1. Articles from christian k. brinkmann

    1-5 of 5
    1. ORCA study: real-world versus reading centre assessment of disease activity of neovascular age-related macular degeneration (nAMD)

      ORCA study: real-world versus reading centre assessment of disease activity of neovascular age-related macular degeneration (nAMD)

      Background/aims The prospective, non-interventional ORCA module of the OCEAN study (Observation of Treatment Patterns with Lucentis in Approved Indications) evaluated the qualiy of spectral domain-optical coherence tomography (SD-OCT) image interpretation and treatment decisions by clinicians in Germany and the impact on visual outcomes over 24 months in patients with neovascular age-related macular degeneration (nAMD). Methods 2286 SD-OCT scans of 205 eyes were independently evaluated by clinicians and reading centres (RCs) regarding signs of choroidal neovascularisation (CNV) activity, including presence of intraretinal fluid, subretinal fluid, and/or increase in pigment epithelial detachments. Agreement between clinicians and RCs was calculated. Treatment ...

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    2. Imaging Geographic Atrophy in Age-Related Macular Degeneration

      Imaging Geographic Atrophy in Age-Related Macular Degeneration
      Advances in retinal imaging technology have largely contributed to the understanding of the natural history, prognostic markers and disease mechanisms of geographic atrophy (GA) due to age-related macular degeneration. There is still no therapy available to halt or slow the disease process. In order to evaluate potential therapeutic effects in interventional trials, there is a need for precise quantification of the GA progression rate. Fundus autofluorescence imaging allows for accurate identification and segmentation of atrophic areas and currently represents the gold standard for evaluating progressive GA enlargement. By means of high-resolution spectral-domain optical coherence tomography, distinct microstructural alterations related to ...
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    3. Tracking Progression with Spectral-Domain Optical Coherence Tomography in Geographic Atrophy Caused by Age-Related Macular Degeneration

      Tracking Progression with Spectral-Domain Optical Coherence Tomography in Geographic Atrophy Caused by Age-Related Macular Degeneration
      Purpose. To investigate, with the use of spectral-domain optical coherence tomography (SD-OCT), microstructural alterations over time in eyes with progressive geographic atrophy (GA) due to age-related macular degeneration. Methods. Forty-six eyes of 26 patients (median age, 77.9 years [interquartile range (IQR), 71.8–81.0]) with GA without evidence of active or previous neovascular disease at baseline were examined by simultaneous confocal scanning laser ophthalmoscopy (cSLO) and SD-OCT. Serial examinations with alignment of follow-up to baseline scans were performed over a median period of 12.2 months (IQR, 10.2–15.3). Longitudinal SD-OCT variations were evaluated, including quantification ...
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    4. Combined Confocal Scanning Laser Ophthalmoscopy and Spectral-Domain Optical Coherence Tomography Imaging of Reticular Drusen Associated with Age-Related Macular Degeneration

      Purpose: To determine microstructural retinal alterations associated with reticular drusen in patients with age-related macular degeneration (AMD) using high-resolution in vivo imaging techniques.Design: Retrospective case series.Participants: A total of 116 eyes of 78 AMD patients with reticular drusen were examined.Methods: Simultaneous spectral-domain optical coherence tomography (SD OCT; 870 nm, 40 000 A-scans/sec) and near-infrared confocal scanning laser ophthalmoscopy (cSLO; 830 nm) were performed using a combined imaging instrument (Spectralis HRA+OCT, Heidelberg Engineering, Heidelberg, Germany). Individual anatomic layers in SD OCT were evaluated and correlated to en face cSLO fundus imaging.Main Outcome Measures: Description of ...
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    5. Morphologic Changes in Patients with Geographic Atrophy Assessed with a Novel Spectral OCT-SLO Combination

      purpose. To investigate the appearance of geographic atrophy in high-resolution optical coherence tomography (OCT) images, the fundus autofluorescence (FAF) pattern, and infrared images simultaneously recorded with a novel combined OCT-scanning laser ophthalmology (SLO) system. methods. Patients aged over 50 years with geographic atrophy secondary to dry age-related macular degeneration (ARMD) were assessed in a prospective cross-sectional study by means of simultaneous spectral OCT-SLO (Spectralis HRA+OCT; Heidelberg Engineering, Heidelberg, Germany). The integrity of the retinal layers was analyzed in the apparently normal areas, the junctional zone between the normal retina and the geographic atrophy, and the atrophic area. The presence ...

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    1-5 of 5
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    1. (3 articles) University of Bonn
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    Tracking Progression with Spectral-Domain Optical Coherence Tomography in Geographic Atrophy Caused by Age-Related Macular Degeneration Imaging Geographic Atrophy in Age-Related Macular Degeneration ORCA study: real-world versus reading centre assessment of disease activity of neovascular age-related macular degeneration (nAMD) Optical Coherence Tomography of the Middle Ear Using Ossiview Role of Optical Coherence Tomography Angiography Imaging in Patients with Diabetes Vitreomacular Traction Surgery from the DISCOVER Study: Intraoperative OCT Utility, Ellipsoid Zone Dynamics, and Outcomes Investigation of Micro-motion Kinematics of Continuum Robots for Volumetric OCT and OCT-guided Visual Servoing Association of Myopia With Microvascular Alterations in Patients With Type 2 Diabetes: An Optical Coherence Tomography Angiography Study Accuracy of Total Corneal Power Calculation for Multifocal Toric Intraocular Lens Implantation: Swept-Source OCT-Based Biometer vs Scheimpflug Tomographer Evaluation of optical coherence tomography findings in adolescents with genetic generalized epilepsy New Method for Reducing Artifactual Flow Deficits Caused by Compensation Techniques in the Choriocapillaris with Optical Coherence Tomography Angiography Topographic Variation of Retinal Vascular Density in Normal Eyes Using Optical Coherence Tomography Angiography