1. Articles from daniel m. de bruin

    1-24 of 34 1 2 »
    1. Computed Tomography–Mediated Registration of Trapeziometacarpal Articular Cartilage Using Intraarticular Optical Coherence Tomography and Cryomicrotome Imaging: A Cadaver Study

      Computed Tomography–Mediated Registration of Trapeziometacarpal Articular Cartilage Using Intraarticular Optical Coherence Tomography and Cryomicrotome Imaging: A Cadaver Study

      Objective Accurate, high-resolution imaging of articular cartilage thickness is an important clinical challenge in patients with osteoarthritis, especially in small joints. In this study, computed tomography (CT) mediated catheter-based optical coherence tomography (OCT) was utilized to create a digital reconstruction of the articular surface of the trapeziometacarpal (TMC) joint and to assess cartilage thickness in comparison to cryomicrotome data. Design Using needle-based introduction of the OCT probe, the articular surface of the TMC joint of 5 cadaver wrists was scanned in different probe positions with matching CT scans to record the intraarticular probe trajectory. Subsequently and based on the acquired ...

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    2. The First In Vivo Needle‐Based Optical Coherence Tomography in Human Prostate: A Safety and Feasibility Study

      The First In Vivo Needle‐Based Optical Coherence Tomography in Human Prostate: A Safety and Feasibility Study

      Objective To demonstrate the safety and feasibility of clinical in vivo needle‐based optical coherence tomography (OCT) imaging of the prostate. Materials and Methods Two patients with prostate cancer underwent each two percutaneous in vivo needle‐based OCT measurements before transperineal template mapping biopsy. The OCT probe was introduced via a needle and positioned under ultrasound guidance. To test the safety, adverse events were recorded during and after the procedure. To test the feasibility, OCT and US images were studied during and after the procedure. Corresponding regions for OCT and biopsy were determined. A uropathologist evaluated and annotated the histopathology ...

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    3. Optical coherence tomography to detect acute esophageal radiation-induced damage in mice: a validation study

      Optical coherence tomography to detect acute esophageal radiation-induced damage in mice: a validation study

      Radiation therapy for patients with non-small-cell lung cancer is hampered by acute radiation-induced toxicity in the esophagus. This study aims to validate that optical coherence tomography (OCT), a minimally invasive imaging technique with high resolution (~10 µm), is able to visualize and monitor acute radiation-induced esophageal damage (ARIED) in mice. We compare our findings with histopathology as the gold standard. Irradiated mice receive a single dose of 40 Gy at proximal and distal spots of the esophagus of 10.0 mm in diameter. We scan mice using OCT at two, three, and seven days post-irradiation. In OCT analysis we define ...

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    4. Acute Airway Effects of Bronchial Thermoplasty Assessed by Optical Coherence Tomography (OCT)

      Acute Airway Effects of Bronchial Thermoplasty Assessed by Optical Coherence Tomography (OCT)

      Background: Bronchial Thermoplasty (BT) is an endoscopic treatment for severe asthma targeting airway smooth muscle (ASM) with thermal energy. The extent of treatment effect is largely unknown. Optical coherence tomography (OCT) is a high resolution imaging technique, using near-infrared light, that generates near-histology cross sectional images of the airway wall. Aim: Assess the extent of acute airway wall effects of BT with OCT and compare these to the untreated right middle lobe (RML). Methods: 15 severe asthma patients were treated with BT. During the third procedure, OCT imaging was performed in BT treated (sub)segmental airways in the upper lobes ...

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    5. Ex-vivo study in nephroureterectomy specimens defining the role of 3-D upper urinary tract visualization using optical coherence tomography and endoluminal ultrasound

      Ex-vivo study in nephroureterectomy specimens defining the role of 3-D upper urinary tract visualization using optical coherence tomography and endoluminal ultrasound

      Minimal invasive endoscopic treatment for upper urinary tract urothelial carcinoma (UUT-UC) is advocated in patients with low-risk disease and limited tumor volume. Diagnostic ureterorenoscopy combined with biopsy is the diagnostic standard. This study aims to evaluate two alternative diagnostic techniques for UUT-UC: optical coherence tomography (OCT) and endoluminal ultrasound (ELUS). Following nephroureterectomy, OCT, ELUS, and computed tomography (CT) were performed of the complete nephroureterectomy specimen. Visualization software (AMIRA®) was used for reconstruction and coregistration of CT, OCT, and ELUS. Finally, CT was used to obtain exact probe localization. Coregistered OCT and ELUS datasets were compared with histology. Coregistration with three-dimensional ...

