness significantly decreased at the ...

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    17. Macular Choroidal Thickness and Volume of Eyes with Reticular Pseudodrusen Using Swept-Source Optical Coherence Tomography

      Macular Choroidal Thickness and Volume of Eyes with Reticular Pseudodrusen Using Swept-Source Optical Coherence Tomography

      Purpose To investigate the choroidal thickness/volume of eyes with reticular pseudodrusen using high-penetration swept-source optical coherence tomography (SS-OCT) and to evaluate the choroidal vasculature changes using en face images. Design Prospective cross sectional study. Methods Thirty-eight eyes with reticular pseudodrusen and 14 normal eyes were studied with prototype SS-OCT. Eyes with reticular pseudodrusen were classified into 3 subgroups: eyes without late age-related macular degeneration (AMD) (group1), eyes with neovascular AMD (group2), and eyes with geographic atrophy (group3). Mean regional choroidal thickness/volume measurements were obtained by three-dimensional (3D) raster scanning. The choroidal vascular area was measured using en face ...

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    18. High-Penetration Optical Coherence Tomography and Enhanced Depth Imaging in Presumed Retinal Pigment Epithelial Hamartoma

      High-Penetration Optical Coherence Tomography and Enhanced Depth Imaging in Presumed Retinal Pigment Epithelial Hamartoma

      Purpose: To report on high-penetrating swept source optical coherence tomography (SS-OCT) imaging and enhanced depth imaging in an eye with presumed retinal pigment epithelial hamartoma . Methods and Patients: A 60-year-old man with presumed retinal pigment epithelial hamartoma underwent complete ophthalmologic examination, including fluorescein angiography, indocyanine green angiography, enhanced depth imaging OCT, and SS-OCT. Results: In the left eye, there were six darkly pigmented, nodular, circumscribed lesions in the macular area. The margins were well defined and were not associated with changes such as edema, exudation, or hemorrhage. Fluorescein angiography revealed a minimally dilated feeding artery and draining vein in each ...

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    19. Tomographic Features of Macula after Successful Macular Hole Surgery

      Tomographic Features of Macula after Successful Macular Hole Surgery

      Purpose. To determine the retinal features associated with a dissociated optic nerve fiber layer (DONFL) appearance after successful macular hole surgery with internal limiting membrane (ILM) peeling. Methods. Forty-seven eyes of 47 patients that underwent pars plana vitrectomy with ILM peeling were examined by spectral-domain optical coherence tomography (SD-OCT). Results. A DONFL appearance was found in 31 (66.0%) eyes on color fundus photography. The postoperative best-corrected visual acuity and its improvements were not significantly different between eyes with and without this appearance. The SD-OCT images showed small inner retinal defects corresponding to each arcuate stria in all eyes with ...

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    20. Sensitivity and Specificity of Detecting Reticular Pseudodrusen in Multimodal Imaging in Japanese Patients

      Sensitivity and Specificity of Detecting Reticular Pseudodrusen in Multimodal Imaging in Japanese Patients

      Purpose: To identify reticular pseudodrusen (RPD) in age-related macular degeneration using multiple imaging modalities, including the blue channel image of fundus photography, infrared reflectance (IR), fundus autofluorescence, near-infrared fundus autofluorescence, confocal blue reflectance, indocyanine green angiography, and spectral-domain optical coherence tomography (SD-OCT), and to compare the sensitivities and specificities of these modalities for detecting RPD. Methods: This study included 220 eyes from 114 patients with newly diagnosed age-related macular degeneration. Patients underwent fundus photography, IR, fundus autofluorescence, near-infrared fundus autofluorescence, confocal blue reflectance, indocyanine green angiography, and SD-OCT in both eyes. Eyes were diagnosed with RPD if they showed reticular ...

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    21. High-Resolution Imaging of Retinal Nerve Fiber Bundles in Glaucoma Using Adaptive Optics Scanning Laser Ophthalmoscopy

      High-Resolution Imaging of Retinal Nerve Fiber Bundles in Glaucoma Using Adaptive Optics Scanning Laser Ophthalmoscopy

      Purpose To detect pathologic changes in retinal nerve fiber bundles in glaucomatous eyes seen on images obtained by adaptive optics (AO) scanning laser ophthalmoscopy (AO SLO). Design Prospective cross-sectional study. Methods Twenty-eight eyes of 28 patients with open-angle glaucoma and 21 normal eyes of 21 volunteer subjects underwent a full ophthalmologic examination, visual field testing using a Humphrey Field Analyzer, fundus photography, red-free SLO imaging, spectral-domain optical coherence tomography, and imaging with an original prototype AO SLO system. Results The AO SLO images showed many hyperreflective bundles suggesting nerve fiber bundles. In glaucomatous eyes, the nerve fiber bundles were narrower ...

