1. Articles from Chao Wang

    1-8 of 8
    1. Highly coherent supercontinuum generation in CS2 infiltrated single-core optical fiber

      Highly coherent supercontinuum generation in CS2 infiltrated single-core optical fiber

      As is generally known, broad-band near-infrared Supercontinuum (SC) is significant for the applications such as pump-probe spectroscopy, nonlinear spectroscopy, frequency combs, or nonlinear optical parametric amplification. We present the first detailed demonstration of approximate near-infrared, octave-spanning SC generation in all-normal dispersion CS2 single-hole liquid core optical fiber (LCOF). By solving the generalized nonlinear Schrödinger equation, the SC at different parameters can be calculated. The influence of important parameters including but not limited to fiber core-diameter, pump wavelength, pump power, and pulse width, on the supercontinuum generation (SCG) of CS2 infiltrated LCOF can be analyzed for optimization of near-infrared SC ...

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    2. Impact of vessel curvature on neointimal healing after stent implantation as assessed by optical coherence tomography

      Impact of vessel curvature on neointimal healing after stent implantation as assessed by optical coherence tomography

      Purpose: Previous studies have indicated that stent implantation could alter the vessel geometry, which may impact the neointimal healing process. Curvature is an important parameter for evaluating vessel geometry. The purpose of our study was to investigate the relationship between vessel curvature and neointimal healing after stent implantation. Methods: Fifty-nine patients with acute coronary syndrome (ACS) who underwent stent implantation were enrolled in the study. According to the post-percutaneous coronary intervention vessel curvature measured by quantitative coronary angiography, patients were divided into high (n = 30) and low (n = 29) curvature groups. Neointimal thickness and area together with the neointimal type ...

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    3. Automatic Quantitative Analysis of Bioresorbable Vascular Scaffold Struts in Optical Coherence Tomography Images Using Region Growing

      Automatic Quantitative Analysis of Bioresorbable Vascular Scaffold Struts in Optical Coherence Tomography Images Using Region Growing

      Bioresorbable vascular scaffolds are new-generation stents that reduce the risk of intimal hyperplasia and late stent thrombosis. Intravascular optical coherence tomography is an important technique to evaluate images about struts. Analyzing strut status, such as apposition and malapposition, is important for the follow-up treatment of patients. Traditionally, it has taken up to 8 hours to manually analyze the strut status. In this study, a new method is presented to detect and quantify struts automatically. Ten pullback runs containing 7720 struts were acquired to validate the algorithm. For apposed/malapposed stent struts, the sensitivity of the method was 93.0% and ...

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    4. EROSION Study (Effective Anti-Thrombotic Therapy Without Stenting: Intravascular Optical Coherence Tomography–Based Management in Plaque Erosion)

      EROSION Study (Effective Anti-Thrombotic Therapy Without Stenting: Intravascular Optical Coherence Tomography–Based Management in Plaque Erosion)

      Background— The initial EROSION study (Effective Anti-Thrombotic Therapy Without Stenting: Intravascular Optical Coherence Tomography–Based Management in Plaque Erosion) demonstrated that patients with acute coronary syndrome caused by plaque erosion might be stabilized with aspirin and ticagrelor without stenting for ≤1 month. However, a long-term evaluation of outcomes is lacking. The aim of this study was to assess whether the initial benefit of noninterventional therapy for patients with acute coronary syndrome caused by plaque erosion is maintained for ≤1 year. Methods and Results— Among 53 patients who completed clinical follow-up, 49 underwent repeat optical coherence tomography imaging at 1 year ...

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    5. Role of Optical Coherence Tomography in Diagnosis and Treatment of Patients with Acute Coronary Syndrome

      Role of Optical Coherence Tomography in Diagnosis and Treatment of Patients with Acute Coronary Syndrome

      Acute coronary syndrome (ACS) is the main cause of death worldwide and the leading cause of disease burden in high-income countries. ACS refers to a constellation of clinical symptoms that are compatible with acute myocardial ischemia. It describes a spectrum of clinical manifestations that result from a common pathophysiological process. The most common cause of ACS are rupture of an atherosclerotic lesion containing a large necrotic core and a thin fibrous cap followed by acute luminal thrombosis. It was thought that a high-resolution imaging modality would be ideal to detect high-risk plaques before their disruption and the formation of an ...

