1. Articles from Stephen A. Boppart

    1-24 of 152 1 2 3 4 5 6 7 »
    1. Economical and compact briefcase spectral-domain optical coherence tomography system for primary care and point-of-care applications

      Economical and compact briefcase spectral-domain optical coherence tomography system for primary care and point-of-care applications

      Development of low-cost and portable optical coherence tomography (OCT) systems is of global interest in the OCT research community. Such systems enable utility broadly throughout a clinical facility, or in remote areas that often lack clinical infrastructure. We report the development and validation of a low-cost, portable briefcase spectral-domain optical coherence tomography (SD-OCT) system for point-of-care diagnostics in primary care centers and/or in remote settings. The self-contained briefcase OCT contains all associated optical hardware, including light source, spectrometer, hand-held probe, and a laptop. Additionally, this system utilizes unique real-time mosaicking of surface video images that are synchronized with rapid ...

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    2. Intraoperative imaging of surgical margins of canine soft tissue sarcoma using optical coherence tomography

      Intraoperative imaging of surgical margins of canine soft tissue sarcoma using optical coherence tomography

      Optical coherence tomography (OCT) is a rapid non‐invasive imaging technique that has shown high sensitivity for intraoperative surgical margin assessment in human breast cancer clinical trials. This promising technology has not been evaluated in veterinary medicine. The objective of this study was to correlate normal and abnormal histological features with OCT images for surgical margins from excised canine soft tissue sarcoma (STS) and to establish image evaluation criteria for identifying positive surgical margins. Fourteen client‐owned dogs underwent surgical resection of a STS and OCT imaging of 2‐4 areas of interest on the resected specimen were performed. Following ...

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    3. Image Data Analyst, GlaxoSmithKline Center for Optical Molecular Imaging, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign

      Image Data Analyst, GlaxoSmithKline Center for Optical Molecular Imaging, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign

      Image Data Analyst GlaxoSmithKline Center for Optical Molecular Imaging Beckman Institute for Advanced Science and Technology University of Illinois at Urbana-Champaign The GlaxoSmithKline Center for Optical Molecular Imaging at the Beckman Institute for Advanced Science and Technology seeks a bright, energetic, and motivated candidate to fill a vacancy for a full-time Image Data Analyst. The purpose of this position is to lead the analysis of image data from translational optical biomedical imaging systems. The successful candidate will need a solid and broad understanding of image analysis software as well as software development including high-level user interface requirements in a Windows ...

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    4. Imaging Research Scientist, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign

      Imaging Research Scientist, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign

      The Biophotonics Imaging Laboratory and the Center for Optical Molecular Imaging at the Beckman Institute for Advanced Science and Technology seek to fill a position for a full-time Imaging Research Scientist. The purpose of this position is to develop and operate optical imaging technologies and systems, and perform and/or manage translational imaging studies involving cell lines, pre-clinical animal models, human subjects, and/or human tissue specimens. This position will work closely with research personnel and physicians, and will also interface with industry partners and collaborators at GlaxoSmithKline. Duties and Responsibilities: Innovate and develop novel optical imaging systems, including both ...

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    5. Intraoperative breast cancer margin detection via polarization-sensitive optical coherence tomography

      Intraoperative breast cancer margin detection via polarization-sensitive optical coherence tomography

      Current standard-of-care for breast conserving surgery (BCS) procedures relies on post-operative histopathology to provide a microscopic view and assessment of surgical margins. To avoid high reoperation rates there has been a great interest in developing new imaging solutions to visualize tissue intraoperatively, and provide real-time feedback on the margin status. Optical coherence tomography (OCT) is a high-resolution label-free, imaging technology that is the optical analogue to ultrasound imaging, except images are based on backscattered near-infrared light. Fundamentally, the contrast mechanism of OCT relies on the light scattering properties associated with different tissue structures. Unlike normal tissue with well-organized tissue structure ...

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    6. Magnetomotive Displacement of the Tympanic Membrane using Magnetic Nanoparticles: Toward Enhancement of Sound Perception

      Magnetomotive Displacement of the Tympanic Membrane using Magnetic Nanoparticles: Toward Enhancement of Sound Perception

      Objective: A novel hearing-aid scheme using magnetomotive nanoparticles (MNPs) as transducers in the tympanic membrane (TM) is proposed, aiming to noninvasively and directly induce a modulated vibration on the TM. Methods: In this feasibility study, iron-oxide (Fe<sub>3</sub>O<sub>4</sub>) nanoparticles were applied on ex vivo rat TM tissues and allowed to diffuse over ~2 hr. Subsequently, magnetic force was exerted on the MNP-laden TM via a programmable electromagnetic solenoid to induce the magnetomotion. Optical coherence tomography (OCT), along with its phase-sensitive measurement capabilities, was utilized to visualize and quantify the nanometer-scale vibrations generated on the ...