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    22. High-Penetration Optical Coherence Tomography and Enhanced Depth Imaging in Presumed Retinal Pigment Epithelial Hamartom

      High-Penetration Optical Coherence Tomography and Enhanced Depth Imaging in Presumed Retinal Pigment Epithelial Hamartom

      Purpose: To report on high-penetrating swept source optical coherence tomography (SS-OCT) imaging and enhanced depth imaging in an eye with presumed retinal pigment epithelial hamartoma . Methods and Patients: A 60-year-old man with presumed retinal pigment epithelial hamartoma underwent complete ophthalmologic examination, including fluorescein angiography, indocyanine green angiography, enhanced depth imaging OCT, and SS-OCT. Results: In the left eye, there were six darkly pigmented, nodular, circumscribed lesions in the macular area. The margins were well defined and were not associated with changes such as edema, exudation, or hemorrhage. Fluorescein angiography revealed a minimally dilated feeding artery and draining vein in each ...

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    23. Three-Dimensional Tomographic Features of Dome-Shaped Macula by Swept-Source Optical Coherence Tomography

      Three-Dimensional Tomographic Features of Dome-Shaped Macula by Swept-Source Optical Coherence Tomography

      Purpose To study the tomographic and pathomorphologic features of dome-shaped maculas with swept-source optical coherence tomography (OCT). Design Prospective, cross-sectional study. Methods The macular area of 51 highly myopic eyes (35 patients) with dome-shaped maculas was studied with swept-source OCT at 1050 nm. Three-dimensional (3-D) data sets were obtained with raster scanning covering a 12 × 8-mm 2 area; 3-D images of the posterior pole were constructed by autosegmentation of the retinal pigment epithelium (RPE). Results In all reconstructed 3-D images of the RPE, 2 outward concavities were seen within the posterior staphyloma and a horizontal ridge was formed between these ...

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    24. Three-beam spectral-domain optical coherence tomography for retinal imaging

      Three-beam spectral-domain optical coherence tomography for retinal imaging

      A three-beam spectral domain optical coherence tomography system (OCT) whose center wavelength is 840 nm was developed. The three beams focus on fundus 3.1 mm apart from each other and are detected by a single line sensor. The distance between the beams is fixed and the beams scan a total area of 10 × 10     mm 2 while keeping this separation during three-dimensional (3-D) measurement. The line rate of the sensor is 70 kHz, therefore the total speed is equivalent to 210k A-scans per second in this system. A 1000 ( x ) × 500 ( z ) × 250 ( y ) voxel volumetric 3D OCT data ...

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    1-24 of 38 1 2 »
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    1. (36 articles) Kyoto University Graduate School of Medicine
    2. (36 articles) Sotaro Ooto
    3. (32 articles) Nagahisa Yoshimura
    4. (18 articles) Akitaka Tsujikawa
    5. (15 articles) Masanori Hangai
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    High-Resolution Imaging of Resolved Central Serous Chorioretinopathy Using Adaptive Optics Scanning Laser Ophthalmoscopy High-Resolution Imaging of the Photoreceptor Layer in Epiretinal Membrane Using Adaptive Optics Scanning Laser Ophthalmoscopy Macular Choroidal Thickness and Volume in Normal Subjects Measured by Swept-Source Optical Coherence Tomography High-Resolution Photoreceptor Imaging in Idiopathic Macular Telangiectasia Type 2 Using Adaptive Optics Scanning Laser Ophthalmoscopy Effects of Age, Sex, and Axial Length on the Three-Dimensional Profile of Normal Macular Layer Structures Automated Assessment of Drusen Using Three-dimensional Spectral-domain Optical Coherence Tomography High-Resolution Imaging of the Retinal Nerve Fiber Layer in Normal Eyes Using Adaptive Optics Scanning Laser Ophthalmoscopy Dome-Shaped Macular Configuration: Longitudinal Changes in the Sclera and Choroid by Swept-Source Optical Coherence Tomography Over Two Years Correlation between optical coherence tomography, multifocal electroretinogram findings and visual acuity in diabetic macular edema Ciliary body length revisited by anterior segment optical coherence tomography: implications for safe access to the pars plana for intravitreal injections Evaluation of retinal vascular structure after epiretinal membrane surgery by optical coherence tomography angiography Bivalirudin vs. Heparin on Radial Artery Thrombosis during Transradial Coronary Intervention: An Optical Coherence Tomography Study