1. Articles from ping xue

    25-32 of 32 « 1 2
    1. Label-free subcellular 3D live imaging of preimplantation mouse embryos with full-field optical coherence tomography

      Label-free subcellular 3D live imaging of preimplantation mouse embryos with full-field optical coherence tomography

      Early patterning and polarity is of fundamental interest in preimplantation embryonic development. Label-free subcellular 3D live imaging is very helpful to its related studies. We have developed a novel system of full-field optical coherence tomography (FF-OCT) for noninvasive 3D subcellular live imaging of preimplantation mouse embryos with no need of dye labeling. 3D digitized embryos can be obtained by image processing. Label-free 3D live imaging is demonstrated for the mouse embryos at various typical preimplantation stages with a spatial resolution of 0.7 µm and imaging rate of 24 fps. Factors that relate to early patterning and polarity, such as ...

      Read Full Article
    2. Spectral-domain optical coherence tomography with a Fresnel spectrometer

      Spectral-domain optical coherence tomography with a Fresnel spectrometer

      We propose a novel spectral-domain optical coherence tomography (SD-OCT) equipped with a Fresnel spectrometer, which utilizes a Fresnel zone plate (FZP) as both dispersion and focusing optics and thus spreads the spectral interferogram evenly in wavenumber domain because of the proportional relation between the focal length of the FZP and the wavenumber. With no need of the conversion calculation from wavelength to wavenumber in conventional SD-OCT, this new design is favorable for fast imaging with high resolution. As only a FZP and CCD are used, the Fresnel spectrometer is simple and compact. It is experimentally shown that its performance is ...

      Read Full Article
    3. Handheld optical coherence tomography device for photodynamic therapy

      Handheld optical coherence tomography device for photodynamic therapy

      Photodynamic therapy (PDT) is a very effective treatment for port wine stains (PWS). To guide and assess PDT treatment, a handheld optical coherence tomography (OCT) probe was designed for real-time imaging of the PWS patient. The system uses a light source with a center wavelength of 1310 nm, -3 dB bandwidth of 90 nm and an optical power of 9 mW. The system also has a spatial resolution of 8 um (lateral) × 7 um (axial), an imaging rate of 4 frames per second, and a 102 dB sensitivity. We then demonstrate that the OCT imaging system can clearly distinguish between ...

      Read Full Article
    4. Wave front division interferometer based optical coherence tomography for sensitivity optimization

      Wave front division interferometer based optical coherence tomography for sensitivity optimization
      Optical coherence tomography (OCT) based on a wave front division (WD) interferometer is demonstrated for the first time. Unlike a conventional amplitude division interferometer based OCT, WD OCT utilizes different wave front portions of the light source for sample and reference arm. Due to easy manipulation of the wavefront portions for sample and reference arm, it is feasible for WD OCT, provided that the source power of light is fixed, to optimize the ratio of light power for sample and reference arm to achieve both high power efficiency and high system sensitivity. The system sensitivity as a function of the ...
      Read Full Article
    5. Imaging port wine stains by fiber optical coherence tomography

      Imaging port wine stains by fiber optical coherence tomography

      We develop a fiber optical coherence tomography (OCT) system in the clinical utility of imaging port wine stains (PWS). We use our OCT system on 41 patients with PWS to document the difference between PWS skin and contralateral normal skin. The system, which operates at 4 frames/s with axial and transverse resolutions of 10 and 9 µm, respectively, in the skin tissue, can clearly distinguish the dilated dermal blood vessels from normal tissue. We present OCT images of patients with PWS and normal human skin. We obtain the structural parameters, including epidermal thickness and diameter and depth of dilated ...

      Read Full Article
    6. Optical coherence tomography for ultrahigh-resolution 3D imaging of cell development and real-time guiding for photodynamic therapy

      Optical coherence tomography is a new emerging technique for cross-sectional imaging with high spatial resolution of micrometer scale. It enables in vivo and non-invasive imaging with no need to contact the sample and is widely used in biological and clinic application. In this paper optical coherence tomography is demonstrated for both biological and clinic applications. For biological application, a white-light interference microscope is developed for ultrahigh-resolution full-field optical coherence tomography (full-field OCT) to implement 3D imaging of biological tissue. Spatial resolution of 0.9µm×1.1µm (transverse×axial) is achieved A system sensitivity of 85 dB is obtained ...

