1. Articles from Mohamed Abou Shousha

    1-14 of 14
    1. Comparison of Autonomous AS-OCT Deep Learning Algorithm and Clinical Dry Eye Tests in Diagnosis of Dry Eye Disease

      Comparison of Autonomous AS-OCT Deep Learning Algorithm and Clinical Dry Eye Tests in Diagnosis of Dry Eye Disease

      Objective: To evaluate a deep learning-based method to autonomously detect dry eye disease (DED) in anterior segment optical coherence tomography (AS-OCT) images compared to common clinical dry eye tests. Methods: In this study, 27,180 AS-OCT images were prospectively collected from 151 eyes of 91 patients. Images were used to train and test the deep learning model. Masked cornea specialist ophthalmologist diagnoses were used as the gold standard. Clinical dry eye tests were performed on patients in the DED group to compare the results of the model. The dry eye tests performed were tear break-up time (TBUT), Schirmer’s test ...

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    2. Multi-Disease Deep-Learning Neural Network for the Diagnosis of Corneal Diseases

      Multi-Disease Deep-Learning Neural Network for the Diagnosis of Corneal Diseases

      Purpose To report a multi-disease deep-learning diagnostic network (MDDN) of common corneal diseases: dry eye syndrome (DES), Fuchs’ endothelial dystrophy (FED), and keratoconus (KCN) using anterior segment optical coherence tomography (AS-OCT) images. Study Design Development of a deep learning neural network diagnosis algorithm Methods A total of 158,220 AS-OCT images from 879 eyes of 478 subjects were used to develop and validate a classification deep network. After a quality check, the network was trained and validated using 134,460 images. We tested the network using a test set of consecutive patients involving 23,760 AS-OCT images of 132 eyes ...

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    3. Pathological-Corneas Layer Segmentation and Thickness Measurement in OCT Images

      Pathological-Corneas Layer Segmentation and Thickness Measurement in OCT Images

      Purpose : The purpose of this study was to propose a new algorithm for the segmentation and thickness measurement of pathological corneas with irregular layers using a two-stage graph search and ray tracing. Methods : In the first stage, a graph, with only gradient edge-cost, is used to segment the air-epithelium and endothelium-aqueous boundaries. In the second stage, a graph, with gradient, directional, and multiplier edge-cost, is used to correct segmentation. The optical coherence tomography (OCT) image is flattened using the air-epithelium boundary and a graph search is used to segment the epithelium-Bowman's and Bowman's-stroma boundaries. Then, the OCT image ...

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    4. Automatic Segmentation of Corneal Microlayers on Optical Coherence Tomography Images

      Automatic Segmentation of Corneal Microlayers on Optical Coherence Tomography Images

      Purpose : To propose automatic segmentation algorithm (AUS) for corneal microlayers on optical coherence tomography (OCT) images. Methods : Eighty-two corneal OCT scans were obtained from 45 patients with normal and abnormal corneas. Three testing data sets totaling 75 OCT images were randomly selected. Initially, corneal epithelium and endothelium microlayers are estimated using a corneal mask and locally refined to obtain final segmentation. Flat-epithelium and flat-endothelium images are obtained and vertically projected to locate inner corneal microlayers. Inner microlayers are estimated by translating epithelium and endothelium microlayers to detected locations then refined to obtain final segmentation. Images were segmented by trained manual ...

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    5. Evaluation of endothelial/Descemet membrane complex of eye bank donor corneas using enhanced depth imaging optical coherence tomography

      Evaluation of endothelial/Descemet membrane complex of eye bank donor corneas using enhanced depth imaging optical coherence tomography

      Objective: We present a novel method for screening eye bank donor corneas using high definition optical coherence tomography (HD-OCT). This technology allows for the quantification of endothelial/Descemet membrane (En/DM) complex thickness ex vivo. Design: Prospective interventional study. Participants: Fifty-two corneal grafts from 27 donors were included in this study. Twenty additional control eyes and 11 eyes with Fuchs’ endothelial corneal dystrophy were also evaluated for comparison. Methods: A custom built, high speed HD-OCT device (Envisu R2210, Bioptigen, Buffalo Grove, IL, USA) was used to obtain images, and custom-made graph-based segmentation software was used to automatically deconstruct corneal images ...