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    6. Impact of statins therapy on morphological changes in lipid-rich plaques stratified by 10-Year framingham risk score: A serial optical coherence tomography study

      Impact of statins therapy on morphological changes in lipid-rich plaques stratified by 10-Year framingham risk score: A serial optical coherence tomography study

      The aim of the study was to investigate the impact of statins therapy on morphological changes of lipid-rich plaques by OCT (optical coherence tomography) in patients with known CHD (coronary heart disease), stratified by FRS. Ninety-seven lipid-rich plaques from sixty-nine patients who received statins therapy and underwent serial OCT images (baseline, 6-month and 12-month) were divided into 2 groups according to the FRS (framingham risk score): low risk group A (FRS<10%, N=35, n=45), moderate to high risk group B (FRS≥10%, N=34, n=52). Fibrous cap thickness (FCT) was measured at its thinnest part 3 times ...

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    7. Management and Outcome of Patients With Acute Coronary Syndrome Caused by Plaque Rupture Versus Plaque Erosion: An Intravascular Optical Coherence Tomography Study

      Management and Outcome of Patients With Acute Coronary Syndrome Caused by Plaque Rupture Versus Plaque Erosion: An Intravascular Optical Coherence Tomography Study

      Background Plaque rupture and erosion are the 2 most common mechanisms for acute coronary syndromes. However, the outcome of these 2 distinct pathologies in patients with acute coronary syndromes has never been studied. Methods and Results We retrospectively studied 141 patients with acute coronary syndromes who underwent optical coherence tomography ( OCT ) imaging of the culprit lesion prior to stenting from the Massachusetts General Hospital OCT Registry. Management (stent versus no stent), poststent OCT findings, and outcomes were compared. Among the 141 culprit lesions, rupture was found in 79 (56%) patients and erosion in 62 (44%). Stent implantation was performed in ...

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    8. Association of circulating levels of neopterin with non-culprit plaque vulnerability in CAD patients an angiogram, optical coherent tomography and intravascular ultrasound study

      Association of circulating levels of neopterin with non-culprit plaque vulnerability in CAD patients an angiogram, optical coherent tomography and intravascular ultrasound study

      Background Neopterin is a pteridine derivative secreted by activated macrophages. Previous studies have shown that neopterin plays a pivotal role in coronary artery disease (CAD); however, the relationship between circulating neopterin and non-culprit plaque vulnerability in patients with CAD remains unclear. In this study, we investigated the correlation of neopterin and vulnerable plaque features in patients with CAD. Methods One hundred and thirty non-culprit plaques from 81 patients with CAD were assessed by angiogram and optical coherence tomography (OCT) as well as intravascular ultrasound (IVUS) imaging. According to the median value of serum neopterin (10.61 nmol/L), patients were ...

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    1-8 of 8
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  2. Topics in the News

    1. (6 articles) Harbin Medical University
    2. (6 articles) Bo Yu
    3. (5 articles) Haibo Jia
    4. (3 articles) Jingbo Hou
    5. (3 articles) Yan Wang
    6. (3 articles) Shaosong Zhang
    7. (2 articles) Harvard University
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    Association of circulating levels of neopterin with non-culprit plaque vulnerability in CAD patients an angiogram, optical coherent tomography and intravascular ultrasound study Management and Outcome of Patients With Acute Coronary Syndrome Caused by Plaque Rupture Versus Plaque Erosion: An Intravascular Optical Coherence Tomography Study Impact of statins therapy on morphological changes in lipid-rich plaques stratified by 10-Year framingham risk score: A serial optical coherence tomography study Role of Optical Coherence Tomography in Diagnosis and Treatment of Patients with Acute Coronary Syndrome EROSION Study (Effective Anti-Thrombotic Therapy Without Stenting: Intravascular Optical Coherence Tomography–Based Management in Plaque Erosion) Automatic Quantitative Analysis of Bioresorbable Vascular Scaffold Struts in Optical Coherence Tomography Images Using Region Growing Impact of vessel curvature on neointimal healing after stent implantation as assessed by optical coherence tomography Highly coherent supercontinuum generation in CS2 infiltrated single-core optical fiber Non Exudative AMD Imaged With SS-OCT- Extension High space-bandwidth in quantitative phase imaging using partially spatially coherent optical coherence microscopy and deep neural network Optical coherence tomography assessment of macrophages accumulation in non-ST-segment elevation acute coronary syndromes Early disability in ambulatory patients with multiple sclerosis: optical coherence tomography versus visual evoked potentials, a comparative study