      Read Full Article
    7. Ultra-high-resolution full-field optical coherence tomography for imaging of a developing embryo

      Optical coherence tomography (OCT) is a new emerging technique for cross-sectional imaging with high spatial resolution of micrometer scale. It enables in vivo and non-invasive imaging with no need to contact the sample and is widely used in biological and clinic application. In this paper a white-light interference microscope is developed for ultrahigh-resolution full-field optical coherence tomography (Full-Field OCT) to implement 3D imaging of biological tissue. The experimental setup is based on a Linnik-type interferometer illuminated by a tungsten halogen lamp via a bundle of fiber. En-face tomographic images are obtained by demodulation of a combination of interferometric images recorded ...

      Read Full Article
    8. Ultrahigh resolution optical coherence tomography with femtosecond Ti:sapphire laser and photonic crystal fiber

      Abstract  Optical coherence tomography (OCT) with ultrahigh axial resolution was achieved by the super-continuum generated by coupling femtosecond pulses from a commercial Ti: sapphire laser into an air-silica microstructure fiber. The visible spectrum of the super-continuum from 450 to 700 nm centered at 540 nm can be generated. A free-space axial OCT resolution of 0.64 µm was achieved. The sensitivity of OCT system was 108 dB with incident light power 3 mW at sample, only 7dB below the theoretical limit. Subcellular OCT imaging was also demonstrated, showing great potential for biomedical application. Content Type Journal ArticleCategory ArticlesDOI 10.1007 ...
      Read Full Article
    25-32 of 32 « 1 2
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics in the News

    1. (32 articles) Ping Xue
    2. (31 articles) Tsinghua University
    3. (22 articles) Chengming Wang
    4. (17 articles) Ning Zhang
    5. (13 articles) Tianyuan Chen
    6. (12 articles) Jing-gao Zheng
    7. (3 articles) Massachusetts Institute of Technology
    8. (3 articles) Tianshi Wang
    9. (2 articles) Peking University
    10. (2 articles) James G. Fujimoto
    11. (1 articles) Sungkyunkwan University
    12. (1 articles) Universidade Federal de São Paulo
    13. (1 articles) Texas A&M University
    14. (1 articles) FDA
    15. (1 articles) University of Southern California
    16. (1 articles) University of Freiburg
    17. (1 articles) Joon Mo Kim
    18. (1 articles) Brian E. Applegate
    19. (1 articles) Wihan Kim
    20. (1 articles) Javier A. Jo
  3. Popular Articles

  4. Picture Gallery

    Imaging port wine stains by fiber optical coherence tomography Label-free subcellular 3D live imaging of preimplantation mouse embryos with full-field optical coherence tomography Feature Of The Week 7/22/12: Label-Free Subcellular 3D Live Imaging of Preimplantation Mouse Embryos With Full-Field Optical Coherence Tomography OCT News 2013 Student Paper Awarded to Jing-gao Zheng from Tsinghua University Feature Of The Week 10/13/13: Tsinghua University Demonstrates a Tiny OCT Endoscopic Probe Using a Hollow Ultrasonic Motor Feature Of The Week 2/2/14: Tsinghua University.Demonstrates Linear-in-Wavenumber Swept Laser with an Acousto-Optic Deflector for OCT Feature Of The Week 11/26/2016: Tsinghua University Demonstrates Optical Computing Technique and Achieves High Speed OCT of 10 Mega-A-Scans/Second. Medical treatment of inflammatory punctual stenosis monitored by anterior segment optical coherence tomography Development and Validation of a Deep Learning System for Diagnosing Glaucoma Using Optical Coherence Tomography Methylene blue-filled biodegradable polymer particles as a contrast agent for optical coherence tomography Optical coherence tomography for thyroid pathology: 3D analysis of tissue microstructure Mathematical Analysis of Texture Indicators for the Segmentation of Optical Coherence Tomography Images