1. Articles from mikhail kirillin

    1-12 of 12
    1. Optical coherence tomography in gynecology: a narrative review

      Optical coherence tomography in gynecology: a narrative review

      Modern gynecologic practice requires noninvasive diagnostics techniques capable of detecting morphological and functional alterations in tissues of female reproductive organs. Optical coherence tomography (OCT) is a promising tool for providing imaging of biotissues with high resolution at depths up to 2 mm. Design of the customized probes provides wide opportunities for OCT use in gynecology. This paper contains a retrospective insight into the history of OCT employment in gynecology, an overview of the existing gynecologic OCT probes, including those for combination with other diagnostic modalities, and state-of-the-art application of OCT for diagnostics of tumor and nontumor pathologies of female genitalia ...

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    2. Towards advanced OCT clinical applications

      Towards advanced OCT clinical applications

      In this paper we report on our recent achievement in application of conventional and cross-polarization OCT (CP OCT) modalities for in vivo clinical diagnostics in different medical areas including gynecology, dermatology, and stomatology. In gynecology, CP OCT was employed for diagnosing fallopian tubes and cervix; in dermatology OCT for monitoring of treatment of psoriasis, scleroderma and atopic dermatitis; and in stomatology for diagnosis of oral diseases. For all considered application, we propose and develop different image processing methods which enhance the diagnostic value of the technique. In particular, we use histogram analysis, Fourier analysis and neural networks, thus calculating different ...

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    3. Differential diagnosis of human bladder mucosa pathologies in vivo with cross-polarization optical coherence tomography

      Differential diagnosis of human bladder mucosa pathologies in vivo with cross-polarization optical coherence tomography

      Quantitative image analysis and parameter extraction using a specific implementation of polarization-sensitive optical coherence tomography (OCT) provides differential diagnosis of mucosal pathologies in in-vivo human bladders. We introduce a cross-polarization (CP) OCT image metric called Integral Depolarization Factor (IDF) to enable automatic diagnosis of bladder conditions (assessment the functional state of collagen fibers). IDF-based diagnostic accuracy of identification of the severe fibrosis of normal bladder mucosa is 79%; recurrence of carcinoma on the post-operative scar is 97%; and differentiation between neoplasia and acute inflammation is 75%. The promising potential of CP OCT combined with image analysis in human urology is ...

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    4. Perspectives of mid-infrared optical coherence tomography for inspection and micrometrology of industrial ceramics

      Perspectives of mid-infrared optical coherence tomography for inspection and micrometrology of industrial ceramics

      Optical coherence tomography (OCT) is a promising tool for detecting micro channels, metal prints, defects and delaminations embedded in alumina and zirconia ceramic layers at hundreds of micrometers beneath surfaces. The effect of surface roughness and scattering of probing radiation within sample on OCT inspection is analyzed from the experimental and simulated OCT images of the ceramic samples with varying surface roughnesses and operating wavelengths. By Monte Carlo simulations of the OCT images in the mid-IR the optimal operating wavelength is found to be 4 µm for the alumina samples and 2 µm for the zirconia samples for achieving sufficient ...

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    5. Feature Of The Week 9/16/12: Institute of Applied Physics/Russian Academy of Sciences Investigates Criteria for Pathology Recognition in Optical Coherence Tomography of Fallopian Tubes

      Feature Of The Week 9/16/12: Institute of Applied Physics/Russian Academy of Sciences Investigates Criteria for Pathology Recognition in Optical Coherence Tomography of Fallopian Tubes

      The problems of revealing causes of infertility and chronic pelvic pains are currently of great significance. The World Health Organization (WHO) reports on the level of infertile marriages which grew up to 12-18% worldwide in the recent 2-3 decades and its classification includes “unexplained infertility”, when there are no visible objective causes of impairment of reproductive function. On the one hand, “unexplained infertility” is associated with prevalence of asymptomatic and subclinical forms of female pelvic diseases while on the other hand it can be explained by imperfection of traditional diagnostic techniques. Currently invasive laparoscopic examination is considered as the preferred ...

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    6. IV International Symposium on Topical Problems of BioPhotonics, Nizhny Novgorod, Russia July 21, 2013

      IV International Symposium on Topical Problems of BioPhotonics, Nizhny Novgorod, Russia July 21, 2013

      The International Symposium Topical Problems of Biophotonics (TPB) is held in Russia once in two years. The aim of the symposium is to provide a forum for biologists, physicists, neuroscientists and medical doctors, to discuss the state of the art of the science of biophotonics, including basic aspects and promising applications, and to give an insight into future advances and research possibilities in this field. The previous TPB events were held in 2007, 2009, and 2011. The IV-th TPB will be held from July 21 through July 27, 2013, starting in Nizhny Novgorod. We hope that the symposium will bring ...

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    7. Criteria for pathology recognition in optical coherence tomography of fallopian tubes

      Criteria for pathology recognition in optical coherence tomography of fallopian tubes

      An increase of infertility and chronic pelvic pains syndrome, a growing level of latent diseases of this group, as well as a stably high percentage (up to 25% for infertility and up to 60% for the chronic pelvic pains syndrome) of undetermined origin raises the requirement for novel introscopic diagnostic techniques. We demonstrate abilities of optical coherence tomography (OCT) as a complementary technique to laparoscopy in diagnostics of fallopian tubes pathologies. We have acquired OCT images of different parts of fallopian tubes in norm and with morphologically proven pathology. Based on comparative analysis of the OCT data and the results ...

