1. Articles from Mette Mogensen

    1-23 of 23
    1. Potential of contrast agents to enhance in vivo confocal microscopy and optical coherence tomography in dermatology: A review

      Potential of contrast agents to enhance in vivo confocal microscopy and optical coherence tomography in dermatology: A review

      Distinction between normal skin and pathology can be a diagnostic challenge. This systematic review summarizes how various contrast agents, either topically delivered, or injected into the skin affect distinction between skin disease and normal skin when imaged by optical coherence tomography (OCT) and confocal microscopy (CM). A systematic review of in vivo OCT and CM studies using exogenous contrast agents on healthy human skin or skin disease was performed. In total, 9 CM studies and 1 OCT study were eligible. Four contrast agents aluminum chloride (AlCl) n=2, indocyanin green (ICG) n=3, sodium fluorescein n=3 and acetic acid ...

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    2. Transfollicular delivery of gold microparticles in healthy skin and acne vulgaris, assessed by in vivo reflectance confocal microscopy and optical coherence tomography

      Transfollicular delivery of gold microparticles in healthy skin and acne vulgaris, assessed by in vivo reflectance confocal microscopy and optical coherence tomography

      Introduction Topical application of gold microparticles (GMPs) for selective photothermolysis is a recently FDA‐cleared therapy for acne vulgaris. Current evidence indicates the potential of optical imaging to non‐invasively visualize GMPs and describe photothermal tissue effects. Objectives To qualitatively and quantitatively describe GMP delivery in vivo and visualize laser‐mediated thermal effects of GMPs in facial skin of acne patients and healthy participants, using reflectance confocal microscopy (RCM) and optical coherence tomography (OCT). Methods Patients with facial acne ( n  = 14), and healthy participants ( n  = 7) were included. RCM and OCT images were acquired at baseline, after GMP application, and ...

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    3. Acne vulgaris severity graded by in vivo reflectance confocal microscopy and optical coherence tomography

      Acne vulgaris severity graded by in vivo reflectance confocal microscopy and optical coherence tomography

      Introduction Acne is an inflammatory disease of the pilosebaceous unit, which can be investigated in vivo using reflectance confocal microscopy (RCM) and optical coherence tomography (OCT). Objectives By means of RCM and OCT to identify morphological characteristics of acne that may be associated with clinical acne severity. Methods Patients with mild to moderate facial acne ( n  = 14, Investigators Global Assessment scale, IGA 1–3), and healthy participants ( n  = 7, IGA 0) were included in this explorative study. A total of 108 RCM image blocks and 54 OCT scans (each RCM and OCT image measuring 6 × 6 mm) were captured from ...

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      Mentions: Mette Mogensen
    4. Two optical coherence tomography systems detect topical gold nanoshells in hair follicles, sweat ducts and measure epidermis

      Two optical coherence tomography systems detect topical gold nanoshells in hair follicles, sweat ducts and measure epidermis

      Optical coherence tomography (OCT) is an optical imaging technology that enables real time, high‐resolution, cross‐sectional and en face investigation of skin by detecting reflected broad‐spectrum near‐infrared light from tissue. OCT provides micron‐scale spatial resolution and millimeter‐scale depth of penetration [1]. Several commercial OCT systems with handheld probes targeted for Dermatology are now available [2].

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    5. In-vivo detection of the skin dermo-epidermal junction by ultrahigh resolution optical coherence tomography

      In-vivo detection of the skin dermo-epidermal junction by ultrahigh resolution optical coherence tomography

      The human skin is comprised by two layers; epidermis and dermis, separated by the dermo-epidermal junction (DEJ). The relevance of depicting DEJ and measurement of the epidermal thickness (ET) is e.g. seen for superficial skin cancers where delineation of DEJ is of prime prognostic importance. Another example is diagnosis of psoriasis where a thickened epidermis and a ridged DEJ is a hallmark. Histopathological examination of biopsied tissue is traditionally performed to trace DEJ and measure ET. An efficient and precise method to locate DEJ and measure ET is optical coherence tomography (OCT) which is an in vivo and non-invasive ...

