1. Articles from Eric A. Swanson

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    1. Wavelength tunable laser device using frequency shifter

      Wavelength tunable laser device using frequency shifter

      A wavelength tunable laser device includes a gain element positioned in an optical cavity that provides optical gain to an optical signal. A frequency shifter that generates a frequency shift as a function of time is positioned in the optical cavity. The optical cavity is configured so that a magnitude of the frequency shift as a function of time generated by the frequency shifter is substantially equal to a frequency separation of a cavity mode of the cavity such that an output of the cavity generates laser light having a wavelength that tunes as a function of time.

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    2. Few-mode fiber endoscope

      Few-mode fiber endoscope

      Disclosed herein are configurations for few-mode fiber optical endoscope systems employing distal optics and few-mode, double-clad or other optical fiber wherein the systems directing an optical beam to a sample via the optical fiber; collecting light backscattered from the sample; direct the backscattered light to a detector via the optical fiber; and detect the backscattered light; wherein the directed optical beam is single mode and the collected light is one or more higher order modes.

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    3. Optical measurement system using multicore optical fiber

      Optical measurement system using multicore optical fiber

      An optical-fiber measurement system includes an optical system that generates light and a spatial optical switch that is coupled to the optical system that processes the light generated by the optical system and generates light at a plurality of spatially distributed optical ports. A respective one of a plurality of optical cores at a first end of a multicore optical fiber is positioned to receive light from a respective one of the plurality of spatially distributed optical ports, where the light generated at the plurality of spatially distributed optical ports propagates through the multicore optical fiber. Distal optics is positioned ...

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    4. Integrated photonic array fed by free-space optics

      Integrated photonic array fed by free-space optics

      An optical system for producing an optical probe beam includes an optical source that generates a free-space optical beam. An optical element is positioned in a path of the free-space optical beam to project the free-space optical beam to generate a projected free-space optical beam. A photonic integrated phased-array component positioned in a path of the projected free-space optical beam to reflect the projected free space optical beam, thereby generating the optical probe beam. The photonic integrated phased-array component comprises a plurality of antenna elements and a substrate positioned proximate to the plurality of antenna elements, wherein the substrate includes ...

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    5. Wavelength tunable laser device

      Wavelength tunable laser device

      A photonic integrated circuit wavelength tunable laser device includes a gain element integrated into a photonic integrated circuit. The gain element provides optical gain to an optical signal. A tunable filter is integrated into the photonic integrated circuit. A modulator is integrated into the photonic integrated circuit that modulates the optical signal as a function of time, wherein the gain element, the tunable filter, and the modulator form a wavelength tunable laser device having a wavelength that tunes as a function of time.

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    6. Estimating Public and Patient Savings From Basic Research—A Study of Optical Coherence Tomography in Managing Antiangiogenic Therapy

      Estimating Public and Patient Savings From Basic Research—A Study of Optical Coherence Tomography in Managing Antiangiogenic Therapy

      Purpose To compare patient and Medicare savings from the use of optical coherence tomography (OCT) in guiding therapy for neovascular age-related macular degeneration (nvAMD) to the research investments made in developing OCT by the National Institutes of Health (NIH) and the National Science Foundation (NSF). Design Observational cohort study. Methods Main outcome measures were spending by Medicare as tracked by Current Procedural Terminology codes on intravitreal injections (67028), retinal OCT imaging (92134), and anti–vascular endothelial growth factor (anti-VEGF) treatment–specific J-codes (J0178, J2778, J9035, J3490, and J3590). These claims were identified from the Medicare Provider Utilization and Payment Data ...

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    7. Feature Of The Week 10/1/2017: Optical Coherence Tomography: from Healthcare Idea to Healthcare Impact.

      Feature Of The Week 10/1/2017: Optical Coherence Tomography: from Healthcare Idea to Healthcare Impact.

      The commercialization and growth of OCT which has occurred over the past 25 years has been highly impactful scientifically, clinically, and economically. Many factors have helped drive this success starting with the clinical need for new cost-effective high-resolution minimally-invasive imaging solutions for various diagnostic and therapeutic applications. But equally important to this success was the intertwined role of researchers, engineers, clinicians, professional societies, government agencies, government funding, regulatory bodies, entrepreneurs, venture capitalists, and small and large corporate entities within the biomedical optics industry and other industries. This talk will review some of the history of the commercialization of OCT and ...

