1. Articles from chi pui pang

    1-9 of 9
    1. Longitudinal evaluation of immediate inflammatory responses after intravitreal AAV2 injection in normal rats by optical coherence tomography

      Longitudinal evaluation of immediate inflammatory responses after intravitreal AAV2 injection in normal rats by optical coherence tomography

      Gene therapy has been proposed as a feasible strategy for RGC survival and optic nerve regeneration. Some preclinical and clinical studies revealed intraocular inflammation after intravitreal injection of adeno-associated virus (AAV) by slit-lamp or indirect ophthalmoscope. Here we evaluate the longitudinal profile of immediate inflammatory responses after AAV2 injection in rat retina and vitreous body by optical coherence tomography (OCT). Adult Fischer F344 rats were intravitreally injected once with saline, AAV2 or zymosan. Retinal thickness and cell infiltration were recorded by OCT longitudinally for 2 months and verified by histological analysis. The transduction rate of single intravitreal AAV2 injection was ...

      Read Full Article
    2. Detection of glaucomatous optic neuropathy with spectral-domain optical coherence tomography: a retrospective training and validation deep-learning analysis

      Detection of glaucomatous optic neuropathy with spectral-domain optical coherence tomography: a retrospective training and validation deep-learning analysis

      Background Spectral-domain optical coherence tomography (SDOCT) can be used to detect glaucomatous optic neuropathy, but human expertise in interpretation of SDOCT is limited. We aimed to develop and validate a three-dimensional (3D) deep-learning system using SDOCT volumes to detect glaucomatous optic neuropathy. Methods We retrospectively collected a dataset including 4877 SDOCT volumes of optic disc cube for training (60%), testing (20%), and primary validation (20%) from electronic medical and research records at the Chinese University of Hong Kong Eye Centre (Hong Kong, China) and the Hong Kong Eye Hospital (Hong Kong, China). Residual network was used to build the 3D ...

      Read Full Article
    3. Assessing sodium iodate induced outer retinal changes in rats using confocal scanning laser ophthalmoscopy and optical coherence tomography

      Assessing sodium iodate induced outer retinal changes in rats using confocal scanning laser ophthalmoscopy and optical coherence tomography

      Purpose: Sodium iodate induces retinal pigment epithelium (RPE) atrophy and photoreceptor degeneration, as seen in the pathogenesis of many retinal diseases. We investigated a new approach of analyzing retinal images using confocal scanning laser ophthalmoscopy (cSLO), which allows longitudinal assessment of sodium iodate induced lesions in the retina of living rats. Methods: Single dose of sodium iodate (25 to 75 mg/kg) was given intravenously to adult Sprague-Dawley rats. Control animals were given normal saline or sodium iodide. The retina was examined by cSLO and optical coherence tomography (OCT) in living rats, which were then sacrificed for histological assessments. Results ...

      Read Full Article
    4. Evaluation of Retinal Nerve Fiber Layer Progression in Glaucoma: A Comparison between the Fast and the Regular Retinal Nerve Fiber Layer Scans

      Evaluation of Retinal Nerve Fiber Layer Progression in Glaucoma: A Comparison between the Fast and the Regular Retinal Nerve Fiber Layer Scans
      Objective: To compare the performance of the fast (256 A-scans in each scan circle) and the regular (512 A-scans in each scan circle) retinal nerve fiber layer (RNFL) scan protocols for detection of glaucoma progression using the Stratus optical coherence tomography (OCT) device (Carl Zeiss Meditec, Dublin, CA). Design: Retrospective, longitudinal study. Participants: One hundred twenty-nine eyes from 72 glaucoma patients. Methods: All patients had been followed up for 2.9 to 6.1 years with a median follow-up of 4 months. All eyes had at least 4 serial RNFL measurements obtained with both the fast and the regular RNFL ...
      Read Full Article
    5. Evaluation of Retinal Nerve Fiber Layer Progression in Glaucoma: A Study on Optical Coherence Tomography Guided Progression Analysis

      ose. To evaluate optical coherence tomography (OCT) retinal nerve fiber layer thickness (RNFLT) measurement for glaucoma progression analysis. Methods. One hundred sixteen eyes of 64 patients with glaucoma who were observed within a period of 5 years were included. All eyes had at least four serial RNFL measurements obtained with the Stratus OCT (Carl Zeiss Meditec, Dublin, CA) and with the first and last measurements separated by at least 3 years. Visual field (VF) testing was performed on the same day as RNFL imaging. Serial average RNFLTs were evaluated with guided progression analysis (GPA). VF progression was assessed with trend ...
      Read Full Article
    6. Longitudinal Variability of Optic Disc and Retinal Nerve Fiber Layer Measurements