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    6. Two Optical Coherence Tomography Systems detect Topical Gold Nanoparticles in Hair follicles, Sweat Ducts and Measure Epidermis

      Two Optical Coherence Tomography Systems detect Topical Gold Nanoparticles in Hair follicles, Sweat Ducts and Measure Epidermis

      Optical coherence tomography (OCT) is an optical imaging technology that enables real time, highresolution, cross-sectional and en face investigation of skin by detecting reflected broad-spectrum near-infrared light from tissue. OCT provides micron-scale spatial resolution and millimeter-scale depth of penetration [1]. Several commercial OCT systems with handheld probes targeted for Dermatology are now available [2]. The ability of OCT to achieve high diagnostic accuracy in skin diseases is hampered by the fact that not all diseases show sufficient contrast to be discriminated from normal skin. The challenge in realizing contrast enhancement in OCT imaging is to achieve signal from exogenous contrast ...

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    7. Vehicle type affects filling of fractional laser-ablated channels imaged by optical coherence tomography

      Vehicle type affects filling of fractional laser-ablated channels imaged by optical coherence tomography

      Ablative fractional laser (AFXL) is an emerging method that enhances topical drug delivery. Penetrating the skin in microscopic, vertical channels, termed microscopic treatment zones (MTZs), the fractional technique circumvents the skin barrier and allows increased uptake of topically applied drugs. This study aims to elucidate the impact of vehicle type on the filling of MTZs from application of liquid, gel, and cream vehicles. Ex vivo pig skin was exposed to 10,600 nm fractional CO 2 laser at 5% density, 120 μm beam diameter, and fluences of 40 and 80 mJ/microbeam (mJ/mb). Six repetitions were performed for each ...

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    8. Fractional laser-assisted drug uptake: Impact of time-related topical application to achieve enhanced delivery

      Fractional laser-assisted drug uptake: Impact of time-related topical application to achieve enhanced delivery

      Background and Objective Ablative fractional laser (AFXL) is acknowledged to increase uptake of topically applied agents in skin. AFXL channels gradually close over time, which may impair this capability. The time frame for applying a drug after AFXL exposure remains to be established. The aim of this study, was to investigate the importance of time-related topical application after AFXL exposure and to relate resultant uptake in skin with AFXL channel morphology and skin integrity. Study Design/Materials and Methods Buttock skin of healthy volunteers ( n  = 11) was exposed to 10,600 nm fractional CO 2 laser using 5% density, 120 ...

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      Mentions: Mette Mogensen
    9. Dynamic Optical Coherence Tomography Capillaroscopy A New Imaging Tool in Autoimmune Connective Tissue Disease

      Dynamic Optical Coherence Tomography Capillaroscopy A New Imaging Tool in Autoimmune Connective Tissue Disease

      Importance Vasculopathy characterized by functional and structural abnormalities of the microcirculation plays an important role in systemic sclerosis and dermatomyositis. Although there are several advantages in using capillaroscopy, the method does not offer insight on the skin architecture, flow status, or morphology of the deeper dermal vessels. Dynamic optical coherence tomography (D-OCT) is a recently developed OCT technique that enables detection of high-speed changes in back-scattered light caused by moving cells in vessels. The high resolution of OCT enables the detection of the papillary loops. Objective To explore the potential for OCT capillaroscopy of the nailfolds using D-OCT. Design, Setting ...

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    10. Spatiotemporal closure of fractional laser-ablated channels imaged by optical coherence tomography and reflectance confocal microscopy

      Spatiotemporal closure of fractional laser-ablated channels imaged by optical coherence tomography and reflectance confocal microscopy

      Background and Objective Optical coherence tomography (OCT) and reflectance confocal microscopy (RCM) offer high-resolution optical imaging of the skin, which may provide benefit in the context of laser-assisted drug delivery. We aimed to characterize postoperative healing of ablative fractional laser (AFXL)-induced channels and dynamics in their spatiotemporal closure using in vivo OCT and RCM techniques. Study design/Materials and Methods The inner forearm of healthy subjects ( n  = 6) was exposed to 10,600 nm fractional CO 2 laser using 5 and 25% densities, 120 μm beam diameter, 5, 15, and 25 mJ/microbeam. Treatment sites were scanned with OCT ...

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    11. Optical Coherence Tomography and Cryosurgery (Book Chapter)

      Optical Coherence Tomography and Cryosurgery (Book Chapter)

      Optical coherence tomography (OCT) provides real-time, cross-sectional skin images to a depth of up to 2 mm. OCT is a convenient and fast imaging technology that can be used bedside. In dermatology, the pretherapeutic delineation of both actinic keratoses (AK) and keratinocyte carcinomas has been a natural focus for applied OCT research, and more recently OCT research has turned on non-invasive monitoring of treatments. Previous studies have found good agreement between OCT images and histopathological images. Cryotherapy is a fast and easy treatment modality frequently used for the treatment of AK lesions in everyday dermatology practise. Cryosurgery with liquid nitrogen ...

