1. Articles from sandra liakopoulos

    1-13 of 13
    1. Atypical Outer Retinal Fluid Accumulation in Choroidal Neovascularization: A Novel OCT Finding

      Atypical Outer Retinal Fluid Accumulation in Choroidal Neovascularization: A Novel OCT Finding

      BACKGROUND AND OBJECTIVE: To report a novel optical coherence tomography (OCT) finding in choroidal neovascularization (CNV). PATIENTS AND METHODS: The authors identified seven eyes with CNV demonstrating the atypical pattern of fluid accumulation within the outer retina on OCT. Patient demographics, best corrected visual acuity and spectral-domain OCT (SD-OCT) images were collected for all available follow-up visits. Volume and area of the fluid were measured on SD-OCT. Microperimetry was performed in one case. RESULTS: The outer retinal fluid was located between the external limiting membrane (ELM) and the outer photoreceptor band on SD-OCT. Within this area, the outer segments of ...

      Read Full Article
    2. Response to anti-VEGF therapy in patients with subretinal fluid and pigment epithelial detachment on spectral-domain optical coherence tomography

      Response to anti-VEGF therapy in patients with subretinal fluid and pigment epithelial detachment on spectral-domain optical coherence tomography

      Purpose To analyse the long-term functional and morphological response of a specific choroidal neovascular membrane (CNV) phenotype to anti-vascular endothelial growth factor (VEGF) therapy. Methods Data from 30 eyes of 30 consecutive patients with subretinal fluid (SRF) and fibrovascular pigment epithelial detachment (PED) due to CNV on spectral-domain optical coherence tomography (SDOCT) with a follow-up of at least 20 months were retrospectively collected. Main outcome measures included change in visual acuity, quantitative and qualitative parameters on SDOCT [photoreceptor layer, outer nuclear layer (ONL), choroid, PED, SRF] and on fluorescein angiography (CNV activity). Subjects were divided into responders and non-responders based ...

      Read Full Article
    3. SD-OCT Thickness Measurements of Various Retinal Layers in Patients with Autosomal Dominant Optic Atrophy due to OPA1 Mutations

      SD-OCT Thickness Measurements of Various Retinal Layers in Patients with Autosomal Dominant Optic Atrophy due to OPA1 Mutations

      Purpose. To specify thickness values of various retinal layers onmacular spectral domainOptical Coherence Tomography (SDOCT) scans in patients with autosomal dominant optic atrophy (ADOA) compared to healthy controls. Methods. SDOCT volume scans of 7 patients with ADOA (OPA-1 mutation) and 14 healthy controls were quantitatively analyzed using manual grading software. Mean thickness values for the ETDRS grid subfields 5–8 were calculated for the spaces neurosensory retina, retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), a combined space of inner plexiform layer/outer plexiform layer/inner nuclear layer (IPL+INL+OPL), and a combined space of outer nuclear ...

      Read Full Article
    4. Grading of Age-Related Macular Degeneration: Comparison between Color Fundus Photography, Fluorescein Angiography, and Spectral Domain Optical Coherence Tomography

      Grading of Age-Related Macular Degeneration: Comparison between Color Fundus Photography, Fluorescein Angiography, and Spectral Domain Optical Coherence Tomography

      Purpose. To compare color fundus photography (FP), fluorescein angiography (FA), and spectral domain optical coherence tomography (SDOCT) for the detection of age-related macular degeneration (AMD), choroidal neovascularisation (CNV), and CNV activity. Methods. FPs, FAs, and SDOCT volume scans from 120 eyes of 66 AMD and control patients were randomly collected. Control eyes were required to show no AMD, but other retinal pathology was allowed. The presence of drusen, pigmentary changes, CNV, and signs for CNV activity was independently analyzed for all imaging modalities. Results. AMD was diagnosed based on FP in 75 eyes. SDOCT and FA showed sensitivity (specificity) of ...

      Read Full Article
    5. Evaluation of Age-related Macular Degeneration With Optical Coherence Tomography

      Evaluation of Age-related Macular Degeneration With Optical Coherence Tomography

      Abstract: Age-related macular degeneration (AMD) is the leading cause of severe visual loss in people aged 50 years or older in the developed world. In recent years, major advances have been made in the treatment of AMD, with the introduction of anti-angiogenic agents, offering the first hope of significant visual recovery for patients with neovascular AMD. In line with these advances, a new imaging modality—optical coherence tomography (OCT)—has emerged as an essential adjunct for the diagnosis and monitoring of patients with AMD. The ability to accurately interpret OCT images is thus a prerequisite for both retina specialists and ...

