1. Articles from matthew brenner

    1-20 of 20
    1. Endoscopic Optical Coherence Tomography for Assessing Inhalation Airway Injury: A Technical Review

      Endoscopic Optical Coherence Tomography for Assessing Inhalation Airway Injury: A Technical Review

      Diagnosis of inhalation injury has been clinically challenging. Currently, assessment of inhalation injury relies on subjective clinical exams and bronchoscopy, which provides little understanding of tissue conditions and results in limited prognostics. Endoscopic Optical coherence tomography (OCT) technology has been recently utilized in the airway for direct assessment of respiratory tract disorders and injuries. Endoscopic OCT is capable of capturing highresolution images of tissue morphology 1-3 mm beneath the surface as well as the complex 3D anatomical shape. Previous studies indicate that changes in airway histopathology can be found in the OCT image almost immediately after inhalation of smoke and ...

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    2. Automatic Proximal Airway Volume Segmentation Using Optical Coherence Tomography for Assessment of Inhalation Injury

      Automatic Proximal Airway Volume Segmentation Using Optical Coherence Tomography for Assessment of Inhalation Injury

      Background Acute respiratory distress syndrome (ARDS) is a severe form of acute lung injury with a mortality rate of up to 40%. Early management of ARDS has been difficult due to the lack of sensitive imaging tools and robust analysis software. We previously designed an optical coherence tomography (OCT) system to evaluate mucosa thickness (MT) post smoke inhalation, but the analysis relied on manual segmentation. The aim of this study is to assess in vivo proximal airway volume (PAV) after inhalation injury using automated OCT segmentation and correlate the PAV to lung function for rapid indication of ARDS. Methods Anesthetized ...

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    3. Point-of-care endoscopic optical coherence tomography detects changes in mucosal thickness in ARDS due to smoke inhalation and burns

      Point-of-care endoscopic optical coherence tomography detects changes in mucosal thickness in ARDS due to smoke inhalation and burns

      Background The prevalence of acute respiratory distress syndrome (ARDS) in mechanically ventilated burn patients is 33%, with mortality varying from 11–46% depending on ARDS severity. Despite the new Berlin definition for ARDS, prompt bedside diagnosis is lacking. We developed and tested a bedside technique of fiberoptic-bronchoscopy-based optical coherence tomography (OCT) measurement of airway mucosal thickness (MT) for diagnosis of ARDS following smoke inhalation injury (SII) and burns. Methods 16 female Yorkshire pigs received SII and 40% thermal burns. OCT MT and PaO 2 -to-FiO 2 ratio (PFR) measurements were taken at baseline, after injury, and at 24, 48, and ...

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    4. Optical coherence tomography imaging to analyze biofilm thickness from distal to proximal regions of the endotracheal tubes

      Optical coherence tomography imaging to analyze biofilm thickness from distal to proximal regions of the endotracheal tubes

      The development of nosocomial ventilator-associated pneumonia (VAP) has been linked to the presence of specific bacteria found in the biofilm that develops in intubated endotracheal tubes of critical care patients. Presence of biofilm has been difficult to assess clinically. Here, we use Optical coherence tomography (OCT), to visualize the biofilm at both the proximal and distal tips. Ultimately, the goal will be to determine if OCT can be a tool to visualize biofilm development and potential interventions to reduce the incidence of VAP.

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    5. Visualizing biofilm formation in endotracheal tubes using endoscopic three-dimensional optical coherence tomography

      Visualizing biofilm formation in endotracheal tubes using endoscopic three-dimensional optical coherence tomography

      Biofilm formation has been linked to ventilator-associated pneumonia, which is a prevalent infection in hospital intensive care units. Currently, there is no rapid diagnostic tool to assess the degree of biofilm formation or cellular biofilm composition. Optical coherence tomography (OCT) is a minimally invasive, nonionizing imaging modality that can be used to provide high-resolution cross-sectional images. Biofilm deposited in critical care patients’ endotracheal tubes was analyzed in vitro . This study demonstrates that OCT could potentially be used as a diagnostic tool to analyze and assess the degree of biofilm formation and extent of airway obstruction caused by biofilm in endotracheal ...

