1. Articles from Chulhong Kim

    1-10 of 10
    1. In Vivo Near Infrared Virtual Intraoperative Surgical Photoacoustic Optical Coherence Tomography

      In Vivo Near Infrared Virtual Intraoperative Surgical Photoacoustic Optical Coherence Tomography

      Since its first implementation in otolaryngological surgery nearly a century ago, the surgical microscope has improved the accuracy and the safety of microsurgeries. However, the microscope shows only a magnified surface view of the surgical region. To overcome this limitation, either optical coherence tomography (OCT) or photoacoustic microscopy (PAM) has been independently combined with conventional surgical microscope. Herein, we present a near-infrared virtual intraoperative photoacoustic optical coherence tomography (NIR-VISPAOCT) system that combines both PAM and OCT with a conventional surgical microscope. Using optical scattering and absorption, the NIR-VISPAOCT system simultaneously provides surgeons with real-time comprehensive biological information such as tumor ...

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    2. Two-axis polydimethylsiloxane-based electromagnetic microelectromechanical system scanning mirror for optical coherence tomography

      Two-axis polydimethylsiloxane-based electromagnetic microelectromechanical system scanning mirror for optical coherence tomography

      Compact size and fast imaging abilities are key requirements for the clinical implementation of an optical coherence tomography (OCT) system. Among the various small-sized technology, a microelectromechanical system (MEMS) scanning mirror is widely used in a miniaturized OCT system. However, the complexities of conventional MEMS fabrication processes and relatively high costs have restricted fast clinical translation and commercialization of the OCT systems. To resolve these problems, we developed a two-axis polydimethylsiloxane (PDMS)-based MEMS (2A-PDMS-MEMS) scanning mirror through simple processes with low costs. It had a small size of 15 × 15 × 15    mm 3 15×15×15  mm3 , was fast ...

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    3. A 2-axis Polydimethylsiloxane (PDMS) based electromagnetic MEMS scanning mirror for optical coherence tomography

      A 2-axis Polydimethylsiloxane (PDMS) based electromagnetic MEMS scanning mirror for optical coherence tomography

      Optical coherence tomography (OCT) is a noninvasive imaging tool for visualizing cross-sectional images of biological tissues on a microscale. Various microelectromechanical system (MEMS) techniques have been applied to OCT for endoscopic catheters and handheld probes. Despite having several advantages such as compact sizes and high speeds for real-time imaging, the complexities of the fabrication processes and relatively high costs were bottlenecks for fast clinical translation and commercialization of the earlier MEMS scanners. To overcome these issues, we developed a 2-axis polydimethylsiloxane (PDMS)-based electromagnetic MEMS scanning mirror based on flexible, cost-effective, and handleable PDMS. The size of this MEMS scanner ...

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    4. Looking Deeper: Multimodal and contrast-enhanced photoacoustic imaging offer a clearer view within tissues for more accurate diagnosis

      Looking Deeper: Multimodal and contrast-enhanced photoacoustic imaging offer a clearer view within tissues for more accurate diagnosis

      Optical imaging modalities such as fluorescence (FL) microscopy, multiphoton microscopy, and optical coherence tomography (OCT) have been well established for high optical contrast and high spatial resolution imaging of biological tissues. However, as they are dependent on ballistic photons, these methods fail to image beyond ~1 mm or so inside biological tissue. In contrast, diffuse optical imaging (DOI), which uses multiple scattered photons for imaging, can image much deeper (up to a several centimeters) into the tissue. Unfortunately, due to strong light scattering in tissues, it fails to maintain the high resolution at the deeper imaging depth. Photoacoustic imaging (PAI ...

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    5. Microscope System, And Method For Providing Augmented Reality Images Of Microscope System

      Microscope System, And Method For Providing Augmented Reality Images Of Microscope System

      Provided is a microscope system. The system comprises: an optical microscope unit for collecting a surface image of an object to be examined; an OCT unit for collecting an optical coherence tomography image of the object to be examined; a PA unit for collecting a photoacoustic image of the object to be examined; an image processing unit for generating an augmented reality image by superimposing the optical coherence tomography image and the photoacoustic image over the surface image; and an image observation unit for making the augmented reality image visible.

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    6. Stimulated penetrating keratoplasty using real-time virtual intraoperative surgical optical coherence tomography

      Stimulated penetrating keratoplasty using real-time virtual intraoperative surgical optical coherence tomography

      An intraoperative surgical microscope is an essential tool in a neuro- or ophthalmological surgical environment. Yet, it has an inherent limitation to classify subsurface information because it only provides the surface images. To compensate for and assist in this problem, combining the surgical microscope with optical coherence tomography (OCT) has been adapted. We developed a real-time virtual intraoperative surgical OCT (VISOCT) system by adapting a spectral-domain OCT scanner with a commercial surgical microscope. Thanks to our custom-made beam splitting and image display subsystems, the OCT images and microscopic images are simultaneously visualized through an ocular lens or the eyepiece of ...