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    8. The ecosystem that powered the translation of OCT from fundamental research to clinical and commercial impact [Invited]

      The ecosystem that powered the translation of OCT from fundamental research to clinical and commercial impact [Invited]

      25 years is a relatively short period of time for a medical technology to become a standard of care impacting the treatment of millions of people every year. Yet 25 years ago there were no OCT companies, no OCT products, no OCT markets, and only one journal article published using the term OCT (optical coherence tomography). OCT has had a tremendous scientific, clinical, and economic impact on society. Today, it is estimated that there are ~30 Million OCT imaging procedures performed worldwide every year and the OCT system market is approaching $1B per year. OCT has helped diagnose patients with ...

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    9. Integrated optical coherence tomography systems and methods

      Integrated optical coherence tomography systems and methods

      Disclosed herein are optical integration technologies, designs, systems and methods directed toward Optical Coherence Tomography (OCT) and other interferometric optical sensor, ranging, and imaging systems wherein such systems, methods and structures employ tunable optical sources, coherent detection and other structures on a single or multichip monolithic integration. In contrast to contemporary, prior-art OCT systems and structures that employ simple, miniature optical bench technology using small optical components positioned on a substrate, systems and methods according to the present disclosure employ one or more photonic integrated circuits (PICs), use swept-source techniques, and employ a widely tunable optical source(s).

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    10. The Development, Commercialization, and Impact of Optical Coherence Tomography

      The Development, Commercialization, and Impact of Optical Coherence Tomography

      This review was written for the special issue of IOVS to describe the history of optical coherence tomography (OCT) and its evolution from a nonscientific, historic perspective. Optical coherence tomography has become a standard of care in ophthalmology, providing real-time information on structure and function – diagnosing disease, evaluating progression, and assessing response to therapy, as well as helping to understand disease pathogenesis and create new therapies. Optical coherence tomography also has applications in multiple clinical specialties, fundamental research, and manufacturing. We review the early history of OCT describing how research and development evolves and the important role of multidisciplinary collaboration ...

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    11. Beyond Better Clinical Care: Optical Coherence Tomography's Economic Impact

      Beyond Better Clinical Care: Optical Coherence Tomography's Economic Impact

      The optical coherence tomography (OCT) industry has grown dramatically in its first 25 years, and while the positive effects on patient clinical care are the most important measure of OCT's success, its contributions to the economy in jobs, tax receipts, and healthcare savings are also noteworthy. The field of optical coherence tomography (OCT) has grown dramatically since its discovery in the early 1990s. The commercialization and growth of OCT, which has occurred over the past 25 years, has been highly impactful scientifically, clinically, and economically. Many factors have helped drive this success, starting with the clinical need for new ...

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    12. Optical Coherence Tomography Industry Has Provided Well Over 20,000 Person-Years of Direct Employment

      Optical Coherence Tomography Industry Has Provided Well Over 20,000 Person-Years of Direct Employment

      The field of Optical Coherence Tomography (OCT) has grown dramatically since its discovery in the early 1990’s. The commercialization and growth of OCT which has occurred over the past 25 years has been highly impactful, scientifically, clinically, and economically. Many factors have helped drive this success starting with the clinical need for new cost-effective high-resolution minimally-invasive imaging solutions for various diagnostic and therapeutic applications. But equally important to this success has been the worldwide ecosystem consisting of the intertwined role of scientists, engineers, clinicians, professional societies, government agencies, government funding, regulatory bodies, entrepreneurs, venture capitalists, and small and large ...

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    13. Congratulations to the Winners of the 2013 OCT News Student Paper Award

      Congratulations to the Winners of the 2013 OCT News Student Paper Award

      OCT News is pleased to announce the four winners of the 2013 student paper award competition. There were numerous submissions and they were judged on novelty, technical merit, and clarity by four judges (two from the USA and two from Europe). The winners are: Pei Ma from Case Western Reserve University for her submission “ Developing Technologies for Electrophysiology Imaging in Embryonic Hearts .” Jing-Gao Zheng from Tsinghua University for his submission “ Understanding Early Patterning and Polarity of Preimplantation Mouse Embryos with Full-Field Optical Coherence Tomography .” Carissa Reynolds from University of California Riverside for her submission “ Using Optical Coherence Tomography to Detect ...

