1. Articles from giuseppe ferrante

    1-14 of 14
    1. EuroIntervention Optical Coherence Tomography Assessment of New Generation Mesh-Covered Stents after Carotid Stenting

      EuroIntervention Optical Coherence Tomography Assessment of New Generation Mesh-Covered Stents after Carotid Stenting

      As a public service to our readership, this article - peer reviewed by the Editors of EuroIntervention - has been published immediately upon acceptance as it was received. The content of this article is the sole responsibility of the authors, and not that of the journal or its publishers. As a public service to our readership, this article - peer reviewed by the Editors of EuroIntervention - has been published immediately upon acceptance as it was received.

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    2. Immediate results of bifurcational stenting assessed with optical coherence tomography

      Immediate results of bifurcational stenting assessed with optical coherence tomography

      Background: A tubular stent may adapt with difficulty to coronary bifurcation lesions (CBLs). Methods: Time domain or frequency domain (FD) optical coherence tomography (OCT) was performed to assess strut apposition immediately after stent implantation across four segments inside the bifurcation, in a consecutive series of patients. OCT pullbacks were performed in the main vessel (MV). Results: A total of 13,142 struts in 45 CBL in 41 patients were assessed. Strut malapposition was significantly more frequent in the half bifurcation facing the side-branch (SB) ostium (42.9%) than in the proximal segment of the bifurcation 11.8%, half bifurcation opposite ...

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    3. Current applications of optical coherence tomography for coronary intervention

      Current applications of optical coherence tomography for coronary intervention

      Opticalcoherencetomography (OCT) is the ‘new kid on the block’ in coronary imaging. This technology offers clinicians a high resolution (approximately 15 μm), that is ten times higher than the currently accepted gold standard of intravascular ultrasound and has emerged as the ideal imaging tool for the assessment of superficial components of coronary plaques and stent struts. Novel OCT systems can perform quick and safe scanning of coronary arteries with a non-occlusive technique. A brief summary containing the key physical principles of OCT technology with particular attention to the novel Fourier domain system is presented. This review will focus on clinical ...

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    4. Thrombus Contribution to Very Late Restenosis of Bare-Metal Stent Treated by Excimer Laser Angioplasty: In Vivo Assessment with Optical Coherence Tomography

      Thrombus Contribution to Very Late Restenosis of Bare-Metal Stent Treated by Excimer Laser Angioplasty: In Vivo Assessment with Optical Coherence Tomography
      A 75-year-old, male ex-smoker with hypertension and family history of ischemic heart disease, previous anterior myocardial infarction, and angioplasty with bare-metal stent implantation to the left anterior descending artery 4 years earlier, developed effort angina. A nuclear myocardial scan documented a stress-inducible perfusion defect in the left ventricular anterior wall. The patient was taking 100 mg aspirin daily and a 300 mg loading dose of clopidogrel was administered the day before coronary angiography. Coronary angiography showed focal proximal in-stent restenosis (Figure 1, Panel A). Optical coherence tomography (OCT) (ImageWire and Imaging System M2, LightLab Imaging, Westford, Massachusetts) was performed using ...
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    5. High Levels of Systemic Myeloperoxidase Are Associated With Coronary Plaque Erosion in Patients With Acute Coronary Syndromes: A Clinicopathological Study

      High Levels of Systemic Myeloperoxidase Are Associated With Coronary Plaque Erosion in Patients With Acute Coronary Syndromes: A Clinicopathological Study

      Background— Systemic levels of myeloperoxidase predict prognosis in patients with acute coronary syndromes and are considered a marker of plaque vulnerability. It is not known whether myeloperoxidase is associated with different coronary morphologies (ie, rupture or erosion of the culprit lesion) in patients with acute coronary syndrome. Methods and Results— Twenty-five consecutive patients (aged 67±11 years; 15 men [60%]; 13 [52%] with non–ST-segment elevation acute coronary syndrome and 12 [48%] with acute ST-segment elevation myocardial infarction) were enrolled. Optical coherence tomography classified the culprit lesion as ruptured in 18 (72%) or eroded in 7 patients (28%) and detected ...

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    6. Optical coherence tomography follow-up of the subintimal tracking and re-entry technique for chronic total occlusion

      Optical coherence tomography follow-up of the subintimal tracking and re-entry technique for chronic total occlusion
      A 44-year-old man, a smoker with dyslipidemia, underwent successful percutaneous coronary intervention (PCI) of a chronic total occlusion in the right coronary artery (RCA). The site of occlusion was very proximal. An attemp to cross the leason was performed using an antegrade approach, during which dissection of the ostium occurred and the guidewire entered the false lumen.
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    7. Simple versus complex approaches to treating coronary bifurcation lesions: direct assessment of stent strut apposition by optical coherence tomography.

      Simple versus complex approaches to treating coronary bifurcation lesions: direct assessment of stent strut apposition by optical coherence tomography.
      Introduction and objectives. Stenting of coronary bifurcation lesions carries an increased risk of stent deformation and malapposition. Anatomical and pathological observations indicate that the high stent thrombosis rate in bifurcations is due to malapposition of stent struts. Methods. Strut apposition was assessed with optical coherence tomography (OCT) in bifurcation lesions treated either using the simple technique of stent implantation in the main vessel only or a complex technique (i.e. Culotte’s). A strut was regarded as malapposed if the gap between its endoluminal surface and the vessel wall was greater than its thickness plus an OCT resolution error margin ...
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    8. Optical coherence tomography assessment of a new dedicated bifurcation stent