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    7. Wavefront measurement using computational adaptive optics

      Wavefront measurement using computational adaptive optics

      In many optical imaging applications, it is necessary to correct for aberrations to obtain high quality images. Optical coherence tomography (OCT) provides access to the amplitude and phase of the backscattered optical field for three-dimensional (3D) imaging samples. Computational adaptive optics (CAO) modifies the phase of the OCT data in the spatial frequency domain to correct optical aberrations without using a deformable mirror, as is commonly done in hardware-based adaptive optics (AO). This provides improvement of image quality throughout the 3D volume, enabling imaging across greater depth ranges and in highly aberrated samples. However, the CAO aberration correction has a ...

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    8. Label-free optical imaging technologies for rapid translation and use during intraoperative surgical and tumor margin assessment

      Label-free optical imaging technologies for rapid translation and use during intraoperative surgical and tumor margin assessment

      The biannual International Conference on Biophotonics was recently held on April 30 to May 1, 2017, in Fremantle, Western Australia. This continuing conference series brought together key opinion leaders in biophotonics to present their latest results and, importantly, to participate in discussions on the future of the field and what opportunities exist when we collectively work together for using biophotonics for biological discovery and medical applications. One session in this conference, entitled “Tumor Margin Identification: Critiquing Technologies,” challenged invited speakers and attendees to review and critique representative label-free optical imaging technologies and their application for intraoperative assessment and guidance in ...

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    9. Review of optical coherence tomography in oncology

      Review of optical coherence tomography in oncology

      The application of optical coherence tomography (OCT) in the field of oncology has been prospering over the past decade. OCT imaging has been used to image a broad spectrum of malignancies, including those arising in the breast, brain, bladder, the gastrointestinal, respiratory, and reproductive tracts, the skin, and oral cavity, among others. OCT imaging has initially been applied for guiding biopsies, for intraoperatively evaluating tumor margins and lymph nodes, and for the early detection of small lesions that would often not be visible on gross examination, tasks that align well with the clinical emphasis on early detection and intervention. Recently ...

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    10. Noninvasive in vivo optical coherence tomography tracking of chronic otitis media in pediatric subjects after surgical intervention

      Noninvasive in vivo optical coherence tomography tracking of chronic otitis media in pediatric subjects after surgical intervention

      In an institutional review board-approved study, 25 pediatric subjects diagnosed with chronic or recurrent otitis media were observed over a period of six months with optical coherence tomography (OCT). Subjects were followed throughout their treatment at the initial patient evaluation and preoperative consultation, surgery (intraoperative imaging), and postoperative follow-up, followed by an additional six months of records-based observation. At each time point, the tympanic membrane (at the light reflex region) and directly adjacent middle-ear cavity were observed in vivo with a handheld OCT probe and portable system. Imaging results were compared with clinical outcomes to correlate the clearance of symptoms ...

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    11. Clinical translation of handheld optical coherence tomography: practical considerations and recent advancements

      Clinical translation of handheld optical coherence tomography: practical considerations and recent advancements

      Since the inception of optical coherence tomography (OCT), advancements in imaging system design and handheld probes have allowed for numerous advancements in disease diagnostics and characterization of the structural and optical properties of tissue. OCT system developers continue to reduce form factor and cost, while improving imaging performance (speed, resolution, etc.) and flexibility for applicability in a broad range of fields, and nearly every clinical specialty. An extensive array of components to construct customized systems has also become available, with a range of commercial entities that produce high-quality products, from single components to full systems, for clinical and research use ...

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    12. Investigating the healing mechanisms of an angiogenesis-promoting topical treatment for diabetic wounds using multimodal microscopy

      Investigating the healing mechanisms of an angiogenesis-promoting topical treatment for diabetic wounds using multimodal microscopy

      Impaired skin wound healing is a significant co-morbid condition of diabetes that is caused by poor microcirculation, among other factors. Studies have shown that angiogenesis, a critical step in the wound healing process in diabetic wounds, can be promoted under hypoxia. In this study, an angiogenesis-promoting topical treatment for diabetic wounds, which promotes angiogenesis by mimicking a hypoxic environment via inhibition of prolyl hydroxylase resulting in elevation or maintenance of hypoxia inducible factor (HIF), was investigated utilizing a custom-built multimodal microscopy system equipped with phase-variance optical coherence tomography (PV-OCT) and fluorescence lifetime imaging microscopy (FLIM). PV-OCT was used to track ...