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    14. Estimates of Ophthalmic OCT Market Size and the Dramatic Reduction in Reimbursement Payments

      Estimates of Ophthalmic OCT Market Size and the Dramatic Reduction in Reimbursement Payments

      Optical coherence tomography has been an unqualified success in the area of ophthalmology. As recently noted by OCT pioneer Dr. Carmen Puliafito, “OCT has revolutionized the treatment of eye diseases on a global basis and it is now routinely used to make clinical decisions about treating patients with blinding diseases such as macular degeneration, diabetic retinopathy, and glaucoma”. Over the past decade the market for ophthalmic OCT systems has grown tremendously and is now over $300M/year; there are ~14 companies making ophthalmic OCT instruments and more on the way; new impressive product features continue to be rolled out; nearly ...

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    15. In Response to Pressure Ontario Government Increases Ophthalmic OCT Reimbursement Fee

      In Response to Pressure Ontario Government Increases Ophthalmic OCT Reimbursement Fee

      Just this past May it seemed the Ontario Government had angered some doctors and patients by reducing the ophthalmic OCT reimbursment rate from about $63 to $25. This set off articles in the press like this one " Doctors and patients upset over Ontario gov't cuts to critical eye exams " where it was expressed by some that this was not in the best interest of Ontario, doctors, or patients. It now seems that this reimbursement has again changed as detailed in this article " Ontario government reaches deal with doctors " where it is quoted that " The optical coherence tomography fee, which ...

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    16. 2013 OCT News Student Paper Award Opportunity Announcement - A Travel Grant and iPad2

      2013 OCT News Student Paper Award Opportunity Announcement - A Travel Grant and iPad2

      OCT News will sponsor three student paper awards of $1,000 each plus a 16Gb iPad2 for each winner. The goal of this grant is to assist in the travel or other expenses of a student working in the area of OCT. For example to attend an OCT Conference such as the upcoming Photonics West conference in San Francisco on February 2nd 2013. To be eligible for this award, the applicant must be a student doing research in the area of Optical Coherence Tomography, the work submitted must be fairly recent and mainly the work of the student. Awards will ...

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    17. Some Historical Statistics on Companies in the Market of Optical Coherence Tomography Systems

      Some Historical Statistics on Companies in the Market of Optical Coherence Tomography Systems

      There are over 36 OCT system companies in the market today in varying stages of maturity. There are other OCT companies that currently exist or started in this time period but are not listed here due to their small scale and/or company status. Many of those companies are listed here along with OCT component companies. There are even more startups and established companies in stealth mode looking to start new product lines. Figure 1 shows a graph of these 36 companies and the approximate time that significant resources were invested in new OCT product development efforts. Table 1 shows ...

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    18. Some Historical Statistics of USPTO Patents in the Field of Optical Coherence Tomography

      Some Historical Statistics of USPTO Patents in the Field of Optical Coherence Tomography

      Patents are obviously an important component of the OCT technology market place. Patents and the motives to file them have many roles. The motive for academics can be either to help enable a startup company the professor or student is involved in or to seek a share in the royalty fees by licensing to a company they are not involved in.[footnote 1] Many academics that start companies have licensed patents they authored from their institution, usually under exclusive terms. Exclusive fundamental patents can be a key factor in solidifying equity financing from investors. In addition, patents can serve as ...

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      Mentions: Samsung
    19. Extracting and compensating dispersion mismatch in ultrahigh-resolution Fourier domain OCT imaging of the retina

      Extracting and compensating dispersion mismatch in ultrahigh-resolution Fourier domain OCT imaging of the retina

      We present a numerical approach to extract the dispersion mismatch in ultrahigh-resolution Fourier domain optical coherence tomography (OCT) imaging of the retina. The method draws upon an analogy with a Shack-Hartmann wavefront sensor. By exploiting mathematical similarities between the expressions for aberration in optical imaging and dispersion mismatch in spectral / Fourier domain OCT, Shack-Hartmann principles can be extended from the two-dimensional paraxial wavevector space (or the x-y plane in the spatial domain) to the one-dimensional wavenumber space (or the z-axis in the spatial domain). For OCT imaging of the retina, different retinal layers, such as the retinal nerve fiber layer ...

