1. Articles from syril dorairaj

    1-10 of 10
    1. Intra-operative optical coherence tomography in glaucoma surgery—a systematic review

      Intra-operative optical coherence tomography in glaucoma surgery—a systematic review

      The application of the OCT in clinical ophthalmology has expanded significantly since its introduction more than 20 years ago. There has been recent growing interest in the application of intra-operative optical coherence tomography (iOCT). The iOCT’s ability to enhance visualisation and depth appreciation has the potential to be further exploited in glaucoma surgery, especially with the emergence of Minimally Invasive Glaucoma Surgery (MIGS)—to facilitate targeted device placement and fine surgical manoeuvres in the angles, the sub-conjunctival layer and the suprachoroidal space. Hence, this study aims to appraise the current literature on the applications of iOCT in glaucoma surgery ...

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    2. In vivo analysis of glaucoma-related features within the optic nerve head using enhanced depth imaging optical coherence tomography

      In vivo analysis of glaucoma-related features within the optic nerve head using enhanced depth imaging optical coherence tomography

      Structural differences between optic nerve head (ONH) parameters in glaucomatous and non-glaucomatous eyes has been documented, however the association between such parameters in patients with different disease stages is yet to be elucidated. We investigated the relationship between different laminar and prelaminar ONH structures using enhanced depth imaging spectral-domain optical coherence tomography (EDI OCT) in a population with and without glaucoma. In this observational case-control study, we prospectively enrolled healthy individuals and glaucomatous patients with different disease stages. All participants underwent EDI OCT imaging (Heidelberg Engineering). Following ONH parameters were measured on serial vertical B-scans by two examiners masked to ...

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    3. Eyes with Large Disc Cupping and Normal Intraocular Pressure: Using Optical Coherence Tomography to Discriminate Those With and Without Glaucoma

      Eyes with Large Disc Cupping and Normal Intraocular Pressure: Using Optical Coherence Tomography to Discriminate Those With and Without Glaucoma

      We evaluated the ability of spectral-domain optic coherence tomography (SD-OCT) to differentiate large physiological optic disc cupping (LPC) from glaucomatous cupping in eyes with intraocular pressure (IOP) within the normal range. We prospectively enrolled patients with glaucoma or presumed LPC. Participants had optic discs with confirmed or suspected glaucomatous damage (defined as a vertical cup-to-disc ratio≥0.6), and all eyes had known untreated IOP<21 mmHg. For glaucomatous eyes, a reproducible glaucomatous visual field (VF) defect was required. LPC eyes required normal VF and no evidence of progressive glaucomatous neuropathy (follow-up≥30 months). Peripapillary retinal nerve fiber layer (pRNFL ...

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    4. Anterior Segment Imaging in Glaucoma

      Anterior Segment Imaging in Glaucoma

      Anterior segment imaging allows objective assessment of the anterior segment of the eye, particularly the anterior chamber angle. Both qualitative and quantitative analyses are possible and aid in detecting and managing closed-angle and open-angle mechanisms in various forms of glaucoma . This review focuses primarily on anterior segment optical coherence tomography and ultrasound biomicroscopy, with emphasis on principles of technology, commercially available devices, and clinical applications in glaucoma with potential advantages and disadvantages of each technology.

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    5. In Vivo Evaluation of Focal Lamina Cribrosa Defects in Glaucoma

      In Vivo Evaluation of Focal Lamina Cribrosa Defects in Glaucoma
      Objectives  To assess focal lamina cribrosa (LC) defects in glaucoma using enhanced depth imaging optical coherence tomography and to investigate their spatial relationships with neuroretinal rim and visual field loss. Methods  Serial horizontal and vertical enhanced depth imaging optical coherence tomographic images of the optic nerve head were obtained from healthy subjects and those with glaucoma. Focal LC defects defined as anterior laminar surface irregularity (diameter, >100 µm; depth, >30 µm) that violates the normal smooth curvilinear contour were investigated regarding their configurations and locations. Spatial consistency was evaluated among focal LC defects, neuroretinal rim thinning/notching, and visual field ...
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    6. Indentation Slitlamp-Adapted Optical Coherence Tomography Technique for Anterior Chamber Angle Assessment

