1. Articles from Jianjiang Xu

    1-15 of 15
    1. Application of Keratograph and Fourier-Domain Optical Coherence Tomography in Measurements of Tear Meniscus Height

      Application of Keratograph and Fourier-Domain Optical Coherence Tomography in Measurements of Tear Meniscus Height

      To compare the interoperator repeatability of tear meniscus height (TMH) measurements obtained with a keratograph and Fourier-domain optical coherence tomography (FD-OCT) and to assess the agreement between the methods.Forty-seven eyes with DED and 41 healthy eyes were analyzed using the Schirmer test I and tear breakup time test (TBUT). The TMH was measured three times with each device. The repeatability of measurements was assessed by within-subject standard deviation (Sw), repeatability (2.77 Sw), coefficient of variation (CoV) and intraclass correlation coefficient (ICC). Efficacy in detecting DED was evaluated in terms of the area under the curve (AUC). The TMHs ...

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    2. Fourier-Domain Optical Coherence Tomographic Assessment of Changes in the Schlemm's Canal of Nonglaucomatous Subjects After Keratoplasty

      Fourier-Domain Optical Coherence Tomographic Assessment of Changes in the Schlemm's Canal of Nonglaucomatous Subjects After Keratoplasty

      Purpose: This study aimed to evaluate the impact of keratoplasty on the in vivo anatomical structures in the Schlemm's canal (SC) of nonglaucomatous subjects using Fourier-domain optical coherence tomography (FD-OCT). Methods: Sixty-six nonglaucomatous eyes that underwent penetrating keratoplasty (PK), deep anterior lamellar keratoplasty (DALK), or triple surgery were enrolled in this prospective, comparative, observational study. The SC imaging was performed using FD-OCT before and after surgery in both the nasal and temporal quadrants. Patient demographics, SC parameters [e.g., cross-sectional area (CSA), meridional diameter of SC (MSC), sagittal diameter of SC (SSC), and circumference (CCF)], and the correlations between ...

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      Mentions: Fudan University
    3. Comparison of the Meibomian Gland Openings by Optical Coherence Tomography in Obstructive Meibomian Gland Dysfunction and Normal Patients

      Comparison of the Meibomian Gland Openings by Optical Coherence Tomography in Obstructive Meibomian Gland Dysfunction and Normal Patients

      Purpose: The aim of this study was to use swept-source anterior segment optical coherence tomography (OCT) to explore imaging the meibomian gland openings and to identify their in vivo characteristics in patients with obstructive meibomian gland dysfunction (MGD) and healthy participants. Methods: We enrolled 49 patients with MGD and 54 health controls in this case-control study. Each participant underwent slit-lamp examination, meibography, and OCT scanning. Sixteen patients with MGD underwent a repeat OCT examination after eyelid massage. The outcome measures included determinations of meibomian gland openings (orifices and terminal ducts) from OCT images and comparisons of the meibomian openings between ...

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      Mentions: Fudan University
    4. Malapposition of graft-host interface after penetrating keratoplasty (PK) and deep anterior lamellar keratoplasty (DALK): an optical coherence tomography study

      Malapposition of graft-host interface after penetrating keratoplasty (PK) and deep anterior lamellar keratoplasty (DALK): an optical coherence tomography study

      Backgroud Previous studies of internal graft-host malappositions have not dealt with the precise ways in which each malapposition affected post-penetrating keratoplasty (post-PK) visual outcomes. In this study, we reviewed our post-PK and post-deep anterior lamellar keratoplasty (post-DALK) keratoconic patients and used anterior segment optical coherence tomography (AS-OCT) to evaluate the associations between graft-host interface (GHI) characteristics and visual outcomes. Methods Novel GHI metrics included: mean graft-host touch (GHT), total prevalence of malapposition proportion (Pm), frequency of apposition (F), size of malapposition (Sm), junctional graft thickness (Tg), junctional host thickness (Th) and the absolute value of difference between Tg and Th ...

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      Mentions: Fudan University
    5. In Vivo Evaluation of the Limbus Using Anterior Segment Optical Coherence Tomography

      In Vivo Evaluation of the Limbus Using Anterior Segment Optical Coherence Tomography

      Purposes : To investigate the limbal structure using anterior segment optical coherence tomography (AS-OCT) and compare the difference between a Chinese Han population and a Caucasian population. Methods : Sixty healthy Chinese Han subjects (109 eyes, Chinese group) and 32 healthy Caucasian subjects (51 eyes, Caucasian group) were included in this comparative cross-sectional study. The central cornea and the superior, inferior, nasal, and temporal limbal regions of each subject underwent Fourier-domain AS-OCT. The following parameters were measured: corneal epithelial thickness (CET), maximum limbal epithelial thickness (LET), the mean LET, the width of limbus, distance between scleral spur and the location where limbal ...