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    6. Can we predict necrosis intra-operatively? Real-time optical quantitative perfusion imaging in surgery: study protocol for a prospective, observational, in vivo pilot study

      Can we predict necrosis intra-operatively? Real-time optical quantitative perfusion imaging in surgery: study protocol for a prospective, observational, in vivo pilot study

      Background Compromised perfusion as a result of surgical intervention causes a reduction of oxygen and nutrients in tissue and therefore decreased tissue vitality. Quantitative imaging of tissue perfusion during reconstructive surgery, therefore, may reduce the incidence of complications. Non-invasive optical techniques allow real-time tissue imaging, with high resolution and high contrast. The objectives of this study are, first, to assess the feasibility and accuracy of optical coherence tomography (OCT), sidestream darkfield microscopy (SDF), laser speckle contrast imaging (LSCI), and fluorescence imaging (FI) for quantitative perfusion imaging and, second, to identify/search for criteria that enable risk prediction of necrosis during ...

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    7. Optical coherence tomography for identification and quantification of human airway wall layers

      Optical coherence tomography for identification and quantification of human airway wall layers

      Background High-resolution computed tomography has limitations in the assessment of airway wall layers and related remodeling in obstructive lung diseases. Near infrared-based optical coherence tomography (OCT) is a novel imaging technique that combined with bronchoscopy generates highly detailed images of the airway wall. The aim of this study is to identify and quantify human airway wall layers both ex-vivo and in-vivo by OCT and correlate these to histology. Methods Patients with lung cancer, prior to lobectomy, underwent bronchoscopy including in-vivo OCT imaging. Ex-vivo OCT imaging was performed in the resected lung lobe after needle insertion for matching with histology. Airway ...

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    8. Applicability of quantitative optical imaging techniques for intraoperative perfusion diagnostics: a comparison of laser speckle contrast imaging, sidestream dark-field microscopy, and optical coherence tomography

      Applicability of quantitative optical imaging techniques for intraoperative perfusion diagnostics: a comparison of laser speckle contrast imaging, sidestream dark-field microscopy, and optical coherence tomography

      . Patient morbidity and mortality due to hemodynamic complications are a major problem in surgery. Optical techniques can image blood flow in real-time and high-resolution, thereby enabling perfusion monitoring intraoperatively. We tested the feasibility and validity of laser speckle contrast imaging (LSCI), optical coherence tomography (OCT), and sidestream dark-field microscopy (SDF) for perfusion diagnostics in a phantom model using whole blood. Microvessels with diameters of 50, 100, and 400 μm were constructed in a scattering phantom. Perfusion was simulated by pumping heparinized human whole blood at five velocities (0 to 20 mm∕s). Vessel diameter and blood flow velocity were assessed ...

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    9. Prostate cancer diagnosis by optical coherence tomography: First results from a needle based optical platform for tissue sampling

      Prostate cancer diagnosis by optical coherence tomography: First results from a needle based optical platform for tissue sampling

      The diagnostic accuracy of Optical Coherence Tomography (OCT) based optical attenuation coefficient analysis is assessed for the detection of prostate cancer. Needle-based OCT-measurements were performed on the prostate specimens. Attenuation coefficients were determined by an earlier described in-house developed software package. The mean attenuation coefficients (benign OCT data; malignant OCT data; p-value Mann-Whitney U test) were: (3.56 mm –1 ; 3.85 mm –1 ; p < 0.0001) for all patients combined. The area under the ROC curve was 0.64. In order to circumvent the effect of histopathology mismatching, we performed a sub-analysis on only OCT data in which tumor ...

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    10. Percutaneous Needle Based Optical Coherence Tomography for the Differentiation of Renal Masses: a Pilot Cohort

      Percutaneous Needle Based Optical Coherence Tomography for the Differentiation of Renal Masses: a Pilot Cohort

      To view the full text, please login as a subscribed user or purchase a subscription . Click here to view the full text on ScienceDirect. The aim of this study is to determine the ability of percutaneous needle based Optical Coherence Tomography (OCT) to differentiate renal masses, by using the attenuation coefficient (μOCT, mm-1) as a quantitative measure. Percutaneous needle based OCT of the kidney was performed in patients presenting with a solid renal mass.