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    12. Optical coherence tomography imaging of non‐melanoma skin cancer undergoing imiquimod therapy

      Optical coherence tomography imaging of non‐melanoma skin cancer undergoing imiquimod therapy

      Purpose To explore the application of optical coherence tomography (OCT) imaging of basal cell carcinomas (BCC) and actinic keratosis (AK) before, during and after imiquimod treatment and the ability of OCT to predict treatment outcome. Methods The study subjects were 20 patients with biopsy-verified BCC (9) or AK (11). Patients were OCT-scanned before, after 1 and 4 weeks of imiquimod treatment and after 3 months. Lesions were identified clinically and with OCT. Thickness and morphology of the lesions were recorded at each visit. Any remaining lesions were biopsied at follow-up. Results Complete data sets were available for 16 patients (8 ...

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    13. Skin Cancer A Practical Approach (Textbook)

      Skin Cancer A Practical Approach (Textbook)

      Optical coherence tomography (OCT) has developed rapidly since its first realisation in medicine and is currently an emerging technology in the diagnosis of skin disease. OCT is an interferometric technique that detects reflected and backscattered light from tissue and is often described as the optical analogue to ultrasound. The inherent safety of the technology allows for in vivo use of OCT in patients. The main strength of OCT is the depth resolution. In dermatology, most OCT research has turned on non-melanoma skin cancer (NMSC) and non-invasive monitoring of morphological changes in a number of skin diseases based on pattern recognition ...

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    14. Optical coherence tomography imaging of telangiectasias during intense pulsed light treatment: a potential tool for rapid outcome assessment

      Optical coherence tomography imaging of telangiectasias during intense pulsed light treatment: a potential tool for rapid outcome assessment

      Vascular malformations commonly occur in the facial region, and can be associated with significant stigma and embarrassment. Studies have shown that even recommended light-based treatments do not always result in complete clearance. This indicates the need for more accurate pre-treatment assessment of vessel morphology to optimize treatment settings and identify possible morphological predictors of the outcome. Fourteen patients (six males, eight females, and aged 37–66 years) with the diagnosis of telangiectasias were enrolled and were all scanned with OCT and digitally photographed before and minutes after IPL treatment. OCT images of the telangiectasias before treatment were displayed as hyporeflective ...

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    15. Cryosurgery Treatment of Actinic Keratoses Monitored by Optical Coherence Tomography

      Cryosurgery Treatment of Actinic Keratoses Monitored by Optical Coherence Tomography

      Background: Optical coherence tomography (OCT) is a non-invasive optical imaging technique providing high-resolution images. OCT may be useful as a monitoring tool during treatment of actinic keratoses (AK) and skin cancer. Objective: To examine and describe how OCT skin morphology changes when the tissue is exposed to the effects of cryotherapy. Methods: Normal ex vivo skin and in vivo AK lesions were examined. Cryotherapy was applied and OCT images were acquired at defined time points. OCT morphology was described. Results: Cryotherapy treatment produced an opaque iceball, and freezing depth could not be monitored by OCT. Vesicle formation after cryotherapy could ...

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    16. How histological features of basal cell carcinomas influence image quality in optical coherence tomography

      How histological features of basal cell carcinomas influence image quality in optical coherence tomography
      Optical coherence tomography (OCT) has the potential to diagnose and measure the depth of nonmelanoma skin cancer (NMSC) in skin, but some lesions appear blurred in OCT images. The aim of this study is to identify histological characteristics of basal cell carcinomas (BCC) that correlate with good quality OCT images of the same lesions. A total of 34 patients with BCC were OCT scanned. The influence of histology parameters (e.g. inflammation, sun damage of skin, carcinoma cell size) on OCT image quality was studied by comparing 15 BCC lesions easily identified compared to 19 BCC lesions that produced only ...
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    17. Optical coherence tomography-current technology and applications in clinical and biomedical research

