1. Articles from karen t. chang

    1-5 of 5
    1. Relationship between angiographic and optical coherence tomographic (OCT) parameters for quantifying choroidal neovascular lesions

      Background To correlate the volume of various spaces on optical coherence tomography (OCT) with fluorescein angiographic (FA) parameters in neovascular age-related macular degeneration (AMD). Methods Sixty-five consecutive cases of active subfoveal choroidal neovascularization (CNV) associated with AMD were retrospectively collected. Area and greatest linear dimension of CNV lesion components were calculated on FA. Corresponding StratusOCT image sets were analyzed using custom software (termed OCTOR), which allows manual measurement of the volume of the neurosensory retina, subretinal fluid, subretinal tissue, and pigment epithelial detachment (PED). Results Area of occult CNV on FA correlated with PED (R = 0.62) and subretinal fluid ...

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    2. Evaluation of Optical Coherence Tomography Central Retinal Thickness Parameters for use as Anatomic Outcomes in Clinical Trials for Neovascular Age-Related Macular Degeneration

      Purpose: To investigate the relationship between automated and manually-derived measurements of central retinal thickness from optical coherence tomography (OCT), and to determine the relationship between foveal center point (FCP) and foveal central subfield (FCS), in neovascular age-related macular degeneration (AMD). Methods: Data from 216 patients newly diagnosed with neovascular AMD, who underwent StratusOCT imaging at diagnosis, were collected. Raw StratusOCT images for each patient were analyzed using publicly available custom software entitled "OCTOR", which allows accurate manual grading of OCT B-scans. Manually-derived central retinal thickness measurements were compared to measurements obtained from automated StratusOCT analysis. Manually obtained measurements of FCP ...

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    3. Relationship Between Optical Coherence Tomography Retinal Parameters and Visual Acuity in Neovascular Age-Related Macular Degeneration

      Purpose To investigate the relationship between optical coherence tomography (OCT)-derived measurements of retinal morphology and visual acuity in patients with neovascular age-related macular degeneration (AMD). Design Retrospective cross-sectional study. Participants A total of 216 consecutive patients (216 eyes) newly diagnosed with neovascular AMD who underwent StratusOCT imaging at the time of diagnosis. Methods Best-corrected Snellen visual acuity was recorded for each patient. Raw exported StratusOCT images for each patient were analyzed using publicly available custom software entitled “OCTOR,” which allows the precise positioning of prespecified boundaries on individual B-scans. Thickness and volume were calculated for morphologic parameters of interest ...

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    4. Comparison of the Optical Coherence Tomographic Features of Choroidal Neovascular Membranes in Pathologic Myopia versus Age-Related Macular Degeneration, using Quantitative Subanalysis

      Aim: To compare the retinal morphologic characteristics of eyes with choroidal neovascularization (CNV) secondary to pathologic myopia versus eyes with CNV secondary to age-related macular degeneration (AMD), using quantitative optical coherence tomography (OCT) subanalysis.Methods: Twenty-one eyes of 21 patients newly diagnosed with CNV secondary to pathologic myopia, and 43 consecutive cases of eyes with newly diagnosed subfoveal CNV secondary to AMD were retrospectively collected. In all patients, StratusOCT images and fluorescein angiograms (FA) were available for analysis. StratusOCT images were analyzed using custom software (termed "OCTOR"), which allowed calculation of the thickness/volume of the neurosensory retina, subretinal fluid ...

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    5. Quantitative Subanalysis of Optical Coherence Tomography after Treatment with Ranibizumab for Neovascular Age-Related Macular Degeneration

      PURPOSE. To investigate the effects of ranibizumab on retinal morphology in patients with neovascular age-related macular degeneration (AMD) using optical coherence tomography (OCT) quantitative subanalysis. METHODS. Data from 95 patients receiving intravitreal ranibizumab for neovascular AMD were collected. StratusOCT images were analyzed using custom software that allows precise positioning of prespecified boundaries on every B-scan. Changes in thickness/volume of the retina, subretinal fluid (SRF), subretinal tissue (SRT), and pigment epithelial detachments (PEDs) at week 1 and at months 1, 3, 6, and 9 after treatment were calculated. RESULTS. Total retinal volume reached its nadir at month 1, with an ...

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    1-5 of 5
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