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    13. Ratiometric analysis of optical coherence tomography–measured in vivo retinal layer thicknesses for the detection of early diabetic retinopathy

      Ratiometric analysis of optical coherence tomography–measured in vivo retinal layer thicknesses for the detection of early diabetic retinopathy

      Influence of diabetes mellitus (DM) and diabetic retinopathy (DR) on parafoveal retinal thicknesses and their ratios was evaluated. Six retinal layer boundaries were segmented from spectral-domain optical coherence tomography images using open-source software. Five study groups: (1) healthy control (HC) subjects, and subjects with (2) controlled DM, (3) uncontrolled DM, (4) controlled DR and (5) uncontrolled DR, were identified. The one-way analyses of variance (ANOVA) between adjacent study groups (i. e. 1 with 2, 2 with 3, etc) indicated differences in retinal thicknesses and ratios. Overall retinal thickness, ganglion cell layer (GCL) thickness, inner plexiform layer (IPL) thickness, and their ...

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    14. Smart phone attachment for 3-D optical coherence tomography imaging

      Smart phone attachment for 3-D optical coherence tomography imaging

      Methods and apparatus for tomographic imaging of a sample. Low-coherence light is split into a sample path and a reference path. A steering optic recombines light in the reference path with light scattered by a sample onto a camera having an areal focal plane array of detector elements such that light in the reference path and light scattered by the sample are characterized by respectively offset propagation vectors at incidence upon the camera. A processor derives depth information from light scattered by the sample on the basis of interference fringes between light in the reference path and light scattered by ...

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    15. Intraoperative optical coherence tomography for soft tissue sarcoma differentiation and margin identification

      Intraoperative optical coherence tomography for soft tissue sarcoma differentiation and margin identification

      Background and Objective Sarcomas are rare but highly aggressive tumors, and local recurrence after surgical excision can occur in up to 50% cases. Therefore, there is a strong clinical need for accurate tissue differentiation and margin assessment to reduce incomplete resection and local recurrence. The purpose of this study was to investigate the use of optical coherence tomography (OCT) and a novel image texture-based processing algorithm to differentiate sarcoma from muscle and adipose tissue. Study Design and Methods In this study, tumor margin delineation in 19 feline and canine veterinary patients was achieved with intraoperative OCT to help validate tumor ...

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    16. Quantitative characterization of mechanically indented in vivo human skin in adults and infants using optical coherence tomography

      Quantitative characterization of mechanically indented in vivo human skin in adults and infants using optical coherence tomography

      Influenced by both the intrinsic viscoelasticity of the tissue constituents and the time-evolved redistribution of fluid within the tissue, the biomechanical response of skin can reflect not only localized pathology but also systemic physiology of an individual. While clinical diagnosis of skin pathologies typically relies on visual inspection and manual palpation, a more objective and quantitative approach for tissue characterization is highly desirable. Optical coherence tomography (OCT) is an interferometry-based imaging modality that enables in vivo assessment of cross-sectional tissue morphology with micron-scale resolution, which surpasses those of most standard clinical imaging tools, such as ultrasound imaging and magnetic resonance ...

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    17. In vivo 3D imaging of the human tympanic membrane using a wide-field diagonal-scanning optical coherence tomography probe

      In vivo 3D imaging of the human tympanic membrane using a wide-field diagonal-scanning optical coherence tomography probe

      A wide-field optical coherence tomography (OCT) probe was developed that adapts a diagonal-scanning scheme for three-dimensional (3D) in vivo imaging of the human tympanic membrane. The probe consists of a relay lens to enhance the lateral scanning range up to 7 mm. Motion artifacts that occur with the use of handheld probes were found to be decreased owing to the diagonal-scanning pattern, which crosses the center of the sample to facilitate entire 3D scans. 3D images could be constructed from a small number of two-dimensional OCT images acquired using the diagonal-scanning technique. To demonstrate the usefulness and performance of the ...

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    18. Computational optical coherence tomography [Invited]

      Computational optical coherence tomography [Invited]

      Optical coherence tomography (OCT) has become an important imaging modality with numerous biomedical applications. Challenges in high-speed, high-resolution, volumetric OCT imaging include managing dispersion, the trade-off between transverse resolution and depth-of-field, and correcting optical aberrations that are present in both the system and sample. Physics-based computational imaging techniques have proven to provide solutions to these limitations. This review aims to outline these computational imaging techniques within a general mathematical framework, summarize the historical progress, highlight the state-of-the-art achievements, and discuss the present challenges.

