1. Articles from florian m. heussen

    1-24 of 24
    1. Retinal vessel diameter changes in different severities of diabetic retinopathy by SD-OCT

      Retinal vessel diameter changes in different severities of diabetic retinopathy by SD-OCT

      To evaluate retinal vessel diameters in relation to different severity grades of diabetic retinopathy (DR) using spectral-domain optical coherence tomography (SD-OCT). Patients with varying degrees of nonproliferative DR (NPDR) underwent circular OCT scans centered on the optic nerve head using a SD-OCT. These cases were retrospectively reviewed. The presence and severity of DR was assessed using Early Treatment Diabetic Retinopathy Study protocols. The 5 largest retinal arterioles and venules were labeled and measured on OCT scans for each patient according to previously published methods. Vertical vessel inner contour diameter, vertical vessel outer contour diameter, and reflectance shadowing width were among ...

      Read Full Article
    2. Subretinal fluid in eyes with active ocular toxoplasmosis observed using spectral domain optical coherence tomography

      Subretinal fluid in eyes with active ocular toxoplasmosis observed using spectral domain optical coherence tomography

      Purpose To describe the clinical finding of subretinal fluid (SRF) in the posterior pole by spectral domain optical coherence tomography (SD-OCT) in eyes with active ocular toxoplasmosis (OT). Design Retrospective case series. Participants Thirty-eight eyes from 39 patients with active OT. Methods Eyes with active OT which underwent SD-OCT were reviewed. SRFs in the posterior pole were further analyzed. Main Outcome Measures Presence of SRF; its accompanying features, e.g. retinal necrosis, cystoid macular edema (CME), choroidal neovascularization (CNV); and longitudinal changes of SRF, including maximum height and total volume before and after treatment. Results SRF presented in 45.5 ...

      Read Full Article
    3. Retinal vessel diameter measurements by spectral domain optical coherence tomography

      Retinal vessel diameter measurements by spectral domain optical coherence tomography

      Purpose To describe a spectral domain optical coherence (OCT)-assisted method of measuring retinal vessel diameters. Methods All Patients with an OCT circle scan centered at the optic nerve head using a Spectralis OCT (Heidelberg Engineering, Heidelberg, Germany) were retrospectively reviewed. Individual retinal vessels were identified on infrared reflectance (IR) images and given unique labels both on IR and spectral domain OCT (SD-OCT). Vessel width and vessel types obtained by IR were documented as ground truth. From OCT, measurements of each vessel, including horizontal vessel contour diameter, vertical vessel contour diameter, horizontal hyperreflective core diameter, and reflectance shadowing width, were ...

      Read Full Article
    4. An easy method to differentiate retinal arteries from veins by spectral domain optical coherence tomography: retrospective, observational case series

      An easy method to differentiate retinal arteries from veins by spectral domain optical coherence tomography: retrospective, observational case series

      Background Recently it was shown that retinal vessel diameters could be measured using spectral domain optical coherence tomography (OCT). It has also been suggested that retinal vessels manifest different features on spectral domain OCT (SD-OCT) depending on whether they are arteries or veins. Our study was aimed to present a reliable SD-OCT assisted method of differentiating retinal arteries from veins. Methods Patients who underwent circular OCT scans centred at the optic disc using a Spectralis OCT (Heidelberg Engineering, Heidelberg, Germany) were retrospectively reviewed. Individual retinal vessels were identified on infrared reflectance (IR) images and given unique labels for subsequent grading ...

      Read Full Article
    5. Evaluation of cystoid change phenotypes in ocular toxoplasmosis using optical coherence tomography

      Evaluation of cystoid change phenotypes in ocular toxoplasmosis using optical coherence tomography

      Purpose To present unique cystoid changes occurring in patients with ocular toxoplasmosis observed in spectral domain optical coherence tomography (OCT). Methods Forty-six patients (80 eyes) with a diagnosis of ocular toxoplasmosis, who underwent volume OCT examination between January 2005 and October 2012, were retrospectively collected. Review of clinical examination findings, fundus photographs, fluorescein angiograms (FA) and OCT image sets obtained at initial visits and follow-up. Qualitative and quantitative analyses of cystoid space phenotypes visualized using OCT. Results Of the 80 eyes included, 17 eyes (15 patients) demonstrated cystoid changes in the macula on OCT. Six eyes (7.5%) had cystoid ...