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    8. Optical coherence tomography for quality assessment of embedded microchannels in alumina ceramic

      Optical coherence tomography for quality assessment of embedded microchannels in alumina ceramic

      Large-scale and cost-effective manufacturing of ceramic micro devices based on tape stacking requires the development of inspection systems to perform high-resolution in-process quality control of embedded manufactured cavities, metal structures and defects. With an optical coherence tomography (OCT) system operating at 1.3 μm and a dedicated automated line segmentation algorithm, layer thicknesses can be measured and laser-machined channels can be verified in alumina ceramics embedded at around 100 μm depth. Monte Carlo simulations are employed to analyze the abilities of OCT in imaging of the embedded channels. The light scattering parameters required as input data for simulations are evaluated ...

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    9. Simulation of optical coherence tomography images by Monte Carlo modeling based on polarization vector approach

      Simulation of optical coherence tomography images by Monte Carlo modeling based on polarization vector approach
      Monte Carlo method is applied for simulation of 2D optical coherence tomography (OCT) images of skin-like model. Layer boundaries in skin model feature curved shape which agrees with physiological structure of human skin. The effect of coherence properties of probing radiation on OCT image formation and speckles in the detected OCT signal is considered. The developed model is employed for image simulation both for conventional and polarization dependent time-domain OCT modalities. Simulation of polarized OCT signal is performed using vector approach developed previously for modeling of electromagnetic field transfer in turbid media.
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    10. Contrasting properties of gold nanoshells and titanium dioxide nanoparticles for optical coherence tomography imaging of skin: Monte Carlo simulations and in vivo study

      Contrasting properties of gold nanoshells and titanium dioxide nanoparticles for optical coherence tomography imaging of skin: Monte Carlo simulations and in vivo study
      The effect of silica/gold nanoshells and titanium dioxide nanoparticles on the optical properties of skin is studied. By implementing in vivo measurements and Monte Carlo simulations, we analyze the efficiency of using these nanoparticles as contrasting agents for optical coherence tomography (OCT) imaging of skin. In vivo measurements are performed on pig skin, where nanoparticle suspension drops have been applied. The identification of skin layers is performed by comparison with corresponding histology images. Experimental results exhibit an increase in contrast of the obtained OCT images after a single nanoparticles application. Multiple applications do not lead to increase in the ...
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    11. Simulation of polarization-sensitive optical coherence tomography images by a Monte Carlo method

      Igor Meglinski, Mikhail Kirillin, Vladimir Kuzmin, Risto Myllylä We introduce a new Monte Carlo (MC) method for simulating optical coherence tomography (OCT) images of complex multilayered turbid scattering media. We demonstrate, for the first time of our knowledge, the use of a MC technique to imitate two-dimensional polarization-sensitive OCT images with ... [Opt. Lett. 33, 1581-1583 (2008)]
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    12. Optical coherence tomography of strongly scattering media (Thesis)

      Optical coherence tomography of strongly scattering media (Thesis)
      Optical coherence tomography (OCT) is a modern rapidly developing technique for non-invasive imaging of the internal structure of optically non-uniform objects based on the principles of lowc oherent interferometry. However, multiple scattering of light in the objects under study brings distortions to the images obtained by OCT. The analysis of formation of the OCT signals is required for understanding the role of multiple scattering in this formation and providing recommendations for optimal configuration of a measuring setup. In the present thesis formation of the OCT signals and images is analyzed implementing Monte Carlo simulations of light propagation in scattering media ...
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    1-12 of 12
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  2. Topics in the News

    1. (11 articles) Mikhail Y. Kirillin
    2. (8 articles) Institute of Applied Physics
    3. (5 articles) Nizhny Novgorod State Medical Academy
    4. (3 articles) University of Oulu
    5. (3 articles) Risto A. Myllylä
    6. (3 articles) Natalia M. Shakhova
    7. (2 articles) Igor V. Meglinski
    8. (2 articles) Natalia D. Gladkova
    9. (2 articles) Elena B. Kiseleva
    10. (2 articles) I. Alex Vitkin
    11. (1 articles) K. U. Leuven
    12. (1 articles) Mount Sinai School of Medicine
    13. (1 articles) University of Toronto
    14. (1 articles) National University of Ireland, Galway
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    Contrasting properties of gold nanoshells and titanium dioxide nanoparticles for optical coherence tomography imaging of skin: Monte Carlo simulations and in vivo study Optical coherence tomography of strongly scattering media (Thesis) Simulation of optical coherence tomography images by Monte Carlo modeling based on polarization vector approach Optical coherence tomography for quality assessment of embedded microchannels in alumina ceramic Criteria for pathology recognition in optical coherence tomography of fallopian tubes IV International Symposium on Topical Problems of BioPhotonics, Nizhny Novgorod, Russia July 21, 2013 Feature Of The Week 9/16/12: Institute of Applied Physics/Russian Academy of Sciences Investigates Criteria for Pathology Recognition in Optical Coherence Tomography of Fallopian Tubes Perspectives of mid-infrared optical coherence tomography for inspection and micrometrology of industrial ceramics Differential diagnosis of human bladder mucosa pathologies in vivo with cross-polarization optical coherence tomography The multi-spectral signal properties of multiple reference optical coherence tomography (Thesis) Calibration-free time-stretch optical coherence tomography with large imaging depth Does Projection Artifact Removal Improve Visualization of Images in Optical Coherence Tomography Angiography?