1. Articles from akio kuroi

    1-21 of 21
    1. Intracoronary pressure increase due to contrast injection for optical coherence tomography imaging

      Intracoronary pressure increase due to contrast injection for optical coherence tomography imaging

      Background Optical coherence tomography (OCT) requires intracoronary injection of contrast media to remove blood from the field of view during image acquisition. Contrast injection may cause a temporal increase in intracoronary pressure. The aim of this study was to compare the intracoronary pressure during contrast injection between OCT and coronary angiography . Methods We measured intracoronary pressure by using a pressure guidewire during contrast injection for OCT and angiography in 30 coronary arteries (mean fractional flow reserve = 0.90 ± 0.03). Contrast media was injected into coronary artery through the guiding catheter by using a mechanical injector pump. Results Intracoronary pressure ...

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    2. Prognosis of spontaneous coronary artery dissection treated by percutaneous coronary intervention with optical coherence tomography

      Prognosis of spontaneous coronary artery dissection treated by percutaneous coronary intervention with optical coherence tomography

      Background Although about half of patients with spontaneous coronary artery dissection (SCAD) face ongoing necrosis, conservative therapy is recommended due to a high complication rate in angiography-guided percutaneous coronary intervention (PCI). The aim of this study was to investigate clinical outcomes of SCAD treated by optical coherence tomography (OCT)-guided PCI. Methods This study consisted of consecutive 306 patients with acute coronary syndrome (ACS) who underwent OCT-guided PCI. Based on the culprit lesion morphology by OCT, patients were assigned to four groups: a SCAD group, a plaque rupture (PR) group, a calcified nodule (CN) group, and an undetermined etiology (UE ...

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    3. Optical Coherence Tomography Predictors for Edge Restenosis After Everolimus-Eluting Stent Implantation

      Optical Coherence Tomography Predictors for Edge Restenosis After Everolimus-Eluting Stent Implantation

      Background— Stent edge restenosis (SER) remains a potential limitation of drug-eluting stents. The aim of this study was to determine optical coherence tomography (OCT) predictors for angiographic late SER after everolimus-eluting stent implantation. Methods and Results— We retrospectively analyzed 319 patients who underwent OCT immediately after everolimus-eluting stent implantation and scheduled 9- to 12-month follow-up angiography. The binary angiographic SER rate was 10% (32/319) in the patients, 8.4% (32/382) in lesions, and 4.4% (33/744) in stent edge segments. In the stent edge segments at post stenting, OCT-derived lipidic plaque (61% versus 20%; P <0.001 ...

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    4. Reduction of in-stent thrombus immediately after percutaneous coronary intervention by pretreatment with prasugrel compared with clopidogrel: An optical coherence tomography study

      Reduction of in-stent thrombus immediately after percutaneous coronary intervention by pretreatment with prasugrel compared with clopidogrel: An optical coherence tomography study

      Background Prasugrel is a new-generation thienopyridine antiplatelet agent that provides more consistent and prompt platelet inhibition than clopidogrel. The aim of this study was to compare in-stent thrombus inhibition effect of pretreatment with prasugrel and clopidogrel by using optical coherence tomography (OCT) immediately after percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS). Methods We performed OCT immediately after PCI in 108 ACS patients pretreated with either prasugrel ( n = 51) or clopidogrel ( n = 57). OCT detected thrombus/plaque protrusion in all stented segments. Results Although stent volume (190.4 ± 119.1 mm 3 vs. 189.4 ± 95.8 mm 3 ...

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    5. Difference of Culprit Lesion Morphologies Between ST-Segment Elevation Myocardial Infarction and Non-ST-Segment Elevation Acute Coronary Syndrome: An Optical Coherence Tomography Study

      Difference of Culprit Lesion Morphologies Between ST-Segment Elevation Myocardial Infarction and Non-ST-Segment Elevation Acute Coronary Syndrome: An Optical Coherence Tomography Study
      Objectives The aim of this study was to investigate the difference of culprit lesion morphologies assessed by optical coherence tomography (OCT) between ST-segment elevation myocardial infarction (STEMI) and non–ST-segment elevation acute coronary syndrome (NSTEACS). Background Autopsy studies have reported that rupture of a thin-cap fibroatheroma and subsequent thrombus formation is the most important mechanism leading to acute coronary syndrome (ACS). Optical coherence tomography is a high-resolution imaging modality that is capable of investigating detailed coronary plaque morphology in vivo. Methods We examined the culprit lesion morphologies by OCT in 89 consecutive patients with acute coronary syndrome (STEMI = 40; NSTEACS ...
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    6. Association of monocyte subset counts with coronary fibrous cap thickness in patients with unstable angina pectoris