      Read Full Article
    6. Optical Coherence Tomographic Correlates of Angiographic Subtypes of Occult Choroidal Neovascularization

      Optical Coherence Tomographic Correlates of Angiographic Subtypes of Occult Choroidal Neovascularization

      Purpose: To compare the optical coherence tomographic (OCT) correlates of two previously described angiographic subtypes of occult choroidal neovascularization (CNV). Methods: We retrospectively analyzed 17 consecutive patients with previously untreated occult CNV who had both fluorescein angiography (FA) and volume spectral domain (SD) OCT images obtained on the same visit. Planimetric grading was performed on the FA images by certified reading center graders to precisely outline the boundaries of the fibrovascular pigment epithelial detachment (FVPED) and/or late leakage of undetermined source (LLUS) components of occult CNV for each case. In the SDOCT images, the inner retinal pigment epithelial (RPE ...

      Read Full Article
    7. Drusen Measurements Comparison By Fundus Photograph Manual Delineation Versus Optical Coherence Tomography Retinal Pigment Epithelial Segmentation Automated Analysis

      Drusen Measurements Comparison By Fundus Photograph Manual Delineation Versus Optical Coherence Tomography Retinal Pigment Epithelial Segmentation Automated Analysis

      Purpose: To compare drusen measurements obtained from color fundus and infrared retromode photographs with those derived from spectral-domain optical coherence tomography. Methods: Drusen lesions identified on the planar (color and infrared) imaging modalities were manually segmented by two independent graders using previously described reading center software to produce quantitative measurements of drusen area and number. The corresponding volume Cirrus OCT datasets were analyzed using commercial retinal pigment epithelium analysis algorithms to segment the retinal pigment epithelium band and estimated the drusen area. Drusen numbers were extracted from retinal pigment epithelium elevation maps. Intraclass correlation coefficients assessed agreement between graders; graders ...

      Read Full Article
    8. The Retinal Disease Screening Study: Retrospective Comparison of Nonmydriatic Fundus Photography and Three-Dimensional Optical Coherence Tomography for Detection of Retinal Irregularities

      The Retinal Disease Screening Study: Retrospective Comparison of Nonmydriatic Fundus Photography and Three-Dimensional Optical Coherence Tomography for Detection of Retinal Irregularities

      Purpose. To determine the sensitivity of three-dimensional optical coherence tomography (3D-OCT) versus single field nonmydriatic fundus photography (FP) for detection of a variety of retinal abnormalities. Methods. Images from consecutive patients in a retina clinic undergoing simultaneous 3D-OCT (512×128) and single, foveal nonmydriatic 45° color fundus imaging with 3D-OCT-1000 in a 4 month-period were retrospectively collected. Findings from each modality were graded independently by two graders as present, questionable, or absent. Irregularities were separated into three categories for intermodality comparisons: epiretinal, retinal/subretinal, and RPE/choroidal irregularities. The approximate location of findings in relation to the 3D-OCT field was ...

      Read Full Article
    9. Comparison of Non-Mydriatic Fundus Photography and Three Dimensional Optical Coherence Tomography for Detection of Retinal Irregularities

      Comparison of Non-Mydriatic Fundus Photography and Three Dimensional Optical Coherence Tomography for Detection of Retinal Irregularities

      Purpose:To determine the sensitivity of detection for retinal abnormalities using 3D-OCT versus single field fundus imaging. Methods:Images from consecutive patients in a retina clinic undergoing simultaneous 3D-OCT (512x128) and single, foveal non-mydriatic 45 degree color fundus imaging with 3D-OCT-1000 (Topcon Corp, Tokyo, Japan) in a 4 months period were retrospectively collected. Findings for each modality were graded independently by two graders as present, questionable or absent. Findings were separated into 3 categories for intermodality comparisons: epiretinal, retinal/subretinal, and RPE/choroidal. The approximate location of findings in relation to the 3D-OCT field was noted as infield and out ...

