1. Articles from Wei Gong

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    1. Toward image quality assessment in optical coherence tomography (OCT) of rat kidney

      Toward image quality assessment in optical coherence tomography (OCT) of rat kidney

      Background Optical coherence tomography (OCT) is a useful tool for the evaluation of structure and function of the kidney, but the image quality can be affected by many factors. Objective The objective of this study was to assess the image quality of different OCT systems in OCT imaging of the living kidney. Methods One swept-source OCT (SSOCT) of 1300 nm, one spectral domain OCT (SDOCT) of 1300 nm and another of 900 nm were used. A FeO phantom was used to establish the point spread function (PSF). Rat kidneys were imaged for image quality assessment. Light penetration in the kidney ...

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    2. Quantitative assessment of skin swelling using optical coherence tomography

      Quantitative assessment of skin swelling using optical coherence tomography

      Background Preclinical and clinical studies suggest that optical coherence tomography (OCT) is a useful tool to visualize inflammatory conditions. Objective The objective of this study was to evaluate the usefulness of combining OCT and various image processing techniques for quantitative assessment of histamine-induced tissue swelling. Methods Both time-domain and frequency-domain OCT were used on a mouse ear model. The ear thickness and volume before and after histamine challenge were determined from pixel locations in 2D scans and voxel number counting in 3D scans. Swelling kinetics was analyzed on 3D contour mapping. Microvessel network was visualized using speckle decorrelation analysis. Results ...

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    3. Optical coherence tomography examination of hair

      Optical coherence tomography examination of hair

      Human hair is a keratinous tissue composed mostly of flexible keratin, which can form a complex architecture consisting of distinct compartments or units (e.g. hair bulb, inner root sheath, shaft). Variations in hair shaft morphology can reflect ethnical diversity, but may also indicate internal diseases, nutritional deficiency, or hair and scalp disorders. Hair shaft abnormalities in cross section and diameter, as well as ultramorphological characterization and follicle shapes, might be visualized non-invasively by high-speed 2D and 3D optical coherence tomography (OCT). In this study, swept source OCT (ThorLabs) was used to examine human hair. Preliminary results showed that the ...

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    4. Variations in optical coherence tomography resolution and uniformity: a multi-system performance comparison

      Variations in optical coherence tomography resolution and uniformity: a multi-system performance comparison

      Point spread function (PSF) phantoms based on unstructured distributions of sub-resolution particles in a transparent matrix have been demonstrated as a useful tool for evaluating resolution and its spatial variation across image volumes in optical coherence tomography (OCT) systems. Measurements based on PSF phantoms have the potential to become a standard test method for consistent, objective and quantitative inter-comparison of OCT system performance. Towards this end, we have evaluated three PSF phantoms and investigated their ability to compare the performance of four OCT systems. The phantoms are based on 260-nm-diameter gold nanoshells, 400-nm-diameter iron oxide particles and 1.5-micron-diameter silica ...

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    5. Optical Coherence Tomography of the Living Human Kidney

      Optical Coherence Tomography of the Living Human Kidney

      Acute tubular necrosis (ATN) induced by ischemia is the most common insult to donor kidneys destined for transplantation. ATN results from swelling and subsequent damage to cells lining the kidney tubules. In this study, we demonstrate the capability of optical coherence tomography (OCT) to image the renal microstructures of living human donor kidneys and potentially provide a measure to determine the extent of ATN. We also found that Doppler-based OCT (i.e., DOCT) reveals renal blood flow dynamics that is another major factor which could relate to post-transplant renal function. All OCT/DOCT observations were performed in a noninvasive, sterile ...

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    6. Multi-system comparison of optical coherence tomography performance with point spread function phantoms

      Multi-system comparison of optical coherence tomography performance with point spread function phantoms

      Point spread function (PSF) phantoms based on unstructured distributions of sub-resolution particles in a transparent matrix have proven effective for evaluating resolution and its spatial variation in optical coherence tomography (OCT) systems. Measurements based on PSF phantoms have the potential to become a standard test method for consistent, objective and quantitative inter-comparison of OCT system performance. Towards this end, we have evaluated three PSF phantoms and investigated their ability to compare the performance of four OCT systems. The phantoms are based on 260-nm-diameter gold nanoshells, submicron-diameter iron oxide particles and 1.5-micron-diameter silica particles. The OCT systems included spectral-domain and ...

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    7. Architecture of healthy and dystrophic muscles detected by optical coherence tomography

      Architecture of healthy and dystrophic muscles detected by optical coherence tomography

      The ability to view individual myofibers is possible with many histological techniques, but not yet with standard in vivo imaging. Optical coherence tomography (OCT) is an emerging technology that can generate high resolution 1–10 µm cross-sectional imaging of tissue in vivo and in real time. Methods : We used OCT to determine architectural differences of tibialis anterior muscles in situ from healthy mice (WT, n = 4) and dystrophic mice ( mdx , n = 4). After diffusion tensor imaging (DTI) and OCT, muscles were harvested, snap-frozen, and sectioned for staining with wheat germ agglutinin. Results : DTI suggested differences in pennation and OCT was ...

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    8. Monitoring tissue response during non-ablative irradiation of photorejuvenation with optical coherence tomography

      With low risk of complications and no down-time, the non-ablative photorejuvenation is playing an increasing role in the therapy of the photodamaged skin. The light dose is one of the key factors that affect the performance of the photorejuvenation. Monitoring the tissue response during the procedure of laser irradiation would help to determine whether the light dose is appropriate. In this study, we developed a new approach to monitor the instant response of tissue irradiated by laser device by measuring the change of the total attenuation coefficient of the tissue with optical coherence tomography. The total attenuation coefficient was deduced ...

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    1-8 of 8
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    1. (7 articles) Fujian Normal University
    2. (4 articles) University of Maryland
    3. (4 articles) Yu Chen
    4. (3 articles) Shusen Xie
    5. (2 articles) Rice University
    6. (2 articles) University of Colorado
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    Architecture of healthy and dystrophic muscles detected by optical coherence tomography Multi-system comparison of optical coherence tomography performance with point spread function phantoms Optical Coherence Tomography of the Living Human Kidney Variations in optical coherence tomography resolution and uniformity: a multi-system performance comparison Optical coherence tomography examination of hair Quantitative assessment of skin swelling using optical coherence tomography Toward image quality assessment in optical coherence tomography (OCT) of rat kidney Monitoring Response to Platelet-Rich Plasma in Patients with Alopecia Areata with Optical Coherence Tomography: A Case Series NONPERFUSION AREA QUANTIFICATION IN BRANCH RETINAL VEIN OCCLUSION: A WIDEFIELD OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY STUDY Nonperfusion Assessment in Retinal Vein Occlusion: Comparison between Ultra-Widefield Fluorescein Angiography and Widefield OCT-Angiography Anatomical Location of the Raphe and Extended Raphe in the Human Retina: Implications for Assessment of the Optic Nerve with OCT Assessing the Influence of OCT-A Device and Scan Size on Retinal Vascular Metrics