Articles from yueli chen

1. Polarization memory effect in optical coherence tomography and dental imaging application

   Explore SPIE Digital Library Aug 1 2011 Dentistry

   

   We report the existence of polarization memory effect (PME) in optical coherence tomography and investigate its potential applications in dental imaging. We performed the study in three steps. First, microsphere scattering phantoms of different sizes were imaged in order to validate experimental results with PME theory. Both linearly and circularly polarized light were used to probe the samples. Second, healthy tooth samples were scanned and polarization memory effect was identified in dentin. In this step, specific verification and signal processing were performed to rule out possible image interpretation by birefringence effect. Third, we evaluated dentin demineralization with PME. Results show ...

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   Mentions: University of Maryland Quing Zhu Yueli L. Chen

2. Documentation of Intraretinal Retinal Pigment Epithelium Migration via High-Speed Ultrahigh-Resolution Optical Coherence Tomography

   Explore Ophthalmology Nov 21 2010 Ophthalmology

   

   Purpose: To describe the features of intraretinal retinal pigment epithelium (RPE) migration documented on a prototype spectral-domain, high-speed, ultrahigh-resolution optical coherence tomography (OCT) device in a group of patients with early to intermediate dry age-related macular degeneration (AMD) and to correlate intraretinal RPE migration on OCT to RPE pigment clumping on fundus photographs. Design: Retrospective, noncomparative, noninterventional case series. Participants: Fifty-five eyes of 44 patients seen at the New England Eye Center between December 2007 and June 2008 with early to intermediate dry AMD. Methods: Three-dimensional OCT scan sets from all patients were analyzed for the presence of intraretinal RPE ...

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   Mentions: University of Pittsburgh Massachusetts Institute of Technology James G. Fujimoto

3. Clinical Assessment of Mirror Artifacts in Spectral Domain Optical Coherence Tomography

   Explore iovs.org Feb 26 2010 Ophthalmology

   

   Purpose: To investigate the characteristics of a spectral domain Optical Coherence Tomography (SD OCT) image artifact known as the "mirror artifact", calculate its prevalence, analyze potential risk factors, measure severity, and correlate it to spherical equivalent and central visual acuity (VA). Methods: Cirrus HD-OCT Macular Cube 512x128 scans taken between January 2008 and February 2009 at the New England Eye Center were analyzed for the presence of mirror artifacts. Artifact severity was analyzed by the degree of segmentation breakdown that it causes on the macular map. A retrospective medical records review was conducted for patients with artifacts and for a ...

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   Mentions: University of Pittsburgh Massachusetts Institute of Technology James G. Fujimoto

4. Ultrahigh speed spectral/Fourier domain OCT imaging in ophthalmology

   Explore SPIE Digital Library Jul 13 2009 Ophthalmology

   Ultrahigh speed Spectral/Fourier domain ophthalmic OCT imaging at 70,000-312,500 axial scans per second is demonstrated using a high speed CMOS camera at 800 nm. Comparative imaging results of the fovea illustrate the performance tradeoffs between different imaging speeds and spectrometer configurations. Dense 3D volumetric acquisitions show minimal motion artifacts when acquired at 250,000 axial scans per second. The porous structure of the lamina cribrosa is shown in en face images extracted from a dense volumetric acquisition of the optical nerve head acquired at 106, 382 axial scans per second. Rapid repeated volume imaging (4D-OCT) shows blood ...

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   Mentions: Massachusetts Institute of Technology James G. Fujimoto Thorlabs

5. Assessment of Artifacts and Reproducibility across Spectral- and Time-Domain Optical Coherence Tomography Devices

   Explore OphSource Jul 8 2009 Ophthalmology

   Purpose: To report the frequency of optical coherence tomography (OCT) scan artifacts and to compare macular thickness measurements, interscan reproducibility, and interdevice agreeability across 3 spectral-domain (SD) OCT (also known as Fourier domain; Cirrus HD-OCT, RTVue-100, and Topcon 3D-OCT 1000) devices and 1 time-domain (TD) OCT (Stratus OCT) device.Design: Prospective, noncomparative, noninterventional case series.Participants: Fifty-two patients seen at the New England Eye Center, Tufts Medical Center Retina Service, between February and August 2008.Methods: Two scans were performed for each of the SD OCT protocols: Cirrus macular cube 512×128 (software version 3.0; Carl Zeiss Meditec, Inc ...

