1. Articles from Michael Larsen

    1-20 of 20
    1. Spectral‐domain optical coherence tomography of retinal vessels in Waldenström's macroglobulinemia

      Spectral‐domain optical coherence tomography of retinal vessels in Waldenström's macroglobulinemia

      Purpose To image retinal blood vessels in patients with Waldenström's macroglobulinemia using optical coherence tomography (OCT). Methods Retrospective case series examining fundus photographs and OCT scans of 16 eyes in eight patients with Waldenström's macroglobulinemia. Analyses included intravascular OCT reflectivity profiles and vessel diameters, and their relation to total immunoglobulin M (IgM) levels. Results In six out of eight patients, cross‐sectional OCT scans of larger retinal vessels (diameter > 100 μm) showed normal intravascular reflectivity and retrovascular shadowing. In two patients with the highest total IgM > 60 g/l, altered intravascular reflectivity, distinct anterior and posterior ...

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    2. Optic Disc Drusen in Children: The Copenhagen Child Cohort 2000 Eye Study

      Optic Disc Drusen in Children: The Copenhagen Child Cohort 2000 Eye Study

      Background: Optic disc drusen (ODD) are seen in up to 2.4% of the general population, but the etiology and pathophysiology of the condition is still unknown. The purpose of this study was to determine the prevalence of ODD in a population-based child cohort and to determine if scleral canal diameter and fetal birth and pubertal parameters are associated with the presence of ODD. Methods: This observational, longitudinal population-based birth cohort study, with a nested case–control, included 1,406 children. Eye examinations were performed when the children were between 11 and 12 years of age. Assessment was performed of ...

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    3. Developmental approach towards high resolution optical coherence tomography for glaucoma diagnostics

      Developmental approach towards high resolution optical coherence tomography for glaucoma diagnostics

      Glaucoma is caused by a pathological rise in the intraocular pressure, which results in a progressive loss of vision by a damage to retinal cells and the optical nerve head. Early detection of pressure-induced damage is thus essential for the reduction of eye pressure and to prevent severe incapacity or blindness. Within the new European Project GALAHAD (Glaucoma Advanced, Label free High Resolution Automated OCT Diagnostics), we will develop a new low-cost and high-resolution OCT system for the early detection of glaucoma. The device is designed to improve diagnosis based on a new system of optical coherence tomography. Although OCT ...

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      Mentions: Michael Larsen
    4. Thickness mapping of individual retinal layers and sectors by Spectralis SD-OCT in Autosomal Dominant Optic Atrophy

      Thickness mapping of individual retinal layers and sectors by Spectralis SD-OCT in Autosomal Dominant Optic Atrophy

      Purpose To assess layer- and location-specific retinal thickness deficits in autosomal dominant optic atrophy (ADOA) using Spectralis SD-OCT. Methods This cross-sectional study included 41 ADOA patients with OPA1 exon 28 (2826delT) mutation [age, 8.6–83.5 years; best-corrected visual acuity (BCVA), 8–89 Early Treatment Diabetic Retinopathy Study (ETDRS) letters] and 55 mutation-free first-degree relatives as healthy controls (age, 8.9–68.7; BCVA, 80–99). Participants underwent routine examination and optical coherence tomography (OCT) with segmentation of the whole retina, inner retinal layers (IRL) and outer retinal layers (ORL). Individual segmentation was performed of the perifoveal retinal nerve ...

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    5. Enhanced-Depth Imaging Optical Coherence Tomography of the Human Choroid In Vivo Compared With Histology After Enucleation

      Enhanced-Depth Imaging Optical Coherence Tomography of the Human Choroid In Vivo Compared With Histology After Enucleation

      Purpose : This study compared in vivo enhanced-depth imaging optical coherence tomography (EDI-OCT) with ex vivo histology of the choroid in human eyes. Methods : Three eyes in three patients with advanced iris melanoma without posterior segment involvement underwent EDI-OCT less than 24 hours prior to enucleation and, in one eye, immediately after enucleation. Following fixation in 4% buffered formaldehyde and paraffin embedding, serial sections of the whole eye were cut horizontally, mounted, stained with hematoxylin-eosin and digitized. Alignment between histology and EDI-OCT was made on landmarks such as retinal vessel, the foveal depression, ciliary arteries, drusen, and nevi. Results : Intra- and ...