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    11. Learning curve and interobserver variance in quantification of the optical coherence tomography attenuation coefficient

      Learning curve and interobserver variance in quantification of the optical coherence tomography attenuation coefficient

      The learning curve and interobserver variance of attenuation coefficient ( μ OCT ) determination from optical coherence tomography (OCT) images were quantified. The μ OCT of normal and diseased vulvar tissues was determined at five time points by three novice students and three OCT experts who reached consensus for reference. Students received feedback between time points. Eventually, variance in μ OCT was smaller in images of diseased tissue than in images of normal vulvar tissue. The difference between the consensus and student μ OCT values was larger for smaller values of μ OCT . We conclude that routine μ OCT determination for tissue classification does not require extensive training.

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    12. Assesment of apoptosis induced changes in scattering using optical coherence tomography

      Assesment of apoptosis induced changes in scattering using optical coherence tomography

      The aim of this study is to identify changes in scattering with optical coherence tomography (OCT) and relate these measurements with mitochondrial changes during the initiation of apoptosis. Human retinal pigment epithelial cells were cultured and apoptosis was induced using 10% alcohol. Using the attenuation coefficient and backscattering, changes were measured during cell death in a cell-pellet and monolayer respectively. To confirm apoptosis, fluorescent activated cell sorting was used. Mitochondrial activity during apoptosis was assessed using an oxidative stress assay and fluorescent confocal microscopy. Pelleted apoptotic cells measured with OCT showed a clear rise while untreated cells showed a very ...

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    13. Optical coherence tomography accurately identifies patients with penile (pre) malignant lesions: A single center prospective study

      Optical coherence tomography accurately identifies patients with penile (pre) malignant lesions: A single center prospective study

      Introduction: Currently, (multiple) biopsies are taken to obtain histopathological diagnosis of suspicious lesions of the penile skin. Optical coherence tomography (OCT) provides noninvasive in vivo images from which epidermal layer thickness and attenuation coefficient (m oct ) can be quantified. We hypothesize that qualitative (image assessment) and quantitative (epidermal layer thickness and attenuation coefficient, m oct ) analysis of penile skin with OCT is possible and may differentiate benign penile tissue from (pre) malignant penile tissue. Materials and Methods: Optical coherence tomography-imaging was performed prior to punch biopsy in 18 consecutive patients with a suspicious lesion at the outpatient clinic of the ...

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    14. Prostate cancer diagnosis: the feasibility of needle-based optical coherence tomography

      Prostate cancer diagnosis: the feasibility of needle-based optical coherence tomography

      The objective of this study is to demonstrate the feasibility of needle-based optical coherence tomography (OCT) and functional analysis of OCT data along the full pullback trajectory of the OCT measurement in the prostate, correlated with pathology. OCT images were recorded using a commercially available C7-XR™ OCT Intravascular Imaging System interfaced to a C7 Dragonfly™ intravascular 0.9-mm-diameter imaging probe. A computer program was constructed for automated image attenuation analysis. First, calibration of the OCT system for both the point spread function and the system roll-off was achieved by measurement of the OCT signal attenuation from an extremely weakly scattering ...

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    15. Detection of buried Barrett’s glands after radiofrequency ablation with volumetric laser endomicroscopy

      Detection of buried Barrett’s glands after radiofrequency ablation with volumetric laser endomicroscopy

      Background and Aims The prevalence and clinical relevance of buried Barrett’s glands (BB) after radiofrequency ablation (RFA) in Barrett’s esophagus (BE) are debated. Recent optical coherence tomography studies demonstrated a high prevalence of BBs. Direct histological correlation, however, has been lacking. Volumetric laser endomicroscopy (VLE) is a second-generation optical coherence tomography system capable of scanning a large surface of the esophageal wall layers with low-power microscopy resolution. The aim was to evaluate whether post-RFA subsquamous glandular structures (SGSs), detected with VLE, actually correspond to BBs by pursuing direct histological correlation with VLE images. Methods In vivo VLE was ...

