1. Articles from Matthias Nahrendorf

    1-3 of 3
    1. Recent Highlights of ATVB: Systems Biology and Noninvasive Imaging of Atherosclerosis

      Recent Highlights of ATVB: Systems Biology and Noninvasive Imaging of Atherosclerosis

      Atherosclerosis is a systemic disease of the arterial vessel wall. Although the mortality due to cardiovascular events is decreasing, the prevalence of atherosclerosis and its comorbidities, and the consequent heath care costs are expected to rise sharply in the near future. 1 Because the precise cause and pathogenesis of this complex, multifactorial disease are still not fully understood, the clinical assessment of cardiovascular risk has been traditionally based on population risk factors (RFs). 2 However, this approach still largely fails to capture the individual’s cardiovascular risk: most cardiovascular events occur in patients with 1 or few traditional RFs, whereas ...

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    2. Advancing biomedical imaging

      Advancing biomedical imaging

      Imaging reveals complex structures and dynamic interactive processes, located deep inside the body, that are otherwise difficult to decipher. Numerous imaging modalities harness every last inch of the energy spectrum. Clinical modalities include magnetic resonance imaging (MRI), X-ray computed tomography (CT), ultrasound, and light-based methods [endoscopy and optical coherence tomography (OCT)]. Research modalities include various light microscopy techniques (confocal, multiphoton, total internal reflection, superresolution fluorescence microscopy), electron microscopy, mass spectrometry imaging, fluorescence tomography, bioluminescence, variations of OCT, and optoacoustic imaging, among a few others. Although clinical imaging and research microscopy are often isolated from one another, we argue that their ...

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    3. Imaging of the unstable plaque: how far have we got?

      Rupture of unstable plaques may lead to myocardial infarction or stroke and is the leading cause of morbidity and mortality in western countries. Thus, there is a clear need for identifying these vulnerable plaques before the rupture occurs. Atherosclerotic plaques are a challenging imaging target as they are small and move rapidly, especially in the coronary tree. Many of the currently available imaging tools for clinical use still provide minimal information about the biological characteristics of plaques, because they are limited with respect to spatial and temporal resolution. Moreover, many of these imaging tools are invasive. The new generation of ...
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    1-3 of 3
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  2. Topics in the News

    1. (3 articles) Harvard University
    2. (3 articles) Massachusetts General Hospital
    3. (1 articles) Academic Medical Center at the University of Amsterdam
    4. (1 articles) Johns Hopkins University
    5. (1 articles) University of Zurich
    6. (1 articles) University of Lausanne
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    Advancing biomedical imaging Recent Highlights of ATVB: Systems Biology and Noninvasive Imaging of Atherosclerosis Forward genetic analysis using OCT screening identifies Sfxn3 mutations leading to progressive outer retinal degeneration in mice Optical coherence tomography characteristics of taxane-induced macular edema and other multimodal imaging findings Comparison of different morphologies of choroidal neovascularization evaluated by optical coherence tomography angiography in age‐related macular degeneration The Use of Optical Coherence Tomography Angiography in the Diagnosis of Inflammatory Type 1 Choroidal Neovascularization Secondary to Tuberculosis: A Case Report Improving the Detection of Glaucoma and Its Progression: A Topographical Approach Vulnerability Zone of Glaucoma Progression in Combined Wide-field Optical Coherence Tomography Event-based Progression Analysis The Application of Non-invasive and Cellular Level Resolution Fullfield Optical Coherence Tomography: Establishment and Analysis of Subcutaneous Cellular Level Image Database of Anatomical Locations in Healthy Volunteers and Evaluation of Usability Anterior Segment Optical Coherence Tomography (AS-OCT) Guided Reversal of Edematous Punctal Occlusion Optical coherence tomography angiography markers associated with treatment response in neovascular age-related macular degeneration Anterior segment optical coherence tomography imaging in peripheral ulcerative keratitis, a corneal structural description