      Optical coherence tomography assessment of a new dedicated bifurcation stent
      Dedicated bifurcation stents should facilitate deployment and improved coverage of bifurcational lesions. We used optical coherence tomography (OCT) to assess bifurcation lesions treated with a dedicated stent implanted in the side branch (SB) in conjunction with drug eluting stents in the main vessel (MV) in a culotte-like fashion.
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    9. An optical coherence tomography study of a biodegradable vs. durable polymer-coated limus-eluting stent: a LEADERS trial sub-study

      Aims: Incomplete endothelialization has been found to be associated with late stent thrombosis, a rare but devastating phenomenon, more frequent after drug-eluting stent implantation. Optical coherence tomography (OCT) has 10 times greater resolution than intravascular ultrasound and thus appears to be a valuable modality for the assessment of stent strut coverage. The LEADERS trial was a multi-centre, randomized comparison of a biolimus-eluting stent (BES) with biodegradable polymer with a sirolimus-eluting stent (SES) using a durable polymer. This study sought to evaluate tissue coverage and apposition of stents using OCT in a group of patients from the randomized LEADERS trial. Methods ...

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    10. A Multicentre Evaluation of the Safety of Intra-Coronary Optical Coherence Tomography

      Optical coherence tomography (OCT) is increasingly being applied to the coronary arteries. However, the risks associated with the imaging procedure are not yet well defined. The purpose of the present multicentre registry was to access the acute complicaitons associated with the clinical use of intera-coronary OCT in a large number of patients.
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    11. Quantitative analysis of intracoronary optical coherence tomography measurements of stent strut apposition and tissue coverage

      Abstract: Background: The introduction of optical coherence tomography (OCT) as an intracoronary imaging modality has allowed accurate assessment of strut apposition and neointimal tissue coverage. This study set out to assess the inter and intraobserver variability of measurements of acute stent apposition and strut tissue coverage using OCT.Methods: Thirty patients were studied (14 immediately after stent implantation and 16 during follow-up angiography [mean of 4.7±2.8 months]) using OCT (LightLab, Westford, Massachusetts, US). Data analysis was performed by 2 experienced observers. Struts were classified as “embedded", “protruding" or “malapposed" to the vessel well and recorded as percentage ...
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    12. Assessment with optical coherence tomography of a new strategy for bifurcational lesion treatment: The Tryton Side-Branch Stent.

      The Tryton-Side Branch StentTM (Tryton Medical, Inc., Newton, MA, USA) is a dedicated stent designed to provide complete carinal coverage of bifurcational lesions. After implantation of a 18 mm cobalt chromium Tryton stent from the left circumflex into the obtuse marginal branch, recrossing with an everolimus eluting Promus stent and final kissing balloon dilatation, optical coherence tomography (OCT) (LightLab Imaging Inc., Westford, MA, USA) was performed with a non-occlusive technique with motorized pullback (3 mm/s) during continuous pump injection of iso-osmolar contrast, in both LCx and OM1. OCT imaging showed good strut apposition at the level of the carina ...
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    13. The use of intra-coronary optical coherence tomography for the assessment of sirolimus-eluting stent fracture

      Drug-eluting stents (DES) have made a tremendous impact on the practice of percutaneous coronary intervention. Recently however, long-term DES failures have become a focal point, particularly with restenosis and thrombosis. An uncommon, yet important cause of DES failure is stent fracture. Of the two established first generation DES, the sirolimus-eluting stent (SES) has been particularly linked to cases of stent fracture, likely as a result of its closed cell design compared with other DES employing an open cell system. We present 2 cases of SES fracture confirmed using high-resolution intravascular optical coherence tomography giving unique insights into the in-vivo appearance ...
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    14. In-vivo characterisation of coronary atherosclerosis with optical coherence tomography

      In-vivo characterisation of coronary atherosclerosis with optical coherence tomography
      The burden of atherosclerosis has triggered intense interest in the study of “vulnerable” plaques at high risk of rupture. Optical coherence tomography (OCT) has recently contributed to the in-vivo visualisation of plaque, providing unique insights into the atherosclerotic process, previously only attainable through postmortem examination. This technique uses near infrared light and an optical imaging wire attached to a patient interface unit with a pullback speed of up to 3.0 mm/s. In this patient, a 62-year-old man with treatment-resistant dyslipidaemia and stable angina, coronary angiography revealed possible non-flow-limiting plaque in the proximal left anterior descending coronary artery (arrow ...
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    1-14 of 14
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    1. (14 articles) Giuseppe Ferrante
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    In-vivo characterisation of coronary atherosclerosis with optical coherence tomography Optical coherence tomography assessment of a new dedicated bifurcation stent Simple versus complex approaches to treating coronary bifurcation lesions: direct assessment of stent strut apposition by optical coherence tomography. Optical coherence tomography follow-up of the subintimal tracking and re-entry technique for chronic total occlusion High Levels of Systemic Myeloperoxidase Are Associated With Coronary Plaque Erosion in Patients With Acute Coronary Syndromes: A Clinicopathological Study Thrombus Contribution to Very Late Restenosis of Bare-Metal Stent Treated by Excimer Laser Angioplasty: In Vivo Assessment with Optical Coherence Tomography Remote scanning for ultra-large field of view in wide-field microscopy and full-field OCT Inadequate Intimal Angiogenesis as a Source of Coronary Plaque Instability Comparison of optical coherence tomography angiography results of adult patients with Familial Mediterranean fever and healthy individuals Intravascular ultrasound or optical coherence tomography-defined anatomic severity and hemodynamic severity assessed by coronary physiologic indices Optical coherence tomography in the assessment of cutaneous cancer margins of the face: an immediate ex vivo study Global Analysis of Macular Choriocapillaris Perfusion in Dry Age-Related Macular Degeneration using Swept-Source Optical Coherence Tomography Angiography