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    16. In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses

      In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses

      Optical coherence tomography (OCT) is the optical equivalent of ultrasound imaging, based on the backscattering of near infrared light. OCT provides real time images with a 15 µm axial resolution at an effective tissue penetration of 2-3 mm. Within the OCT images the loss of signal intensity per millimeter of tissue penetration, the attenuation coefficient, is calculated. The attenuation coefficient is a tissue specific property, providing a quantitative parameter for tissue differentiation. Until now, renal mass treatment decisions have been made primarily on the basis of MRI and CT imaging characteristics, age and comorbidity. However these parameters and diagnostic methods ...

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    17. The Value of Optical Coherence Tomography in Determining Surgical Margins in Squamous Cell Carcinoma of the Vulva: A Single-Center Prospective Study.

      The Value of Optical Coherence Tomography in Determining Surgical Margins in Squamous Cell Carcinoma of the Vulva: A Single-Center Prospective Study.

      Background: Vulvar squamous cell carcinoma (VSCC) is treated with wide local excision. The challenge is to remove as much skin as necessary to prevent recurrence, but meanwhile preserve genital skin to diminish morbidity. Optical coherence tomography (OCT) is a noninvasive imaging tool that produces cross-sectional images. Optical coherence tomography could be helpful in determining appropriate surgical margins during excision of VSCC. Objective: This study aimed to assess the value of OCT in determining appropriate surgical margins in patients operated for VSCC. We hypothesize that benign tissue will differ qualitatively (presence of clear epidermal layers) and quantitatively (epidermal layer thickness and ...

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    18. Treatment of coronary bifurcation lesions with the Absorb bioresorbable vascular scaffold in combination with the Tryton dedicated coronary bifurcation stent: evaluation using two- and three-dimensional optical coherence tomography

      Treatment of coronary bifurcation lesions with the Absorb bioresorbable vascular scaffold in combination with the Tryton dedicated coronary bifurcation stent: evaluation using two- and three-dimensional optical coherence tomography

      Aims: The Tryton bifurcation stent has been developed to improve clinical outcomes after treatment of bifurcation lesions. Limited data are available on the use of the Absorb bioresorbable vascular scaffold (BVS) in bifurcation lesions with side branches >2 mm. We present here the acute procedural results and midterm clinical follow-up of the first-in-man combined use of the Tryton stent and the Absorb scaffold for the treatment of complex bifurcation lesions. Methods and results: Ten patients treated with the Tryton stent in combination with Absorb BVS were included in the current report. Offline two- and three-dimensional optical coherence tomography (OCT) analyses ...

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    19. Side branch healing patterns of the Tryton dedicated bifurcation stent: a 1-year optical coherence tomography follow-up study

      Side branch healing patterns of the Tryton dedicated bifurcation stent: a 1-year optical coherence tomography follow-up study

      The bare-metal Tryton Side Branch (SB) Stent™ (Tryton Medical, Durham, NC, USA) is used with a drug-eluting stent (DES) in the main branch (MB) to treat bifurcation lesions. It is argued that a drug-eluting Tryton-version is needed to improve clinical outcomes, although previous registries have shown good clinical results. More insights in neo-intimal hyperplasia (NIH) growth patterns of the Tryton treatment strategy are needed to decide if and where to drug-coat the stent. Ten patients returned for follow-up angiography (mean follow-up time 393 ± 103 days) and optical coherence tomography (OCT) pullbacks from the MB were obtained in all patients and ...

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    20. Clinical applications of functional optical coherence tomography (Thesis)

      Clinical applications of functional optical coherence tomography (Thesis)

      The purpose of the work presented in this thesis is to show the potential of functional optical coherence tomography (OCT) to discriminate pathological from normal tissues in several clinical settings, by means of the attenuation coefficient. To that end, several fundamental studies were carried out to increase the fundamental understanding of the measured signals (in phantoms, during apoptosis) and both ex and in vivo investigations are performed in the urological and gynecological clinic.

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    21. Feature Of The Week 11/10/13: Volumetric In-Vivo Visualization of Upper Urinary Tract Tumors Using Optical Coherence Tomography: A Pilot Study

      Feature Of The Week 11/10/13: Volumetric In-Vivo Visualization of Upper Urinary Tract Tumors Using Optical Coherence Tomography: A Pilot Study

      Optical Coherence Tomography (OCT) has proven a powerful tool for ophthalmologists to make clinical decisions for a wide range of blinding diseases and the there are now ~20 million ophthalmic OCT patient scans per year. Significant progress is also being made in intravascular imaging where OCT is emerging as a tool for both clinical decision making and the understanding of cardiovascular disease and development of new therapeutic tools. OCT also has the potential to impact the understanding, diagnosis, and treatment of some forms of cancer. There are many leading research groups around the world that are making excellent progress in ...