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    6. Dark adaptation in relation to choroidal thickness in healthy young subjects: a cross-sectional, observational study

      Dark adaptation in relation to choroidal thickness in healthy young subjects: a cross-sectional, observational study

      Background Dark adaptation is an energy-requiring process in the outer retina nourished by the profusely perfused choroid. We hypothesized that variations in choroidal thickness might affect the rate of dark adaptation. Method Cross-sectional, observational study of 42 healthy university students (mean age 25 ± 2.0 years, 29 % men) who were examined using an abbreviated automated dark adaptometry protocol with a 2° diameter stimulus centered 5° above the point of fixation. The early, linear part of the rod-mediated dark adaptation curve was analyzed to extract the time required to reach a sensitivity of 5.0 × 10 −3 cd/m2 (time to ...

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    7. OPTICAL COHERENCE TOMOGRAPHY IN JUVENILE NEURONAL CEROID LIPOFUSCINOSIS

      OPTICAL COHERENCE TOMOGRAPHY IN JUVENILE NEURONAL CEROID LIPOFUSCINOSIS

      Purpose: To report optical coherence tomography findings obtained in two patients with juvenile neuronal ceroid lipofuscinosis. Methods: Two case reports. Results: Two 7-year-old girls presented with decreased visual acuity, clumsiness, night blindness, and behavioral problems. Optical coherence tomography showed an overall reduction in thickness of the central retina, as well as the outer and the inner retinal layers. The degenerative retinal changes were the same, despite different mutations in the CLN3 gene. Conclusion: In these rare cases of juvenile neuronal ceroid lipofuscinosis, optical coherence tomography enabled unambiguous detection of prominent morphologic abnormalities of the retina at the patient's first ...

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    8. OPTICAL COHERENCE TOMOGRAPHY IN JUVENILE NEURONAL CEROID LIPOFUSCINOSIS

      OPTICAL COHERENCE TOMOGRAPHY IN JUVENILE NEURONAL CEROID LIPOFUSCINOSIS

      Purpose: To report optical coherence tomography findings obtained in two patients with juvenile neuronal ceroid lipofuscinosis. Methods: Two case reports. Results: Two 7-year-old girls presented with decreased visual acuity, clumsiness, night blindness, and behavioral problems. Optical coherence tomography showed an overall reduction in thickness of the central retina, as well as the outer and the inner retinal layers. The degenerative retinal changes were the same, despite different mutations in the CLN3 gene. Conclusion: In these rare cases of juvenile neuronal ceroid lipofuscinosis, optical coherence tomography enabled unambiguous detection of prominent morphologic abnormalities of the retina at the patient's first ...

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    9. Mechanism of Retinal Pigment Epithelium Tear Formation Following Intravitreal Anti–Vascular Endothelial Growth Factor Therapy Revealed by Spectral-Domain Optical Coherence Tomography

      Mechanism of Retinal Pigment Epithelium Tear Formation Following Intravitreal Anti–Vascular Endothelial Growth Factor Therapy Revealed by Spectral-Domain Optical Coherence Tomography

      Purpose To demonstrate the mechanism by which retinal pigment epithelium (RPE) tears occur in eyes with neovascular age-related macular degeneration (AMD) treated with intravitreal anti–vascular endothelial growth factor (VEGF) agents using spectral-domain optical coherence tomography (OCT). Design Retrospective observational case series. Methods OCT images of 8 eyes that developed RPE tears following the administration of intravitreal anti-VEGF agents for neovascular AMD were evaluated. Pretear and posttear images were compared in order to elucidate the mechanism by which RPE tears occur in this setting. Results In all eyes, pretear images revealed a vascularized pigment epithelial detachment (PED) containing hyperreflective material ...