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    6. In vivo detection of inhalation injury in large airway using three-dimensional long-range swept-source optical coherence tomography

      In vivo detection of inhalation injury in large airway using three-dimensional long-range swept-source optical coherence tomography

      We report on the feasibility of using long-range swept-source optical coherence tomography (OCT) to detect airway changes following smoke inhalation in a sheep model. The long-range OCT system (with axial imaging range of 25 mm) and probe are capable of rapidly obtaining a series of high-resolution full cross-sectional images and three-dimensional reconstructions covering 20-cm length of tracheal and bronchial airways with airway diameter up to 25 mm, regardless of the position of the probe within the airway lumen. Measurements of airway thickness were performed at baseline and postinjury to show mucosal thickness changes following smoke inhalation.

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    7. Integrated IVUS-OCT for Real-Time Imaging of Coronary Atherosclerosis

      Integrated IVUS-OCT for Real-Time Imaging of Coronary Atherosclerosis

      Accurate assessment of atherosclerotic plaque characteristics and the subsequent tailoring of optimal therapy holds great promise for preventing acute coronary syndromes (ACS) and life-threatening sequelae 1 . Combined use of optical coherence tomography (OCT) and intravascular ultrasound (IVUS) was proposed as a potential method for accurate assessment of plaque characteristics and vulnerability ( 2 , ). However, significant challenges remain in trying to adapt an integrated OCT-IVUS system for clinical applications. We report here a fully integrated intracoronary OCT-IVUS imaging technique to visualize atherosclerotic plaque in living animals and human coronary arteries from cadavers with high resolution and deep penetration capability simultaneously.

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    8. Endoscopic long range fourier domain optical coherence tomography (LR-FD-OCT)

      Endoscopic long range fourier domain optical coherence tomography (LR-FD-OCT)

      An endoscopic swept-source Fourier Domain optical coherence tomographic system (FDOCT system) for imaging of tissue structure includes a Fourier Domain mode locked (FDML), high speed, narrow line-width, wavelength swept source, an OCT interferometer having a sample arm, a reference arm, a detection arm, and a source arm coupled to the swept source, an endoscopic probe coupled to the sample arm, and a data processing circuit coupled to the detection arm. The swept source includes a long optic fiber functioning as a cavity, a high optical gain lasing module, and a tunable narrow bandwidth bandpass filter for wavelength selection combined to ...

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    9. Integrated intravascular optical coherence tomography (OCT) - ultrasound (US) catheter for characterization of atherosclerotic plaques in vivo

      Integrated intravascular optical coherence tomography (OCT) - ultrasound (US) catheter for characterization of atherosclerotic plaques in vivo

      A miniature integrated intravascular optical coherence tomography (OCT) - ultrasound (US) catheter for real-time imaging of atherosclerotic plaques has been developed, providing high resolution and deep tissue penetration at the same time. This catheter, with an outer diameter of 1.18mm, is suitable for imaging in human coronary arteries. The first in vivo 3D imaging of atherosclerotic microstructure in a rabbit abdominal aorta obtained by an integrated OCT-US catheter is presented. In addition, in vitro imaging of cadaver coronary arteries were conducted to demonstrate the imaging capabilities of this integrated catheter to classify different atherosclerotic plaque types.

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    10. Investigating in vivo airway wall mechanics during tidal breathing with optical coherence tomography

      Investigating in vivo airway wall mechanics during tidal breathing with optical coherence tomography
      Optical coherence tomography (OCT) is a nondestructive imaging technique offering high temporal and spatial resolution, which makes it a natural choice for assessing tissue mechanical properties. We have developed methods to mechanically analyze the compliance of the rabbit trachea in vivo using tissue deformations induced by tidal breathing, offering a unique tool to assess the behavior of the airways during their normal function. Four-hundred images were acquired during tidal breathing with a custom-built endoscopic OCT system. The surface of the tissue was extracted from a set of these images via image processing algorithms, filtered with a bandpass filter set at ...
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    11. Novel combined miniature optical coherence tomography ultrasound probe for in vivo intravascular imaging