      Association of monocyte subset counts with coronary fibrous cap thickness in patients with unstable angina pectoris
      Abstract: Objectives: We examined whether distinct monocyte subsets relate in specific ways to coronary fibrous cap thickness (FCT) in patients with unstable angina pectoris (UAP).Methods: Forty patients with UAP who underwent percutaneous coronary intervention were enrolled in this study. The changes in the non-culprit FCT were assessed by optical coherence tomography (OCT) at baseline and after 9 months. The distinct monocyte subsets (CD14+CD16−CCR2+ and CD14+CD16+CX3CR1+) were measured by flow cytometry.Results: The percent change in FCT showed significantly negative correlation with the percent changes in CD14+CD16+CX3CR1+ monocytes, but not CD14+CD16−CCR2+ monocytes ...
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    7. Relation of Microchannel Structure Identified by Optical Coherence Tomography to Plaque Vulnerability in Patients With Coronary Artery Disease

      Relation of Microchannel Structure Identified by Optical Coherence Tomography to Plaque Vulnerability in Patients With Coronary Artery Disease
      Increased neovascularization in atherosclerotic plaques is associated with plaque vulnerability. The high resolution of optical coherence tomography (OCT) might provide a chance to directly visualize plaque neovascularization in vivo. The aim of the present study was to investigate the relation between microchannels in culprit plaques identified by OCT and plaque vulnerability in patients with coronary artery disease. A total of 63 consecutive patients with coronary artery disease who had undergone both OCT and intravascular ultrasound before any interventions to examine culprit lesion morphologies were enrolled. Microchannel was defined as a no-signal tubuloluminal structure on the cross-sectional optical coherence tomographic image ...
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    8. Multiple Coronary Lesion Instability in Patients With Acute Myocardial Infarction as Determined by Optical Coherence Tomography

      Autopsy studies have suggested that acute myocardial infarction (AMI) represents a pan-coronary process of vulnerable plaque development. We performed multifocal optical coherence tomographic (OCT) examination to compare coronary lesion instability between AMI and stable angina pectoris (SAP). A total of 42 patients with AMI (n = 26) or SAP (n = 16) who had multivessel disease and underwent multivessel coronary intervention were enrolled in the present study. The OCT examination was performed not only in the infarct-related/target lesions, but also in the noninfarct-related/nontarget lesions. OCT-derived thin-cap fibroatheroma (TCFA) was defined as a lesion with a fibrous cap thickness of
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    9. Activated Platelet is Associated With Subclinical Stent Thrombosis Detected by Optical Coherence Tomography

      Activated Platelet is Associated With Subclinical Stent Thrombosis Detected by Optical Coherence Tomography

      Backgrounds: While stent thrombosis is a critical issue in the drug-eluting stent era, there are few monitoring markers for stent thrombosis. Optical coherence tomography (OCT) introducing as a high-resolution modality allows us to assess plaque characteristics, including in-stent micro-thrombus. We hypothesized that in vivo activated platelet was associated with in-stent thrombus formation. The aim of this study was to investigate the relationship between in vivo platelet activity and in-stent thrombus formation assessed by OCT. Methods: We enrolled 54 patients who were treated with coronary stent. OCT was performed at a 8-month follow-up angiography. The frequency of uncovered struts was assessed ...

