1. Articles from Makoto Araie

    1-23 of 23
    1. Glaucomatous vertical vessel density asymmetry of the temporal raphe detected with optical coherence tomography angiography

      Glaucomatous vertical vessel density asymmetry of the temporal raphe detected with optical coherence tomography angiography

      Changes in retinal vasculature and ocular circulation may play an important role in the glaucoma development and progression. We evaluated the vertical asymmetry across the temporal raphe of the deep retinal layer vessel density, using swept-source optical coherence tomography angiography (SS-OCTA), and its relationship with the central visual field (VF) loss. Thirty-four eyes of 27 patients with open-angle glaucoma were included. SS-OCTA macular scanning was performed within a 3 × 3 mm (300 × 300 pixels) volume, centred on the fovea. The relationships between the vertical asymmetrical deep retinal vessel density reduction (ADRVD) across the temporal raphe and various ocular parameters were ...

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    2. Clinical Assessment of Scleral Canal Area in Glaucoma Using Spectral Domain Optical Coherence Tomography

      Clinical Assessment of Scleral Canal Area in Glaucoma Using Spectral Domain Optical Coherence Tomography

      Purpose To investigate anterior scleral canal (ASC) area in the eyes with glaucoma using spectral-domain optical coherence tomography (SD-OCT). Design Cross-sectional study. Methods This study included 206 eyes of 103 patients with glaucoma classified as 66 eyes of 33 patients with unilateral glaucoma and 140 eyes of 70 patients with bilateral glaucoma. Radial scan enhanced depth imaging SD-OCT centered on the optic disc was performed, and parameters that present ASC area such as ASC opening and the largest ASC area were obtained in each eye. The largest ASC area was the largest cross-sectional area of the ASC region identified between ...

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      Mentions: Makoto Araie
    3. Using Deep Learning and transform learning to accurately diagnose early-onset glaucoma from macular optical coherence tomography images

      Using Deep Learning and transform learning to accurately diagnose early-onset glaucoma from macular optical coherence tomography images

      Purpose To construct and evaluate a Deep Learning (DL) model to diagnose early glaucoma from spectral domain optical coherence tomography (SD-OCT) images. Design AI diagnostic tool development, evaluation, and comparison Methods Setting: multiple institutional practices. Study population Pre-training data consisted of 4316 OCT images (RS3000, Nidek) from 1565 eyes with open angle glaucoma (OAG) irrespective of the stage of glaucoma and 193 normal eyes. Training data included OCT-1000/2000 (Topcon) from 94 eyes of 94 early OAG patients (mean deviation: MD >-5.0 dB) and 84 eyes of 84 normal subjects. Testing data included OCT-1000/2000 from 114 eyes of ...

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    4. Glaucomatous changes in lamina pores shape within the lamina cribrosa using wide bandwidth, femtosecond mode-locked laser OCT

      Glaucomatous changes in lamina pores shape within the lamina cribrosa using wide bandwidth, femtosecond mode-locked laser OCT

      Purpose The lamina cribrosa (LC) is known to play a critical role in the pathogenesis of glaucoma. Although it has been reported that striae-shaped or slit-shaped lamina pores are more frequent in eyes with primary open angle glaucoma (POAG), this observation is based only on fundus photography. The primary object of this study is to perform layer-by-layer comparisons of the shape of lamina pores within the LC in vivo. Design Cross-sectional study. Methods Optic nerve head B-scans were obtained using custom-made broad-wavelength optical coherence tomography with a mode-locked laser. A total of 300 single B-scans per eye were obtained and ...

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    5. Validating the usefulness of the 'Random Forests’ classifier to diagnose early glaucoma with optical coherence tomography

      Validating the usefulness of the 'Random Forests’ classifier to diagnose early glaucoma with optical coherence tomography

      Purpose To validate the usefulness of the 'Random Forests’ classifier to diagnose early glaucoma with spectral domain optical coherence tomography (SD-OCT). Method Design: Comparison of diagnostic algorithms Setting: multiple institutional practice Study participants Training dataset included 94 eyes of 94 open angle glaucoma (OAG) patients and 84 eyes of 84 normal subjects and testing dataset included 114 eyes of 114 OAG patients and 82 eyes of 82 normal subjects. In both groups, OAG eyes with mean deviation (MD) values better than -5.0 dB were included. Observation Procedure Using the training dataset, classifiers were built to discriminate between glaucoma and ...

