1. Articles from Matthias Nahrendorf

    1-3 of 3
    1. Recent Highlights of ATVB: Systems Biology and Noninvasive Imaging of Atherosclerosis

      Recent Highlights of ATVB: Systems Biology and Noninvasive Imaging of Atherosclerosis

      Atherosclerosis is a systemic disease of the arterial vessel wall. Although the mortality due to cardiovascular events is decreasing, the prevalence of atherosclerosis and its comorbidities, and the consequent heath care costs are expected to rise sharply in the near future. 1 Because the precise cause and pathogenesis of this complex, multifactorial disease are still not fully understood, the clinical assessment of cardiovascular risk has been traditionally based on population risk factors (RFs). 2 However, this approach still largely fails to capture the individual’s cardiovascular risk: most cardiovascular events occur in patients with 1 or few traditional RFs, whereas ...

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    2. Advancing biomedical imaging

      Advancing biomedical imaging

      Imaging reveals complex structures and dynamic interactive processes, located deep inside the body, that are otherwise difficult to decipher. Numerous imaging modalities harness every last inch of the energy spectrum. Clinical modalities include magnetic resonance imaging (MRI), X-ray computed tomography (CT), ultrasound, and light-based methods [endoscopy and optical coherence tomography (OCT)]. Research modalities include various light microscopy techniques (confocal, multiphoton, total internal reflection, superresolution fluorescence microscopy), electron microscopy, mass spectrometry imaging, fluorescence tomography, bioluminescence, variations of OCT, and optoacoustic imaging, among a few others. Although clinical imaging and research microscopy are often isolated from one another, we argue that their ...

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    3. Imaging of the unstable plaque: how far have we got?

      Rupture of unstable plaques may lead to myocardial infarction or stroke and is the leading cause of morbidity and mortality in western countries. Thus, there is a clear need for identifying these vulnerable plaques before the rupture occurs. Atherosclerotic plaques are a challenging imaging target as they are small and move rapidly, especially in the coronary tree. Many of the currently available imaging tools for clinical use still provide minimal information about the biological characteristics of plaques, because they are limited with respect to spatial and temporal resolution. Moreover, many of these imaging tools are invasive. The new generation of ...
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    1-3 of 3
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  2. Topics in the News

    1. (3 articles) Harvard University
    2. (3 articles) Massachusetts General Hospital
    3. (1 articles) Academic Medical Center at the University of Amsterdam
    4. (1 articles) Johns Hopkins University
    5. (1 articles) University of Zurich
    6. (1 articles) University of Lausanne
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    Advancing biomedical imaging Recent Highlights of ATVB: Systems Biology and Noninvasive Imaging of Atherosclerosis Measurement of the Shrinkage of Natural and Simulated Lesions on Root Surfaces using CP-OCT Optic-Net: A Novel Convolutional Neural Network for Diagnosis of Retinal Diseases from Optical Tomography Images Double layer sign: A new optical coherence tomography finding in active tubercular serpiginous-like choroiditis to monitor activity Influence of Epiretinal Membranes on the Retinal Nerve Fiber Layer Thickness Measured by Spectral Domain Optical Coherence Tomography in Glaucoma High signal-to-noise ratio reconstruction of low bit-depth optical coherence tomography using deep learning New Method of Quantitative Analysis of Hard Exudate Using Optical Coherence Tomography: Application in Diabetic Macular Edema Characterization and oxygen saturation study of human retinal blood vessels evaluated by spectroscopic Optical Coherence Tomography Angiography Optical coherence tomography angiography and arterial hypertension: A role in identifying subclinical microvascular damage? Enhanced Depth Imaging Optical Coherence Tomography of Optic Nerve Head Drusen in Children Evaluation of surgically excised breast tissue microstructure using wide‐field optical coherence tomography