      PURPOSE. To evaluate the longitudinal variability of optic disc and retinal nerve fiber layer (RNFL) measurements obtained from optical coherence tomography (OCT), scanning laser polarimetry (SLP), and confocal scanning laser ophthalmoscopy (CSLO). METHODS. Forty-five normal and 43 glaucomatous eyes of 88 subjects were analyzed in this longitudinal study. RNFL thickness was measured by OCT (StatusOCT; Carl Zeiss Meditec, Dublin, CA) and SLP (GDx VCC; Carl Zeiss Meditec). Neuroretinal rim area was measured by CSLO (HRT 3; Heidelberg Engineering, GmbH, Dossenheim, Germany). Three separate measurements taken over an average period of 8.8 ± 1.2 months were used to evaluate measurement ...
      Read Full Article
    7. Comparison of Macular Thickness Measurements between Time Domain and Spectral Domain Optical Coherence Tomography

      Macular thickness measurements obtained from spectral domain optical coherence tomography (OCT) were significantly greater than those obtained from time domain OCT because of the more posteriorly located retinal boundary (RPE in 3D OCT versus the inner and outer segment photoreceptor interface in Stratus OCT). Lower measurement variability was observed in spectral domain OCT. Clinicians should be aware of the measurement differences between the two instruments.
      Read Full Article
    8. Anterior Chamber Angle Measurement with Anterior Segment Optical Coherence Tomography: A Comparison between Slit Lamp OCT and Visante OCT

      PURPOSE. To compare anterior chamber angle measurements obtained from two anterior segment optical coherence tomography (OCT) instruments and to evaluate their agreements and interobserver reproducibility. METHODS. Forty-nine eyes from 49 healthy normal subjects were studied. The anterior chamber angle was imaged with the Visante anterior segment OCT (Carl Zeiss Meditec, Dublin, CA) and the slit lamp OCT (SLOCT, Heidelberg Engineering, GmbH, Dossenheim, Germany) on one randomly selected eye in each subject and measured by two independent observers. The angle-opening distance (AOD 500), the trabecular–iris angle (TIA 500), and the trabecular–iris space area (TISA 500) at the nasal and ...
      Read Full Article
    9. Repeatability and reproducibility of anterior chamber angle measurement with anterior segment optical coherence tomography

      Aim: To evaluate the repeatability and reproducibility of anterior chamber angle measurement obtained by anterior segment optical coherence tomography. Methods: Twenty-five normal subjects were invited for anterior chamber angle imaging with an anterior segment optical coherence tomography (OCT) on one randomly selected eye in three separate visits within a week. Each eye was imaged three times under room light (light intensity = 368 lux) and three times in the dark during the first visit. In the subsequent visits, each eye was imaged once in the light and once in the dark. The angle opening distance (AOD 500) and the trabecular–iris ...
      Read Full Article
    1-9 of 9
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics in the News

    1. (8 articles) The Chinese University of Hong Kong
    2. (6 articles) UCSD
    3. (3 articles) Carl Zeiss Meditec
    4. (2 articles) University of Hong Kong
    5. (2 articles) Duke University
    6. (1 articles) Stanford University
    7. (1 articles) Heidelberg Engineering
    8. (1 articles) Konyang University
  3. Popular Articles

  4. Picture Gallery

    Evaluation of Retinal Nerve Fiber Layer Progression in Glaucoma: A Comparison between the Fast and the Regular Retinal Nerve Fiber Layer Scans Assessing sodium iodate induced outer retinal changes in rats using confocal scanning laser ophthalmoscopy and optical coherence tomography Detection of glaucomatous optic neuropathy with spectral-domain optical coherence tomography: a retrospective training and validation deep-learning analysis Longitudinal evaluation of immediate inflammatory responses after intravitreal AAV2 injection in normal rats by optical coherence tomography Repeatability of Optical Coherence Tomography Angiography Measurements in Patients with Retinal Vein Occlusion Retinal Vascularization Analysis on Optical Coherence Tomography Angiography before and after Intraretinal or Subretinal Fluid Resorption in Exudative Age-Related Macular Degeneration: A Pilot Study Anterior‐segment optical coherence tomography of filtering blebs in the early postoperative period of ab externo SIBS microshunt implantation with mitomycin C: Morphological analysis and correlation with intraocular pressure reduction Combining artificial intelligence and robotics: a novel fully automated optical coherence tomography-based approach for eye disease screening Impact of fundus pigmentation on retinal layer visibility on investigational bedside optical coherence tomography in preterm infants Vascular morphology in facial solar lentigo assessed by optical coherence tomography angiography Macular vascular changes in pregnant women with gestational diabetes mellitus by optical coherence tomography angiography Feasibility of peripheral OCT imaging using a novel integrated SLO ultra-widefield imaging swept-source OCT device