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    6. Age-related Changes in Human Schlemm’s Canal: An In Vivo Optical Coherence Tomography-based Study

      Age-related Changes in Human Schlemm’s Canal: An In Vivo Optical Coherence Tomography-based Study

      Purpose: To investigate age-related changes in human Schlemm’s canal (SC) using spectral-domain optical coherence tomography (SD-OCT). Methods: A total of 125 normal eyes were imaged using SD-OCT nasally and temporally. The age-related variations of SC sagittal diameter and cross-sectional area (CSA) from four age groups [A (16–20 years), B (21–40 years), C (41–60 years), and D (61–80 years)] were analyzed with Spearman correlation. Results: The positive detection rates of SC showed a significantly downward trend with age. The mean CSA was 13,296 ± 1,897 μm2 nasally and 14,552 ± 2,589 μm2 temporally. The ...

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    7. Measurement of corneal and limbal epithelial thickness by anterior segment optical coherence tomography and in vivo confocal microscopy

      Measurement of corneal and limbal epithelial thickness by anterior segment optical coherence tomography and in vivo confocal microscopy

      Background To compare corneal epithelial thickness (CET) and limbal epithelial thickness (LET) measured by anterior segment optical coherence tomography (AS-OCT) and in vivo confocal microscope (IVCM) in normal subjects, and evaluate the consistency between them. Methods Thirty-eight normal subjects (17 men and 21 women) were enrolled in this study. AS-OCT was performed at central cornea and the superior, inferior, nasal and temporal limbus. Then followed by IVCM examination performed at the same location. Agreement was analyzed by mean difference (AS-OCT minus IVCM), 95 % limits of agreement (LoA) (1.96 standard deviation of the difference), and Bland-Altman analysis. Results The average ...

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    8. Optimising keratoplasty for Peters' anomaly in infants using spectral-domain optical coherence tomography

      Optimising keratoplasty for Peters' anomaly in infants using spectral-domain optical coherence tomography

      Purpose To present in vivo anterior segment optical coherence tomography (OCT) features of infants with Peters' anomaly obtained during presurgical examination under general anaesthesia, and to evaluate the impact of OCT features on surgical decision making. Methods This is a single-centre, consecutive, observational case series including 44 eyes of 27 infants with Peters' anomaly (5–18 months) undergoing keratoplasty. Medical records of patients were reviewed retrospectively. Clinical features and OCT findings, along with their impact on surgical decision-making were analysed. Results Of 27 patients, 10 had unilateral and 17 had bilateral disease. Two patients with mild disease (three eyes) had ...

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    9. Histopathologic and Optical Coherence Tomography Observation After Descemet’s Stripping Endothelial Keratoplasty in Rabbits

      Histopathologic and Optical Coherence Tomography Observation After Descemet’s Stripping Endothelial Keratoplasty in Rabbits

      Objectives: To study the histopathologic and optical coherence tomography changes after Descemet’s Stripping Endothelial Keratoplasty in rabbits. Materials and Methods: Descemet’s Stripping Endothelial Keratoplasty was performed in 14 rabbit eyes and descemetorhexis was performed in 10 rabbits, as control. Histopathologic examination and anterior-segment optical coherence tomography were conducted in the Descemet’s Stripping Endothelial Keratoplasty group at 1, 2, 4, and 8 weeks. For the control group, histopathologic examination was performed before surgery and at 1, 2, 4, and 8 weeks after surgery. Results: In the Descemet’s Stripping Endothelial Keratoplasty group, corneas cleared completely within 2 weeks ...

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    10. Assessment of Corneal Epithelial Thickness in Dry Eye Patients

      Assessment of Corneal Epithelial Thickness in Dry Eye Patients

      Purpose To investigate the features of corneal epithelial thickness topography with Fourier-domain optical coherence tomography (OCT) in dry eye patients. Methods In this cross-sectional study, 100 symptomatic dry eye patients and 35 normal subjects were enrolled. All participants answered the ocular surface disease index questionnaire and were subjected to OCT, corneal fluorescein staining, tear breakup time, Schirmer 1 test without anesthetic (S1t), and meibomian morphology. Several epithelium statistics for each eye, including central, superior, inferior, minimum, maximum, minimum − maximum, and map standard deviation, were averaged. Correlations of epithelial thickness with the symptoms of dry eye were calculated. Results The mean ...

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    11. Optical Coherence Tomography Assessment of Angle Anatomy Changes After Trabeculectomy in Primary Angle-Closure Glaucoma

      Optical Coherence Tomography Assessment of Angle Anatomy Changes After Trabeculectomy in Primary Angle-Closure Glaucoma

      Purpose: Using anterior chamber optical coherence tomography to evaluate changes in angle anatomy in patients with primary angle-closure glaucoma (PACG) before and after trabeculectomy. Methods: This is a prospective observational study in 38 eyes of 38 patients with PACG, who underwent trabeculectomy. We used customized software to analyze optical coherence tomography images (Visante) of all participants before and after the surgical treatment. Multivariate linear regression analysis was performed for predictors of percentage change in mean angle parameters, including scleral spur angle, angle opening distance, angle recess area, and trabecular-iris surface area. The main outcome measures were changes in angle parameters ...