      Read Full Article
    10. Different phenotypes of the appearance of the outer plexiform layer on optical coherence tomography

      Different phenotypes of the appearance of the outer plexiform layer on optical coherence tomography

      Purpose To present a selected case series of different phenotypes of the normal outer plexiform layer (OPL) visualized by optical coherence tomography (OCT). Methods Five cases were selected to represent the spectrum of appearances of the OPL in this case series. Categorical descriptions of each manifestation were then developed. Additional SD-OCT scans were obtained from a normal volunteer to further support the hypothesis. Results The inner one-third of the OPL typically appears hyperreflective on OCT, while the outer two-thirds (Henle fiber layer) may have a more varied appearance. Six different phenotypes of Henle fiber layer reflectivity were noted in this ...

      Read Full Article
    11. Evaluation of the Axial Location of Cystoid Spaces in Retinal Vein Occlusion Using Optical Coherence Tomography

      Evaluation of the Axial Location of Cystoid Spaces in Retinal Vein Occlusion Using Optical Coherence Tomography

      Purpose: To analyze the axial distribution of intraretinal cystoid changes in patients with retinal vein occlusion (RVO), incorporating a new hypothesis about the optical coherence tomographic boundary between the outer nuclear layer and the outer plexiform layer. Methods: Data were collected from patients with RVO who underwent spectral domain coherence tomography imaging. For each image set, certified graders evaluated each retinal layer for cystoid macular edema, defined as hyporeflective intraretinal cystoid spaces. Subretinal fluid, if present, was also noted. Results: Forty-eight eyes were evaluated (24 branch RVO, 18 central RVO, 6 hemiretinal vein occlusion). Cystoid macular edema was present in ...

      Read Full Article
    12. The Retinal Disease Screening Study: Prospective Comparison of Nonmydriatic Fundus Photography and Optical Coherence Tomography for Detection of Retinal Irregularities

      The Retinal Disease Screening Study: Prospective Comparison of Nonmydriatic Fundus Photography and Optical Coherence Tomography for Detection of Retinal Irregularities

      Purpose. To compare the sensitivity of volume scanning with optical coherence tomography (OCT) to nonmydriatic color fundus photography (FP) for the detection of retinal irregularities in asymptomatic populations. Methods. Asymptomatic subjects without known ocular disease were recruited over a 6-month period. For each eye, two undilated 45° fundus images and four undilated volume OCT image sets covering the macula and optic nerve were obtained. Color images were evaluated for irregularities both inside and outside the area covered by OCT. OCT image sets were evaluated for internal limiting membrane irregularities, abnormal retinal thickness, hyper/hyporeflective features, and photoreceptor/retinal pigment epithelium ...

      Read Full Article
    13. The Retinal Disease Screening Study: Prospective Comparison of Non-Mydriatic FP and Optical Coherence Tomography for Detection of Retinal Irregularities

      The Retinal Disease Screening Study: Prospective Comparison of Non-Mydriatic FP and Optical Coherence Tomography for Detection of Retinal Irregularities

      Purpose:To compare the sensitivity of volume scanning with optical coherence tomography (OCT), to non-mydriatic fundus photography, for the detection of retinal abnormalities in asymptomatic populations. Methods:Asymptomatic subjects without known ocular disease recruited over a six-month period .For each eye, two undilated 45º fundus images, and four undilated volume OCT image sets covering the macula and optic nerve, were obtained. Fundus photographs were evaluated for abnormalities both inside and outside the fundal area covered by OCT. OCT image sets were evaluated for internal limiting membrane irregularities, abnormal retinal thickness, hyper/hyporeflective foci, and photoreceptor/retinal pigment epithelium irregularities. Detection ...

      Read Full Article
    14. Juxtapapillary Pigment Epithelium Detachment Observed in Asymptomatic Participants using Optical Coherence Tomograph

      Juxtapapillary Pigment Epithelium Detachment Observed in Asymptomatic Participants using Optical Coherence Tomograph

      Purpose. To use three-dimensional optical coherence tomography (3D-OCT) to assess the prevalence of juxtapapillary retinal pigment epithelial detachments (jPED) in an asymptomatic population. Methods. Asymptomatic participants (i.e. family members of patients) were prospectively recruited over a six-month period. Each subject completed a questionnaire prior to the acquisition of two undilated 45º fundus images and two undilated raster 3D-OCT scans (512x128) covering the macula and optic nerve from each eye using 3D-OCT-1000 (Topcon Co, Tokyo). Fundus images were graded for the presence of peripapillary atrophy (PPA), peripapillary pigment (PPP), drusen in the macula and drusen elsewhere; while 3D-OCT scans were ...