      Optical coherence tomography-current technology and applications in clinical and biomedical research
      Optical coherence tomography (OCT) is a noninvasive imaging technique that provides real-time two- and three-dimensional images of scattering samples with micrometer resolution. By mapping the local reflectivity, OCT visualizes the morphology of the sample. In addition, functional properties such as birefringence, motion, or the distributions of certain substances can be detected with high spatial resolution. Its main field of application is biomedical imaging and diagnostics. In ophthalmology, OCT is accepted as a clinical standard for diagnosing and monitoring the treatment of a number of retinal diseases, and OCT is becoming an important instrument for clinical cardiology. New applications are emerging ...
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    18. Accuracy in the Diagnosis of Non-Melanoma Skin Cancer

      Early diagnosis is a key factor in the overall prognosis for skin cancer patients. By increasing diagnostic accuracy, a potential decrease in morbidity and mortality of non-melanoma skin cancer (NMSC) can be achieved. A variety of non-invasive technologies aimed at diagnosing and quantifying skin cancer have been developed during the past decades. Accurate diagnostic test assessment involves several phases and should ideally be performed prior to the clinical introduction of new test or technologies. Dermoscopy is currently the most widely accepted and most frequently used imaging tool in dermatology. Ultrasound imaging has also gained a wide clinical acceptance. Well-established medical ...
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    19. Optical Coherence Tomography for Imaging of Skin and Skin Diseases

      Optical coherence tomography (OCT) is an emerging imaging technology based on light reflection. It provides real-time images with up to 2-mm penetration into the skin and a resolution of approximately 10 μm. It is routinely used in ophthalmology. The normal skin and its appendages have been studied, as have many diseases. The method can provide accurate measures of epidermal and nail changes in normal tissue. Skin cancer and other tumors, as well as inflammatory diseases, have been studied and good agreement found between OCT images and histopathological architecture. OCT also allows noninvasive monitoring of morphologic changes in skin diseases and ...
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    20. OCT imaging of skin cancer and other dermatological diseases

      Optical coherence tomography (OCT) provides clinicians and researchers with micrometer-resolution, in vivo, cross-sectional images of human skin up to several millimeter depth. This review of OCT imaging applied within dermatology covers the application of OCT to normal skin, and reports on a large number of applications in the fields of non-melanoma skin cancer, malignant melanomas, psoriasis and dermatitis, infestations, bullous skin diseases, tattoos, nails, haemangiomas, and other skin diseases
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    21. Assessment of Optical Coherence Tomography Imaging in the Diagnosis of Non-Melanoma Skin Cancer and Benign Lesions Versus Normal Skin: Observer-Blinded Evaluation by Dermatologists and Pathologists

      BACKGROUND Optical coherence tomography (OCT) is an optical imaging technique that may be useful in diagnosis of non-melanoma skin cancer (NMSC). OBJECTIVES To describe OCT features in NMSC such as actinic keratosis (AK) and basal cell carcinoma (BCC) and in benign lesions and to assess the diagnostic accuracy of OCT in differentiating NMSC from benign lesions and normal skin. METHODS AND MATERIALS OCT and polarization-sensitive (PS) OCT from 104 patients were studied. Observer-blinded evaluation of OCT images from 64 BCCs, 1 baso-squamous carcinoma, 39 AKs, two malignant melanomas, nine benign lesions, and 105 OCT images from perilesional skin was performed ...
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    22. Machine-learning classification of non-melanoma skin cancers from image features obtained by optical coherence tomography

      Background/purpose: A number of publications have suggested that optical coherence tomography (OCT) has the potential for non-invasive diagnosis of skin cancer. Currently, individual diagnostic features do not appear sufficiently discriminatory. The combined use of several features may however be useful. Methods: OCT is based on infrared light, photonics and fibre optics. The system used has an axial resolution of 10 μm, lateral 20 μm. We investigated the combined use of several OCT features from basal cell carcinomas (BCC) and actinic keratosis (AK). We studied BCC (41) and AK (37) lesions in 34 consecutive patients. The diagnostic accuracy of the ...
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    23. Imaging of intradermal tattoos by optical coherence tomography

      Background/purpose: Tattoos have become increasingly popular followed by a growing demand for tattoo removal, and yet there is little knowledge and monitoring of tattoo pigment deposition in skin layers. The purpose of this pilot study is to describe optical coherence tomography image characteristics of intradermal tattoos. Methods: We included five black tattoos in 3 female volunteers, 39, 35 and 30 years old. In vivo imaging of tattoo pigments in the skin is possible with optical coherence tomography (OCT), a novel non-invasive, in vivo optical imaging technology with a resolution and a penetration in skin high enough for visualization of ...
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    1-23 of 23
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