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   Mentions: University of Pittsburgh Massachusetts Institute of Technology James G. Fujimoto

6. Three-dimensional pointwise comparison of human retinal optical property at 845 and 1060 nm using optical frequency domain imaging

   Explore SPIE Digital Library Apr 28 2009 Ophthalmology

   To compare the optical properties of the human retina, 3-D volumetric images of the same eye are acquired with two nearly identical optical coherence tomography (OCT) systems at center wavelengths of 845 and 1060 nm using optical frequency domain imaging (OFDI). To characterize the contrast of individual tissue layers in the retina at these two wavelengths, the 3-D volumetric data sets are carefully spatially matched. The relative scattering intensities from different layers such as the nerve fiber, photoreceptor, pigment epithelium, and choroid are measured and a quantitative comparison is presented. OCT retinal imaging at 1060 nm is found to have ...

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   Mentions: Johannes F. de Boer Massachusetts General Hospital Harvard University

7. A prototype hybrid intraoperative probe for ovarian cancer detection

   Explore opticsinfobase.org Apr 19 2009 Gynecology , Oncology , Probes

   

   A novel prototype intraoperative system combining positron detection and optical coherence tomography (OCT) imaging has been developed for early ovarian cancer detection. The probe employs eight plastic scintillating fiber tips for preferential detection of local positron activity surrounding a central scanning OCT fiber providing volumetric imaging of tissue structure in regions of high radiotracer uptake. Characterization measurements of positron sensitivity, spatial response, and position mapping are presented for Tl204/Cs137 sources as well as 18F-FDG. In conjunction with co-registered frequency domain OCT measurements the results demonstrate the potential for a miniaturized laparoscopic probe offering simultaneous functional localization and structural imaging ...

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   Mentions: Quing Zhu Yueli L. Chen Yi Yang

8. Three-dimensional ultrahigh resolution optical coherence tomography imaging of age-related macular degeneration

   Explore opticsinfobase.org Mar 2 2009 Ophthalmology

   

   Ultrahigh resolution optical coherence tomography (OCT) enhances the ability to visualize different intra retinal layers. In age-related macular degeneration (AMD), pathological changes in individual retinal layers, including photoreceptor inner and outer segments and retinal pigment ... [Opt. Express 17, 4046-4060 (2009)]

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   Mentions: University of Pittsburgh Massachusetts Institute of Technology James G. Fujimoto

9. Ultrahigh speed spectral/Fourier domain ophthalmic OCT imaging

   Explore SPIE Digital Library Feb 18 2009 Ophthalmology , Tunable Sources

   Ultrahigh speed spectral / Fourier domain optical coherence tomography (OCT) imaging using a CMOS line scan camera with acquisition rates of 70,000 - 312,500 axial scans per second is investigated. Several design configurations are presented to illustrate trade-offs between acquisition speed, sensit ... [Proc. SPIE 7163, 716307 (2009)] published Wed Feb 18, 2009.

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   Mentions: Massachusetts Institute of Technology James G. Fujimoto Thorlabs

10. Ultrahigh-Speed Optical Coherence Tomography for Three-Dimensional and En Face Imaging of the Retina and Optic Nerve Head

    Explore iovs.org Oct 28 2008 Ophthalmology

    Ultrahigh-speed swept-source optical coherence tomography (OCT) imaging of the retina and optic nerve is demonstrated at 249,000 axial scans per second and 1060 nm, while methods for en face visualization of the retina, choroid, and lamina cribrosa are investigated.

