1. Articles from James B. Kobler

    1-7 of 7
    1. Integrating optical coherence tomography with laryngeal videostroboscopy

      Integrating optical coherence tomography with laryngeal videostroboscopy

      During clinical voice assessment, laryngologists and speech-language pathologists rely heavily on laryngeal endoscopy with videostroboscopy to evaluate pathology and dysfunction of the vocal folds. The cost effectiveness, ease of use, and synchronized audio and visual feedback provided by videostroboscopic assessment serve to maintain its predominant clinical role in laryngeal imaging. However, significant drawbacks include only two-dimensional spatial imaging and the lack of subsurface morphological information. A novel endoscope will be presented that integrates optical coherence tomography that is spatially and temporally co-registered with laryngeal videoendoscopic technology through a common path probe. Optical coherence tomography is a non-contact, micron-resolution imaging technology ...

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    2. Simultaneous 3D imaging of sound-induced motions of the tympanic membrane and middle ear ossicles

      Simultaneous 3D imaging of sound-induced motions of the tympanic membrane and middle ear ossicles

      Efficient transfer of sound by the middle ear ossicles is essential for hearing. Various pathologies can impede the transmission of sound and thereby cause conductive hearing loss. Differential diagnosis of ossicular disorders can be challenging since the ossicles are normally hidden behind the tympanic membrane (TM). Here we describe the use of a technique termed optical coherence tomography (OCT) vibrography to view the sound-induced motion of the TM and ossicles simultaneously. With this method, we were able to capture three-dimensional motion of the intact TM and ossicles of the chinchilla ear with nanometer-scale sensitivity at sound frequencies from 0.5 ...

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    3. Subnanometer optical coherence tomographic vibrography

      Subnanometer optical coherence tomographic vibrography

      The ability to quantify and visualize submicrometer-scale oscillatory motions of objects in three dimensions has a wide range of application in acoustics, materials sciences, and medical imaging. Here we demonstrate that volumetric snapshots of rapid periodic motion can be captured using optical coherence tomography (OCT) with subnanometer-scale motion sensitivity and microsecond-scale temporal resolution. This technique, termed OCT vibrography, was applied to generate time-resolved volumetric vibrographs of a miniature drum driven acoustically at several kilohertz.

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    4. Triggered optical coherence tomography for capturing rapid periodic motion

      Triggered optical coherence tomography for capturing rapid periodic motion
      Quantitative cross-sectional imaging of vocal folds during phonation is potentially useful for diagnosis and treatments of laryngeal disorders. Optical coherence tomography (OCT) is a powerful technique, but its relatively low frame rates makes it challenging to visualize rapidly vibrating tissues. Here, we demonstrate a novel method based on triggered laser scanning to capture 4-dimensional (4D) images of samples in motu at audio frequencies over 100 Hz. As proof-of-concept experiments, we applied this technique to imaging the oscillations of biopolymer gels on acoustic vibrators and aerodynamically driven vibrations of the vocal fold in an ex vivo calf larynx model. Our results ...
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    5. Methods And Arrangements For Analysis, Diagnosis, And Treatment Monitoring Of Vocal Folds By Optical Coherence Tomography

      Methods And Arrangements For Analysis, Diagnosis, And Treatment Monitoring Of Vocal Folds By Optical Coherence Tomography
      Exemplary embodiments of an apparatus and a method can be provided. For example, a first information can be obtained for at least one signal that is (i) at least partially periodic and (ii) associated with at least one structure. In addition, a second information associated with the structure can be generated at multiple time points within a single cycle of the at least one signal. The second information can include information for the structure below a surface thereof. Further, it is possible to generate a third information based on the first information and the second information, where the third information ...
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    6. Dynamic imaging of vocal fold oscillation with four-dimensional optical coherence tomography

      Dynamic imaging of vocal fold oscillation with four-dimensional optical coherence tomography

      Optical coherence tomography (OCT) can provide high-resolution ([sim]10-15 [mu]m/pixel) images of vocal fold microanatomy, as demonstrated previously. We explored physiologically triggered Fourier-domain OCT for imaging vocal folds during phonation. The goal is to visualize dynamic histological cross sections and four-dimensional data sets where multiple planes are displayed in synchronized motion. If feasible, this approach could be a useful research tool and spur development of new clinical instrumentation.A Fourier-domain, triggered OCT system was created and tested in experiments on excised calf larynges to obtain preliminary observations and characterize important factors affecting image quality.Larynges were imaged during ...

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    7. Real-time tracking of vocal fold injections with optical coherence tomography

      Abstract Objectives/Hypothesis: Optical coherence tomography (OCT) is a promising new imaging modality that can help discern the layered microstructure of vocal folds. In the future, subepithelial injections of implants will improve vocal fold pliability where there is stiffness of phonatory mucosa. Using OCT both to delineate the depth of subepithelial injections real-time and to serially image the implant over time would be valuable, and has not been demonstrated previously. Study Design: Ex vivo study using excised calf larynges and survival study using canines in vivo. Methods: An investigation was done employing real-time OCT imaging of subepithelial injection pulses into ...
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    1-7 of 7
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  2. Topics in the News

    1. (7 articles) Harvard University
    2. (7 articles) Massachusetts General Hospital
    3. (3 articles) Boston University
    4. (1 articles) Massachusetts Eye and Ear Infirmary
    5. (1 articles) Massachusetts Institute of Technology
    6. (1 articles) Korea Advanced Institute of Science and Technology
    7. (1 articles) Physical Sciences Incorporated
    8. (1 articles) Massachusetts Eye and Ear Infirmary
    9. (1 articles) Indiana University
    10. (1 articles) Kitasato University
    11. (1 articles) University of Washington
    12. (1 articles) Duke University
    13. (1 articles) National Research Council Canada
    14. (1 articles) University of Toronto
    15. (1 articles) MedLumics
    16. (1 articles) Alcon
    17. (1 articles) Abbott
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    Dynamic imaging of vocal fold oscillation with four-dimensional optical coherence tomography Methods And Arrangements For Analysis, Diagnosis, And Treatment Monitoring Of Vocal Folds By Optical Coherence Tomography Triggered optical coherence tomography for capturing rapid periodic motion Subnanometer optical coherence tomographic vibrography Simultaneous 3D imaging of sound-induced motions of the tympanic membrane and middle ear ossicles Integrating optical coherence tomography with laryngeal videostroboscopy Prediction of Retinal Ganglion Cell Counts Considering Various Displacement Methods From OCT-Derived Ganglion Cell-Inner Plexiform Layer Thickness Changes of blood flow in macular zone of patients with diabetic retinopathy at different stages evaluated by optical coherence tomography angiography Very late stent thrombosis lacking findings of the typical causes on optical coherence tomography in a patient with SARS-CoV-2 Coarsening of choriocapillaris on optical coherence tomography angiography as a sign of acute idiopathic blind spot enlargement Valve-Like Outflow System Behavior With Motion Slowing in Glaucoma Eyes: Findings Using a Minimally Invasive Glaucoma Surgery-MIGS-Like Platform and Optical Coherence Tomography Imaging Optical Coherence Tomography Evaluation of Carotid Artery Stenosis and Stenting in Patients With Previous Cervical Radiotherapy