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    22. Three-dimensional optical coherence tomography evaluation of a left main bifurcation lesion treated with ABSORB® bioresorbable vascular scaffold including fenestration and dilatation of the side branch - Corrected Proof

      Three-dimensional optical coherence tomography evaluation of a left main bifurcation lesion treated with ABSORB® bioresorbable vascular scaffold including fenestration and dilatation of the side branch - Corrected Proof

      Previous trials on the ABSORB (Abbott Vascular, Santa Clara, USA) everolimus-eluting bioresorbable vascular scaffold (BVS) were predominated by relatively low-risk lesions, excluding patients with left main coronary artery (LMCA) lesions and bifurcation lesions involving side branches >2mm . Little is known about the safety and feasibility of fenestration and dilation of the side branch ostium after BVS placement .

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    23. Optical coherence tomography in vulvar intraepithelial neoplasia

      Optical coherence tomography in vulvar intraepithelial neoplasia

      Vulvar squamous cell carcinoma (VSCC) is a gynecological cancer with an incidence of two to three per 100,000 women. VSCC arises from vulvar intraepithelial neoplasia (VIN), which is diagnosed through painful punch biopsy. In this study, optical coherence tomography (OCT) is used to differentiate between normal and VIN tissue. We hypothesize that (a) epidermal layer thickness measured in OCT images is different in normal tissue and VIN, and (b) quantitative analysis of the attenuation coefficient ( μ oct ) extracted from OCT data differentiates VIN from normal vulvar tissue. Twenty lesions from 16 patients are imaged with OCT. Directly after data acquisition ...

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    24. Feature Of The Week 9/2/12: Academic Medical Center at The University of Amsterdam Investigates Comparison of RNFL Thickness Measurements by SD-OCT Systems Using a Phantom Eye Model

      Feature Of The Week 9/2/12: Academic Medical Center at The University of Amsterdam Investigates Comparison of RNFL Thickness Measurements by SD-OCT Systems Using a Phantom Eye Model

      We developed a multi-layered phantom eye model that distinguishes instrumental from biological variation, to quantify differences in retinal nerve fiber layer (RNFL) thickness measurements by various spectral-domain optical coherence tomography (SD-OCT) systems. The eye model comprised a glass lens, water as vitreous and silicone elastomer based layers mimicking the retina (top layer thickness = 49 µm). We tested 3 RTVue OptoVue, 3 Cirrus Zeiss, 3 3DOCT-1000 Topcon and 3 Spectralis Heidelberg SD-OCT systems. With each system the layered phantom eye model was measured 5 times. An average RNFL thickness and standard deviation were determined by the apparatus using a circular scan ...

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    1-24 of 34 1 2 »
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    1. (34 articles) Daniël M. de Bruin
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    Optical phantoms of varying geometry based on thin building blocks with controlled optical properties Quantitative measurement of attenuation coefficients of bladder biopsies using optical coherence tomography for grading urothelial carcinoma of the bladder Advanced Diagnostics in Renal Mass Using Optical Coherence Tomography: A Preliminary Report Biphasic Oxidation of Oxy-Hemoglobin in Bloodstains Comparison of retinal nerve fiber layer thickness measurements by spectral-domain optical coherence tomography systems using a phantom eye model Feature Of The Week 9/2/12: Academic Medical Center at The University of Amsterdam Investigates Comparison of RNFL Thickness Measurements by SD-OCT Systems Using a Phantom Eye Model Feature Of The Week 11/10/13: Volumetric In-Vivo Visualization of Upper Urinary Tract Tumors Using Optical Coherence Tomography: A Pilot Study IMAGING TECHNIQUE FROM BECKMAN LAB NAMED TOP 10 MICROSCOPY INNOVATION Optical coherence refraction tomography University of Southern California Receives NIH Grant for Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel Disease Columbia University Receives NIH Grant  for Measures of Human Receptor and post Receptor Activity Multimodal Imaging of Multiple Evanescent White Dot Syndrome: A New Interpretation