1. Articles from alistair c. lindsay

    1-14 of 14
    1. ABSORB Biodegradable Stents Versus Second-Generation Metal Stents : A Comparison Study of 100 Complex Lesions Treated Under OCT Guidance

      ABSORB Biodegradable Stents Versus Second-Generation Metal Stents : A Comparison Study of 100 Complex Lesions Treated Under OCT Guidance

      Objectives The aim of this study was to compare the acute performance of the PLLA ABSORB bioresorbable vascular scaffold (BVS) (Abbott Vascular, Santa Clara, California) with second-generation metal drug-eluting stents (DES) in complex coronary artery lesions. Background Thick polymer-based BVS have different mechanical properties than thin second-generation DES. Data on the acute performance of BVS are limited to simple coronary lesions treated in trials with strict inclusion criteria. Methods Fifty complex coronary lesions (all type American College of Cardiology/American Heart Association B2-C) treated with a BVS undergoing a final optical coherence tomography (OCT) examination were compared with an equal ...

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    2. Optical coherence tomography characteristics of in-stent restenosis are different between first and second generation drug eluting stents ☆

      Optical coherence tomography characteristics of in-stent restenosis are different between first and second generation drug eluting stents ☆

      Aims Characterization of neointimal tissue is essential to understand the pathophysiology of in-stent restenosis (ISR) after drug eluting stent (DES) implantation. Using optical coherence tomography (OCT), we compared the morphologic characteristics of ISR between first and second generation DES. Methods and Results OCT was performed in 66 DES-ISR, defined as > 50% angiographic diameter stenosis within the stented segment. Patients with ISR of first generation sirolimus-eluting stents (SES), paclitaxel eluting stents (PES) and second generation zotarolimus-eluting stents (ZES), everolimus-eluting stents (EES) and biolimus-eluting stents (BES) were enrolled. Quantitative and qualitative ISR tissue analysis was performed at 1-mm intervals along the entire ...

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    3. Predictors of Stent Strut Malapposition in Calcified Vessels Using Frequency-Domain Optical Coherence Tomography

      Predictors of Stent Strut Malapposition in Calcified Vessels Using Frequency-Domain Optical Coherence Tomography

      Background and Aims. Malapposition of stent struts to the arterial wall and suboptimal stent expansion have been linked with poor outcomes following percutaneous coronary intervention (PCI). The purpose of this study was to use optical coherence tomography (OCT) to investigate stent strut malapposition in relation to calcium distribution. Methods and Results. Twenty-three PCI patients underwent OCT before and after stent deployment. Patient and procedural details and lesion characteristics — including the extent and depth of calcification — were measured, and the number of malapposed struts following final postdilatation was quantified. Patient and lesion characteristics associated with malapposition were assessed using univariate and ...

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    4. Optical coherence tomography to guide the treatment of chronic total occlusions (Book Chapter)

      Optical coherence tomography to guide the treatment of chronic total occlusions (Book Chapter)

      Intra-coronary imaging can enhance the success rate of CTO recanalization, improving the mid- to long-term outcome, and decreasing the incidence of sub-optimal stent deployment. Percutaneous coronary interventions (PCI) to chronic total occlusions (CTO) of the coronary arteries are amongst the most challenging lesions faced by the interventional cardiologist. This chapter aims to describe the role of a recently introduced technology optical coherence tomography (OCT) in the treatment of CTO, outlining the principles underlying the use of OCT, summarizing research on the use of this technique to date, and proposing possible future applications in percutaneous coronary interventions. Intravascular ultrasound (IVUS) continues ...

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    5. Putting the microscope on stent thrombosis

      Putting the microscope on stent thrombosis

      Intravascular ultrasound (IVUS) initially gained widespread use in interventional cardiology as a technique to prevent stent thrombosis (ST) by detecting and avoiding angiographically unapparent underexpansion, malapposition and incomplete lesion coverage. In a seminal report from the Milan group, a large series of patients receiving stents for complex lesions showed a very low incidence of thrombosis using aspirin alone1—in contrast with the more aggressive anticoagulation regimes that had been used up to that point—when IVUS guidance was used. The results were subsequently duplicated in a small multicentre study (MUSIC) which used stringent criteria of stent deployment and expansion.2 ...

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    6. Non-invasive imaging of atherosclerosis

      Non-invasive imaging of atherosclerosis

      Atherosclerosis is an inflammatory disease that causes most myocardial infarctions, strokes, and acute coronary syndromes. Despite the identification of multiple risk factors and widespread use of drug therapies, it still remains a global health concern with associated costs. It is well known that the risks of atherosclerotic plaque rupture are not well correlated with stenosis severity. Lumenography has a central place for defining the site and severity of vascular stenosis as a prelude to intervention for relief of symptoms due to blood flow limitation. Atherosclerosis develops within the arterial wall; this is not imaged by lumenography and hence it provides ...

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    7. Choosing the right cell: guidance with three-dimensional optical coherence tomography of bifurcational stenting

      Choosing the right cell: guidance with three-dimensional optical coherence tomography of bifurcational stenting

      A 36-year-old male with progressive exertional angina, inducible anterolateral ischaemia, and single-vessel disease involving the bifurcation left anterior descending coronary artery (LAD)/first diagonal branch (Panel 1A). Panel 1B shows the three-dimensional (3D)-optical coherence tomography (OCT) image of a 2.75 × 28 mm Integrity RESOLUTE® stent with a wire crossing the...