      Read Full Article
    15. Evaluation of Age-related Macular Degeneration With Optical Coherence Tomography

      Evaluation of Age-related Macular Degeneration With Optical Coherence Tomography

      Abstract: Age-related macular degeneration (AMD) is the leading cause of severe visual loss in people aged 50 years or older in the developed world. In recent years, major advances have been made in the treatment of AMD, with the introduction of anti-angiogenic agents, offering the first hope of significant visual recovery for patients with neovascular AMD. In line with these advances, a new imaging modality—optical coherence tomography (OCT)—has emerged as an essential adjunct for the diagnosis and monitoring of patients with AMD. The ability to accurately interpret OCT images is thus a prerequisite for both retina specialists and ...

      Read Full Article
    16. Effect Of Angle Of Incidence On Macular Thickness And Volume Measurements Obtained By Spectral-Domain Optical Coherence Tomography

      Effect Of Angle Of Incidence On Macular Thickness And Volume Measurements Obtained By Spectral-Domain Optical Coherence Tomography

      Purpose:To evaluate the effect of angle of incidence on macular thickness and volume measurements obtained by spectral-domain optical coherence tomography (SDOCT) Methods: 30 eyes from 15 healthy young subjects underwent macular cube volume scans (512 x 128 protocol) following dilation using the Cirrus SDOCT. Scans were obtained by positioning the scanning beam in the center of the dilated pupil, as well as in four eccentric positions (approximately 3 mm from the center), superior, inferior, nasal, and temporal, For creating oblique angles of incidence between the light beam and the retina. In all cases, the region scanned by the volume ...

      Read Full Article
    17. Morphometric Spectral-Domain Optical Coherence Tomography Features of Epiretinal Membrane Correlate with Visual Acuity in Patients with Uveitis

      Morphometric Spectral-Domain Optical Coherence Tomography Features of Epiretinal Membrane Correlate with Visual Acuity in Patients with Uveitis

      Purpose To identify visually significant spectral-domain optical coherence tomography (SD-OCT) features of epiretinal membranes (ERM) in patients with uveitis. Design Retrospective cohort and cross-sectional study. Methods Eighty consecutive eyes with uveitis and SD-OCT–documented ERM were included. Clinical data were collected at the time of diagnosis of ERM and at the final visit. SD-OCT images at the last visit were evaluated to identify fovea and ERM configuration and structural changes. Changes of 10% and 20% in central subfield thickness between initial and last SD-OCT were calculated and correlated with visual acuity (VA). An ERM thickness map was created using validated ...

      Read Full Article
    18. Assessment of Differential Pharmacodynamic Effects using Optical Coherence Tomography in Neovascular Age-Related Macular Degeneration

      Assessment of Differential Pharmacodynamic Effects using Optical Coherence Tomography in Neovascular Age-Related Macular Degeneration

      Purpose: To assess the differential pharmacodynamic effects of bevacizumab (Avastin), pegaptanib (Macugen), and verteporfin photodynamic therapy (PDT), using novel OCT parameters, in a recently completed phase III/IV clinical trial. Methods: Data from 122 patients participating in the Avastin (Bevacizumab) for Choroidal neovascularization (ABC) trial, were evaluated. Stratus OCT images were analyzed using custom software - changes in volume of the neurosensory retina, subretinal fluid (SRF), pigment epithelium detachment (PED), and subretinal tissue, were calculated over the 54-week trial period. Results: Reductions in retinal oedema were more than twice as great from bevacizumab than pegaptanib (-0.82 mm3 versus -0.31 ...