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    6. Correlation between Lamina Cribrosa Tilt Angles, Myopia and Glaucoma Using OCT with a Wide Bandwidth Femtosecond Mode-Locked Laser

      Correlation between Lamina Cribrosa Tilt Angles, Myopia and Glaucoma Using OCT with a Wide Bandwidth Femtosecond Mode-Locked Laser

      Purpose To measure horizontal and vertical lamina cribrosa (LC) tilt angles and investigate associated factors using prototype optical coherence tomography (OCT) with a broad wavelength laser light source. Design Cross sectional study. Methods Twenty-eight no glaucoma eyes (from 15 subjects) and 25 glaucoma eyes (from 14 patients) were enrolled. A total of 300 optic nerve head B-scans were obtained in 10 µm steps and the inner edge of Bruch's membrane opening (BMO) was identified as the reference plane. The vertical and horizontal angles between BMO line and approximate the best-fitting line for the surface of the LC were measured ...

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    7. Three-dimensional optic nerve head images using optical coherence tomography with a broad bandwidth, femtosecond, and mode-locked laser

      Three-dimensional optic nerve head images using optical coherence tomography with a broad bandwidth, femtosecond, and mode-locked laser

      Purpose The aim of this study was to demonstrate the fine laminar structure of the optic nerve head (ONH), in vivo, using a broad wavelength, ultra-high resolution, and optically coherent tomography (OCT) system. Methods This high-resolution OCT system, based on a 200 nm bandwidth spectrometer and an 8 femtosecond ultra-short, mode-locked, coherent laser light source, enabled in vivo cross-sectional ONH imaging with 2.0 μm axial resolution. A total of 300 optic disc B-scans, which consisted of 300 × 2048 pixels, were obtained in 10 μm steps. Three-dimensional images were rendered from these images to obtain n face images of the ...

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    8. Discriminating between Glaucoma and Normal Eyes Using Optical Coherence Tomography and the ‘Random Forests’ Classifier

      Discriminating between Glaucoma and Normal Eyes Using Optical Coherence Tomography and the ‘Random Forests’ Classifier

      Purpose To diagnose glaucoma based on spectral domain optical coherence tomography (SD-OCT) measurements using the ‘Random Forests’ method. Methods SD-OCT was conducted in 126 eyes of 126 open angle glaucoma (OAG) patients and 84 eyes of 84 normal subjects. The Random Forests method was then applied to discriminate between glaucoma and normal eyes using 151 OCT parameters including thickness measurements of circumpapillary retinal nerve fiber layer (cpRNFL), the macular RNFL (mRNFL) and the ganglion cell layer-inner plexiform layer combined (GCIPL). The area under the receiver operating characteristic curve (AROC) was calculated using the Random Forests method adopting leave-one-out cross validation ...

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    9. Correlation of Magnetic Resonance Imaging optic nerve parameters to Optical Coherence Tomography and the visual field in glaucoma

      Correlation of Magnetic Resonance Imaging optic nerve parameters to Optical Coherence Tomography and the visual field in glaucoma

      Background To determine the viability of using MRI measurement of optic nerve morphology as an objective analysis of glaucomatous damage. Design Retrospective study conducted at Tohoku University Hospital. Participants Thirty-eight eyes of 19 patients with open angle glaucoma. Methods Patients were scanned with T2-weighted and 3-T diffusion tensor MRI, and parameters of the optic nerve, including fractional anisotropy, apparent diffusion coefficient, and cross-sectional area, were determined. Conventional parameters of glaucomatous damage, including circumpapillary and macular retinal nerve fiber layer thickness, and mean deviation and average total deviation of the central 16 test points from the Humphrey Field Analyzer, were then ...

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    10. Iridotrabecular contact observed using anterior segment three-dimensional OCT in eyes with a shallow peripheral anterior chamber

      Iridotrabecular contact observed using anterior segment three-dimensional OCT in eyes with a shallow peripheral anterior chamber

      Purpose: To evaluate the prevalence and range of iridotrabecular contact (ITC) in eyes with a shallow peripheral anterior chamber (AC) by using anterior segment swept-source optical coherence tomography (AS-SS-OCT) and to compare the results with those obtained with ultrasound biomicroscopy (UBM) and gonioscopy. Methods: Forty-three shallow peripheral AC eyes in 43 consecutive patients underwent gonioscopy. Cross-sectional images throughout the angle circumference (i.e., 360 degrees) were obtained with AS-SS-OCT (SS-1000 CASIA, Tomey) and those of the peripheral AC at the 3, 6, 9, and 12 o'clock positions were obtained with UBM (UD-1000, Tomey). Results: ITC evaluated with AS-SS-OCT included ...