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    10. Flow patterns on spectral-domain optical coherence tomography reveal flow directions at retinal vessel bifurcations

      Flow patterns on spectral-domain optical coherence tomography reveal flow directions at retinal vessel bifurcations

      Purpose: To study intravascular characteristics of flowing blood in retinal vessels using spectral-domain optical coherence tomography (SD-OCT). Methods: Examination of selected arterial bifurcations and venous sites of confluence in 25 healthy 11-year-old children recruited as an ad hoc subsample from the population-based, observational Copenhagen Child Cohort 2000 study. Results: The blood stream in retinal arteries maintains a figure-of-8 SD-OCT profile consistent with a laminar flow in concentric sheets and a parabolic velocity distribution up to the point of divergence at arterial bifurcations. In contrast, the blood stream at the site of confluence of two retinal veins remains divided into two ...

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    11. Retinal and choroidal intravascular spectral-domain optical coherence tomography

      Retinal and choroidal intravascular spectral-domain optical coherence tomography

      Purpose:  To examine retinal and choroidal blood vessels using spectral-domain optical coherence tomography (SD-OCT). Methods:  Retrospective case series. Results:  Scans through retinal blood vessels in healthy subjects demonstrated vessel wall reflexes and a tri-layer profile of the blood column on longitudinal scans and a figure-of-eight configuration on cross-sectional scans. Intravascular reflectivity decreased with increasingly oblique angles of observation and was absent when blood flow was parallel to the line of sight. The high blood flow in the choroidal vessels in healthy subjects and the low flow in the retinal vessels in patients with ocular ischaemic syndrome and central retinal artery ...

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    12. Local retinal sensitivity in relation to specific retinopathy lesions in diabetic macular oedema

      Local retinal sensitivity in relation to specific retinopathy lesions in diabetic macular oedema

      Purpose:  To study microperimetric macular sensitivity in diabetic macular oedema (DMO) in relation to lesion characteristics obtained by optical coherence tomography (OCT), colour fundus photography, and fluorescein angiography (FA). Methods:  The study comprised 20 eyes in 15 patients with nonproliferative diabetic retinopathy and recently diagnosed untreated DMO. Investigations included microperimetry, fluorescein angiography, colour fundus photography, and OCT. All measures and gradings were made for each of the nine fields of an early treatment diabetic retinopathy study macula template. Statistical analysis was made using Spearman’s nonparametric test including field and mean values within fields. Comparisons were made within the study ...

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    13. Evaluation of macular structure and function by OCT and electrophysiology in patients with vitelliform macular dystrophy due to mutations in BEST1

      Purpose: To analyze retinal structure and function in vitelliform macular dystrophy (VMD) due to mutations in BEST1. Methods: Patients from five Swedish and four Danish families were examined with electrooculography (EOG), full-field electroretinography (ffERG), multifocal ERG (mfERG), optical coherence tomography (OCT) and fundus autofluorescence photography (FAF). Genetic analysis of the BEST1 gene was performed by direct sequencing. Results: Mutations in BEST1 have been reported previously in the Swedish families. In the Danish families, four disease-causing missense mutations were found, one of which is novel; c.936C>A (p.Asp312Glu). The mutation was homozygous in a nine-year old boy and heterozygous ...
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    14. Macular morphology and visual acuity after macular hole surgery with or without internal limiting membrane peeling

      Aim: To examine postoperative macular morphology and visual outcome after 12 months in relation to internal limiting membrane (ILM) peeling versus no peeling, indocyanine green (ICG)-staining, and reoperation in eyes that achieved macular hole closure after surgery. Methods: Seventy-four eyes with closed stage 2 or 3 macular holes were recruited from a randomized clinical trial comparing (1) vitrectomy without ILM peeling, (2) vitrectomy with 0.05 % isotonic ICG-assisted ILM peeling, and (3) vitrectomy with 0.15 % trypan blue-assisted ILM peeling. Contrast-enhanced Stratus optical coherence tomography was used to assess central foveal thickness (CFT), central photoreceptor layer thickness (CPRT), central ...

