1. Articles from dennis shun chiu lam

    1-13 of 13
    1. Optic Disc Imaging with Spectral-Domain Optical Coherence Tomography: Variability and Agreement Study with Heidelberg Retinal Tomograph

      Optic Disc Imaging with Spectral-Domain Optical Coherence Tomography: Variability and Agreement Study with Heidelberg Retinal Tomograph

      Objective To evaluate the agreement of optic disc measurements obtained with the Cirrus high-density optical coherence tomography (HD-OCT) and the Heidelberg retina tomograph (HRT) and compare the intervisit, test–retest variability between the instruments. Design Prospective, cross-sectional study. Participants Two hundred seven subjects (109 glaucoma and 98 normal subjects). Methods One eye from each individual was selected randomly for optic disc imaging by the Cirrus HD-OCT and the HRT. Areas of the optic disc and the cup, cup volume, vertical cup-to-disc ratio and cup-to-disc area ratio were compared between the instruments. The OCT measurements were corrected for ocular magnification using ...

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    2. Measurement of Photoreceptor Layer in Glaucoma: A Spectral-Domain Optical Coherence Tomography Study

      Measurement of Photoreceptor Layer in Glaucoma: A Spectral-Domain Optical Coherence Tomography Study
      To measure and compare photoreceptor layer thickness between normal and glaucomatous eyes using spectral-domain optical coherence tomography (OCT). Methods. Thirty-eight healthy normal volunteers and 47 glaucoma patients were included in the analysis. One eye from each participant was randomly selected for macula imaging by a spectral-domain OCT (3D OCT-1000, Topcon, Tokyo, Japan). The foveal and parafoveal (1.5 mm from the fovea) outer nuclear layer (ONL) and inner and outer segments (IS+OS) layer thicknesses were measured by a single masked observer. The measurements were repeated 3 times in a random sample of 30 normal eyes to determine the repeatability ...
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    3. Diagnostic Classification of Retinal Nerve Fiber Layer Measurement in Myopic Eyes: A Comparison Between Time-Domain and Spectral-Domain Optical Coherence Tomography

      Diagnostic Classification of Retinal Nerve Fiber Layer Measurement in Myopic Eyes: A Comparison Between Time-Domain and Spectral-Domain Optical Coherence Tomography
      Purpose: To evaluate and compare the diagnostic classification of retinal nerve fiber layer (RNFL) measurement between time-domain and spectral-domain optical coherence tomography (OCT) in myopic eyes.Design: Prospective, observational study.Methods: A total of 97 eyes from 97 healthy myopic subjects were included. The RNFL in each eye was imaged sequentially with the Stratus OCT and the Cirrus HD-OCT (Carl Zeiss Meditec). With reference to the built-in normative database, the number of abnormal diagnostic classifications (borderline or outside normal limits) in each OCT device was analyzed and compared using the likelihood ratio chi-square test. Multiple logistic regression analysis was performed ...
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    4. Evaluation of Retinal Nerve Fiber Layer Progression in Glaucoma: A Comparison between the Fast and the Regular Retinal Nerve Fiber Layer Scans

      Evaluation of Retinal Nerve Fiber Layer Progression in Glaucoma: A Comparison between the Fast and the Regular Retinal Nerve Fiber Layer Scans
      Objective: To compare the performance of the fast (256 A-scans in each scan circle) and the regular (512 A-scans in each scan circle) retinal nerve fiber layer (RNFL) scan protocols for detection of glaucoma progression using the Stratus optical coherence tomography (OCT) device (Carl Zeiss Meditec, Dublin, CA). Design: Retrospective, longitudinal study. Participants: One hundred twenty-nine eyes from 72 glaucoma patients. Methods: All patients had been followed up for 2.9 to 6.1 years with a median follow-up of 4 months. All eyes had at least 4 serial RNFL measurements obtained with both the fast and the regular RNFL ...
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    5. Evaluation of Retinal Nerve Fiber Layer Progression in Glaucoma: A Study on Optical Coherence Tomography Guided Progression Analysis

      ose. To evaluate optical coherence tomography (OCT) retinal nerve fiber layer thickness (RNFLT) measurement for glaucoma progression analysis. Methods. One hundred sixteen eyes of 64 patients with glaucoma who were observed within a period of 5 years were included. All eyes had at least four serial RNFL measurements obtained with the Stratus OCT (Carl Zeiss Meditec, Dublin, CA) and with the first and last measurements separated by at least 3 years. Visual field (VF) testing was performed on the same day as RNFL imaging. Serial average RNFLTs were evaluated with guided progression analysis (GPA). VF progression was assessed with trend ...
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    6. Retinal Nerve Fiber Layer Imaging with Spectral-Domain Optical Coherence Tomography: A Study on Diagnostic Agreement with Heidelberg Retinal Tomograph

      Objective To evaluate and compare the diagnostic agreement and performance for glaucoma detection between a confocal scanning laser ophthalmoscope and a spectral-domain optical coherence tomograph (OCT). Design Prospective, cross-sectional study. Participants One hundred fifty-five subjects (79 glaucoma and 76 normal subjects). Methods One eye from each individual was selected randomly for optic disc and retinal nerve fiber layer (RNFL) imaging by the Heidelberg Retinal Tomograph (HRT; Heidelberg Engineering, GmbH, Dossenheim, Germany) and the Spectralis OCT (Heidelberg Engineering), respectively. Glaucoma was defined based on the presence of visual field defects with the Humphrey visual field analyzer (Carl Zeiss Meditec, Dublin, CA ...
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    7. Assessment of Scleral Spur Visibility With Anterior Segment Optical Coherence Tomography