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    10. Impact of Culprit Lesion Characteristics on Microvascular Obstruction in Patients With Acute Coronary Syndrome: An Optical Coherence Tomography and Cardiac Magnetic Resonance Imaging Study

      Background: The degree of myocardial damage is an important determinant of clinical outcomes in patients with acute coronary syndrome (ACS). We have reported that lesion characteristics are associated with slow flow phenomenon. The aim of this study was to investigate whether culprit lesion characteristics identified by optical coherence tomography (OCT) were associated with microvascular obstruction (MVO) assessed by contrast-enhanced magnetic resonance imaging (ce-MRI) in patients with ACS. Methods: We enrolled 46 patients with ACS who were successfully recanalized with primary percutaneous coronary intervention (PCI). They were divided into a thin-cap fibroatheroma (TCFA) group (n=17) and a non-TCFA group (n ...
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    11. Advantage of next-generation frequency-domain optical coherence tomography compared with conventional time-domain system in the assessment of coronary lesion

      Background: Intracoronary optical coherence tomography (OCT) is a high-resolution imaging modality used for evaluation of coronary lesion morphology. However, current time-domain OCT (TD-OCT) have a number of limitations with regard to both procedural usage and safety in the clinical setting. The next-generation frequency-domain OCT (FD-OCT), which has a much faster frame rate and pullback speed than TD-OCT, is expected to overcome these limitations. The aim of this study was to evaluate the feasibility and usability of next generation FD-OCT in the assessment of coronary lesions. Methods: A comparison study was performed between FD-OCT and TD-OCT from the aspect of usability ...
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    12. Head to head comparison between the conventional balloon occlusion method and the non-occlusion method for optical coherence tomography

      Abstract: Background: Optical coherence tomography (OCT) has been introduced as a high-resolution imaging modality for the coronary arteries. The current OCT system, however, has a serious limitation in that the image acquisition method requires a soft balloon occlusion to avoid signal scattering from red blood cells.Purpose: The purpose of this study was to compare OCT images from the conventional balloon occlusion method and a non-occlusion image acquisition method, the continuous-flushing method, in the clinical setting.Methods: OCT was performed with the conventional balloon occlusion method and the continuous-flushing method sequentially in 23 patients with stable angina. The image quality ...
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    13. Relationship Between Coronary Arterial Remodeling, Fibrous Cap Thickness and High-Sensitivity C-Reactive Protein Levels in Patients With Acute Coronary Syndrome

      Thin-capped fibroatheroma (TCFA) is a recognized precursor lesion for acute coronary syndrome (ACS). Positive remodeling (PR) is the predominant pattern of arterial remodeling in patients with ACS. The aim of this study was to evaluate the relationship between coronary arterial remodeling, fibrous cap thickness and high-sensitivity C-reactive protein (hs-CRP) concentration in patients with ACS. Methods and Results: The 47 consecutive ACS patients were enrolled in this study. Arterial remodeling of culprit plaque was assessed by intravascular ultrasound, and fibrous cap thickness was measured by optical coherence tomography. The remodeling index (RI) was calculated as lesion divided by the reference external ...
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    14. Lipid-rich plaque and myocardial perfusion after successful stenting in patients with non-ST-segment elevation acute coronary syndrome: an optical coherence tomography study

      Aims: Although some recent guidelines recommend an early invasive strategy for non-ST-segment elevation acute coronary syndrome (NSTEACS), several studies have failed to identify any benefit for very early intervention for NSTEACS. The no-reflow phenomenon may inhibit the expected benefit from very early recanalization for NSTEACS subjects. The aim of this study was to investigate whether optical coherence tomography (OCT) could predict no-reflow in patients with NSTEACS. Methods and results: This study comprised 83 consecutive patients with NSTEACS who underwent OCT and successful emergent primary stenting. On the basis of post-stent TIMI flow, patients were divided into two groups: no-reflow group ...
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    15. Morphology of Exertion-Triggered Plaque Rupture in Patients With Acute Coronary Syndrome. An Optical Coherence Tomography Study

      Background—Plaque rupture and secondary thrombus formation play key roles in the onset of acute coronary syndrome (ACS). One pathological study suggested that the morphologies of plaque rupture differed between rest-onset and exertion-triggered rupture in men who experienced sudden death. The aim of the present study was to use optical coherence tomography to investigate the relationship in patients with ACS between the morphology of a ruptured plaque and the patient's activity at the onset of ACS. Methods and Results—The study population was drawn from 43 consecutive ACS patients (with or without ST-segment elevation) who underwent optical coherence tomography ...
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    16. Relationship between Coronary Arterial Remodeling and Fibrous Cap Thickness in Patients with Acute Coronary Syndrome