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    11. Circle and Grid-wise Analyses of Peripapillary Nerve Fiber Layers by Spectral Domain Optical Coherence Tomography in Early Stage Glaucoma

      Circle and Grid-wise Analyses of Peripapillary Nerve Fiber Layers by Spectral Domain Optical Coherence Tomography in Early Stage Glaucoma

      PURPOSE. To study diagnostic performances of circle and grid-wise analyses of peripapillary retinal nerve fiber layer thickness (RNFLT) using spectral domain optical coherence tomography (SD-OCT) in early stage glaucoma. METHODS. Eighty-nine open-angle glaucoma (OAG) eyes (mean deviation, -2.5 ± 1.8 dB) and 89 age-matched normal eyes were studied. Peripapillary RNFLT was analyzed using SD-OCT raster scan in a 6.0 × 6.0 mm area. Averaged RNFLT was calculated over 0.1 × 0.1, 0.21 × 0.21, or 0.42 × 0.42 mm grids in the peripapillary area (grid method), or arcuate sector areas between 2.8 and 4 ...

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    12. Fundus oculi observation device, ophthalmologic image processing device, and program

      Fundus oculi observation device, ophthalmologic image processing device, and program

      A fundus oculi observation device capable of defining which part in the result of analysis of the layer thickness of a fundus oculi is a part obtained by analyzing a vascular region is provided. A fundus oculi observation device 1 forms a plurality of tomographic images G1-Gm of a fundus oculi Ef. A layer thickness distribution calculator 231 calculates layer thickness distribution of the fundus oculi Ef in a cross section of a tomographic image G based on the tomographic images G1-Gm. A vascular region specifying part 234 specifies a vascular region in the tomographic image G. A controller 210 ...

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    13. Reproducibility of Thickness Measurements of Macular Inner Retinal Layers Using SD-OCT with or without Correction of Ocular Rotation

      Reproducibility of Thickness Measurements of Macular Inner Retinal Layers Using SD-OCT with or without Correction of Ocular Rotation

      Purpose. To evaluate the inter-visit reproducibility of spectral-domain optical coherence tomography (SD-OCT) measurement of the macular retinal nerve fiber layer thickness (mRNFLT), combined ganglion cell layer and inner plexiform layer (GCL+IPL) thickness, and ganglion cell complex (GCC) thicknesses (sum of mRNFLT and GCL+IPL thicknesses) compared with that of circumpapillary RNFLT (cpRNFLT) and the effect of ocular rotation on reproducibility. Methods. SD-OCT imaging was performed twice on different days in one eye of 58 normal subjects and 73 glaucoma patients. The reproducibility was evaluated for the entire 4.8 mm x 4.8 mm macular area and sub-areas (upper ...

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    14. Test–retest variability in structural parameters measured with glaucoma imaging devices

      Test–retest variability in structural parameters measured with glaucoma imaging devices

      In addition to classical stereo-disc photography, various glaucoma imaging devices were developed in the last two decades to quantitatively measure and record glaucoma-related structural parameters of the eye. In determining whether or not the glaucomatous damage progressed from baseline and in estimating the number of test results’ optimal frequency needed to confirm disease progression, information relating to the test–retest variability of measurement results provided by each imaging device is indispensable. Such information enables the clinician to apply these devices in practice. The test–retest variability of a system is usually estimated using the Bland–Altman analysis and by calculating ...

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    15. Spectral-Domain Optical Coherence Tomography of β-zone Peripapillary Atrophy: Influence of Myopia and Glaucoma

      Spectral-Domain Optical Coherence Tomography of β-zone Peripapillary Atrophy: Influence of Myopia and Glaucoma

      Purpose: To investigate the influence of glaucoma and myopia on the cross-sectional configuration of β-zone peripapillary atrophy (PPA-β) using spectral-domain optical coherence tomography (SD-OCT). Methods: Among 100 eyes of 100 consecutive patients with POAG regardless of intraocular pressure level and 100 eyes of 100 normal subjects, cross-sectional B-scan images of PPA-β obtained with SD-OCT were evaluated. PPA bed configurations were classified and associated factors were studied with multivariate analysis. Results: In 147 eyes with PPA-β (84 POAG and 63 normal eyes; P = 0.0012), PPA bed were composed of straight (14 POAG and 27 normal eyes) or downward-curved (19 and ...