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    Mentions: Desmond C. Adler University of Pittsburgh Massachusetts Institute of Technology

11. Ultrahigh speed Spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second

    Explore opticsinfobase.org Sep 11 2008 Ophthalmology , Tunable Sources

    

    We demonstrate ultrahigh speed spectral / Fourier domain optical coherence tomography (OCT) using an ultrahigh speed CMOS line scan camera at rates of 70,000 - 312,500 axial scans per second. Several design configurations are characterized to illustrate trade-offs between acquisition speed, ... [Opt. Express 16, 15149-15169 (2008)]

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    Mentions: Massachusetts Institute of Technology James G. Fujimoto Thorlabs

12. In Vivo Three-Dimensional Imaging of Neovascular Age-Related Macular Degeneration Using Optical Frequency Domain Imaging at 1050 nm

    Explore iovs.org Apr 10 2008 Ophthalmology , Tunable Sources

    PURPOSE. To assess the application of optical frequency domain imaging (OFDI) at 1050 nm for the detection of choroidal neovascularization (CNV) in age-related macular degeneration (AMD) and its response to treatment. Three patients presenting with blurred vision and exudative AMD were imaged before and after anti-VEGF treatment with ranibizumab. METHODS. The patients were imaged with OFDI, a swept-source–based, high-speed optical coherence tomography (OCT) system developed at the Wellman Center for Photomedicine. A center wavelength of 1050 nm was used that has been demonstrated to provide better imaging of the deeper structures of the retina below the RPE, such as ...

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    Mentions: Johannes F. de Boer Massachusetts General Hospital Harvard University

13. Spectrally balanced detection for optical frequency domain imaging

    Explore opticsinfobase.org Nov 27 2007 Tunable Sources

    In optical frequency domain imaging (OFDI) or swept-source optical coherence tomography, balanced detection is required to suppress relative intensity noise (RIN). A regular implementation of balanced detection by combining reference and sample arm signal in a 50/50 coupler and detecting the ... [Opt. Express 15, 16390-16399 (2007)]

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    Mentions: Johannes F. de Boer Massachusetts General Hospital Harvard University

14. Frequency tracking in optical Doppler tomography using an adaptive notch filter

    Explore SPIE Digital Library Mar 1 2007

    Optical Doppler tomography is a valuable functional extension of optical coherence tomography (OCT) that can be used to study subsurface blood flows of biological tissues. We propose a novel frequency estimation technique that uses an adaptive notch filter (ANF) to track the depth-resolved Doppler frequency. This new technique is a minimal-parameter filter and works in the time domain without the need of Fourier transformation. Therefore, the algorithm has a computationally efficient structure that may be well suited for implementation in real-time ODT systems. Our simulations and imaging results also demonstrate that this filter has good performance in terms of noise ...

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    Mentions: Quing Zhu Yueli L. Chen University of Connecticut

15. High-speed imaging of human retina in vivo with swept-source optical coherence tomography

    Explore opticsinfobase.org Dec 16 2006 Ophthalmology

    We present the first demonstration of human retinal imaging in vivo using optical frequency domain imaging (OFDI) in the 800-nm range. With 460-μW incident power on the eye, the sensitivity is 91 dB at maximum and >85 dB over 2-mm depth range. The axial resolution is 13 μm in air. We acquired images of retina at 43,200 depth profiles per second and a continuous acquisition speed of 84 frames/s (512 A-lines per frame) could be maintained over more than 2 seconds.

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    Mentions: Johannes F. de Boer Massachusetts General Hospital Harvard University

16. Hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic models

    Explore SPIE Digital Library Jul 15 2005 Cardiology

    We evaluate the performance of our novel hybrid optical coherence tomography (OCT) and scintillating probe, demonstrate simultaneous OCT imaging and scintillating detection, and validate the system using an atherosclerotic rabbit model. Preliminary data obtained from the rabbit model suggest that our prototype positron probe detects local uptake of fluorodeoxyglucose (FDG) labeled with 18F positron (beta) radionuclide emitter, and the high-uptake regions correlate with sites of injury and extensive atherosclerosis areas. Preliminary data also suggest that coregistered high-resolution OCT images provide imaging of detailed plaque microstructures, which cannot be resolved by positron detection.