      Novel combined miniature optical coherence tomography ultrasound probe for in vivo intravascular imaging

      We have developed a miniature integrated optical coherence tomography (OCT) ultrasound (US) probing system for intravascular imaging applications. In the OCT probe, the light coming out of a single mode fiber is focused by a gradient-index lens and then reflected by a right-angle prism from the side of the probe into the sample. It was combined with a 35 MHz PMN-PT side-viewing ultrasound transducer to obtain the ultrasound image as well. The OCT and ultrasound probes were integrated as a single probe to obtain OCT and ultrasound images simultaneously. The integrated probe has an outer diameter of 0.69 mm ...

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    12. Integrated optical coherence tomography - ultrasound system and miniaturized probes for intravascular imaging

      Integrated optical coherence tomography - ultrasound system and miniaturized probes for intravascular imaging

      We report on the development of a multimodal optical coherence tomography (OCT) - ultrasound (US) system and miniaturized OCT-US probe for intravascular imaging. Both OCT optical components and a US transducer were integrated into a single probe, enabling both OCT and US imaging at the same time. A miniaturized OCT-US probe using a single element transducer was designed with a maximum outer diameter of 0.8 mm, which is suitable for in vivo intravascular imaging. The integrated OCT-US imaging system adopted a two-channel data acquisition card to digitize both OCT and US signals. Simultaneous OCT and US data processing and image ...

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    13. Quantification of airway thickness changes in smoke-inhalation injury using in-vivo 3-D endoscopic frequency-domain optical coherence tomography

      Quantification of airway thickness changes in smoke-inhalation injury using in-vivo 3-D endoscopic frequency-domain optical coherence tomography

      Smoke inhalation injury is frequently accompanied by cyanide poisoning that may result in substantial morbidity and mortality, and methods are needed to quantitatively determine extent of airway injury. We utilized a 3-D endoscopic frequency-domain optical coherence tomography (FD-OCT) constructed with a swept-source laser to investigate morphological airway changes following smoke and cyanide exposure in rabbits. The thickness of the mucosal area between the epithelium and cartilage in the airway was measured and quantified. 3-D endoscopic FD-OCT was able to detect significant increases in the thickness of the tracheal walls of the rabbit beginning almost immediately after smoke inhalation injuries which ...

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    14. In vivo early detection of smoke-induced airway injury using three-dimensional swept-source optical coherence tomography

      In vivo early detection of smoke-induced airway injury using three-dimensional swept-source optical coherence tomography
      We report on the feasibility of rapid, high-resolution, 3-D swept-source optical coherence tomography (SSOCT) to detect early airway injury changes following smoke inhalation exposure in a rabbit model. The SSOCT system obtains 3-D helical scanning using a microelectromechanical system motor-based endoscope. Real-time 2-D data processing and image display at the speed of 20 frames/s are achieved by adopting the technique of parallel computing. Longitudinal images are reconstructed via an image processing algorithm to remove motion artifacts caused by ventilation and pulse. Quantitative analyses of tracheal airway thickness as well as thickness distribution along tracheal circumference are also performed based ...
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    15. Detection and monitoring of early airway injury effects of half-mustard (2-chloroethylethylsulfide) exposure using high-resolution optical coherence tomography

      Optical coherence tomography (OCT) is a noninvasive, high-resolution imaging technology capable of delivering real-time, near-histologic images of tissues. Mustard gas is a vesicant-blistering agent that can cause severe and lethal damage to airway and lungs. The ability to detect and assess airway injury in the clinical setting of mustard exposure is currently limited. The purpose of this study is to assess the ability to detect and monitor progression of half-mustard [2-chloroethylethylsulfide (CEES)] airway injuries with OCT techniques. A ventilated rabbit mustard exposure airway injury model is developed. A flexible fiber optic OCT probe is introduced into the distal trachea to ...
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    16. Optical coherent tomographic (OCT) imaging apparatus and method using a fiber bundle

