1. Articles from Svetlana Ruvinskaya

    1-3 of 3
    1. Optical coherence tomography for the quantitative study of cerebrovascular physiology

      Optical coherence tomography for the quantitative study of cerebrovascular physiology

      Doppler optical coherence tomography (DOCT) and OCT angiography are novel methods to investigate cerebrovascular physiology. In the rodent cortex, DOCT flow displays features characteristic of cerebral blood flow, including conservation along nonbranching vascular segments and at branch points. Moreover, DOCT flow values correlate with hydrogen clearance flow values when both are measured simultaneously. These data validate DOCT as a noninvasive quantitative method to measure tissue perfusion over a physiologic range.

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    2. Quantitative cerebral blood flow with Optical Coherence Tomography

      Quantitative cerebral blood flow with Optical Coherence Tomography

      Vivek J. Srinivasan, Sava Sakadžić, Iwona Gorczynska, Svetlana Ruvinskaya, Weicheng Wu, James G. Fujimoto, David A. BoasAbsolute measurements of cerebral blood flow (CBF) are an important endpoint in studies of cerebral pathophysiology. Currently no accepted method exists for in vivo longitudinal monitoring of CBF with high resolution in rats and mice. Using three-dimensional Doppler Optical Coherence Tomography and ... [Opt. Express 18, 2477-2494 (2010)]

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    3. Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography

      Depth-resolved microscopy of cortical hemodynamics with optical coherence tomography

      We describe depth-resolved microscopy of cortical hemodynamics with high-speed spectral/Fourier domain optical coherence tomography (OCT). Stimulus-evoked changes in blood vessel diameter, flow, and total hemoglobin were measured in the rat somatosensory cortex. The results show OCT measurements of hemodynamic changes during functional activation and represent an important step toward understanding functional hyperemia at the microscopic level.

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    1-3 of 3
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  2. Topics in the News

    1. (3 articles) Harvard University
    2. (3 articles) Massachusetts General Hospital
    3. (3 articles) Vivek J. Srinivasan
    4. (3 articles) David A. Boas
    5. (2 articles) Massachusetts Institute of Technology
    6. (2 articles) James G. Fujimoto
    7. (2 articles) Iwona Gorczynska
    8. (1 articles) Nicolaus Copernicus University
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