1. Articles from Motohiro Shirakashi

    1-3 of 3
    1. Effects of Age, Sex, and Axial Length on the Three-Dimensional Profile of Normal Macular Layer Structures

      Effects of Age, Sex, and Axial Length on the Three-Dimensional Profile of Normal Macular Layer Structures
      Purpose. To identify sex-related differences and age-related changes in individual retinal layer thicknesses in a population of healthy eyes across the lifespan, using spectral domain optical coherence tomography (SD-OCT). Methods. In seven institutes in Japan, mean thicknesses of the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), photoreceptor inner segment (IS), and photoreceptor outer segment (OS) were measured using SD-OCT with a new automated segmentation protocol in 256 healthy subjects. Results. Interoperator coefficients of variability for measurements of each layer ranged from 0 ...
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    2. Peripapillary Retinal Nerve Fiber Layer Thickness Determined by Spectral-Domain Optical Coherence Tomography in Ophthalmologically Normal Eyes

      Peripapillary Retinal Nerve Fiber Layer Thickness Determined by Spectral-Domain Optical Coherence Tomography in Ophthalmologically Normal Eyes
      Objectives  To evaluate the peripapillary distribution of retinal nerve fiber layer thickness (RNFLT) in normal eyes using spectral-domain optical coherence tomography and to study potentially related factors. Methods  In 7 institutes in Japan, RNFLT in 7 concentric peripapillary circles with diameters ranging from 2.2 to 4.0 mm were measured using spectral-domain optical coherence tomography in 251 ophthalmologically normal subjects. Multiple regression analysis for the association of RNFLT with sex, age, axial length, and disc area was performed. Results  Retinal nerve fiber layer thickness decreased linearly from 125 to 89 µm as the measurement diameter increased (P < .001, mixed linear model). Retinal nerve fiber layer thickness correlated with age in all diameters (partial correlation coefficient [PCC] = –0.40 to –0.32; P < .001) and negatively correlated with disc area in the 2 innermost circles but positively correlated in the 3 outermost circles (PCC = –0.30 to –0.22 and 0.17 to 0.20; P ≤ .005). Sex and axial length did not correlate with RNFLT (P > .08). The ...
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    3. Three-dimensional Profile of Macular Retinal Thickness in Normal Japanese Eyes

      Purpose: To demonstrate the 3-dimensional macular thickness distribution in normal subjects by spectral domain optical coherence tomography (SD-OCT) and evaluate its association with sex, age, and axial length. Methods: Mean regional retinal thickness measurements on the Early Treatment Diabetic Retinopathy Study (ETDRS) layout were obtained by 3-dimensional raster scanning (6 X 6 mm) using SD-OCT in 248 normal eyes of 248 Japanese subjects. Results: Mean foveal thickness was 222 ± 19 µm; it was significantly greater in men (226 ± 19 µm) than in women (218 ± 18 µm; P = 0.002) and did not correlate with age in either sex. Mean sectorial ...
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    1-3 of 3
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  2. Topics in the News

    1. (3 articles) Osaka University
    2. (3 articles) Kyoto University Graduate School of Medicine
    3. (3 articles) Hitomi Saito
    4. (3 articles) Nagahisa Yoshimura
    5. (3 articles) Masanori Hangai
    6. (3 articles) Makoto Araie
    7. (3 articles) Atsuo Tomidokoro
    8. (3 articles) Aiko Iwase
    9. (2 articles) Gunma University
    10. (2 articles) Sotaro Ooto
    11. (1 articles) Academic Medical Center at the University of Amsterdam
    12. (1 articles) Jichi Medical University
    13. (1 articles) University of Milan
    14. (1 articles) Bern University Hospital
    15. (1 articles) Capital Medical University
    16. (1 articles) Nanjing University of Science and Technology
    17. (1 articles) Martin S. Zinkernagel
    18. (1 articles) Junya Ako
    19. (1 articles) Frank D. Verbraak
    20. (1 articles) Giovanni Staurenghi
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