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    7. Combined photoacoustic and optical coherence tomography using a single near-infrared supercontinuum laser source

      Combined photoacoustic and optical coherence tomography using a single near-infrared supercontinuum laser source

      . We developed an integrated dual-modal photoacoustic and optical coherence tomography (PA-OCT) system using a single near-infrared supercontinuum laser source to simultaneously provide both optical absorption and scattering contrasts. A pulsed broadband supercontinuum source was generated by a pulsed Nd:YAG laser and a photonic-crystal fiber. When we imaged two colored hairs, the black hair was visible in both PA and OCT images, whereas the white hair was only mapped in the OCT image. The single laser source will potentially allow us to implement relatively simple, cheap, and compact dual-modal PA-OCT systems, which are key criteria for fast clinical translation and ...

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    8. Dual-modal photoacoustic and optical coherence tomography using a single near-infrared supercontinuum laser source

      Dual-modal photoacoustic and optical coherence tomography using a single near-infrared supercontinuum laser source

      We report the development of a combined dual-modal photoacoustic and optical coherence tomography (PA-OCT) system using a single near-infrared (NIR) supercontinuum laser source which can provide both optical absorption and scattering contrasts simultaneously. By using a small sized pulsed Nd:YAG microchip laser and a photonic crystal fiber, we fabricated a pulsed broadband supercontinuum source from 600 to 1700 nm. Under the same optical hardware system, intrinsically registered PA and OCT images are acquired in a single scanning. In order to demonstrate feasibility of our system, we successfully acquired the PA and OCT images of black and white hairs images ...

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    9. Investigation of Neovascularization in Three-Dimensional Porous Scaffolds In Vivo by a Combination of Multiscale Photoacoustic Microscopy and Optical Coherence Tomography

      Investigation of Neovascularization in Three-Dimensional Porous Scaffolds In Vivo by a Combination of Multiscale Photoacoustic Microscopy and Optical Coherence Tomography

      It is a grand challenge to visualize and assess in vivo neovascularization in a three-dimensional (3D) scaffold non-invasively, together with high spatial resolution and deep penetration depth. Here we used multiscale photoacoustic microscopy (PAM), including acoustic-resolution PAM (AR-PAM) and optical-resolution PAM (OR-PAM), to chronically monitor neovascularization in an inverse opal scaffold implanted in a mouse model up to six weeks by taking advantage of the optical absorption contrast intrinsic to hemoglobin molecules in red blood cells. By combining with optical coherence tomography (OCT) based on optical scattering contrast, we also demonstrated the capability to simultaneously image and analyze the vasculature ...

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    10. In vivo photoacoustic tomography and its clinical application.

      High-resolution volumetric optical imaging modalities, such as confocal microscopy, two-photon microscopy, and optical coherence tomography, have become increasingly important in biomedicine. However, due to strong light scattering, the penetration depths of these imaging modalities are limited to the optical transport mean free path (1 mm) in biological tissues. Photoacoustic imaging, an emerging hybrid modality that can provide strong endogenous and exogenous optical absorption contrasts with high ultrasonic spatial resolution, has overcome the fundamental depth limitation while maintaining high spatial resolution. The image resolution, as well as the maximum imaging depth, is scalable with ultrasonic frequency within the reach of diffuse ...
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    1-10 of 10
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  2. Topics in the News

    1. (7 articles) Jeehyun Kim
    2. (7 articles) Changho Lee
    3. (6 articles) Kyungpook National University
    4. (2 articles) Washington University in St. Louis
    5. (2 articles) State University of New York at Buffalo
    6. (2 articles) Lihong V. Wang
    7. (2 articles) Mansik Jeon
    8. (1 articles) University of Ulsan
    9. (1 articles) Li Li
    10. (1 articles) Min Yong Jeon
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    Investigation of Neovascularization in Three-Dimensional Porous Scaffolds In Vivo by a Combination of Multiscale Photoacoustic Microscopy and Optical Coherence Tomography Dual-modal photoacoustic and optical coherence tomography using a single near-infrared supercontinuum laser source Combined photoacoustic and optical coherence tomography using a single near-infrared supercontinuum laser source Stimulated penetrating keratoplasty using real-time virtual intraoperative surgical optical coherence tomography Microscope System, And Method For Providing Augmented Reality Images Of Microscope System Looking Deeper: Multimodal and contrast-enhanced photoacoustic imaging offer a clearer view within tissues for more accurate diagnosis A 2-axis Polydimethylsiloxane (PDMS) based electromagnetic MEMS scanning mirror for optical coherence tomography Two-axis polydimethylsiloxane-based electromagnetic microelectromechanical system scanning mirror for optical coherence tomography In Vivo Near Infrared Virtual Intraoperative Surgical Photoacoustic Optical Coherence Tomography Perimeter Medical Imaging Closes Oversubscribed $C4.4M Financing Time-domain optical coherence tomography system based on moving-optical-wedge interferometer ML and AI: At the Forefront of Ophthalmology