1. Articles from Keith M. Channon

    1-9 of 9
    1. The impact of blood pressure variability on coronary arterial lumen dimensions as assessed by optical coherence tomography in patients with ST-elevation myocardial infarction

      The impact of blood pressure variability on coronary arterial lumen dimensions as assessed by optical coherence tomography in patients with ST-elevation myocardial infarction

      Background Patients with ST-elevation Myocardial Infarction treated by primary percutaneous coronary intervention (PPCI) experience drastic hemodynamic systemic changes (i.e., blood pressure) during the different phases of the procedure. Optical coherence tomography is often used to unveil the underlying cause of STEMI (pre-PCI) and to optimize stent implantation (post-PCI). The impact of blood pressure variability on coronary lumen remains uncertain. This study aimed to investigate the relationship between blood pressure variability, before and after PCI, and coronary arterial lumen dimensions of the infarct-related artery. Methods We measured systolic, diastolic and mean arterial blood pressure (SBP, DBP, and MAP; respectively) at ...

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    2. Dual quantitative coronary angiography accurately quantifies intracoronary thrombotic burden in patients with acute coronary syndrome: Comparison with optical coherence tomography imaging

      Dual quantitative coronary angiography accurately quantifies intracoronary thrombotic burden in patients with acute coronary syndrome: Comparison with optical coherence tomography imaging

      Background Dual quantitative coronary angiography (QCA) has been recently tested for assessment of intracoronary thrombus volume in experimental models. The present study aimed to validate dual QCA in vivo for the assessment of thrombus burden by exploring the correlations between dual QCA-thrombus volume and optical coherence tomography (OCT)-derived indices of thrombotic burden. Methods and results Fifty-one patients with ACS and angiographic evidence of thrombus undergoing OCT of the culprit lesion before stenting were included. Dual QCA-thrombus volume was calculated as difference between edge-detection and video-densitometry area functions along the target segment. Culprit lesion was categorized using the Ambrose's ...

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    3. The influence of coronary plaque morphology assessed by optical coherence tomography on final microvascular function after stenting in patients with ST-elevation myocardial infarction

      The influence of coronary plaque morphology assessed by optical coherence tomography on final microvascular function after stenting in patients with ST-elevation myocardial infarction

      Objectives: The index of microcirculatory resistance (IMR) provides a reproducible assessment of the status of coronary microvasculature in patients with ST-elevation myocardial infarction (STEMI). Frequency-domain optical coherence tomography (FD-OCT) enables detailed assessment of the morphology of coronary plaque. We sought to determine the influence of the initial culprit coronary plaque anatomy within the infarct-related artery on IMR after stenting in STEMI. Patients and methods: In 25 STEMI patients IMR was measured immediately before and after stent implantation. FD-OCT imaging was performed at the same time points and atherothrombotic volume (ATV) before stenting, prolapsed+floating ATV after stenting and [DELTA]ATV ...

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    4. OCT imaging of aorto-coronary vein graft pathology modified by external stenting: 1-year post-surgery

      OCT imaging of aorto-coronary vein graft pathology modified by external stenting: 1-year post-surgery

      Aims The Venous External Support Trial (VEST) evaluated whether a novel external stent attenuated saphenous vein graft (SVG) disease assessed with intravascular ultrasound 1 year following coronary artery bypass graft (CABG) surgery. This sub-study assessed SVGs with and without external stenting using optical coherence tomography (OCT). The aim of this study was to accurately compare quantitative and qualitative features of SVGs with and without a novel external stent using OCT. Methods and results Twenty-four of 30 patients (65 ± 8 years) enrolled in VEST underwent coronary angiography with OCT imaging using a non-occlusive technique. Quantitative analysis of lumen area was performed ...

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    5. Treatment of recurrent vein graft “stent-in-stent” re-stenosis guided by optical coherence tomography

      Treatment of recurrent vein graft “stent-in-stent” re-stenosis guided by optical coherence tomography
      A 78year old man presented with recurrent in-stent re-stenosis of the saphenous vein graft to the right coronary artery (RCA), causing unstable angina. He received coronary artery bypass grafting (CABG) 25years previously with a left internal mammary artery (LIMA) graft to the left anterior descending artery (LAD) and a saphenous vein graft (SVG) to the RCA. Surgery provided medium term relief but progressive disease in the saphenous vein grafts led to recurrence of symptoms.
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    6. Optical Coherence Tomography-Guided Stenting of a Large Coronary Aneurysm: Images at Implantation and at 6 Months

      Optical Coherence Tomography-Guided Stenting of a Large Coronary Aneurysm: Images at Implantation and at 6 Months
      Intravascular imaging with optical coherence tomography (OCT) can produce high-resolution images (10–20 µm) of the coronary vessel wall and is being increasingly used to provide insight into coronary pathology and neointima formation following coronary stenting. Fourier domain OCT (FD-OCT) permits a greater scan diameter than time domain OCT and enables larger-caliber coronary structures to be effectively imaged. We present a case of a large, symptomatic and expanding right coronary artery aneurysm treated with FD-OCT-guided pericardial covered stenting and describe the OCT findings immediately after stent deployment and at 6 months.
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    7. Intimal Dissection Causing Late Thrombosis of a Covered Stent: Optical Coherence Tomography Appearances

      Late thrombosis is a rare but a potentially catastrophic complication of coronary stenting procedures.1 It is recognized to occur in both bare metal and drug-eluting stents2 and seems to occur at a low incidence (0.6% per year) for at least 3 years postprocedure.3 Intravascular imaging with optical coherence tomography (OCT) can provide high-resolution images (10 to 20 µm) of the coronary vessel wall and is being increasingly used to provide insight into the risks and mechanisms of late stent thrombosis (ST).4 Covered stents are occasionally used in situations where percutaneous intervention has caused coronary perforation or ...
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    1-9 of 9
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    Optical Coherence Tomography-Guided Stenting of a Large Coronary Aneurysm: Images at Implantation and at 6 Months Radial Artery Graft String Sign Due to Lumen Obliteration by Neointima: Insight From Optical Coherence Tomography OCT Characteristics of Saphenous Vein Graft Atherosclerosis Treatment of recurrent vein graft “stent-in-stent” re-stenosis guided by optical coherence tomography OCT imaging of aorto-coronary vein graft pathology modified by external stenting: 1-year post-surgery The influence of coronary plaque morphology assessed by optical coherence tomography on final microvascular function after stenting in patients with ST-elevation myocardial infarction Dual quantitative coronary angiography accurately quantifies intracoronary thrombotic burden in patients with acute coronary syndrome: Comparison with optical coherence tomography imaging The impact of blood pressure variability on coronary arterial lumen dimensions as assessed by optical coherence tomography in patients with ST-elevation myocardial infarction Medical treatment of inflammatory punctual stenosis monitored by anterior segment optical coherence tomography Development and Validation of a Deep Learning System for Diagnosing Glaucoma Using Optical Coherence Tomography Methylene blue-filled biodegradable polymer particles as a contrast agent for optical coherence tomography Optical coherence tomography for thyroid pathology: 3D analysis of tissue microstructure