      Purpose: To develop a grading system to evaluate the scleral spur visibility and to investigate the association between this and the angle width. Methods: Sixty healthy normal subjects (33 with open angles and 27 with narrow angles on dark room gonioscopy) underwent anterior segment imaging with the Visante OCT (Carl Zeiss Meditec, Dublin, CA). The anterior chamber angles at 12-o' clock hour positions were imaged and analyzed. The scleral spur at each clock hour position was independently graded by 2 observers. A scleral spur visibility score (SSVS) of 2 denotes clear visibility of the scleral spur. SSVS of 0 and ...
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    8. Retinal Nerve Fiber Layer Imaging with Spectral-Domain Optical Coherence Tomography: A Variability and Diagnostic Performance Study

      Objective: To evaluate and compare the retinal nerve fiber layer (RNFL) measurement variability, diagnostic sensitivity and specificity for glaucoma detection, and strength of the structure–function association obtained with a spectral-domain optical coherence tomography (OCT) device (Cirrus HD-OCT; Carl Zeiss Meditec, Inc., Dublin, CA) and a time-domain OCT device (Stratus OCT; Carl Zeiss Meditec, Inc.).Design: Prospective, cross-sectional study.Participants: Ninety-seven normal subjects and 83 glaucoma patients.Methods: One eye from each subject was imaged with Cirrus HD-OCT and Stratus OCT. Sixteen and 31 normal eyes were selected randomly to evaluate intravisit repeatability and intervisit reproducibility, respectively. The agreement of ...
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    9. Longitudinal Evaluation of Optic Disc Measurement Variability With Optical Coherence Tomography and Confocal Scanning Laser Ophthalmoscopy.

      Purpose: To evaluate and compare the longitudinal variability of optical coherence tomography (OCT) and confocal scanning laser ophthalmoscopy (CSLO) optic disc measurements. Methods: A total of 25 normal and 50 glaucomatous eyes from 75 subjects were included in the analysis. The optic disc was measured by OCT and CSLO. Three separate measurements collected over an average period of 8.5±0.9 months were used to evaluate reproducibility. Univariate and multivariate regression analyses were performed to evaluate the associations between age, refraction, diagnosis (glaucoma or normal), visual field mean deviation, optic disc area, signal strength variance (OCT), optic disc area ...
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    10. Quantitative Assessment of Lens Opacities with Anterior Segment Optical Coherence Tomography

      Purpose: To evaluate the reliability of lens density measurement with anterior segment optical coherence tomography (OCT) and its association with the Lens Opacity Classification System Version III (LOCS III) grading. Methods: Fifty-five eyes from 55 age-related cataract patients were included. One eye from each subject was selected at random for lens evaluation. After dilation, lens photographs were taken with a slit lamp and graded against the LOCS III standardized condition. Anterior segment OCT imaging was performed on the same eyes with high resolution scan. The association between the anterior segment OCT nucleus density measurement and LOCS III nuclear opalescence (NO ...
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    11. Relationship between Retinal Nerve Fiber Layer Measurement and Signal Strength in Optical Coherence Tomography

      Purpose To examine the relationship between signal strength and retinal nerve fiber layer (RNFL) thickness measured by optical coherence tomography (OCT). Design Observational cross-sectional study. Participants Forty normal subjects were recruited. Methods Retinal nerve fiber layer (RNFL) thickness was measured by Stratus OCT (Carl Zeiss Meditec, Dublin, CA). In each eye, the focusing knob was adjusted to obtain 6 images with different signal strengths ranging from 5 to 10. The relationships between signal strength and RNFL thickness were examined using the Spearman correlation coefficient. The differences of RNFL thicknesses were compared with repeated-measures analysis of variance. Main Outcome Measures Retinal ...
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    12. Anterior Chamber Angle Measurement with Anterior Segment Optical Coherence Tomography: A Comparison between Slit Lamp OCT and Visante OCT

      PURPOSE. To compare anterior chamber angle measurements obtained from two anterior segment optical coherence tomography (OCT) instruments and to evaluate their agreements and interobserver reproducibility. METHODS. Forty-nine eyes from 49 healthy normal subjects were studied. The anterior chamber angle was imaged with the Visante anterior segment OCT (Carl Zeiss Meditec, Dublin, CA) and the slit lamp OCT (SLOCT, Heidelberg Engineering, GmbH, Dossenheim, Germany) on one randomly selected eye in each subject and measured by two independent observers. The angle-opening distance (AOD 500), the trabecular–iris angle (TIA 500), and the trabecular–iris space area (TISA 500) at the nasal and ...
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    13. Repeatability and reproducibility of anterior chamber angle measurement with anterior segment optical coherence tomography

      Aim: To evaluate the repeatability and reproducibility of anterior chamber angle measurement obtained by anterior segment optical coherence tomography. Methods: Twenty-five normal subjects were invited for anterior chamber angle imaging with an anterior segment optical coherence tomography (OCT) on one randomly selected eye in three separate visits within a week. Each eye was imaged three times under room light (light intensity = 368 lux) and three times in the dark during the first visit. In the subsequent visits, each eye was imaged once in the light and once in the dark. The angle opening distance (AOD 500) and the trabecular–iris ...
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    1-13 of 13
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