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      Mentions: Fudan University
    12. Age-Related Changes in Human Corneal Epithelial Thickness Measured with Anterior Segment Optical Coherence Tomography

      Age-Related Changes in Human Corneal Epithelial Thickness Measured with Anterior Segment Optical Coherence Tomography

      Purpose: To measure corneal and limbal epithelial thickness (ET) in normal subjects and to evaluate its variation with age by using anterior segment optical coherence tomography (AS-OCT). Methods: 180 normal subjects (180 healthy eyes) were enrolled and divided into four groups according to age: A (0-20 years), B (21-40 years), C (41-60 years), D (>60 years). Cornea and limbus were imaged with OCT. Corneal ET (CET) was obtained automatically by the built-in analysis software of the OCT system. Limbal ET (LET) in four quadrants was manually measured from OCT images. Results: CET of central 2-mm diameter zone in groups A ...

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    13. Anterior Chamber Angle Assessment by Anterior-segment Optical Coherence Tomography After Phacoemulsification With or Without Goniosynechialysis in Patients With Primary Angle Closure Glaucoma

      Anterior Chamber Angle Assessment by Anterior-segment Optical Coherence Tomography After Phacoemulsification With or Without Goniosynechialysis in Patients With Primary Angle Closure Glaucoma

      Purpose: To evaluate changes of anterior chamber angle (ACA) by anterior-segment optical coherence tomography (AS-OCT) in patients with primary angle closure glaucoma (PACG) following phacoemulsification (phaco) with or without goniosynechialysis (GSL). Methods: Patients with PACG recruited into 2 randomized controlled trials comparing phaco-GSL versus phaco were pooled for analysis. Images of ACA were obtained by AS-OCT before surgery, and at 1 and 2 weeks, and 1, 3, and 6 months after surgery. The following parameters were analyzed: angle opening distance (AOD) at 500 and 750 [mu]m from the scleral spur, trabecular-iris space area (TISA) at 500 and 750 [mu ...

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    14. Spectral-Domain Optical Coherence Tomographic Assessment of Schlemm's Canal in Chinese Subjects with Primary Open-angle Glaucoma

      Spectral-Domain Optical Coherence Tomographic Assessment of Schlemm's Canal in Chinese Subjects with Primary Open-angle Glaucoma

      Purpose To evaluate in vivo features of Schlemm's canal (SC) in patients with primary open-angle glaucoma (POAG) with spectral-domain optical coherence tomography (SD-OCT) and to investigate the relationship of SC size with intraocular pressure (IOP) and glaucoma severity. Design Prospective, comparative study. Participants Fifty Chinese patients with newly diagnosed POAG who had not undergone surgery and 50 normal Chinese subjects from a population-based, cross-sectional study in Shanghai. Methods All participants underwent SD-OCT. The diameter and area of SC were examined in the temporal and nasal sections and measured with customized software. Main Outcome Measures Patient demographics, repeatability and reproducibility ...

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      Mentions: Fudan University
    15. The Analysis of Tear Meniscus in Soft Contact Lens Wearers by Spectral Optical Coherence Tomography

      Purpose: To evaluate the changes of tear meniscus in eyes fitted with soft contact lens (SCL) by spectral optical coherence tomography (SOCT). Methods: Thirty-three contact lens wearers who wore daily-wear frequent-replacement SCL with 55% water content for more than 6 years on average, and 33 normal subjects were enrolled in this study. The meniscus at the central lower lid of the left eye was examined by SOCT. For the lens wearers, the examination was performed twice: once with contact lens and once without. For the non-lens wearers, the examination was performed only once. The image of lower tear meniscus was ...

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      Mentions: Fudan University
    1-15 of 15
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    Spectral-Domain Optical Coherence Tomographic Assessment of Schlemm's Canal in Chinese Subjects with Primary Open-angle Glaucoma Anterior Chamber Angle Assessment by Anterior-segment Optical Coherence Tomography After Phacoemulsification With or Without Goniosynechialysis in Patients With Primary Angle Closure Glaucoma Age-Related Changes in Human Corneal Epithelial Thickness Measured with Anterior Segment Optical Coherence Tomography Optical Coherence Tomography Assessment of Angle Anatomy Changes After Trabeculectomy in Primary Angle-Closure Glaucoma Assessment of Corneal Epithelial Thickness in Dry Eye Patients Histopathologic and Optical Coherence Tomography Observation After Descemet’s Stripping Endothelial Keratoplasty in Rabbits Optimising keratoplasty for Peters' anomaly in infants using spectral-domain optical coherence tomography Measurement of corneal and limbal epithelial thickness by anterior segment optical coherence tomography and in vivo confocal microscopy Age-related Changes in Human Schlemm’s Canal: An In Vivo Optical Coherence Tomography-based Study Editorial – Optical Coherence Tomography Angiography: Considerations Regarding Diagnostic Parameters Imaging of the optic nerve: technological advances and future prospects Optical coherence tomography assessment of pulmonary vascular remodeling in advanced heart failure. The OCTOPUS-CHF study