      A fiber-optic bundle based optical coherence tomography (OCT) probe method is demonstrated in a multimode optical fiber bundle based OCT system. The system can achieve a lateral resolution of 12 .mu.m and an axial resolution of 10 .mu.m using a super-luminescent diode source. This imaging approach eliminates any moving parts in the probe and has a primary advantage for use in extremely compact and safe OCT endoscopes to image internal organs and great potential to be combined with confocal endoscopic microscopy.
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    17. 3D in vivo swept source endoscopic OCT based on rigid GRIN lens rod probe

      In this manuscript, we report a fast speed swept source endoscopic OCT system utilizing a 4.5mm diameter rigid GRIN lens rod probe. The rigid probe has a tunable working distance with tuning range 0~7mm. The system could take front scanning images with speed of 40frames per second (512 A line per fr ... [Proc. SPIE 7168, 716812 (2009)] published Thu Feb 19, 2009.
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    18. Real-time swept source optical coherence tomography imaging of the human airway using a microelectromechanical system endoscope and digital signal processor

      Jianping Su, Jun Zhang, Lingfeng Yu et al. A fast-scan-rate swept laser for optical coherence tomography (OCT) is suitable to record and analyze a 3-D image volume. However, the whole OCT system speed is limited by data streaming, processing, and storage. In this case, postprocessing is a common technique. Endoscopic clinical applications pr ... [J. Biomed. Opt. 13, 030506 (2008)] published Tue Jul 1, 2008.
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    19. In vivo optical coherence tomography detection of differences in regional large airway smoke inhalation induced injury in a rabbit model

      Matthew Brenner, Kelly Kreuter, Johnny Ju et al. Smoke inhalation injury causes acute airway injury that may result in airway compromise with significant morbidity and mortality. We investigate the ability of high resolution endobronchial optical coherence tomography (OCT) to obtain real-time images for quantitatively assessing regional difference ... [J. Biomed. Opt. 13, 034001 (2008)] published Mon Jun 23, 2008.
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    20. Detection of acute smoke-induced airway injury in a New Zealand white rabbit model using optical coherence tomography

      Matthew Brenner, Kelly Kreuter, David Mukai et al. Optical coherence tomography (OCT) is a micron scale high-resolution optical technology that can provide real-time in vivo images noninvasively. The ability to detect airway mucosal and submucosal injury rapidly will be valuable for a range of pulmonary applications including assessment of acute inh ... [J. Biomed. Opt. 12, 051701 (2007)] published Mon Oct 29, 2007.
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    1-20 of 20
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  2. Topics in the News

    1. (20 articles) UC Irvine
    2. (18 articles) Zhongping Chen
    3. (18 articles) Matthew Brenner
    4. (4 articles) University of Southern California
    5. (4 articles) Jun Zhang
    6. (4 articles) Xiang Li
    7. (4 articles) Joseph C. Jing
    8. (4 articles) Jiechen Yin
    9. (4 articles) Qifa Zhou
    10. (4 articles) K. Kirk Shung
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    13. (1 articles) Université Pierre et Marie Curie
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    In vivo early detection of smoke-induced airway injury using three-dimensional swept-source optical coherence tomography Quantification of airway thickness changes in smoke-inhalation injury using in-vivo 3-D endoscopic frequency-domain optical coherence tomography Integrated optical coherence tomography - ultrasound system and miniaturized probes for intravascular imaging Novel combined miniature optical coherence tomography ultrasound probe for in vivo intravascular imaging Investigating in vivo airway wall mechanics during tidal breathing with optical coherence tomography Changes in the Retinal Microvasculature Measured Using Optical Coherence Tomography Angiography According to Age Direct en-face, speckle-reduced images using angular-compounded Master-Slave optical coherence tomography A case report of a recurrent early and late Bioresorbable vascular scaffold thrombosis: serial angiography and optical coherence tomography findings Optical coherence tomography angiography as a novel approach to contactless evaluation of sublingual microcirculation: A proof of principle study Functional optical coherence tomography and photoacoustic microscopy imaging for zebrafish larvae Plasma Ceramides in Relation to Coronary Plaque Characterization Determined by Optical Coherence Tomography Retinal neurodegeneration in patients with end-stage renal disease assessed by spectral-domain optical coherence tomography