      Read Full Article
    19. Automated Characterization of Pigment Epithelial Detachment using Optical Coherence Tomography

      Automated Characterization of Pigment Epithelial Detachment using Optical Coherence Tomography
      Purpose: To assess the accuracy of automated classification of pigment epithelial detachments (PED) using a software algorithm applied to spectral-domain optical coherence tomography (SD-OCT) scans. Methods: Cirrus HD OCT volume scans (512 × 128 cube) were retrospectively collected from 46 eyes of 33 patients with evidence of PEDs in the setting of age-related macular degeneration (AMD, n =28) or central serous chorioretinopathy (CSCR, n=5). From these eyes, 168 PEDs were automatically detected using the Cirrus HD OCT RPE Elevation Analysis tool. Two independent, certified Doheny Image Reading Center (DIRC) OCT graders classified these PEDs into three categories: Serous, Drusenoid or ...
      Read Full Article
    20. Simple Estimation of Clinically-Relevant Lesion Volumes using Spectral Domain-Optical Coherence Tomography in Neovascular Age-Related Macular Degeneration

      Simple Estimation of Clinically-Relevant Lesion Volumes using Spectral Domain-Optical Coherence Tomography in Neovascular Age-Related Macular Degeneration

      Purpose: To evaluate simple methods of estimating the volume of clinically-relevant features in neovascular age-related macular degeneration (NVAMD) using spectral domain OCT (SD-OCT). Methods: Using a database of NVAMD cases imaged with macular cube (512 x 128) SD-OCT scans from either a Cirrus HD-OCT (Carl Zeiss Meditec, Inc., Dublin, CA) or a 3D-OCT-1000 (Topcon, Inc., Tokyo, Japan), we retrospectively selected visits where CME, SRF or a PED were evident. Patients with single visits were analyzed in the cross-sectional analysis (CSA) and those with a baseline visit and 3 or more follow-up visits in the longitudinal analysis (LA). The volume of ...

      Read Full Article
    21. Spatial Distribution of Posterior Pole Choroidal Thickness by Spectral Domain Optical Coherence Tomography

      Spatial Distribution of Posterior Pole Choroidal Thickness by Spectral Domain Optical Coherence Tomography
      Purpose: To study the spatial distribution of posterior pole choroidal thickness (CT) in healthy eyes using spectral domain optical coherence tomography (OCT). Methods: Fifty-nine eyes from 30 subjects with no retinal or choroidal disease were examined with the Cirrus HD-OCT (Carl Zeiss Meditec) using macular volume cube scanning protocols. A randomly chosen-subset also had multi-field analysis performed (volume scans centered on and surrounding the optic nerve head (ONH)). CT was manually quantified using a validated reading center tool (“3D-OCTOR”). For macular scans, mean CT was calculated for each Early Treatment Diabetic Retinopathy Study (ETDRS) subfield. Compound “posterior pole” CT maps ...
      Read Full Article
    22. Comparison of manually corrected retinal thickness measurements from multiple spectral-domain optical coherence tomography instruments

      Comparison of manually corrected retinal thickness measurements from multiple spectral-domain optical coherence tomography instruments

      Background/aims To compare retinal thickness measurements from three different spectral domain optical coherence instruments when manual segmentation is employed to standardise retinal boundary locations. Methods 40 eyes of 21 healthy subjects were scanned on the Cirrus HD-OCT, Topcon 3D-OCT-2000 and Heidelberg Spectralis-OCT. Raw data were imported into custom grading software (3D-OCTOR). Manual segmentation was performed on every data set, and retinal thickness values in the foveal central subfield were computed. Results 37 eyes of 20 subjects were gradable on every machine. The average retinal thicknesses for these eyes were 236.7 µm (SD 20.1), 235.7 µm (SD ...

      Read Full Article
    23. Comparison of the Optical Coherence Tomographic Features of Choroidal Neovascular Membranes in Pathologic Myopia versus Age-Related Macular Degeneration, using Quantitative Subanalysis

      Aim: To compare the retinal morphologic characteristics of eyes with choroidal neovascularization (CNV) secondary to pathologic myopia versus eyes with CNV secondary to age-related macular degeneration (AMD), using quantitative optical coherence tomography (OCT) subanalysis.Methods: Twenty-one eyes of 21 patients newly diagnosed with CNV secondary to pathologic myopia, and 43 consecutive cases of eyes with newly diagnosed subfoveal CNV secondary to AMD were retrospectively collected. In all patients, StratusOCT images and fluorescein angiograms (FA) were available for analysis. StratusOCT images were analyzed using custom software (termed "OCTOR"), which allowed calculation of the thickness/volume of the neurosensory retina, subretinal fluid ...