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    15. Axonal loss occurs early in dominant optic atrophy

      Purpose: This study set out to investigate retinal nerve fibre layer (RNFL) thickness and best corrected visual acuity (BCVA) in relation to age in healthy subjects and patients with OPA1 autosomal dominant optic atrophy (DOA).Methods: We carried out a cross-sectional investigation of RNFL thickness and ganglion cell layer density in 30 healthy subjects and 10 patients with OPA1 DOA using optical coherence tomography (OCT). We then performed a regression analysis of RNFL thickness and BCVA versus age.Results: Both healthy subjects and DOA patients demonstrated a gradual reduction in RNFL thickness with age; the relationship was best described statistically ...

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    16. Correlation between intraretinal changes in diabetic macular oedema seen in fluorescein angiography and optical coherence tomography

      Abstract.Purpose: To study the relationship between intraretinal optical coherence tomography (OCT) and fluorescein angiography (FA) findings in eyes with diabetic macular oedema (DMO).Methods: We carried out a retrospective observational case series. ...

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    17. Optical coherence tomography and vessel diameter changes after intravitreal bevacizumab in diabetic macular oedema

      Purpose: To assess the effect of intravitreal bevacizumab on diabetic macular oedema (DMO) and retinal vessel calibres. Methods: We performed a consecutive case series study in which 10 consecutive eyes with diffuse DMO, two of which had not previously been treated, received an intravitreal injection of bevacizumab 1 mg, which was followed by two more injections at 6-week intervals. Fundus photography and optical coherence tomography (OCT) were carried out at baseline immediately before injection and at 1, 2.5 and 4 months after the first injection. Outcome measures were best corrected visual acuity (BCVA) in Early Treatment Diabetic Retinopathy Study ...

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    18. The predictive value of optical coherence tomography after grid laser photocoagulation for diffuse diabetic macular oedema

      Purpose: To assess the predictive value of optical coherence tomography (OCT) mapping of retinal thickness and intraretinal morphological changes after macular grid for diffuse diabetic macular oedema (DMO). Methods: We carried out a prospective, non-controlled, case series study, in which 28 consecutive eyes with previously untreated diffuse DMO underwent fundus photography and OCT at baseline and at 1, 3 and 6 months after treatment. Results: Macular photocoagulation was followed by a significant reduction in retinal thickness in the foveal centre (− 80 μm) and in the foveal subfield (− 65 μm) from baseline to 6 months (p 0.05). The relative decrease ...

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    1-20 of 20
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    1. (18 articles) Michael Larsen
    2. (16 articles) University of Copenhagen
    3. (7 articles) Birgit Sander
    4. (2 articles) Technical University of Denmark (DTU)
    5. (2 articles) Thomas M. Jørgensen
    6. (1 articles) LuEsther T. Mertz Retinal Research Center
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    Local retinal sensitivity in relation to specific retinopathy lesions in diabetic macular oedema Retinal and choroidal intravascular spectral-domain optical coherence tomography Flow patterns on spectral-domain optical coherence tomography reveal flow directions at retinal vessel bifurcations Mechanism of Retinal Pigment Epithelium Tear Formation Following Intravitreal Anti–Vascular Endothelial Growth Factor Therapy Revealed by Spectral-Domain Optical Coherence Tomography Optical coherence tomography through a rigid borescope applied to quantification of articular cartilage thickness in a porcine knee model An Experimental Review of Optical Coherence Tomography Systems for Noninvasive Assessment of Hard Dental Tissues Low-Cost, Portable System Takes OCT Beyond Ophthalmology Comparison of diagnostic performance in assessing the rewiring position into a jailed side branch between online 3D reconstruction systems version 1.1 and 1.2 derived from optical frequency domain imaging Corneal sublayer thickness in patients with pseudoexfoliation syndrome evaluated by anterior segment optical coherence tomography Paediatric optical coherence tomography normative databases: A real need Optical Coherence Tomography Assessment of Macular and Choroidal Thickness in Patients with Proliferative Diabetic Retinopathy in Relation to Hemoglobin A1C Ultra-Widefield Protocol Enhances Automated Classification of Diabetic Retinopathy Severity with Optical Coherence Tomography Angiography