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    Mentions: Yale University Quing Zhu Yueli L. Chen

17. Characterization of dentin, enamel, and carious lesions by a polarization-sensitive optical coherence tomography system

    Explore opticsinfobase.org Apr 10 2005 Dentistry

    Enamel and dentin are the primary components of human teeth. Both of them have a strong polarization effect. We designed a polarization-sensitive optical coherence tomography (PSOCT) system to study the spatially resolved scattering and polarization phenomena of teeth. The system is constructed in free space to avoid the complexity of polarization control in fiber-based PSOCT. The structural features of enamel were evaluated in five human teeth that had no visible evidence of caries. The teeth were subsequently sectioned in mesial distal orientation and coronal orientation. Then the structural aspects of dentin were evaluated. OCT images were made of the mantel ...

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    Mentions: Quing Zhu Yueli L. Chen University of Connecticut

18. Digital signal processor-based real-time optical Doppler tomography system

    Explore SPIE Digital Library Apr 21 2004

    We present a real-time data-processing and display unit based on a custom-designed digital signal processor (DSP) module for imaging tissue structure and Doppler blood flow. The DSP module is incorporated into a conventional optical coherence tomography system. We also demonstrate the flexibility of embedding advanced Doppler processing algorithms in the DSP module. Two advanced velocity estimation algorithms previously introduced by us are incorporated in this DSP module. Experiments on Intralipid flow demonstrate that a pulsatile flow of several hundred pulses per minute can be faithfully captured in M-scan mode by this DSP system. In vivo imaging of a rat's ...

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    Mentions: Quing Zhu Yueli L. Chen Shikui Yan

Topics in the News

1. (18 articles) Yueli L. Chen
2. (8 articles) Massachusetts Institute of Technology
3. (8 articles) James G. Fujimoto
4. (7 articles) Tufts University
5. (7 articles) Jay S. Duker
6. (6 articles) University of Connecticut
7. (6 articles) Quing Zhu
8. (5 articles) University of Pittsburgh
9. (5 articles) Vivek J. Srinivasan
10. (5 articles) Joel S. Schuman
11. (2 articles) Sun Yat-Sen University
12. (2 articles) National Institutes of Health
13. (1 articles) Thomas Jefferson University
14. (1 articles) Massachusetts General Hospital
15. (1 articles) Devers Eye Institute
16. (1 articles) Chang Gung University
17. (1 articles) Guillermo J. Tearney
18. (1 articles) Carol L. Shields
19. (1 articles) Eric A. Swanson
20. (1 articles) Meng-Tsan Tsai

Popular Articles

• Spectrally balanced detection for optical frequency domain imaging  
• Ultrahigh speed Spectral / Fourier domain OCT ophthalmic imaging at 70,000 to 312,500 axial scans per second  
• A prototype hybrid intraoperative probe for ovarian cancer detection  
• Ultrahigh-Speed Optical Coherence Tomography for Three-Dimensional and En Face Imaging of the Retina and Optic Nerve Head  
• Ultrahigh speed spectral/Fourier domain ophthalmic OCT imaging  
• Three-dimensional ultrahigh resolution optical coherence tomography imaging of age-related macular degeneration  
• Clinical Assessment of Mirror Artifacts in Spectral Domain Optical Coherence Tomography  
• Ultrahigh speed spectral/Fourier domain OCT imaging in ophthalmology  
• Assessment of Artifacts and Reproducibility across Spectral- and Time-Domain Optical Coherence Tomography Devices  
• Polarization memory effect in optical coherence tomography and dental imaging application  

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