      Read Full Article
    24. Quantitative Subanalysis of Optical Coherence Tomography after Treatment with Ranibizumab for Neovascular Age-Related Macular Degeneration

      PURPOSE. To investigate the effects of ranibizumab on retinal morphology in patients with neovascular age-related macular degeneration (AMD) using optical coherence tomography (OCT) quantitative subanalysis. METHODS. Data from 95 patients receiving intravitreal ranibizumab for neovascular AMD were collected. StratusOCT images were analyzed using custom software that allows precise positioning of prespecified boundaries on every B-scan. Changes in thickness/volume of the retina, subretinal fluid (SRF), subretinal tissue (SRT), and pigment epithelial detachments (PEDs) at week 1 and at months 1, 3, 6, and 9 after treatment were calculated. RESULTS. Total retinal volume reached its nadir at month 1, with an ...

      Read Full Article
    1-24 of 24
  1. Categories

    1. Applications:

      Art, Cardiology, Dentistry, Dermatology, Developmental Biology, Gastroenterology, Gynecology, Microscopy, NDE/NDT, Neurology, Oncology, Ophthalmology, Other Non-Medical, Otolaryngology, Pulmonology, Urology
    2. Business News:

      Acquisition, Clinical Trials, Funding, Other Business News, Partnership, Patents
    3. Technology:

      Broadband Sources, Probes, Tunable Sources
    4. Miscellaneous:

      Jobs & Studentships, Student Theses, Textbooks
  2. Topics in the News

    1. (24 articles) Florian M. Heussen
    2. (20 articles) University of Southern California
    3. (20 articles) Srinivas R. Sadda
    4. (16 articles) Yanling Ouyang
    5. (14 articles) Pearse A. Keane
    6. (13 articles) Alexander C. Walsh
    7. (10 articles) University College London
    8. (8 articles) Carl Zeiss Meditec
    9. (5 articles) Topcon Medical Systems
    10. (4 articles) Heidelberg Engineering
    11. (1 articles) Medical University of Vienna
    12. (1 articles) Harvard University
    13. (1 articles) NYU Langone Medical Center
    14. (1 articles) Massachusetts General Hospital
    15. (1 articles) Tianjin University
    16. (1 articles) University of Hong Kong
    17. (1 articles) Semmelweis University
    18. (1 articles) Guillermo J. Tearney
    19. (1 articles) Arnaud Dubois
    20. (1 articles) Ursula Schmidt-Erfurth
  3. Popular Articles

  4. Picture Gallery

    Comparison of manually corrected retinal thickness measurements from multiple spectral-domain optical coherence tomography instruments Spatial Distribution of Posterior Pole Choroidal Thickness by Spectral Domain Optical Coherence Tomography Simple Estimation of Clinically-Relevant Lesion Volumes using Spectral Domain-Optical Coherence Tomography in Neovascular Age-Related Macular Degeneration Automated Characterization of Pigment Epithelial Detachment using Optical Coherence Tomography Assessment of Differential Pharmacodynamic Effects using Optical Coherence Tomography in Neovascular Age-Related Macular Degeneration Morphometric Spectral-Domain Optical Coherence Tomography Features of Epiretinal Membrane Correlate with Visual Acuity in Patients with Uveitis Effect Of Angle Of Incidence On Macular Thickness And Volume Measurements Obtained By Spectral-Domain Optical Coherence Tomography Evaluation of Age-related Macular Degeneration With Optical Coherence Tomography Selective retinex enhancement based on the clustering algorithm and block-matching 3D for optical coherence tomography images Artificial intelligence, the internet of things, and virtual clinics: ophthalmology at the digital translation forefront Detecting glaucoma based on spectral domain optical coherence tomography imaging of peripapillary retinal nerve fiber layer: a comparison study between hand-crafted features and deep learning model Comparison of line‐field confocal optical coherence tomography images with histological sections: Validation of a new method for in vivo and non‐invasive quantification of superficial dermis thickness