      Read Full Article
    6. Relationship between angiographic and optical coherence tomographic (OCT) parameters for quantifying choroidal neovascular lesions

      Background To correlate the volume of various spaces on optical coherence tomography (OCT) with fluorescein angiographic (FA) parameters in neovascular age-related macular degeneration (AMD). Methods Sixty-five consecutive cases of active subfoveal choroidal neovascularization (CNV) associated with AMD were retrospectively collected. Area and greatest linear dimension of CNV lesion components were calculated on FA. Corresponding StratusOCT image sets were analyzed using custom software (termed OCTOR), which allows manual measurement of the volume of the neurosensory retina, subretinal fluid, subretinal tissue, and pigment epithelial detachment (PED). Results Area of occult CNV on FA correlated with PED (R = 0.62) and subretinal fluid ...

      Read Full Article
    7. Accuracy of Retinal Thickness Measurements obtained with Cirrus Optical Coherence Tomography

      Aim: To report the frequency and severity of retinal thickness measurement errors in a Fourier domain optical coherence tomography (FDOCT) device, Cirrus OCT. Methods: Data from 209 eyes undergoing Cirrus OCT imaging with the Macular Cube protocol were collected. For each eye, the position of the automated retinal boundary lines used by the Cirrus OCT software for thickness calculations was assessed using a 6-point categorical scale. The presence of errors was correlated with various parameters including: retinal morphologic features and disease diagnosis. Results: Errors of retinal boundary detection were observed in 57.5% of eyes, but were severe in only ...

      Read Full Article
    8. Comparison of Clinically Relevant Findings from High-Speed Fourier-Domain and Conventional Time-Domain Optical Coherence Tomography

      Purpose To compare the sensitivities of high-speed Fourier-domain optical coherence tomography (FD-OCT) and conventional time-domain (TD) OCT for the detection of clinical findings important in the management of common vitreoretinal disorders. Design Prospective, observational study. Methods FD-OCT scans (128 B scans × 512 A scans) were obtained using a prototype instrument (3 D-OCT; Topcon, Tokyo, Japan) in 50 eyes of 28 consecutive patients undergoing conventional high-resolution (6 B scans × 512 A scans) TD-OCT imaging (Stratus OCT; Carl Zeiss Meditec, Dublin, California, USA). Each image set was reviewed independently for the presence of clinical findings of interest, and device sensitivities were calculated ...

      Read Full Article
    9. Evaluation of Optical Coherence Tomography Central Retinal Thickness Parameters for use as Anatomic Outcomes in Clinical Trials for Neovascular Age-Related Macular Degeneration

      Purpose: To investigate the relationship between automated and manually-derived measurements of central retinal thickness from optical coherence tomography (OCT), and to determine the relationship between foveal center point (FCP) and foveal central subfield (FCS), in neovascular age-related macular degeneration (AMD). Methods: Data from 216 patients newly diagnosed with neovascular AMD, who underwent StratusOCT imaging at diagnosis, were collected. Raw StratusOCT images for each patient were analyzed using publicly available custom software entitled "OCTOR", which allows accurate manual grading of OCT B-scans. Manually-derived central retinal thickness measurements were compared to measurements obtained from automated StratusOCT analysis. Manually obtained measurements of FCP ...

      Read Full Article
    10. Quantitative Optical Coherence Tomography Findings in Various Subtypes of Neovascular Age-Related Macular Degeneration

      PURPOSE. To compare the volume of various spaces visible on optical coherence tomography (OCT) images in different angiographic lesion subtypes of neovascular age-related macular degeneration (AMD). METHODS. Sixty-six cases of previously untreated, active subfoveal choroidal neovascularization (CNV) associated with AMD were retrospectively collected. CNV lesions were classified as occult with no classic CNV, minimally classic CNV, predominantly classic CNV, or CNV lesions with associated retinal angiomatous proliferation (RAP). Corresponding OCT image sets were analyzed by trained graders using previously validated custom software that allows manual placement of boundaries on OCT B-scans. Spaces delineated by these boundaries included the neurosensory retina ...
      Read Full Article
    11. Relationship Between Optical Coherence Tomography Retinal Parameters and Visual Acuity in Neovascular Age-Related Macular Degeneration

      Purpose To investigate the relationship between optical coherence tomography (OCT)-derived measurements of retinal morphology and visual acuity in patients with neovascular age-related macular degeneration (AMD). Design Retrospective cross-sectional study. Participants A total of 216 consecutive patients (216 eyes) newly diagnosed with neovascular AMD who underwent StratusOCT imaging at the time of diagnosis. Methods Best-corrected Snellen visual acuity was recorded for each patient. Raw exported StratusOCT images for each patient were analyzed using publicly available custom software entitled “OCTOR,” which allows the precise positioning of prespecified boundaries on individual B-scans. Thickness and volume were calculated for morphologic parameters of interest ...