      The aim of this study was to evaluate the relationship between coronary arterial remodeling and the thickness of fibrous cap in patients with acute coronary syndrome (ACS). Thin-capped fibroatheroma is recognized as a precursor lesion for ACS. Positive remodeling (PR) is predominant pattern of arterial remodeling in patients with ACS. However, the relationship between PR and the thickness of fibrous cap has not been elucidated in vivo. We enrolled 41 patients with ACS who underwent both intravascular ultrasound (IVUS) and optical coherence tomography (OCT). The arterial remodeling was assessed by IVUS and the thickness of fibrous cap was measured by ...
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    17. Distribution and Frequency of Thin-Capped Fibroatheromas and Ruptured Plaques in the Entire Culprit Coronary Artery in Patients With Acute Coronary Syndrome as Determined by Optical Coherence Tomography

      The aim of this study was to investigate the distribution and frequency of thin-capped fibroatheromas (TCFAs) within the entire length of culprit coronary arteries in patients with acute coronary syndrome. Our population was drawn from 43 consecutive patients with acute coronary syndrome (with or without ST-segment elevation) who underwent optical coherence tomography to visualize the entire culprit coronary artery using a nonocclusive optical coherence tomographic technique. Patients were categorized divided into a TCFA group or a no-TCFA group on the basis of the optical coherence tomographic findings. There were no differences in baseline characteristics or angiographic findings between the 2 ...
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    18. Comparison of Vascular Response After Sirolimus-Eluting Stent Implantation Between Patients With Unstable and Stable Angina Pectoris: A Serial Optical Coherence Tomography Study

      A Serial Optical Coherence Tomography Study Objectives: The aim of the present study was to compare lesion morphologies after sirolimus-eluting stent (SES) implantation between patients with unstable angina pectoris (UAP) and stable angina pectoris (SAP) with the use of optical coherence tomography (OCT). Background: The lesion morphologies before and after coronary stenting have been proposed as important predictors of clinical outcome. The high resolution of OCT provides detailed information of coronary vessel wall. Methods: We enrolled 55 patients (UAP: n = 24, SAP: n = 31), and examined lesion morphologies by using OCT at pre- and post-SES implantation and 9 months' follow-up ...

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    19. Implication of Plaque Color Classification for Assessing Plaque Vulnerability

      Objectives: The purpose of this study was to assess the relationship between plaque color evaluated by coronary angioscopy and fibrous cap thickness estimated by optical coherence tomography (OCT) in vivo. Background: Yellow color intensity of coronary plaque evaluated by coronary angioscopy might be associated with plaque vulnerability. Methods: Seventy-seven coronary artery plaques in patients with acute coronary syndrome were observed by angioscopy and OCT. Plaque color was graded as white, light yellow, yellow, or intensive yellow. Results: There were significant differences among the groups classified by plaque color with respect to the fibrous cap thickness estimated by OCT: 389 ± 74 ...

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    1-21 of 21
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    Activated Platelet is Associated With Subclinical Stent Thrombosis Detected by Optical Coherence Tomography Relation of Microchannel Structure Identified by Optical Coherence Tomography to Plaque Vulnerability in Patients With Coronary Artery Disease Association of monocyte subset counts with coronary fibrous cap thickness in patients with unstable angina pectoris Difference of Culprit Lesion Morphologies Between ST-Segment Elevation Myocardial Infarction and Non-ST-Segment Elevation Acute Coronary Syndrome: An Optical Coherence Tomography Study VIS-OCT Opens Eyes to New Approaches Optical biopsy of penile cancer with in vivo confocal laser endomicroscopy Polarization-sensitive optical coherence elastography Evaluation of 1-year follow-up results of macular telangiectasia type 2 cases by optical coherence tomography angiography Effect of night work on image quality of optical coherence tomography angiography Fire Ant Punctate Keratopathy A Novel Diagnosis Based on Clinical and Anterior Segment Optical Coherence Tomography Findings Comparison of clinical outcomes of different components of diabetic macular edema on optical coherence tomography A Pilot Optical Coherence Tomography Angiography Study on Superficial and Deep Capillary Plexus Foveal Avascular Zone in Patients With Beta-Thalassemia Major