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    8. Feature Of The Week 1/1/12: University of Oxford Investigates Molecular Imaging with OCT Using Ligand-Conjugated Microparticles that Detect Activated Endothelial Cells

      Feature Of The Week 1/1/12: University of Oxford Investigates Molecular Imaging with OCT Using Ligand-Conjugated Microparticles that Detect Activated Endothelial Cells
      Optical Coherence Tomography (OCT) is a high resolution imaging technique used to assess superficial atherosclerotic plaque morphology. Utility of OCT may be enhanced by contrast agents targeting molecular mediators of inflammation. We have previously described the use of microparticles of iron oxide (MPIO) as a contrast agent for MRI that can be targeted to molecular mediators of inflammation via conjugation of specific antibodies. 1 and 4.5 μm diameter MPIO in suspension were visualised and accurately quantified using a LightLab optical coherence tomography system. Bound to PECAM-1 on a plane of cultured endothelial cells under static conditions, 1 μm MPIO ...
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    9. Molecular imaging with optical coherence tomography using ligand-conjugated microparticles that detect activated endothelial cells: Rational design through target quantification

      Molecular imaging with optical coherence tomography using ligand-conjugated microparticles that detect activated endothelial cells: Rational design through target quantification
      Objectives Optical coherence tomography (OCT) is a high resolution imaging technique used to assess superficial atherosclerotic plaque morphology. Utility of OCT may be enhanced by contrast agents targeting molecular mediators of inflammation. Methods and results Microparticles of iron oxide (MPIO; 1 and 4.5μm diameter) in suspension were visualized and accurately quantified using a clinical optical coherence tomography system. Bound to PECAM-1 on a plane of cultured endothelial cells under static conditions, 1μm MPIO were also readily detected by OCT. To design a molecular contrast probe that would bind activated endothelium under conditions of shear stress, we quantified the expression ...
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    10. Optical coherence tomography: has its time come?

      Optical coherence tomography: has its time come?
      Cardiologists using intravascular ultrasound (IVUS) towards the end of the past millennium can recall the time when enthusiasm for a method that was initially seen purely as a powerful research tool began to be substituted by the awareness that intravascular imaging had the potential to revolutionise our understanding of the mechanisms of coronary interventions. Such a revolution occurred in Milan when Antonio Colombo and his group applied ultrasound to elucidate the mechanism of stent thrombosis, at that time common despite high levels of anticoagulation. 1 Many early adopters of optical coherence tomography (OCT) have a similar perception now. A research ...
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    11. Jailed side branches: fate of unapposed struts studied with 3D frequency-domain optical coherence tomography

      Jailed side branches: fate of unapposed struts studied with 3D frequency-domain optical coherence tomography

      We report the case of a 64-year-old man treated for stable angina with two bare-metal stents in the proximal-mid segment of the left anterior descending artery at the bifurcation with the first diagonal and second septal branches without final kissing balloon dilatation. Seven months later he complained of recurrent angina. Frequency-domain optical coherence tomography (OCT) with three-dimensional (3D) reconstruction was performed, showing a thick rim of neointimal proliferation at the ostium of both branches, causing severe restenosis. Deployment of a stent in a bifurcation main branch without opening the struts at the side-branch ostium may facilitate focal restenosis.

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    12. Optical coherence tomography for guidance in bifurcation lesion treatment

      Optical coherence tomography for guidance in bifurcation lesion treatment

      Images acquired of coronary vessels during a pullback of time-domain optical coherence tomography (OCT) are influenced y the dynamics of the heart. T his study explores the feasibility of applying an in-house developed retrospective imaging-based gating method for OCT and the influence of catheter dislocation and luminal changes during the cardiac cycle on the outcome of quantitative OCT (QOCT).

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    13. Form to function: current and future roles for atherosclerosis imaging in drug development

      There is a pressing need for robust imaging markers to assist in the development of drugs for the treatment of atherosclerosis. Conventional imaging methods provide quantitative and morphological data but may be inadequate for assessing a new generation of therapies that modify plaque biology directly. Here, we compare the main imaging modalities used to image atherosclerosis in the clinical-trial setting, and assess their ability to predict clinical outcomes for a given sample size. We consider how emerging molecular and cellular imaging techniques could offer the possibility to quantify changes in biological function at the level of the plaque, even without ...
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    1-14 of 14
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    1. (10 articles) Royal Brompton Hospital
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    Optical coherence tomography for guidance in bifurcation lesion treatment Jailed side branches: fate of unapposed struts studied with 3D frequency-domain optical coherence tomography Optical coherence tomography: has its time come? Molecular imaging with optical coherence tomography using ligand-conjugated microparticles that detect activated endothelial cells: Rational design through target quantification Feature Of The Week 1/1/12: University of Oxford Investigates Molecular Imaging with OCT Using Ligand-Conjugated Microparticles that Detect Activated Endothelial Cells Choosing the right cell: guidance with three-dimensional optical coherence tomography of bifurcational stenting Non-invasive imaging of atherosclerosis Optical coherence tomography for guidance of distal cell recrossing in bifurcation stenting: choosing the right cell matters Putting the microscope on stent thrombosis Quantifying the Separation Between the Retinal Pigment Epithelium and Bruch's Membrane using Optical Coherence Tomography in Patients with Inherited Macular Degeneration Texture preservation and speckle reduction in poor optical coherence tomography using the convolutional neural network Research Assistant in Optical Coherence Tomography (OCT) to Image the Eye at University of Kent