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    20. Some Historical Statistics of Academic Publications in the Field of Optical Coherence Tomography

      Some Historical Statistics of Academic Publications in the Field of Optical Coherence Tomography

      Figure 1 shows an example of the dramatic growth in OCT papers since the first OCT paper by Huang, et al in 1991. Table 1 shows the data in more detail. A few things are very obvious, including that the rate of growth of OCT publications is dramatic (~200 papers/year) and the publications are dominated by ophthalmology, followed by general technology, and cardiology. The legend on the right hand side of the figure shows the number of cumulative publications by subject area from 1991 to 2012. In this analysis only title and abstract were considered. The result is that ...

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    21. Duke University Wins an NIH Grant on Computer Aided Classification of Diabetic Macular Edema

      Duke University Wins an NIH Grant on Computer Aided Classification of Diabetic Macular Edema

      Duke University Received a 2013 a NIH Grant for $384,751 on Computer Aided Classification of Diabetic Macular Edema.  The principal investigator is Sina Farsiu.  The program began in 2012 and ends in 2017.  Below is a summary of the work. There are currently no well-established methods to identify and evaluate the mechanisms underlying diabetic macular edema (DME) pathobiology, one of the leading causes of blindness among working-age Americans. As such, the development of pathophysiology-specific therapeutic agents for DME is limited, and the selection of therapies personalized for individual patients remains subjective. Our long-term goal is to develop automated methods ...

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    22. OPTICAL COHERENCE TOMOGRAPHY/BIOIMAGING: One decade and $500M: The impact of federal funding on OCT - Part 2

      OPTICAL COHERENCE TOMOGRAPHY/BIOIMAGING: One decade and $500M: The impact of federal funding on OCT - Part 2
      EDITOR'S NOTE: This article is the follow-up article to "One decade and $500M: The impact of federal funding on OCT—Part 1," which appears in the September/October 2011 issue of BioOptics World. Over the past decade, governments around the world have invested hundreds of millions of dollars in research and development involving optical coherence tomography (OCT). Part Two of this two-part article explores the return on that investment in terms of product and economic growth in the for-profit sector. By Eric A. Swanson As discussed in Part 1 of this article, determining the impact of research dollars for ...
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    23. Optical Coherence Tomography/Bioimaging: One decade and $500M: The impact of federal funding on OCT—Part 1

      Optical Coherence Tomography/Bioimaging: One decade and $500M: The impact of federal funding on OCT—Part 1
      Over the past decade, governments around the world have invested hundreds of millions of dollars in research and development involving optical coherence tomography (OCT). Part One of this two-part article explores where the money has come from, and where it has gone, and begins to uncover the return on that investment—which will be further explored in Part Two.
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    1-24 of 46 1 2 »
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    Fiber optic needle probes for optical coherence tomography imaging Method and apparatus for performing optical measurements Some Historical Statistics of Academic Publications in the Field of Optical Coherence Tomography Some Historical Statistics of USPTO Patents in the Field of Optical Coherence Tomography Some Historical Statistics on Companies in the Market of Optical Coherence Tomography Systems 2013 OCT News Student Paper Award Opportunity Announcement - A Travel Grant and iPad2 Estimates of Ophthalmic OCT Market Size and the Dramatic Reduction in Reimbursement Payments Congratulations to the Winners of the 2013 OCT News Student Paper Award Optical Coherence Tomography Industry Has Provided Well Over 20,000 Person-Years of Direct Employment Feature Of The Week 10/1/2017: Optical Coherence Tomography: from Healthcare Idea to Healthcare Impact. Quantification of biomechanical properties of human corneal scar using acoustic radiation force optical coherence elastography Longitudinal changes in complete avascular area assessed using anterior segmental optical coherence tomography angiography in filtering trabeculectomy bleb