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    6. Diagnosis of Ocular Surface Lesions Using Ultra–High-Resolution Optical Coherence Tomography

      Diagnosis of Ocular Surface Lesions Using Ultra–High-Resolution Optical Coherence Tomography

      Purpose To assess the use of ultra–high-resolution (UHR) optical coherence tomography (OCT) in the diagnosis of ocular surface lesions. Design Prospective, noncomparative, interventional case series. Participants Fifty-four eyes of 53 consecutive patients with biopsy-proven ocular surface lesions: 8 primary acquired melanosis lesions, 5 amelanotic melanoma lesions, 2 nevi, 19 ocular surface squamous neoplasia lesions, 1 histiocytosis lesion, 6 conjunctival lymphoma lesions, 2 conjunctival amyloidosis lesions, and 11 pterygia lesions. Intervention Ultra–high-resolution OCT imaging of the ocular surface lesions. Main Outcome Measures Clinical course and photographs, UHR OCT image, and histopathologic findings. Results Ultra–high-resolution OCT images of all ...

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    7. Ultra-High Resolution Optical Coherence Tomography for Differentiation of Ocular Surface Squamous Neoplasia and Pterygia

      Ultra-High Resolution Optical Coherence Tomography for Differentiation of Ocular Surface Squamous Neoplasia and Pterygia
      Objective To assess the use of an ultra–high-resolution (UHR) optical coherence tomography (OCT) as an adjuvant diagnostic tool in distinguishing ocular surface squamous neoplasia (OSSN) and pterygia. Design Prospective case series. Participants Thirty-four eyes of 34 patients with conjunctival lesions clinically suspicious for OSSN or pterygia. Methods All patients were photographed and then imaged with a custom-built UHR OCT device. Subsequently, each patient underwent excisional or incisional biopsy with histopathologic diagnosis. Main Outcome Measures Comparison of preoperative UHR OCT images and the corresponding histopathologic specimen; comparison of epithelial thickness between the 2 groups as measured by UHR OCT. Results ...
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    8. Ultra-High Resolution Optical Coherence Tomography for Imaging the Anterior Segment of the Eye

      Ultra-High Resolution Optical Coherence Tomography for Imaging the Anterior Segment of the Eye

      Developments in optical coherence tomography (OCT) have expanded its clinical applications for ultra-high resolution imaging of the anterior segment of the human eye. This review presents the latest advances for imaging the anterior segment of the eye using ultra-high resolution OCT (UHR-OCT). Unique applications of UHR-OCT technology in clinical and basic scientific laboratory research are discussed and a summary of the results is provided. The authors focused on the use of UHR-OCT for imaging of tear dynamics, contact lens interactions with the corneal surface, and in vivo histological diagnosis of disorders of the cornea, as well as the future direction ...

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    9. Topographic Thickness of Bowman's Layer Determined by Ultra-High Resolution Spectral Domain–Optical Coherence Tomography

      Topographic Thickness of Bowman's Layer Determined by Ultra-High Resolution Spectral Domain–Optical Coherence Tomography
      Purpose. To characterize the thickness profile of the corneal epithelium and the Bowman's layer across the horizontal meridian. Methods. Forty-four eyes of 22 healthy subjects were investigated in this study. Ultra-high resolution anterior segment spectral domain–optical coherence tomography (SD-OCT) was used to assess the topographic thickness of the epithelium and the Bowman's layer across the cornea. Thicknesses at five locations, including the center, midperiphery, and periphery close to the limbus, on both the nasal and the temporal sides along the horizontal meridian, were analyzed. Results. Mean epithelial thickness at the central cornea was 52.5 ± 2.4 ...
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    10. Diagnosis and Management of Conjunctival and Corneal Intraepithelial Neoplasia Using Ultra High-Resolution Optical Coherence Tomography

      Diagnosis and Management of Conjunctival and Corneal Intraepithelial Neoplasia Using Ultra High-Resolution Optical Coherence Tomography
      Purpose: To report a novel diagnostic technique and a case series of conjunctival and corneal intraepithelial neoplasia (CCIN) diagnosed and followed up using prototype ultra high-resolution (UHR) optical coherence tomography (OCT).Design: Prospective, noncomparative, interventional case series.Participants: Seven eyes of 7 consecutive patients with CCIN treated using topical interferon alfa-2b or 5-fluorouracil and 7 eyes of 6 consecutive patients with history of surgically excised pterygia.Intervention: Ultra high-resolution OCT imaging of the ocular surface at primary diagnosis of CCIN and during the follow-up period until resolution of the lesion. Ultra high-resolution OCT images of sites of excised pterygia also ...
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    11. Epithelial Ingrowth After Descemet Stripping Automated Endothelial Keratoplasty: Description of Cases and Assessment With Anterior Segment Optical Coherence Tomography