      Indentation Slitlamp-Adapted Optical Coherence Tomography Technique for Anterior Chamber Angle Assessment
      Gonioscopy remains the gold-standard method for evaluation of the anterior chamber angle. Different imaging devices have been developed to study angle anatomy, including ultrasound biomicroscopy,1 slitlamp-adapted optical coherence tomography (SL-OCT),2 and Scheimpflug photography.3 In eyes with angle closure, indentation gonioscopy is necessary to determine the underlying pathophysiology and to differentiate between appositional closure and peripheral anterior synechiae. A technique to perform indentation gonioscopy with ultrasound biomicroscopy using a small eyecup has been previously reported.4 Although SL-OCT has been used to evaluate eyes with angle closure, its clinical applicability is usually limited to measurements of angle parameters ...
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    7. Assessment of Scleral Spur Visibility With Anterior Segment Optical Coherence Tomography

      Purpose: To develop a grading system to evaluate the scleral spur visibility and to investigate the association between this and the angle width. Methods: Sixty healthy normal subjects (33 with open angles and 27 with narrow angles on dark room gonioscopy) underwent anterior segment imaging with the Visante OCT (Carl Zeiss Meditec, Dublin, CA). The anterior chamber angles at 12-o' clock hour positions were imaged and analyzed. The scleral spur at each clock hour position was independently graded by 2 observers. A scleral spur visibility score (SSVS) of 2 denotes clear visibility of the scleral spur. SSVS of 0 and ...
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    8. Intra-observer and Inter-observer Reliability and Reproducibility of Slit-Lamp–Adapted Optical Coherence Tomography for Evaluation of Anterior Chamber Depth and Central Corneal Thickness

      BACKGROUND AND OBJECTIVE To evaluate the intra-observer and inter-observer reproducibility of anterior chamber depth (ACD) and central corneal thickness (CCT) measurements taken by slit-lamp–adapted optical coherence tomography (SL-OCT) and to evaluate concordance of CCT and ACD values obtained by SL-OCT with gold standard devices. PATIENTS AND METHODS Three images of each eye were taken by two different operators using SL-OCT. ACD and CCT values obtained by each operator were determined and compared to one another and to ultrasonic pachymetry (CCT) and axial OCT biometry (ACD) values obtained by a third, masked operator. Intra-observer and inter-operator reproducibility was assessed using ...
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    9. Quantitative Evaluation of Anterior Segment Parameters in the Era of Imaging

      Quantitative Evaluation of Anterior Segment Parameters in the Era of Imaging
      Purpose To review the parameters for quantitative assessment of the anterior segment and iridocorneal angle and to develop a comprehensive schematic for the evaluation of angle anatomy and pathophysiology by high-resolution imaging. Methods The published literature of the last 15 years was reviewed, analyzed, and organized into a construct for assessment of anterior segment processes. Results Modern anterior segment imaging techniques have allowed us to devise new quantitative parameters to improve the information obtained. Ultrasound biomicroscopy, slit-lamp optical coherence tomography, and anterior segment optical coherence tomography provide high-resolution images for analysis of physiologic and pathologic processes. These include iridocorneal angle ...
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    10. Intra-observer and Inter-observer Reliability and Reproducibility of Slit-Lamp–Adapted Optical Coherence Tomography for Evaluation of Anterior Chamber Depth and Central Corneal Thickness

      BACKGROUND AND OBJECTIVE To evaluate the intra-observer and inter-observer reproducibility of anterior chamber depth (ACD) and central corneal thickness (CCT) measurements taken by slit-lamp–adapted optical coherence tomography (SL-OCT) and to evaluate concordance of CCT and ACD values obtained by SL-OCT with gold standard devices. PATIENTS AND METHODS Three images of each eye were taken by two different operators using SL-OCT. ACD and CCT values obtained by each operator were determined and compared to one another and to ultrasonic pachymetry (CCT) and axial OCT biometry (ACD) values obtained by a third, masked operator. Intra-observer and inter-operator reproducibility was assessed using ...
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    1-10 of 10
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