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    19. Low-cost hand-held probe for depth-resolved low-coherence interferometry

      Low-cost hand-held probe for depth-resolved low-coherence interferometry

      We report on the development of a low-cost hand-held low-coherence interferometric imaging system based on the principle of linear optical coherence tomography (Linear OCT), a technique which was first proposed in the early 2000s as a simpler alternative to the conventional time-domain and Fourier-domain OCT. A bench-top implementation of the proposed technique is first presented and validated. The axial resolution, SNR, and sensitivity roll-of of the system was estimated to be 5.2 μm and 80 dB, and 3.7 dB over a depth of 0.15 mm, respectively. After validating the bench-top system, two hand-held probe implementations for contact-based ...

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    20. Inverse scattering for frequency-scanned full-field optical coherence tomography

      Inverse scattering for frequency-scanned full-field optical coherence tomography

      Full-field optical coherence tomography (OCT) is able to image an entire en face plane of scatterers simultaneously, but typically the focus is scanned through the volume to acquire three-dimensional structure. By solving the inverse scattering problem for full-field OCT, we show it is possible to computationally reconstruct a three-dimensional volume while the focus is fixed at one plane inside the sample. While a low-numerical-aperture (NA) OCT system can tolerate defocus because the depth of field is large, for high NA it is critical to correct for defocus. By deriving a solution to the inverse scattering problem for full-field OCT, we ...

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    21. Post-Doctoral Research Associate Positions at the University of Illinois at Urbana-Champaign

      Post-Doctoral Research Associate Positions at the University of Illinois at Urbana-Champaign

      The Biophotonics Imaging Laboratory and the Center for Optical Molecular Imaging at the Beckman Institute for Advanced Science and Technology on the campus of the University of Illinois at Urbana-Champaign have immediate openings for two post-doctoral research associates in the area of optical imaging systems for biomedical applications. Headed and directed by Prof. Stephen Boppart, the Biophotonics Imaging Laboratory and the Center for Optical Molecular Imaging are dynamic and productive interdisciplinary research and training environments focused on developing novel optical biomedical imaging technologies, translating them into clinical applications, and driving them toward commercialization for improving healthcare. Specific position descriptions include ...

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    22. A Mosaicking Approach for In Vivo Thickness Mapping of the Human Tympanic Membrane Using Low Coherence Interferometry

      A Mosaicking Approach for In Vivo Thickness Mapping of the Human Tympanic Membrane Using Low Coherence Interferometry

      The thickness of the human tympanic membrane (TM) is known to vary considerably across different regions of the TM. Quantitative determination of the thickness distribution and mapping of the TM is of significant importance in hearing research, particularly in mathematical modeling of middle-ear dynamics. Change in TM thickness is also associated with several middle-ear pathologies. Determination of the TM thickness distribution could therefore also enable a more comprehensive diagnosis of various otologic diseases. Despite its importance, very limited data on human TM thickness distribution, obtained almost exclusively from ex vivo samples, are available in the literature. In this study, the ...

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    23. Filtering for unwrapping noisy Doppler optical coherence tomography images for extended microscopic fluid velocity measurement range

      Filtering for unwrapping noisy Doppler optical coherence tomography images for extended microscopic fluid velocity measurement range

      In this Letter, we report the first application of two phase denoising algorithms to Doppler optical coherence tomography (DOCT) velocity maps. When combined with unwrapping algorithms, significantly extended fluid velocity dynamic range is achieved. Instead of the physical upper bound, the fluid velocity dynamic range is now limited by noise level. We show comparisons between physical simulated ideal velocity maps and the experimental results of both algorithms. We demonstrate unwrapped DOCT velocity maps having a peak velocity nearly 10 times the theoretical measurement range.

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    24. Automated computational aberration correction method for broadband interferometric imaging techniques

      Automated computational aberration correction method for broadband interferometric imaging techniques

      Numerical correction of optical aberrations provides an inexpensive and simpler alternative to the traditionally used hardware-based adaptive optics techniques. In this Letter, we present an automated computational aberration correction method for broadband interferometric imaging techniques. In the proposed method, the process of aberration correction is modeled as a filtering operation on the aberrant image using a phase filter in the Fourier domain. The phase filter is expressed as a linear combination of Zernike polynomials with unknown coefficients, which are estimated through an iterative optimization scheme based on maximizing an image sharpness metric. The method is validated on both simulated data ...

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    1-24 of 152 1 2 3 4 5 6 7 »
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