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    16. Effects of Age, Sex, and Axial Length on the Three-Dimensional Profile of Normal Macular Layer Structures

      Effects of Age, Sex, and Axial Length on the Three-Dimensional Profile of Normal Macular Layer Structures
      Purpose. To identify sex-related differences and age-related changes in individual retinal layer thicknesses in a population of healthy eyes across the lifespan, using spectral domain optical coherence tomography (SD-OCT). Methods. In seven institutes in Japan, mean thicknesses of the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), photoreceptor inner segment (IS), and photoreceptor outer segment (OS) were measured using SD-OCT with a new automated segmentation protocol in 256 healthy subjects. Results. Interoperator coefficients of variability for measurements of each layer ranged from 0 ...
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    17. Variation in Optic Nerve and Macular Structure with Age and Race with Spectral-Domain Optical Coherence Tomography

      Variation in Optic Nerve and Macular Structure with Age and Race with Spectral-Domain Optical Coherence Tomography
      Purpose: To evaluate the effects of age and race on optic disc, retinal nerve fiber layer, and macular measurements with spectral-domain optical coherence tomography (SD OCT).Design: Cross-sectional observational study.Participants: Three hundred fifty adult subjects without ocular disease.Methods: Data from SD OCT imaging of the optic nerve head, peripapillary retinal nerve fiber layer (RNFL), and macula of 632 eyes from 350 subjects without ocular disease were imaged with SD OCT. Multivariate models were used to determine the effect of age and race on quantitative measurements of optic disc, RNFL, and macula.Main Outcome Measures: Optic nerve, RNFL, and ...
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    18. Identification of Schlemm's Canal and Its Surrounding Tissues by Anterior Segment Fourier Domain Optical Coherence Tomography

      Identification of Schlemm's Canal and Its Surrounding Tissues by Anterior Segment Fourier Domain Optical Coherence Tomography
      Purpose: To identify Schlemm's canal (SC) and trabecular meshwork (TM) by an anterior segment Fourier-domain optical coherence tomography (AS-FD-OCT) with the histological confirmation in enucleated human eyes and to quantitatively evaluate SC and TM in living human eyes. Methods: In enucleated human eyes, the imaging of the anterior chamber angle by AS-FD-OCT was performed before and after surgical expansion of the SC with an injection of a viscoelastic material, followed by histological examination. In sixty living human eyes, the agreement of identification of SC between examiners was evaluated with the Cohen's kappa values, and the lengths of SC ...
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    19. Peripapillary Retinal Nerve Fiber Layer Thickness Determined by Spectral-Domain Optical Coherence Tomography in Ophthalmologically Normal Eyes

      Peripapillary Retinal Nerve Fiber Layer Thickness Determined by Spectral-Domain Optical Coherence Tomography in Ophthalmologically Normal Eyes
      Objectives  To evaluate the peripapillary distribution of retinal nerve fiber layer thickness (RNFLT) in normal eyes using spectral-domain optical coherence tomography and to study potentially related factors. Methods  In 7 institutes in Japan, RNFLT in 7 concentric peripapillary circles with diameters ranging from 2.2 to 4.0 mm were measured using spectral-domain optical coherence tomography in 251 ophthalmologically normal subjects. Multiple regression analysis for the association of RNFLT with sex, age, axial length, and disc area was performed. Results  Retinal nerve fiber layer thickness decreased linearly from 125 to 89 µm as the measurement diameter increased (P < .001, mixed linear model). Retinal nerve fiber layer thickness correlated with age in all diameters (partial correlation coefficient [PCC] = –0.40 to –0.32; P < .001) and negatively correlated with disc area in the 2 innermost circles but positively correlated in the 3 outermost circles (PCC = –0.30 to –0.22 and 0.17 to 0.20; P ≤ .005). Sex and axial length did not correlate with RNFLT (P > .08). The ...
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    20. Automated layer segmentation of macular OCT images using dual-scale gradient information