      Epithelial Ingrowth After Descemet Stripping Automated Endothelial Keratoplasty: Description of Cases and Assessment With Anterior Segment Optical Coherence Tomography
      Purpose: To describe 5 cases of epithelial ingrowth after Descemet stripping automated endothelial keratoplasty (DSAEK) and the use of anterior segment optical coherence tomography (AS-OCT) to describe the areas of ingrowth. Methods: Five cases with epithelial ingrowth after DSAEK were examined with commercially available AS-OCT and/or a novel custom-built ultrahigh resolution (UHR) AS-OCT. Argon laser photocoagulation was also used to confirm epithelial ingrowth on the iris surface. Pathological evidence of epithelial ingrowth was noted in an eye that underwent corneoscleral grafting for extensive ingrowth through a fistulous tract. Results: Epithelial ingrowth was solely in the graft-host interface in 1 ...
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    12. Topographical thickness of Bowman's layer determined by ultra-high resolution spectral domain optical coherence tomography

      Topographical thickness of Bowman's layer determined by ultra-high resolution spectral domain optical coherence tomography
      Purpose: To characterize the thickness profile of the corneal epithelium and Bowman's layer across the horizontal meridian. Methods: Forty-four eyes of 22 normal subjects were investigated in this study. Ultra-high resolution anterior segment spectral domain optical coherence tomography (SD-OCT) was used to assess the topographical thickness of the epithelium and Bowman's layer across the cornea. The thickness at five locations, including the center, mid-periphery, and periphery close to the limbus, on both nasal and temporal sides along the horizontal meridian was analyzed. Results: The mean epithelial thickness at the central cornea was 52.5 ± 2.4 μm. It ...
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    13. Ultra High-Resolution Anterior Segment Optical Coherence Tomography in the Evaluation of Anterior Corneal Dystrophies and Degenerations

      Ultra High-Resolution Anterior Segment Optical Coherence Tomography in the Evaluation of Anterior Corneal Dystrophies and Degenerations
      Purpose: To evaluate the clinical usefulness of a spectral-domain ultra high-resolution anterior segment optical coherence tomography (UHR OCT) in examination, diagnosis, and management of various anterior corneal dystrophies and degenerations.Design: Noncomparative case series.Participants: Fifty-nine eyes of 38 consecutive patients were enrolled in the study and included 28 eyes of 14 patients with anterior corneal dystrophies, 21 eyes of 19 patients with anterior corneal degenerations or neoplasia, and 10 eyes of 5 patients with normal corneas.Methods: Subjects were imaged using a novel custom-built UHR OCT. Images were used to evaluate and describe the characteristics of anterior corneal dystrophies ...
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    14. Use of Ultra-High-Resolution Optical Coherence Tomography to Detect in Vivo Characteristics of Descemet's Membrane in Fuchs' Dystrophy

      Purpose: To demonstrate the capability of ultra-high-resolution (UHR) anterior segment optical coherence tomography (OCT) to image Descemet's membrane (DM) and measure its thickness in vivo. (2) To evaluate the use of DM characteristics and thickness in the diagnosis of Fuchs' dystrophy.Design: Case-control study.Participants: Twenty eyes of 12 Fuchs' dystrophy patients, 20 eyes of 13 young normal, and 20 eyes of 15 elderly normal subjects.Methods: Subjects were imaged using novel, custom-built UHR-OCT. Images were used to describe the characteristics of DM. Custom-made software was used to measure DM thickness and central corneal thickness (CCT). Specimens of DM ...
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    1-14 of 14
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    Ultra High-Resolution Anterior Segment Optical Coherence Tomography in the Evaluation of Anterior Corneal Dystrophies and Degenerations Topographical thickness of Bowman's layer determined by ultra-high resolution spectral domain optical coherence tomography Epithelial Ingrowth After Descemet Stripping Automated Endothelial Keratoplasty: Description of Cases and Assessment With Anterior Segment Optical Coherence Tomography Diagnosis and Management of Conjunctival and Corneal Intraepithelial Neoplasia Using Ultra High-Resolution Optical Coherence Tomography Topographic Thickness of Bowman's Layer Determined by Ultra-High Resolution Spectral Domain–Optical Coherence Tomography Ultra-High Resolution Optical Coherence Tomography for Imaging the Anterior Segment of the Eye Ultra-High Resolution Optical Coherence Tomography for Differentiation of Ocular Surface Squamous Neoplasia and Pterygia Diagnosis of Ocular Surface Lesions Using Ultra–High-Resolution Optical Coherence Tomography Evaluation of endothelial/Descemet membrane complex of eye bank donor corneas using enhanced depth imaging optical coherence tomography Trojan-Horse Diameter-Reducible Nanotheranostics for Macroscopic/Microscopic Imaging-Monitored Chemo-Antiangiogenic Therapy Thickness of retinal pigment epithelium–Bruch’s membrane complex in adult Chinese using optical coherence tomography Interocular symmetry of optical coherence tomography parameters in healthy children and adolescents