      Read Full Article
    12. Comparison of the Optical Coherence Tomographic Features of Choroidal Neovascular Membranes in Pathologic Myopia versus Age-Related Macular Degeneration, using Quantitative Subanalysis

      Aim: To compare the retinal morphologic characteristics of eyes with choroidal neovascularization (CNV) secondary to pathologic myopia versus eyes with CNV secondary to age-related macular degeneration (AMD), using quantitative optical coherence tomography (OCT) subanalysis.Methods: Twenty-one eyes of 21 patients newly diagnosed with CNV secondary to pathologic myopia, and 43 consecutive cases of eyes with newly diagnosed subfoveal CNV secondary to AMD were retrospectively collected. In all patients, StratusOCT images and fluorescein angiograms (FA) were available for analysis. StratusOCT images were analyzed using custom software (termed "OCTOR"), which allowed calculation of the thickness/volume of the neurosensory retina, subretinal fluid ...

      Read Full Article
    13. Quantitative Subanalysis of Optical Coherence Tomography after Treatment with Ranibizumab for Neovascular Age-Related Macular Degeneration

      PURPOSE. To investigate the effects of ranibizumab on retinal morphology in patients with neovascular age-related macular degeneration (AMD) using optical coherence tomography (OCT) quantitative subanalysis. METHODS. Data from 95 patients receiving intravitreal ranibizumab for neovascular AMD were collected. StratusOCT images were analyzed using custom software that allows precise positioning of prespecified boundaries on every B-scan. Changes in thickness/volume of the retina, subretinal fluid (SRF), subretinal tissue (SRT), and pigment epithelial detachments (PEDs) at week 1 and at months 1, 3, 6, and 9 after treatment were calculated. RESULTS. Total retinal volume reached its nadir at month 1, with an ...

      Read Full Article
    1-13 of 13
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics in the News

    1. (13 articles) Sandra Liakopoulos
    2. (12 articles) University of Southern California
    3. (11 articles) University of Cologne
    4. (11 articles) Srinivas R. Sadda
    5. (10 articles) Pearse A. Keane
    6. (9 articles) Alexander C. Walsh
    7. (4 articles) Carl Zeiss Meditec
    8. (3 articles) University College London
    9. (3 articles) Florian M. Heussen
    10. (1 articles) David Geffen School of Medicine
    11. (1 articles) Yonsei University
    12. (1 articles) LuEsther T. Mertz Retinal Research Center
    13. (1 articles) Thomas Jefferson University
    14. (1 articles) Università Vita-Salute San Raffaele
    15. (1 articles) University of Coimbra
    16. (1 articles) Florida International University
    17. (1 articles) Ki Hean Kim
    18. (1 articles) Carol L. Shields
    19. (1 articles) K. Bailey Freund
    20. (1 articles) Frank D. Verbraak
  3. Popular Articles

  4. Picture Gallery

    Evaluation of Age-related Macular Degeneration With Optical Coherence Tomography Response to anti-VEGF therapy in patients with subretinal fluid and pigment epithelial detachment on spectral-domain optical coherence tomography Human versus Machine: Comparing a Deep Learning Algorithm to Human Gradings for Detecting Glaucoma on Fundus Photographs Absolute linear-in-k spectrometer designs enabled by freeform optics Association of retinal biomarkers and choroidal vascularity index on optical coherence tomography using binarization method in retinitis pigmentosa Skin Imaging using Ultrasound Imaging, Optical Coherence Tomography, Confocal Microscopy, and Two-Photon Microscopy in Cutaneous Oncology Deep learning-based automated detection of retinal diseases using optical coherence tomography images Evaluation of the effects of selective laser trabeculoplasty on anterior segment parameters by anterior segment optical coherence tomography An optical coherence tomography-based grading of diabetic maculopathy proposed by an international expert panel: The European School for Advanced Studies in Ophthalmology classification Microscope-Integrated Optical Coherence Tomography-guided Drainage of Acute Corneal Hydrops in Keratoconus Combined with Suturing and Gas-aided Reattachment of Descemet Membrane” Semiautomated optical coherence tomography-guided robotic surgery for porcine lens removal The Use of Optical Coherence Tomography and Convolutional Neural Networks to Distinguish Normal and Abnormal Oral Mucosa