      Automated layer segmentation of macular OCT images using dual-scale gradient information
      A novel automated boundary segmentation algorithm is proposed for fast and reliable quantification of nine intra-retinal boundaries in optical coherence tomography (OCT) images. The algorithm employs a two-step segmentation schema based on gradient information in dual scales, utilizing local and complementary global gradient information simultaneously. A shortest path search is applied to optimize the edge selection. The segmentation algorithm was validated with independent manual segmentation and a reproducibility study. It demonstrates high accuracy and reproducibility in segmenting normal 3D OCT volumes. The execution time is about 16 seconds per volume (480x512x128 voxels). The algorithm shows potential for quantifying images from ...
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    21. Evaluation of optic nerve head configurations of superior segmental optic hypoplasia by spectral-domain optical coherence tomography

      Evaluation of optic nerve head configurations of superior segmental optic hypoplasia by spectral-domain optical coherence tomography
      Aims To characterise the optic nerve head (ONH) configurations of superior segmental optic hypoplasia (SSOH) using a spectral-domain optical coherence tomography (SD-OCT). Methods Horizontal cross-sectional images of the ONH were obtained by a SD-OCT in 20 eyes of 14 patients with clinically typical SSOH and 20 age- and refraction-matched normal eyes. Results Extension of retinal pigment epithelium (RPE) over the disc margin was observed in 20 eyes (100%) with SSOH and eight (40%) control eyes (p<0.001). The maximum length of the overhanging RPE measured at the nasal disc margin was significantly longer in eyes with SSOH than in ...
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    22. Cross-sectional Anatomic Configurations of Peripapillary Atrophy Evaluated with Spectral Domain-Optical Coherence Tomography

      Purpose. To evaluate the cross-sectional configurations of peripapillary atrophy (PPA)- and -β in ophthalmologically normal subjects using spectral domain-optical coherence tomography (SD-OCT). Methods. One hundred twenty normal subjects had a complete ophthalmic examination including axial length measurement, standard automated perimetry, fundus imaging with photography, and SD-OCT (3D OCT-1000; Topcon Inc., Tokyo, Japan). PPA- and -β were identified in color photographs of the optic disc. Cross-sectional B-mode images of the peripapillary retina and sclera, including PPA- and -β obtained with SD-OCT, were analyzed. Results. Of 120 normal eyes, 120 (100%) had PPA- and 90 (75%) had PPA-β. In OCT images of ...
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    23. Three-dimensional Profile of Macular Retinal Thickness in Normal Japanese Eyes

      Purpose: To demonstrate the 3-dimensional macular thickness distribution in normal subjects by spectral domain optical coherence tomography (SD-OCT) and evaluate its association with sex, age, and axial length. Methods: Mean regional retinal thickness measurements on the Early Treatment Diabetic Retinopathy Study (ETDRS) layout were obtained by 3-dimensional raster scanning (6 X 6 mm) using SD-OCT in 248 normal eyes of 248 Japanese subjects. Results: Mean foveal thickness was 222 ± 19 µm; it was significantly greater in men (226 ± 19 µm) than in women (218 ± 18 µm; P = 0.002) and did not correlate with age in either sex. Mean sectorial ...
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    1-23 of 23
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    1. (21 articles) Makoto Araie
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    Evaluation of optic nerve head configurations of superior segmental optic hypoplasia by spectral-domain optical coherence tomography Automated layer segmentation of macular OCT images using dual-scale gradient information Peripapillary Retinal Nerve Fiber Layer Thickness Determined by Spectral-Domain Optical Coherence Tomography in Ophthalmologically Normal Eyes Identification of Schlemm's Canal and Its Surrounding Tissues by Anterior Segment Fourier Domain Optical Coherence Tomography Variation in Optic Nerve and Macular Structure with Age and Race with Spectral-Domain Optical Coherence Tomography Effects of Age, Sex, and Axial Length on the Three-Dimensional Profile of Normal Macular Layer Structures Spectral-Domain Optical Coherence Tomography of β-zone Peripapillary Atrophy: Influence of Myopia and Glaucoma Test–retest variability in structural parameters measured with glaucoma imaging devices Correlation between optical coherence tomography, multifocal electroretinogram findings and visual acuity in diabetic macular edema Ciliary body length revisited by anterior segment optical coherence tomography: implications for safe access to the pars plana for intravitreal injections Evaluation of retinal vascular structure after epiretinal membrane surgery by optical coherence tomography angiography Bivalirudin vs. Heparin on Radial Artery Thrombosis during Transradial Coronary Intervention: An Optical Coherence Tomography Study